New England Journal of Medicine, Volume 382, Issue 22, Page 2137-2145, May 2020.
Wed May 27, 2020 11:56
New England Journal of Medicine, Volume 382, Issue 22, Page 2166-2168, May 2020.
Wed May 27, 2020 11:56
New England Journal of Medicine, Volume 382, Issue 22, Page 2168-2169, May 2020.
Wed May 27, 2020 11:56
New England Journal of Medicine, Volume 382, Issue 22, Page 2129-2136, May 2020.
Wed May 27, 2020 11:56
New England Journal of Medicine, Volume 382, Issue 22, Page 2164-2166, May 2020.
Wed May 27, 2020 11:56
Abstract Purpose Osteosarcoma is the most common bone tumor, mainly affecting adolescents and young adults, and metastatic disease has poor outcomes with a dismal overall survival. Currently, chemotherapy is the standard of care with limited results, finding that new therapies could improve these outcomes. Preclinical and clinical studies have suggested a possible important role of ErbB pathway aberrations in osteosarcoma etiology....
Thu May 28, 2020 14:12
Abstract Purpose Carbohydrate antigen (CA) 19-9 has been established as the main serum marker for patients with intrahepatic cholangiocarcinoma (ICC). The aim of this study was to compare the prognostic value of CA 19-9 changes versus response determined by imaging in patients with ICC undergoing chemotherapy. Methods Between 2003 and...
Thu May 28, 2020 14:12
Abstract Purpose To identify key factors for the best practice of knowledge transfer from high-income settings to low- and middle-income settings. Results Interactive sessions led to the identification of European learnings that can and should be shared beyond Europe. Furthermore, methods were characterised which may lead to successful...
Thu May 28, 2020 14:12
Abstract Purpose Complementary and alternative medicine (CAM) use is common amongst cancer patients. However, there is growing concern about its safety and efficacy. Online crowdfunding campaigns represent a unique avenue to understand the cancer patient’s perspective for using CAM or declining conventional cancer therapy (CCT). Methods ...
Thu May 28, 2020 14:12
Abstract Purpose Approximately 30% of NSCLC patients cannot obtain tissue sample or sufficient tissue sample for molecular subtyping. Cell-free circulating tumor DNA (ctDNA) in plasma is a potential alternative specimen type to assess genomic variants in patients with non-small cell lung cancer (NSCLC). The purpose of this study was to identify the genomic alteration profile of ctDNA in real-world Chinese NSCLC patients. ...
Thu May 28, 2020 14:12
Abstract Purpose As a type of cancer with the highest morbidity and mortality, lung squamous cell carcinoma (LUSC) has a very poor prognosis. Long-non-coding RNA (lncRNA) has recently attracted attentions because it can play the role of competing endogenous RNA (ceRNA) to inhibit microRNA (miRNA) functions. In this study, we aimed to find prognosis-related lncRNAs, miRNAs and mRNAs and construct a prognosis-related ceRNA network....
Thu May 28, 2020 14:12
Abstract Nosocomial infections caused by COVID-19 will result in the immediate closure of the infected medical facility due to the highly contagious nature of COVID-19, further worsening medical shortages. We performed a Delphi consulting study to develop a risk model based on the experience of recently resumed activities in many cancer hospitals in China. Similar method had been used in a Chinese cancer hospital and effectively reduced the nosocomial Infection. We believe that...
Thu May 28, 2020 14:12
Abstract Background DNA topoisomerase and telomerase enzymes are popular targets of several anti-tumor drugs. Smooth proceeding of telomeric recombination requires Topoisomerase II (Top2), which is involved in telomere-telomere recombination through functioning in relaxation of positive supercoils among the cells adopting telomerase-independent Alternative lengthening of telomere (ALT) pathway. Most of the inhibitors reported...
Thu May 28, 2020 14:12
Abstract Background It has been shown that local ablative procedures enable downsizing, reduce drop-out from the waiting list and improve prognosis after liver transplantation. It is still unclear whether a response to the local ablative therapy is due to a favorable tumor biology or if a real benefit in tumor stabilization exists, particularly in complete pathological response. ...
Thu May 28, 2020 14:12
Abstract Purpose As the number of cancer survivors in the United States increases, quantifying the risks and burden of second primary cancers (SPCs) among cancer survivors will help develop long-term prevention and surveillance strategies. We describe the risk of developing a SPC among survivors of 10 cancer sites with the highest survival rates in the United States. ...
Thu May 28, 2020 14:12
Abstract Purpose Oral mucositis is a debilitating inflammatory disorder observed in patients undergoing active cancer treatment, particularly cancer of the head and neck region. A key pathway believed to be involved in the pathogenesis of oral mucositis is the formation of reactive oxygen species (ROS). The identification of compounds that can inhibit this pathway may therefore be of benefit in treating this disorder. The kava...
Thu May 28, 2020 14:12
Abstract Purpose The usual first-line strategy of wild-type EGFR (wtEGFR) non-small cell lung cancer (NSCLC) remains cisplatin-based chemotherapy. However, cisplatin often loses effectiveness because most tumors acquire drug resistance over time. As EGFR is the most important pro-survival/proliferation signal receptor in NSCLC cells, we aimed at investigating whether cisplatin resistance is related to EGFR activation and further...
Thu May 28, 2020 14:12
Balantidium coli, a parasitic unicellular ciliate, often causes asymptomatic balantidiasis of the colon, but extraintestinal disease may occur rarely in immunosuppressed individuals. Renal balantidiasis associate...
Thu May 28, 2020 03:00
Publication date: Available online 27 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Bailin Pan, Runlei Zhao, Siqiao Wu, Hengju Lin, Yan Long, Guang Hao, Jing Chen, Fuhong Nian
Thu May 28, 2020 14:01
Publication date: Available online 27 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Sara van Bekkum, Dirk-Jan J.C. van der Avoort, J. Michiel Zuidam, J. Henk Coert
Thu May 28, 2020 14:01
Abstract The purpose of this recommendation of the Oncology Task Force of the European Society of Paediatric Radiology (ESPR) is to indicate reasonable applications of whole-body MRI in children with cancer and to address useful protocols to optimize workflow and diagnostic performance. Whole-body MRI as a radiation-free modality has been increasingly performed over the last two decades, and newer applications, as in screening of children with germ-line mutation cancer-related...
Thu May 28, 2020 03:00
Abstract The Fontan operation is performed for various cardiac lesions with single-ventricle physiology. The survival rate of Fontan patients is increasing for adolescents and young adults, with an expected 30-year survival of >80%. Medical health care providers including specialists in organ systems and pediatric radiologists need to improve their knowledge about the Fontan circulation and the various organ complications to monitor care. In this review the author explains the...
Thu May 28, 2020 03:00
Related ArticlesSemen quality from patients affected by seminomatous and non-seminomatous testicular tumor. Int Braz J Urol. 2020 May 10;46: Authors: Xavier R, de Carvalho RC, Fraietta R Abstract Testicular cancer is considered a rare disease affecting approximately 1% to 2% of the male population. This neoplasm has a cure rate of over 95%; as a result, a major concern is the future of fertility of carriers from this disease. There are several histological...
Thu May 28, 2020 15:02
Related ArticlesClinicopathologic and molecular characterization of NTRK-rearranged thyroid carcinoma (NRTC). Mod Pathol. 2020 May 26;: Authors: Chu YH, Dias-Santagata D, Farahani AA, Boyraz B, Faquin WC, Nosé V, Sadow PM Abstract Primary thyroid neoplasms with actionable NTRK rearrangements are rare, and their clinical behavior, histologic characteristics, and molecular landscape are not well understood. We report an institutional series of eleven NTRK-rearranged...
Thu May 28, 2020 13:59
Related ArticlesPLZF-RARα, NPM1-RARα, and Other Acute Promyelocytic Leukemia Variants: The PETHEMA Registry Experience and Systematic Literature Review. Cancers (Basel). 2020 May 21;12(5): Authors: Sobas M, Talarn-Forcadell MC, Martínez-Cuadrón D, Escoda L, García-Pérez MJ, Mariz J, Mela-Osorio MJ, Fernández I, Alonso-Domínguez JM, Cornago-Navascués J, Rodríguez-Macias G, Amutio ME, Rodríguez-Medina C, Esteve J, Sokół A, Murciano-Carrillo T, Calasanz MJ, Barrios M, Barragán...
Thu May 28, 2020 13:59
Related ArticlesClinical Characteristics of Korean Breast Cancer Patients Who Carry Pathogenic Germline Mutations in Both BRCA1 and BRCA2: A Single-Center Experience. Cancers (Basel). 2020 May 21;12(5): Authors: Hur JY, Kim JY, Ahn JS, Im YH, Lee J, Kwon M, Park YH Abstract There are few reports of breast cancer patients who carry germline mutations in both germline breast cancer susceptibility genes 1 (gBRCA1) and 2 (gBRCA2). In this study, we analyzed...
Thu May 28, 2020 13:59
Related ArticlesTspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner. Cancers (Basel). 2020 May 21;12(5): Authors: El Kharbili M, Cario M, Béchetoille N, Pain C, Boucheix C, Degoul F, Masse I, Berthier-Vergnes O Abstract Melanoma is the most aggressive skin cancer with an extremely challenging therapy. The dermal-epidermal junction (DEJ) degradation and subsequent...
Thu May 28, 2020 13:59
Related ArticlesMultifocal Urinary Bladder Paragangliomas With Negative 68Ga-DOTATATE Uptake and Positive 123I-MIBG Uptake. Clin Nucl Med. 2020 Mar;45(3):e156-e157 Authors: Parra LA, Swanson SK, Salomao MA, Yang M Abstract We report a case of an adult male patient with multifocal urinary bladder paragangliomas, which were negative on Ga-DOTATATE PET/CT scan, but positive on I-MIBG SPECT/CT scan. While the Ga-DOTA analog PET/CT exhibits superior performance...
Thu May 28, 2020 13:59
Related ArticlesTreatment challenges in pediatric Cushing's disease: Review of the literature with particular emphasis on predictive factors for the disease recurrence. Endocrine. 2019 11;66(2):125-136 Authors: Pasternak-Pietrzak K, Moszczyńska E, Szalecki M Abstract Cushing's disease (CD) is a rare endocrine condition caused by a corticotroph pituitary tumor that produces adrenocorticotropic hormone. The current state of knowledge of CD treatment...
Thu May 28, 2020 13:59
Related ArticlesIntraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases. APMIS. 2020 Mar;128(3):191-200 Authors: Palicelli A Abstract Intraductal carcinomas (IDCs) are rare, not well-characterized salivary gland tumors. A systematic literature review of pure IDCs (without stromal invasion) of low-grade (LG-IDCs) or high-grade (HG-IDCs) was performed: IDCs were classified using the apocrine (AR+/S100-)...
Thu May 28, 2020 13:59
Related ArticlesExposure to anti-PD-1 causes functional differences in tumor-infiltrating lymphocytes in rare solid tumors. Eur J Immunol. 2019 12;49(12):2245-2251 Authors: Creasy CA, Forget MA, Singh G, Tapia C, Xu M, Stephen B, Sabir S, Meric-Bernstam F, Haymaker C, Bernatchez C, Naing A Abstract The pervasive use of therapeutic antibodies targeting programmed cell death protein 1 (PD-1) to boost anti-tumor immunity has positioned this approach to...
Thu May 28, 2020 13:59
Related ArticlesASO Author Reflections: De-escalation of Breast Cancer Surgery-A Leap Forward. Ann Surg Oncol. 2019 12;26(Suppl 3):711-712 Authors: Özkurt E, Golshan M PMID: 31468219 [PubMed - indexed for MEDLINE]
Thu May 28, 2020 13:59
Related ArticlesAddressing delays in the diagnosis of pheochromocytoma/paraganglioma. Expert Rev Endocrinol Metab. 2019 09;14(5):359-363 Authors: Ilias I, Thomopoulos C Abstract Introduction: Pheochromocytomas/paragangliomas (PPG) are rare tumors. In theory the diagnosis of PPG should be straightforward. In clinical practice, however, considerable delays are noted in establishing such a diagnosis. Areas covered: We assess the characteristics of various...
Thu May 28, 2020 13:59
Related ArticlesSignet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma. Br J Cancer. 2019 09;121(6):505-510 Authors: Korphaisarn K, Morris V, Davis JS, Overman MJ, Fogelman DR, Kee BK, Dasari A, Raghav KPS, Shureiqi I, Trupti M, Wolff RA, Eng C, Menter DG, Hamilton S, Kopetz S Abstract BACKGROUND: Signet ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer (CRC). The aim of this study...
Thu May 28, 2020 13:59
Related ArticlesA case of checkpoint inhibitor-induced celiac disease. J Immunother Cancer. 2019 08 05;7(1):203 Authors: Alsaadi D, Shah NJ, Charabaty A, Atkins MB Abstract BACKGROUND: Immune checkpoint inhibitors (ICIs) have now become standard of care treatment for many malignancies. ICIs are associated with unique immune mediated adverse events (irAEs) due to dysregulation of immune activation. As treatment with ICIs is becoming more common, rare...
Thu May 28, 2020 13:59
Related ArticlesCharacteristics of metastatic brachial plexopathy in patients with breast cancer. Support Care Cancer. 2020 Apr;28(4):1913-1918 Authors: Kim J, Jeon JY, Choi YJ, Choi JK, Kim SB, Jung KH, Ahn JH, Kim JE, Seo S Abstract PURPOSE: Brachial plexopathy in cancer patients is a rare but significant complication that causes pain and disability of the upper extremities. Clinical features of breast cancer patients with metastatic brachial plexopathy...
Thu May 28, 2020 13:59
Related ArticlesDevelopment and validation of a nomogram for prognosis of sinonasal squamous cell carcinoma. Int Forum Allergy Rhinol. 2019 09;9(9):1030-1040 Authors: Quan H, Yan L, Zhang H, Zou L, Yuan W, Wang S Abstract BACKGROUND: Sinonasal squamous cell carcinoma (SNSCC) is a rare malignancy with varied outcomes. The aim of this study was to develop a nomogram for predicting survival of patients with SNSCC. METHODS: From the Surveillance,...
Thu May 28, 2020 13:59
Related ArticlesClinical outcomes and prognostic factors in patients with no less than three distant organ system metastases from differentiated thyroid carcinoma. Endocrine. 2019 11;66(2):254-265 Authors: Zhang XY, Sun JW, Qiu ZL, Wang Y, Chen XY, Zhao JH, Luo QY Abstract OBJECTIVES: For patients with differentiated thyroid carcinoma (DTC), distant metastases are commonly identified in the lungs and bones. However, they are relatively rare in other...
Thu May 28, 2020 13:59
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