Ameloblastic neoplasia spectrum: a cross-sectional study of MMPS expression and proliferative activity.

Related Articles

Ameloblastic neoplasia spectrum: a cross-sectional study of MMPS expression and proliferative activity.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Nov 24;

Authors: da Silva AD, Nóbrega TG, Saudades AW, Otero MI, Danilevicz CK, Magnusson AS, Saraiva Homem de Carvalho AL, Rados PV, Carrard VC, Visioli F, Sant'Ana Filho M

Abstract
OBJECTIVE: To compare the proliferation and the expression of matrix metalloproteinases (MMPs; MMP-2 and MMP-9) in solid and unicystic ameloblastomas with ameloblastic carcinomas.
STUDY DESIGN: Five cases of ameloblastic carcinoma (AC), 18 cases of solid ameloblastoma (SA), and seven of unicystic ameloblastoma (UA) were selected. The immunohistochemical expression of MMPs was assessed by the percentage of positive tumor cells and stained stroma. The mean argyrophilic nucleolar organizer region (AgNOR) and the percentage of cells with more than one AgNOR per nucleus were evaluated.
RESULTS: Statistically significant higher mean AgNOR was observed in AC than in SA and UA. MMP-2 was expressed similarly in tumor and stroma among groups. MMP-9 was higher in the stroma of SA than that of UA (P = .0484).
CONCLUSIONS: The cell proliferation was related to the greater aggressiveness of AC. High expression of MMP-2 and MMP-9 in all lesions highlighted the importance of these enzymes in the biology of ameloblastic tumors.

PMID: 26899292 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1oGO4nJ
via IFTTT