Risk of Major Limb Amputation in diabetic foot ulcer and accompanying disease: A meta-analysis

Publication date: Available online 5 August 2017
Source:Journal of Plastic, Reconstructive & Aesthetic Surgery
Author(s): Jin Yong Shin, Si-Gyun Roh, Basel Sharaf, Nae-Ho Lee
BackgroundLimb amputation in diabetic patients raises important issues regarding lower quality of life and survival rates. This meta-analysis is aimed to identify predictive factors accompanying diseases with high major amputation rates in diabetic patients.MethodsA systematic literature review and meta-analysis were performed using MEDLINE, EMBASE and Cochrane databases. Eight variables were extracted from the included studies and evaluated based on major amputation rates. The Newcastle-Ottawa scale (NOS) was utilized to assess the quality of the studies.ResultsThe search strategy identified 101 publications. After screening, 10 articles were selected for review. Hypertension, ischemic heart disease, cerebrovascular disease and peripheral vascular disease were identified as predictive variables of higher major amputation rate.ConclusionsAlthough further investigation of long-term and prospective studies is needed, we identified four variables as predisposing factors for higher major amputation in diabetic patients through meta-analysis.



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