Comparative Evaluation Of Healing Pattern After Surgical Excision Of Oral Mucosal Lesions By Using Platelet Rich Fibrin (Prf) Membrane And Collagen Membrane As Grafting Materials- A Randomized Clinical Trial

Publication date: Available online 8 March 2018
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Monica Mahajan, Mithilesh Kumar Gupta, Chandrashekhar Bande, Vikas Meshram
PurposeTo compare the healing potential of platelet rich fibrin membrane (PRF) and collagen membrane in oral mucosal healing.Patients and MethodsThirty patients having oral premalignant lesions were randomly included in the study and divided in two Groups A and B. After excising lesions under local anesthesia, Group A and B patients were grafted with PRF membrane and collagen membrane, respectively. Patients were evaluated at 7^th, 15^th, 30^th and 60^th days postoperatively for pain, healing and complications such as recurrence, fibrosis, scar hypertrophy and loss of vestibular depth.ResultsIn Group A, 66.66% of patients reported significantly less pain postoperatively at 15^th day follow-up than those treated in Group B. 30^th day follow-up showed 86.66% cases in Group A showing no pain as compared to 60% in Group B. Pain scores were similar at the 7^th and 60^th follow-up days. Healing was accelerated in Group A on 15^th and 30^th day follow-up, but it was the same on the 60^th day. Complications like fibrosis, loss of vestibular depth and scar hypertrophy was seen in Group B. Recurrence were seen in 1 patient from Group A at the 60^th day follow-up.ConclusionPRF proved to be a better alternative to collagen membrane for grafting of the oral mucosal surgical defects. However, further study with larger sample size is required to prove its efficacy.



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