Analysis of GNA13 Protein in Follicular Lymphoma and its Association With Poor Prognosis

GNA13 is a G protein involved in modulating tumor proliferative capacity, infiltration, metastasis, and migration. Genomic alteration of GNA13 was frequently observed in follicular lymphoma (FL). In this study, we examined 167 cases of FL by immunostaining of GNA13 using tissue microarray to evaluate the clinical significance. There were 26 GNA13-positive cases (15.6%) and 141 GNA13-negative cases (84.4%). GNA13-positive cases had a higher incidence of early progression of disease for which disease progression was recognized within 2 years compared with GNA13-negative cases (P=0.03). There were no significant differences in other clinicopathologic factors including histological grade, BCL2-IGH translocation, immunohistochemical phenotype, and Follicular Lymphoma International Prognostic Index. In addition, overall survival and progression-free survival were poorer in GNA13-positive cases than in GNA13-negative cases (P=0.009 and 0.005, respectively). In multivariate analysis, GNA13 positivity was found to be a poor prognostic factor for overall survival and progression-free survival. Thus, GNA13 protein expression was an independent prognostic factor and may affect disease progression in FL. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://ift.tt/1hexVwJ Present address: Noriaki Yoshida, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. J.S., H.M., and N.Y. were responsible for conception and design. T.K., T.S, K.M., Y.I., K. Kato, K.N., and K.A. provided study materials or patients. J.S., H.M., N.Y., T.K., Y.S., D.K., and K. Kawamoto performed collection and assembly of data. J.S., H.M., N.Y., K.S., T.T., M.S., and K.O. performed data analysis and interpretation. J.S. wrote the manuscript. Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Correspondence: Hiroaki Miyoshi, MD, PhD, Department of Pathology, School of Medicine, Kurume University, Kurume, Japan 830-0011 (e-mail: miyoshi_hiroaki@med.kurume-u.ac.jp). Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

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