Possible association between Helicobacter pylori infection and vocal fold leukoplakia.

Possible association between Helicobacter pylori infection and vocal fold leukoplakia.

Head Neck. 2018 Mar 06;:

Authors: Chen M, Chen J, Yang Y, Cheng L, Wu HT

Abstract
BACKGROUND: Several studies have indicated the larynx as possible Helicobacter pylori (H. pylori) reservoirs. This study explored the association between H. pylori and vocal fold leukoplakia.
METHODS: The case-control study involved 51 patients with vocal fold leukoplakia and 35 control patients with vocal polyps. Helicobacter pylori was detected in tissues by the rapid urease test, nested polymerase chain reaction (PCR), and single-step PCR. The H. pylori-specific immunoglobulin antibodies were detected in plasma by enzyme-linked immunosorbent assay (ELISA).
RESULTS: Helicobacter pylori-positive rate of vocal fold leukoplakia and vocal polyps was 23.5% versus 11.4% (P = .157), 37.2% versus 14.3% (P = .020), 27.5% versus 8.6% (P = .031), and 70.6% versus 68.6% (P = .841) detected by rapid urease test, nested PCR, single-step PCR, and ELISA, respectively. Regression analysis indicated that H. pylori infection (P = .044) was the independent risk factor for vocal fold leukoplakia.
CONCLUSION: Helicobacter pylori infection exists in the larynx and may be associated with vocal fold leukoplakia.

PMID: 29509297 [PubMed - as supplied by publisher]

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