The role of serum vitamin D levels in vitiligo.

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The role of serum vitamin D levels in vitiligo.

Postepy Dermatol Alergol. 2016 Aug;33(4):300-2

Authors: Karagün E, Ergin C, Baysak S, Erden G, Aktaş H, Ekiz Ö

Abstract
INTRODUCTION: Vitiligo is a common acquired pigmentary skin disorder. Vitamin D is responsible for skin pigmentation, increases tyrosinase activity and melanogenesis, and exhibits immunoregulatory functions. Low levels of vitamin D are associated with many autoimmune diseases, including systemic lupus, diabetes mellitus, rheumatoid arthritis, multiple sclerosis and alopecia areata. Few reports have evaluated serum vitamin D levels in vitiligo patients, and their results are conflicting.
AIM: To evaluate serum vitamin D levels of vitiligo patients and compare the results with controls.
MATERIAL AND METHODS: In total, 50 vitiligo patients and 47 controls were enrolled in the study. Vitamin D levels were measured from blood samples. Group comparisons were performed using appropriate statistical methods.
RESULTS: The patients had lower serum vitamin D levels than the controls, but this difference was not significant (p = 0.570).
CONCLUSIONS: It remains unknown whether vitamin D deficiency causes vitiligo. Larger controlled studies are required to prove whether low circulating vitamin D is a causative factor in vitiligo.

PMID: 27605903 [PubMed]

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