Nature Communications, Published online: 07 September 2020; doi:10.1038/s41467-020-18302-1Transcriptional anti-repressors have been largely absent in the design of regulated genetic circuits. Here, the authors present a workflow of the engineering of non-natural anti-reperssors that can be built into NOT oriented logic gates.
Mon Sep 07, 2020 03:00
Nature Communications, Published online: 07 September 2020; doi:10.1038/s41467-020-18288-wClonal ascidians are able to undergo whole body regeneration (WBR), where entire new bodies can be regenerated from blood vessel fragments. Here, the authors provide evidence in Botrylloides diegensis supporting pou3 and vasa expressing blood-borne cells isolated with anti-IA6 antibody as candidate stem cells responsible for WBR.
Mon Sep 07, 2020 03:00
Nature Communications, Published online: 07 September 2020; doi:10.1038/s41467-020-18311-0Extracellular vesicles (EVs) are present in circulation at relatively early stages of disease, providing potential opportunities for early cancer diagnosis. Here, the authors report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific EV purification system for early detection of HCC by performing digital scoring on the purified EVs.
Mon Sep 07, 2020 03:00
Nature Communications, Published online: 07 September 2020; doi:10.1038/s41467-020-18177-2Hollow multishell structures (HoMSs) consist of multiple shells with voids between them that provide separate reaction environments within the same assembly. Here, the authors used TiO2-HoMS to deliver a broad-spectrum antibacterial agent, in three-stages and in response to environmental changes.
Mon Sep 07, 2020 03:00
Nature Communications, Published online: 07 September 2020; doi:10.1038/s41467-020-18200-6Drugs of abuse have been shown to perturb circadian rhythms. Here, the authors show in mice that cocaine exposure modulates circadian gene expression in the striatum through a previously unappreciated pathway that involves dopamine D2 receptors and the nuclear receptor PPARγ.
Mon Sep 07, 2020 03:00
Nature Communications, Published online: 07 September 2020; doi:10.1038/s41467-020-18290-2DNA glycosylases are lesion-specific enzymes that recognize specific nucleobase damages and catalyze their excision through cleavage of the glycosidic bond. Here, the authors present the crystal structures of human 8-oxoguanine (oxoG) DNA glycosylase bound to undamaged DNA and to DNA containing an intrahelical oxoG lesion and further analyse these structures with molecular dynamics simulations, which allows...
Mon Sep 07, 2020 03:00
Nature Communications, Published online: 07 September 2020; doi:10.1038/s41467-020-18297-9Identification of individuals at risk of severe COVID-19 disease could inform treatment and public health planning. Here, the authors develop and validate a risk prediction model for COVID-19 mortality in Israel by building a model for severe respiratory infection and recalibrating it using COVID-19 case fatality rates.
Mon Sep 07, 2020 03:00
Nature Communications, Published online: 07 September 2020; doi:10.1038/s41467-020-17887-xThe relationship between atmospheric CO2 and climate during the Eocene greenhouse remains uncertain. Here authors show that Eocene CO2 and climate sensitivity was high during the warmest intervals and declined as global climate cooled, with implications for the Earth’s future warming climate.
Mon Sep 07, 2020 03:00
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