Publication date: January 2018
Source:Clinical Neurology and Neurosurgery, Volume 164
Author(s): Chirag K. Patel, Ravi Vemaraju, James Glasby, Joanne Shires, Tessa Northmore, Malik Zaben, Caroline Hayhurst
ObjectivesMaximal surgical resection of high grade brain tumours is associated with improved overall survival (OS). It carries the risk of neurological deterioration leading to worsening performance status (PS), which may affect overall survival and preclude patients from adjuvant therapy. We aim to review the changes in performance status of patients undergoing resection of high grade tumours and metastases and the impact of changes on overall survival.Patients and methodsA prospective study of the perioperative performance status of 75 patients who underwent primary resection of malignant primary brain tumour or solitary metastasis in a single centre. Data on patients' demographics, tumour histology and overall survival were also collected. WHO performance status was recorded pre-operatively and at intervals following surgery.ResultsOf the 75 patients (35 males, 40 females, median age 61 years at diagnosis), 50 had primary malignant brain tumours, 25 had metastasis. Although PS dropped at postoperative day 1 in 14 patients (18.7%), 28% improved by day 5 and there was significant improvement by day 14 (41%, p=0.02). The number of patients with PS 3 or worse changed from 4% pre-operatively (n=3) to 8% (n=6). Overall survival is better in those whose PS remained improved or unchanged at 2 weeks after surgery compared to those whose PS deteriorated; high grade glioma median survival 15.67 vs. 2.4 months (p=0.005) and metastasis median survival 8.53 vs.2.33 months (p=0.001).ConclusionOur data demonstrates that although PS may deteriorate immediately after surgery, the majority of patients regain their baseline PS or improve by 2 weeks postoperatively; decisions on fitness for adjuvant treatment should therefore be delayed until then. In those patients whose PS declines following surgery overall survival is poor.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2jnEwOa
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
►
2020
(1051)
- ► Δεκεμβρίου (292)
- ► Σεπτεμβρίου (60)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
▼
2017
(33948)
-
▼
Δεκεμβρίου
(6715)
-
▼
Δεκ 06
(409)
- Pedicled iliac crest bone flap transfer for the tr...
- Long-term stability of dental adhesive incorporate...
- Quantifying the prognostic significance in gliobla...
- Practical prognostic score for predicting the exte...
- Clinical outcomes of primary intracranial malignan...
- Brain tumors associated with psychogenic non-epile...
- A right amygdalohippocampectomy: A diagnostic chal...
- Trends in peri-operative performance status follow...
- Spinal muscular atrophy with progressive myoclonic...
- Circadian rhythm in idiopathic normal pressure hyd...
- Bilateral facial nerve palsies secondary to chroni...
- Cerebral Arterio-Venous Malformations in the Paedi...
- Quantitative texture analysis in the prediction of...
- Clinical and radiographic comparison of cervical d...
- Prediction of Persistent Hemodynamic Depression af...
- Comparison of dynamic cervical implant versus ante...
- SMART coils for intracranial aneurysm embolization...
- Intraventricular hemorrhage related to AVM rupture...
- Primary sinonasal tuberculosis: Our experiences in...
- The role of Mannose-binding lectin 2 (MBL2) gene p...
- Surgical strategy for frontal sinus inverted papil...
- Intracranial metastasis of follicular thyroid carc...
- Atypical multiple metastasis of recurrent pleomorp...
- Venous thromboembolism events after breast reconst...
- Génioplasties d’augmentation prothétiques et osseu...
- Le lambeau médial sural perforant : bases anatomiq...
- Author Index: Volume 45
- Editorial Board
- BMP-2 plasmid DNA-loaded chitosan films – A new st...
- Corrigendum to “The influence of different abutmen...
- EACMFS Awards
- Keyword index: Volume 45
- Contents: Volume 45
- Subcranial and orthognathic surgery for obstructiv...
- Announcements
- Author Index: Volume 45
- Editorial Board
- BMP-2 plasmid DNA-loaded chitosan films – A new st...
- Corrigendum to “The influence of different abutmen...
- EACMFS Awards
- Keyword index: Volume 45
- Contents: Volume 45
- Subcranial and orthognathic surgery for obstructiv...
- Announcements
- Issue Information - TOC
- Issue Information - Journal Info page
- Wrist accelerometry for physical activity measurem...
- Limitations in learning: How treatment verificatio...
- Treatment planning considerations for permanent br...
- The mechanism study of miR-125b in occurrence and ...
- Asymmetrical Arterial Diameters
- Re: “Management of Atherosclerotic Carotid and Ver...
- Floating Aortic Thrombus in a Non-aneurysmal and N...
- Response to “Re. Management of Atherosclerotic Car...
- Double Banana Technique: A Fruity Solution for Tre...
- Efficient Differentiation of Bone Marrow Mesenchym...
- Widespread enlarged perivascular spaces associated...
- The underlying physiological basis of the desert r...
- Development of a Web-Based Psychosocial Interventi...
- Reply
- Chronic obstructive pulmonary disease exacerbation...
- HER2 copy number of circulating tumour DNA functio...
- The use of palliative medications before death fro...
- Improved stratification of pT1 melanoma according ...
- C-statistic: A brief explanation of its constructi...
- Toxocara species exposure, symptoms of asthma, and...
- Spectrum and prevalence of reactions to marijuana ...
- Could calcium channel blockers treat 2 illnesses w...
- Table of Contents
- Editorial Board
- Innate lymphoid cells and allergic disease
- Instructions for Authors
- Baseline asthma burden, comorbidities, and biomark...
- Burden of skin pain in atopic dermatitis
- Author Index to Volume 119, 2017
- Information for Readers
- Increasing our knowledge base of asthma
- The clinical role of fractional exhaled nitric oxi...
- Restrictive surgical approach to palliate angina i...
- Contents: Volume 45
- Keyword index: Volume 45
- Announcements
- EACMFS Awards
- Author Index: Volume 45
- Editorial Board
- Diagnostic and treatment effects of sialendoscopy ...
- Factors influencing recurrent emergency department...
- Cannabinoids for epilepsy: What do we know and whe...
- Electroencephalography and behavior patterns durin...
- On Exploring Vocal Ornamentation in Byzantine Chant
- Neuronal dynamics supporting formation and recombi...
- Altered synaptic transmission and maturation of hi...
- Robust mixture modeling reveals category-free sele...
- Rhythmic arm cycling training improves walking and...
- Response inhibition activates distinct motor corti...
- Phasic and Tonic Cell Types in the Zebra Finch Aud...
- Reward activations and face fields in monkey cingu...
- The influence of vertical disparity gradient and c...
- BOLD temporal variability differentiates wakefulne...
- Task dependence of odor discrimination: choosing b...
-
▼
Δεκ 06
(409)
- ► Σεπτεμβρίου (6470)
-
▼
Δεκεμβρίου
(6715)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου