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Abstract Objective The objective of this systematic review was to determine the effectiveness of preoperative oral pregabalin for anxiety control, the most effective dosage regimen, its impact on postoperative pain, and its adverse effects. Materials and methods A search was conducted of PubMed/Medline and clinicaltrials.gov (National Library of Medicine,...
Thu May 28, 2020 03:00
Abstract Objectives The purpose of the present study is to (1) evaluate the oral health-related quality of life (OHRQoL) among a group of Egyptian children and early adolescents with type-1 diabetes mellitus (T1DM) aged from 8 to 14 years and the impact of individual, environmental, oral health care and biological independent predictors (2) assess oral health status (OHS) in terms of oral hygiene, caries experience, untreated carious cavities...
Thu May 28, 2020 03:00
Abstract Ulcerative colitis (UC) is a type of inflammatory bowel disease characterized by inflammation of the large intestine, rectal bleeding, and abdominal pain. It can be alleviated by certain bioactive compounds, including α-linolenic acid (ALA), which is a bioactive component in fermented black radish (Raphanus sativus L. var. niger). The aim of this study was to evaluate the anti-inflammatory effects of ALA in dextran sulfate sodium...
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Abstract Securidaca inappendiculata Hassk. is a traditional Chinese anti-rheumatic herbal medicine native to southern China. In this study, we identified a possible TLR4 inhibitor from this plant. General effects of its xanthone-rich fraction (XRF) on inflammation in vitro were investigated by immunoblotting experiments performed on lipopolysaccharides (LPS)-treated RAW264.7 cells, and the possible ligand of TLR4 within was screened...
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Analytical ChemistryDOI: 10.1021/acs.analchem.0c00652
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00111
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01161
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01695
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00425
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04745
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00762
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00450
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05793
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00473
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01256
Thu May 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00782
Thu May 28, 2020 07:00
Abstract Habenula neurons are constantly active. The level of activity affects mood and behaviour, with increased activity in the lateral habenula reflecting exposure to punishment and a switch to passive coping and depression. Here, we identify GABAergic neurons that could reduce activity in the lateral habenula of larval zebrafish. GAD65/67 immunohistochemistry and imaging of gad1b:DsRed transgenic fish suggest the presence of GABAergic terminals in the neuropil and between cell bodies in the...
Thu May 28, 2020 13:22
Abstract The field of learning and memory has largely focused their efforts on memory formation, deeming the act of forgetting as a necessary and unavoidable error of the brain's storage system. However, recent studies show that forgetting might be a purposeful mechanism with dedicated molecular pathways. This has opened new avenues for the study of memory processes and their manipulation. This review article focuses on the proposed molecular pathways that could underlie forgetting (postsynaptic...
Thu May 28, 2020 12:40
Future Oncology, Ahead of Print.
Wed May 27, 2020 13:45
Future Oncology, Ahead of Print.
Wed May 27, 2020 13:33
Future Oncology, Ahead of Print.
Wed May 27, 2020 11:45
Abstract NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for neurotransmission and memory. At the cellular level, the effects of activating these receptors includes long‐term potentiation (LTP) or depression (LTD). The NMDA receptor is a stringently gated cation channel permeable to Ca2+, and it shares the molecular architecture of a tetrameric ligand‐gated ion channel with the other family members. Its subunits, however, have uniquely long cytoplasmic C‐terminal...
Thu May 28, 2020 12:15
ABSTRACT Deregulation of GSK‐3β is strongly implicated in a variety of serious brain conditions, such as Alzheimer disease, bipolar disorder and schizophrenia. To understand how GSK‐3β becomes dysregulated in these conditions it is important to understand its physiological functions in the central nervous system. In this context, GSK‐3β plays a role in the induction of NMDA receptor‐dependent long‐term depression (LTD) and several substrates for GSK‐3β have been identified in this form of synaptic...
Thu May 28, 2020 11:50
Abstract Neurodegenerative disorders present with progressive and irreversible degeneration of the neurons. The most common neurodegenerative disorder is Alzheimer’s disease (AD) affecting 50 million people worldwide in 2017, expected to be doubled every 20 years. Primarily affected by age, AD is the cause for old‐age dementia, progressive memory loss, dysfunctional thoughts, confusion, cognitive impairment and personality changes. Neuroglia formerly understood as “glue” of the brain neurons consisting...
Thu May 28, 2020 17:09
Abstract The phenotypic instability of adult tissue‐derived Schwann cell‐like cells (SCLCs) as revealed upon withdrawal of glia‐inducing culture supplements limits their clinical utility for cell therapy and disease modelling. We previously overcame this limitation by co‐culturing bone marrow‐derived SCLCs with neurons purified from developing rat and subsequently human sensory neurons such that direct contact between cell types accomplished the cell‐intrinsic switch to the Schwann cell fate. Here,...
Wed May 27, 2020 14:11
Abstract Glutaric acidemia type I (GA‐I) is a cerebral organic disorder characterized by the accumulation of glutaric acid (GA) and seizures. Since seizures are precipitated in children with GA‐I and the mechanisms underlying this disorder are not well established, we decided to investigate the role of nitric oxide (NO) in GA‐induced convulsive behavior in pup rats. Pup male Wistar rats (18‐day‐old) were anesthetized and placed in stereotaxic apparatus for cannula insertion into the striatum for...
Wed May 27, 2020 11:53
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04532
Thu May 28, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02351
Thu May 28, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03040
Thu May 28, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04029
Thu May 28, 2020 07:00
Delta Airlines is increasing flights to many regions of the world from its hubs. (Miguel Angel Sanz/Unsplash/)This story originally featured on Flying Magazine.While it’s certainly not time to claim victory of any sort for airline travel over the COVID-19 virus, metrics released last week does at least offer a bit of encouraging news to people who depend on air carriers. Transportation Safety Administration data is a good place to begin since that agency keeps a close eye on the number of passengers...
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A eucalyptus flower (BecBartell/Pixabay/)The radiata pine has unwittingly taken root across the world. Its native range is confined to a small section of the California coast and a few islands along Baja California. Today, millions of acres of the tree are spread across South America, New Zealand, South Africa, Spain, and Australia.Fast-growing exotic species like radiata pine, acacia, and eucalyptus are commonly used in forestry and carbon sequestration efforts. Indeed, tree-planting may be an important...
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Keep it cool. (Depositphotos/)Veggies, fruits, breads, soups, and meals of every kind can be kept for weeks to months at a time in the freezer instead of just mere days like in the fridge. If you’re looking to stock up on groceries and ready-cooked meals to save time between supermarket trips, a dedicated upright freezer offers plenty more space than your average refrigerator and allows you the flexibility to use the freezer the way it was intended—for storing food for longer periods. There are many...
Thu May 28, 2020 22:54
Glacier moss balls in Alaska (Tim Bartholomaus/)At a science-themed happy hour in a bar located in between the University of Idaho and Washington State University, glaciologist Scott Hotaling was talking about his research on ice worms. It was a late Friday afternoon in 2018. Sophie Gilbert, a wildlife ecologist, and Tim Bartholomaus, a glaciologist and geophysicist, both professors at the University of Idaho, sat at the bar, surrounded by graduate students, postdocs, and professors. Gilbert and...
Thu May 28, 2020 19:00
Keep it flowing. (Bence Boros via Unsplash/)The concept of an “essential” home appliance is sometimes objective. It may be difficult to convince some that a personal beer tap is one of those can’t-live-without things, so you may have to get creative with your sales pitch. Luckily, whether you’re a hardcore home brew enthusiast or just someone who needs the kegerator do contribute something—anything—to the home experience other than frosty brews, there is an option for you.Here are some of the best...
Thu May 28, 2020 17:10
Protecting yourself from the elements should be a priority when you're trapped in the wilderness. (Tim MacWelch/)This story was originally featured on Outdoor Life.Shelter is your top priority in most survival emergencies. Severe weather conditions can kill within a few hours if you don’t have some type of shelter to defend you from the elements. Luckily, there are a wide array of techniques and materials for escaping the elements. Check out my top 15 favorite survival shelters.1. Round lodgeThe...
Thu May 28, 2020 16:14
Turn up when you pull-up. ( Danielle Cerullo via Unsplash/)If you’ve ever gotten to the gym only to discover to your horror that you’ve forgotten your headphones, you understand how ready access to music or podcasts is as vital to your exercise routine as water and sneakers. You need your hype music or soothing true crime narrative to get you through, and your headphones better be there for the long haul.Luckily, there are a number of gym-ready options to choose from. Sweatproof, durable, and capable...
Thu May 28, 2020 16:11
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