Αρχειοθήκη ιστολογίου

Τρίτη 2 Ιανουαρίου 2018

Local changes in computational non-rapid eye movement sleep depth in infants

Publication date: February 2018
Source:Clinical Neurophysiology, Volume 129, Issue 2
Author(s): Anna-Liisa Satomaa, Outi Saarenpää-Heikkilä, Eero Huupponen, Turkka Kirjavainen, Juhani Heinonen, Sari-Leena Himanen
ObjectiveDeep NREM sleep and its hallmark EEG phenomenon slow wave activity (SWA) are under homeostatic control in adults. SWA is also locally regulated as it increases in the brain areas that have been used intensively. Moreover, in children, SWA is a marker of cortical maturation. In the present study the local properties of NREM sleep depth were evaluated using the quantitative mean frequency method. We aimed to study if age is related to NREM sleep depth in young infants. In addition, we studied if young infants have local differences in their NREM sleep.MethodsAmbulatory over-night polysomnographies were recorded in 59 healthy and full-term infants at the age of one month. The infants were divided into two age groups (<44 weeks and ≥44 weeks) to allow maturational evaluations.ResultsThe quantitative sleep depth analysis showed differences between the age groups. In addition, there were local sleep depth differences within the age groups.ConclusionsThe sleep depth change with age is most likely related to cortical maturation, whereas the local sleep depth gradients might also reflect the use-dependent properties of SWA.SignificanceThe results support the idea that young infants have frontal cortical processing.



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