Tacrolimus Optic Neuropathy

Background: Tacrolimus (FK506, Prograf) is a potent immunosuppressant, which inhibits cytokine synthesis and blocks T-cell development. Optic neuropathy from tacrolimus toxicity is very uncommon but, when present, can result in severe vision loss. Methods: Case series and review of the literature. Results: We present 3 patients with tacrolimus optic neuropathy after bone marrow transplantation complicated by graft-vs-host disease and demonstrate the differing clinical and radiologic presentation of this presumed toxic optic neuropathy. Conclusions: Tacrolimus optic neuropathy can manifest in a multitude of clinical presentations and can have devastating visual consequences. Address correspondence to Nailyn Rasool, MD, FRCPC, 245 Fort Washington Avenue, Apt 3B, New York, NY 10032; E-mail: Nailyn.rasool@gmail.com The authors report no funding/conflicts of interest. © 2018 by North American Neuro-Ophthalmology Society

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