CSF {beta}-amyloid and white matter damage: unravelling the neuropathology of Alzheimers disease

White matter lesion load may be associated with lower CSF β-amyloid levels in Alzheimer's disease (AD) subjects

The great advance of neuroimaging techniques witnessed in the last 10 years has enabled an intensive debate on the role of white matter (WM) lesions in the pathophysiology of AD. Once regarded by the early literature as a common result of cerebrovascular pathology, WM alterations, particularly those found in predementia stages, have been consistently linked to neurodegeneration processes by recent multimodal studies. One particular relevant issue is whether WM primary degeneration evolves independently from grey matter (GM) atrophy or occurs as a secondary product of cortical atrophy, as posited by the Wallerian degeneration hypothesis.1 2 The work from Pietroboni et al3 thus sheds light on this theme by investigating some putative mechanisms linking amyloid deposition and WM load in patients with low and high AB_1–42 levels.

The...

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2Dw2qxZ