Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01526A, PaperVictor Vinoth, Pugazhenthiran Nalandhiran, Mangalaraja R Viswanathan, Asad Syed, Nataj Marraiki, hector Valdes, Sambandam AnandanThe huge demand for the clinical diagnosis of diabetes mellitus has prompted the development of great-performance sensing platforms for glucose detection. Non-enzymatic glucose sensors are getting always closer to their...The content of this RSS Feed (c) The Royal Society of Chemistry
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Abstract Due to the complicated histopathological characteristics of renal neoplasms, traditional distinguishing of clear‐cell renal‐cell carcinoma (ccRCC) by naked eyes of experienced pathologist remains labor‐intensive and time‐consuming. Here, we extracted quantitative features of hematoxylin‐eosin stained images using CellProfiler and performed machine‐learning method to develop and verify a novel computational recognition of digital pathology for diagnosis and prognosis of ccRCC patients in...
Mon Sep 07, 2020 20:51
Abstract In patients with pancreatic ductal adenocarcinoma (PDAC), optimal treatment selection, including multimodality regimens such as neoadjuvant chemoradiotherapy (NACRT) can be clinically transformative. Unfortunately, currently no predictive biomarkers are available that can guide the use of NACRT in PDAC patients. Accordingly, herein we developed a novel gene signature that can pre‐operatively predict NACRT‐sensitivity in PDAC patients. Herein, we evaluated the performance of a 10‐gene panel...
Mon Sep 07, 2020 20:50
Abstract Scant evidence exists to support the association of opium use with head and neck cancer, limited to the larynx and oral cavity. In a multicenter case‐control study ‐Iran Opium and Cancer study (IROPICAN), we recruited 633 cases of head and neck squamous cell carcinoma (HNSCC) (254 lip and oral cavity, 54 pharynx, 327 larynx, and 28 other sub‐sites within the head and neck) and 3065 frequency‐matched controls from April 2016 to April 2019. Odds ratios (ORs) for opium use and 95% confidence...
Mon Sep 07, 2020 20:47
Abstract Studies of sleep duration in relation to the risk of site‐specific cancers other than breast cancer are scarce. Furthermore, the available results are inconclusive and the causality remains unclear. We aimed to investigate the potential causal associations of sleep duration with overall and site‐specific cancers using the Mendelian randomization (MR) design. Single‐nucleotide polymorphisms associated with the sleep traits identified from a genome‐wide association study were used as instrumental...
Mon Sep 07, 2020 20:46
Abstract Thermal ablation is a point‐of‐care ablative treatment technique for cervical intraepithelial neoplasia(CIN). However, limited information is available about its efficacy in low‐ and middle‐income countries. We evaluated the efficacy of thermal ablation in treatment of CIN detected through high‐risk human papillomavirus(HPV) screening in China. Women positive on high‐risk HPV and having colposcopically suspected lesions eligible for ablation underwent colposcopy, biopsy and thermal ablation...
Mon Sep 07, 2020 20:46
Abstract Sex hormonal differences may contribute to the strong male predominance in esophageal adenocarcinoma (EAC), but whether sex hormone levels influence survival in EAC is unstudied. This study aimed to assess associations between pre‐diagnostic sex hormone levels and survival in EAC. In population‐based cohort study, 244 male EAC patients from the Janus Serum Bank Cohort in Norway were followed up through 2018. Associations between pre‐diagnostic serum levels of 12 sex hormone measures and...
Mon Sep 07, 2020 20:46
Abstract Positron emission tomography and computed tomography (PET‐CT) is widely used to assess the response to radiotherapy. However, the ability of PET‐CT to predict treatment failure in human papillomavirus (HPV)‐related squamous cell carcinoma of the head and neck (HNSCC) is unsatisfactory. We quantified circulating tumor HPV type16 DNA (ctHPV16DNA) using optimized droplet digital PCR (ddPCR) in 35 patients with HPV16‐related HNSCC, who received radiotherapy with or without chemotherapy, and...
Mon Sep 07, 2020 20:45
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