What's the FOX Got to Do with the KITten? Regulating the Lineage-Specific Transcriptional Landscape in GIST [In the Spotlight]

Summary: Transcriptional regulation of the KIT receptor tyrosine kinase, a master regulator in gastrointestinal stromal tumors (GIST) and their precursors, the interstitial cells of Cajal (ICC), is part of a positive feedback loop involving the transcription factor ETV1. A new study now shows that the forkhead box (FOX) family transcription factor FOXF1 not only is an upstream regulator of ETV1 and hence ICC/GIST lineage-specific gene transcription, but also functions as lineage-specific pioneer factor with an active role in chromatin rearrangement to facilitate ETV1 binding and transcriptional activity. Cancer Discov; 8(2); 146–9. ©2018 AACR.

See related article by Ran et al., p. 234.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2nXEiPp