Nerve alterations showing autophagy in two patients with lichen aureus

Lichen aureus is a rare, chronic, persistent purpuric dermatosis clinically characterised by striking yellow- to bronze-colored lesions. Histologically, lichen aureus differs from other pigmented purpuric dermatoses in containing dense, band-like infiltrates closely associated with the epidermis. This report describes two patients with lichen aureus, a 20-year-old woman with a lesion on her right arm and a 51-year-old man with a lesion on the right side of his groin. Skin biopsy specimens revealed almost identical findings in both patients, including dense band-like infiltrates containing lymphocytes, histiocytes with hemosiderin deposits scattered extravasated red blood cells and nerve alterations at the dermo-epidermal interface. The nerves within the lesions were filled with granules, which stained positive with antibody to microtubule-associated protein 1A/1B-light chain 3, suggesting autophagy within the nerves. These altered nerves were present only in areas of band-like dermal lymphocytic infiltration. Electron microscopy of the lesions showed the accumulation of autophagosomes in Schwann cells. To our knowledge, this report is the first to describe nerve alterations showing autophagy in patients with lichen aureus.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2HBzVSZ