Sleep-dependent motor sequence memory consolidation in individuals with periodic limb movements

Introduction: Periodic limb movement disorder (PLMD) is a neurodegenerative disease resulting from striatal dopamine deficiency, characterized by periodic limb movements (PLMs), associated with disrupted non-rapid eye movement (NREM) sleep. Motor skill memory consolidation recruits the striatum, and learning-dependent striatal activation is associated with NREM sleep. Therefore, we investigated whether individuals with clinically significant PLMs had learning and sleep-related memory deficits, and if these deficits related to sleep quality and symptom severity.

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