Abstract Objectives Myocardial ischaemia/reperfusion (MI/R) injury is associated with adverse cardiovascular outcomes after acute myocardial infarction. However, the molecular mechanisms underlying MI/R injury are unclear. This study investigated the role of long non‐coding RNA (lncRNA) Oip5‐as1 in regulating mitochondria‐mediated apoptosis during MI/R injury. Materials and methods Sprague‐Dawley rats were subjected to MI/R induced by ligation of the left anterior descending coronary artery...
19m
[ Title ] Prevalence and risk factors of sarcopenia in commuting rehabilitation service users [ Author ] Takahiro Shiba,Yohei Sawaya,Tamaki Hirose,Masahiro Ishizaka,Akira Kubo,Tomohiko Urano [ Publication date ] 2020-05-29 [ DOI ] https://doi.org/10.3143/geriatrics.57.149
20m
Objectives: To assess the validity of the subtotal petrosectomy (STP) technique in problematic cases of cochlear implant (CI) surgery, and review indications, outcomes, and related controversies. Study Design: This is a retrospective review of data from a private quaternary referral center of otology and skull base surgery. Patients and Methods: A review of patients who underwent CI with STP (STP-CI) as the leading approach was performed. Demographics, indications, surgical details, and main outcomes...
37m
Abstract Purpose of Review The aim of this report is to review the current literature regarding the diagnosis, treatment, management, and rehabilitation of congenital cytomegalovirus (cCMV)–associated sensorineural hearing loss (SNHL). Recent Findings Hearing-targeted CMV screening is successful in identifying cases of cCMV-related hearing loss. However,...
1h
With covid-19 disrupting global healthcare services, people affected by life threatening conditions such as cancer have faced substantial treatment delays or modifications. In the pandemic’s early...
1h
Timely and appropriate application of methylprednisolone in severe and critical COVID-19 patients could effectively avoid invasive mechanical ventilation and reduce the mortality.
2h
Abstract Background Cervical cancer ranks fourth amongst the commonest malignancies worldwide and the second most prevalent cancer afflicting women in low-to-middle income countries (LMICs), hence, of great public health importance. LMICs are the most affected regions as evidenced by their high prevalence of the disease. Mortality associated with cervical neoplasms is preventable through the implementation of recommended preventive...
2h
On March 17th, 2020, the Association of American Medical Colleges released a communication recommending that medical students be withdrawn from all clinical rotations.1 While the duration for which this pause will persist remains elusive, the acute need for social distancing and shortages in personal protective equipment are likely to keep medical students at a distance from clinical learning environments for some time.2 As the pandemic continues to unfold, online and virtual teaching resources are...
2h
Residues of cannabis found on stone altars from a shrine in what was once the Biblical Kingdom of Judah suggest the plant was burned for its psychoactive effects
2h
The accumulation of amyloid Tau aggregates is implicated in Alzheimer’s disease (AD) and other tauopathies. Molecular chaperones are known to maintain protein homeostasis. Here we show that an ATP-dependent human chaperone system disassembles Tau fibrils in vitro. We found that this function is mediated by the core chaperone HSC70, assisted by specific co-chaperones, in particular class B J‑domain proteins and a heat shock protein 110 (Hsp110)-type nucleotide exchange factor (NEF). The Hsp70 disaggregation...
2h
Acute myeloid leukemia (AML) with mixed lineage leukemia 1 (MLL1) gene rearrangement is characterized by increased expression of a set of homeodomain transcription factors, including homeobox A9 (HOXA9 ) and HOXA10. The target genes for these regulators include fibroblast growth factor 2 (FGF2) and Ariadne RBR E3 ubiquitin ligase 2 (ARIH2). FGF2 induces leukemia stem cell expansion in MLL1-rearranged AML. ARIH2 encodes TRIAD1, an E3 ubiquitin ligase required for termination of emergency granulopoiesis...
2h
Long-noncoding RNAs (lncRNAs) have been shown to play key roles in a variety of biological activities of the cell. However, less is known about how lncRNAs respond to environmental cues, and what transcriptional mechanisms regulate their expression. Studies from our laboratory have shown that the lncRNA Tug1 (taurine upregulated gene 1) is crucial for progression of diabetic kidney disease, a major microvascular complication of diabetes. Using a combination of proximity labeling with the engineered...
2h
Triple-negative breast cancer (TNBC) is an aggressive cancer subtype for which effective therapies are unavailable. TNBC has a high frequency of tumor protein P53 (P53) and phosphatase and tensin homolog (PTEN) deficiencies, and combined P53/PTEN deficiency is associated with poor prognosis and poor response to anticancer therapies. In this study, we discovered that combined P53/PTEN deficiency in TNBC activates expression of the transcription factor mesenchyme homeobox 1 (MEOX1). We found that MEOX1...
2h
Telemedicine and e-Health, Ahead of Print.
2h
Journal of Interferon &Cytokine Research, Ahead of Print.
2h
Journal of Interferon &Cytokine Research, Ahead of Print.
2h
Zusammenfassung Hintergrund Die Präzisionsonkologie ist für betroffene Patienten mit großen Hoffnungen auf einen Therapieerfolg verbunden. Die Datenlage zu klinischem Nutzen von präzisionsonkologischen Ansätzen ist uneinheitlich und die Komplexität der Thematik stellt hohe Anforderungen an das Patientenverständnis. Die Führung dieser Patienten stellt neue Herausforderungen an die behandelnden Onkologen. ...
2h
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