Probable drug–drug interaction between erlotinib and amiodarone causes severe neurotoxicity in a patient with advanced lung cancer

Drug–drug interactions (DDIs) are of great concern in the treatment of cancer, especially when target therapies, such as tyrosine kinase inhibitors, are being used. Here, we report a case of probable DDI between erlotinib and amiodarone leading to severe neurotoxicity. Amiodarone inhibits P-glycoprotein (P-gp), for which erlotinib is a substrate. P-gp is an important drug transporter that is involved in limiting the blood–brain barrier penetration of erlotinib. Clinicians should be aware of emerging data characterizing the effect of the P-gp transport system on drug exposure and its potential for DDI.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2FLqSNT