Αρχειοθήκη ιστολογίου

Τετάρτη 6 Δεκεμβρίου 2017

Practical prognostic score for predicting the extent of resection and neurological outcome of gliomas in the sensorimotor area

elsevier-non-solus.png

Publication date: January 2018
Source:Clinical Neurology and Neurosurgery, Volume 164
Author(s): Giannantonio Spena, Federico D'Agata, Pier Paolo Panciani, Luciano Buttolo, Michela Buglione di Monale Bastia, Marco Maria Fontanella
ObjectiveIn this prospective study, we assessed the utility of a novel prognostic score (PS) in guiding the surgical strategy of patients with sensorimotor area gliomas.Patients and methodsForm December 2012 to April 2016, we collected data from patients diagnosed with brain gliomas in the sensorimotor area. All the patients had intraoperatively confirmed contiguity or continuity with sensorimotor cortical and subcortical structures. Several clinical and radiological factors were analyzed to generate a PS for each patient (range 1–8). The end-points included the extent of resection (EOR) and neurological outcome (modified Rankin Score; mRS). We assessed the predictive power of the PS using different analyses. Crosstabs analyses and Fisher's exact test (Fet) were used to evaluate the possible predictive parameters, and for the classification of positive or negative outcomes for the chosen proxies; the significance threshold was set at p<0.05.ResultsUsing independent t-tests, we compared the mRS at different time points (pre, post, and at 6 months) for 2 subgroups from the total sample using a cut-off PS value of 4. For the EOR, a PS value of ≥5 was predictive of successful outcome, a value of 4 indicated an uncertain outcome, and a value of ≤3 predicted a worse outcome.ConclusionsThis PS value can be easily used in clinical settings to help predict the functional outcome and EOR in sensorimotor area tumors. Integration with information from fMRI, DTI, and TMS, along with MRI spectroscopy could further enhance the value of this PS.



from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2nDPJyI

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου