Thyroid Stimulating Hormone Levels are Associated with Cardiometabolic Risk Factors in Euthyroid Adolescents.

Thyroid Stimulating Hormone Levels are Associated with Cardiometabolic Risk Factors in Euthyroid Adolescents.

Thyroid. 2016 Sep 6;

Authors: Le TN, Celi F, Wickham EP

Abstract
BACKGROUND: Increased TSH levels and free T3 to free T4 (fT3:fT4) ratios, even within the euthyroid range, have been associated with cardiometabolic risk factors in adults but are less characterized in youth. We sought to determine relations between TSH, thyroid hormones, and cardiometabolic risk factors in euthyroid adolescents.
METHODS: Data were extracted from the United States NHANES (National Health and Nutrition Examination Survey, 2007-2010) for univariate and multivariate analyses of TSH, thyroid hormones, body mass index (BMI), blood pressure, lipids, and glucose metabolism. Subjects aged 12-18 years, with normal TSH and anti-TPO-antibody levels, without history of thyroid disease, diabetes, or treatment of hypertension/dyslipidemia (n=1,167) were included. TSH and thyroid hormones were assessed for impact on BMI Z-score, systolic and diastolic blood pressure (SBP, DBP), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), and triglycerides, and glucose metabolism.
RESULTS: Univariate analyses revealed positive linear relations between TSH and SBP, TC, fasting and 2-hour glucose, and HOMA-IR (homeostasis model assessment of insulin resistance). The fT3:fT4 ratio negatively correlated with HDL-C but positively with BMI Z-score, SBP, triglycerides, fasting and 2-hour glucose, fasting insulin, and HOMA-IR. In multivariate analyses controlling for age, sex, race, and BMI Z-score, relations between TSH and both TC and fasting glucose remained significant, and the fT3:fT4 ratio was positively associated with fasting glucose and HOMA-IR.
CONCLUSIONS: In an unselected population of euthyroid U.S. adolescents, TSH and thyroid hormones correlate with multiple cardiometabolic risk factors, with age- and sex-independent effects on cholesterol and glucose metabolism.

PMID: 27599541 [PubMed - as supplied by publisher]

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