Major Durable Response of Pembrolizumab in Chemotherapy Refractory Small Cell Bladder Cancer: A Case Report:
Small cell carcinoma of the urinary bladder is a rare subtype (incidence of 1–9/1,000,000), characterized by an aggressive behavior with early metastasis and poor prognosis. Chemotherapy, radiation, and surgery are the usual treatment options, but to date, no accepted standard treatment exists. Since small cell bladder cancer shares similar clinicopathological features with small cell lung cancer, the same type of chemotherapy has been used. Recently, immune checkpoint inhibitors have shown effect in small cell lung cancer, but data regarding small cell bladder cancer is insufficient. Here we present a case where a 73-year-old male with chemorefractory metastatic small cell bladder cancer received a successful treatment with immune checkpoint inhibitor pembrolizumab resulting in a major durable response and no side effects. To our knowledge, this is the second case report on successful treatment of the rare subtype of small cell bladder cancer with an immune checkpoint inhibitor, supporting the use of pembrolizumab as a therapeutic option for small cell bladder cancer. Serum neuron-specific enolase was a useful biomarker both for chemo- and immunotherapy response.
Case Rep Oncol 2020;13:1059–1066
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
▼
2020
(1051)
- ► Δεκεμβρίου (292)
-
▼
Σεπτεμβρίου
(60)
-
▼
Σεπ 08
(40)
- Medicine by Alexandros G. Sfakianakis
- Antibodies
- Royal Society of Chemistry (Great Britain) Socie...
- Novel therapeutic strategies for treating Pseudomo...
- Aberrantly expressed lncRNAs and mRNAs after botul...
- Transcriptomic Analysis of Peripheral Blood Mononu...
- Major Durable Response of Pembrolizumab in Chemoth...
- Complete Clinical Response in Stage IVB Endometrio...
- Primary Undifferentiated Pericardial Sarcoma after...
- “Suprascapular canal”: Anatomical and topographica...
- Meranzin hydrate elicits antidepressant effects an...
- Experimental autoimmune encephalopathy (EAE)-induc...
- IL-10 production by ILC2s requires Blimp-1 and cMa...
- Chest Computed Tomography Findings in Asymptomatic...
- Inhaled Molgramostim Therapy in Autoimmune Pulmona...
- Efficacy of oral rosuvastatin intervention on HDL ...
- Non-glucose risk factors in the pathogenesis of di...
- Although cow’s milk is rich in calcium, it does no...
- Guidelines Suggesting Children Avoid Plant-Based M...
- Novel basophil activation test in diagnosis of pov...
- Challenges in Skin Testing for Progestogen Hyperse...
- combining OCT with autofluorescence imaging for id...
- Biomedicine & Pharmacotherapy
- Acta Cirurgica Brasileira
- Nature Communications - current - nature.com sci...
- American Society for Stereotactic and Functional...
- American Journal of Otolaryngology
- Journal of Neurosurgical Anesthesiology - Curren...
- Clinical Imaging
- Clinical Cancer Research Online First Articles
- BioMed Research International
- Nanomaterials<
- Molecules
- International Journal of Molecular Sciences
- International Journal of Environmental Research ...
- Cells
- Cancers
- Antibiotics
-
▼
Σεπ 08
(40)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
►
2017
(33948)
- ► Δεκεμβρίου (6715)
- ► Σεπτεμβρίου (6470)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου