Lasting effects of early postnatal use of clomipramine on sleep-wakefulness cycle are ameliorated by ICV microinjection of Orexin-a (Hypocretin-1) and Orexin-b (Hypocretin-2)

Introduction: The main goal of present study was to consider hypothalamic Orexin (Hypocretin) producing neurons as the neurochemicaly identified cell population functional over-activation of which will contribute to the normalization of sleep-wakefulness disturbances produced in adult rats by their early postnatal exposure to Clomipramine. Pre-clinical studies have shown before that early postnatal exposure of rat pups to Clomipramine have lasting effects manifested in adult age in behavioral and sleep disturbances alike to disorders characteristic for major depressive disease (MDD).

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