USP6 gene rearrangement differentiate primary paranasal sinus solid aneurysmal bone cyst from other giant cell-rich lesions, report of a rare case

Publication date: Available online 5 December 2017
Source:Human Pathology
Author(s): Hung-Ru Li, Chih-Feng Tai, Hsuan-Ying Huang, Ying-Tai Jin, Yi-Ting Chen, Sheau-Feng Yang
Aneurysmal bone cysts (ABCs) mostly occur in the metaphysis of long bones. Primary paranasal ABCs are extremely rare and most reported cases reveal typical histopathological features including cystic space with fibrous septa and hemorrhage. Solid variant ABCs or solid ABCs lacking cyst formation may be histologically indistinguishable from giant cell reparative granulomas (GCRGs), giant cell tumor of bone (GCTB), and brown tumor. Here we report the case of a 24-year-old female with a paranasal mass diagnosed as USP6-rearranged solid ABC, mimicking GCRG, GCTB and brown tumor. For paranasal sinus bone or soft tissue tumors contatining numberous giant cells, molecular analysis including the USP6 gene may serve as a useful diagnostic tool to distinguish solid ABCs from other giant cell-rich lesions.



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