Reciprocal Interactions Among OSA, Obesity, and Sleep Duration

Abstract

Purpose of Review

Obesity has become a serious public health concern worldwide in recent decades. Obesity is the most important factor in and a predictor of obstructive sleep apnea (OSA), and as high as 70% of patients with OSA are obese. The purpose of this review was to investigate reciprocal interactions among OSA, obesity, and sleep duration from recent studies.

Recent Findings

It was thought that chronic intermittent hypoxia and sleep fragmentation over the years in persons with sleep apnea could lead to changes in central control of energy regulation. There is an emerging concept that OSA itself may in turn reinforce the obese state. Given the plausible reciprocal relationship between obesity and OSA, treating OSA with continuous positive airway pressure (CPAP) could be thought to act against weight gain as previously reported. However, recent studies revealed that CPAP therapy actually resulted in weight gain. On the other hand, it has been discussed that short sleep duration induced obesity through appetite-related hormones such as leptin and ghrelin. In addition, it has been reported that OSA induced short sleep duration.

Conclusions

Thus, to consider the relationship between OSA and obesity, it is important to know the reciprocal relationships among OSA, obesity, and short sleep duration.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader https://ift.tt/2HtCoyn