Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation. Conflicts of Interest and Source of Funding: Supported in parts by the National Sustainability Program I (NPU I) Nr. LO1503 and by the grant SVV–2017 No. 260 391 provided by the Ministry of Education Youth and Sports of the Czech Republic. The NGS analysis was in part supported by Ignyta Inc., San Diego, CA. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Correspondence: Alena Skalova, MD, PhD, Sikl's Department of Pathology, Medical Faculty of Charles University, Faculty Hospital, E. Benese 13, Plzen 305 99, Czech Republic (e-mail: skalova@fnplzen.cz). Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

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