Related ArticlesSleep disturbance in adults with sickle cell disease: relationships with executive and psychological functioning. Ann Hematol. 2020 May 27;: Authors: Rhodes A, Martin S, Wolters P, Rodriguez Y, Toledo-Tamula MA, Struemph K, Fitzhugh C, Hsieh M, Tisdale J Abstract Sleep disturbance is common among children with sickle cell disease (SCD) and is related to neurocognitive difficulties. However, research on sleep disturbances and related variables...
Thu May 28, 2020 13:51
Related ArticlesMolecular patterns in salivary duct carcinoma identify prognostic subgroups. Mod Pathol. 2020 May 26;: Authors: Mueller SA, Gauthier MA, Blackburn J, Grady JP, Kraitsek S, Hajdu E, Dettmer MS, Dahlstrom JE, Lee CS, Luk PP, Yu B, Giger R, Kummerfeld S, Clark JR, Gupta R, Cowley MJ Abstract Salivary duct carcinoma (SDCa) is a rare cancer with high rate of metastases and poor survival despite aggressive multimodality treatment. This study...
Thu May 28, 2020 13:51
Related ArticlesSurgical training in gynecologic oncology: Past, present, future. Gynecol Oncol. 2020 May 23;: Authors: Hoffman MS, Chi DS, Clarke-Pearson DL, Cliby W, Creasman W, Underwood PB Abstract The purpose of this paper is to review the surgical care related to training in gynecologic oncology, from past, present and future perspectives. A marked decline in the incidence of cervical cancer as well as improvements in radiation therapy have led...
Thu May 28, 2020 13:51
Related ArticlesEye Movements and White Matter are Associated with Emotional Control in Children Treated for Brain Tumors. J Int Neuropsychol Soc. 2020 May 27;:1-15 Authors: Moxon-Emre I, Taylor MJ, Farb NAS, Oyefiade AA, Taylor MD, Bouffet E, Laughlin S, Skocic J, de Medeiros CB, Mabbott DJ Abstract OBJECTIVE: Children treated for brain tumors often experience social and emotional difficulties, including challenges with emotion regulation; our goal...
Thu May 28, 2020 13:51
Related ArticlesClinical sequelae of the novel coronavirus: does COVID-19 infection predispose patients to cancer? Future Oncol. 2020 May 27;: Authors: Hays P Abstract As cancer patients are clinically known to be predisposed to COVID-19 infection, a corollary question of whether COVID-19 infection predisposes to cancer is explored. This article seeks to establish an association between novel coronavirus sequelae and cancer. A literature review on COVID-19...
Thu May 28, 2020 13:51
Related ArticlesImmunological Basis of Genesis of Hepatocellular Carcinoma: Unique Challenges and Potential Opportunities through Immunomodulation. Vaccines (Basel). 2020 May 23;8(2): Authors: Jayant K, Habib N, Huang KW, Podda M, Warwick J, Arasaradnam R Abstract A majority of hepatocellular carcinoma (HCC) develops in the setting of persistent chronic inflammation as immunological mechanisms have been shown to play a vital role in the initiation, growth...
Thu May 28, 2020 13:51
Related ArticlesClinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas. Cancers (Basel). 2020 May 21;12(5): Authors: Milanesio MC, Giordano S, Valabrega G Abstract Despite significant improvements in surgical and medical management, high grade serous ovarian cancer (HGSOC) still represents the deadliest gynecologic malignancy and the fifth most frequent cause of cancer-related mortality in women in the USA. Since DNA repair...
Thu May 28, 2020 13:51
Related ArticlesThe Contribution of Spanish Science to Patents: Medicine as Case of Study. Int J Environ Res Public Health. 2020 May 21;17(10): Authors: Cascajares M, Alcayde A, Garrido-Cardenas JA, Manzano-Agugliaro F Abstract Investments in research and development (R&D) and innovation are expensive, and one wishes to be assured that there is positive feedback and to receive guidance on how to direct investments in the future. The social or economic...
Thu May 28, 2020 13:51
Related ArticlesHigh-throughput, single-particle tracking reveals nested membrane domains that dictate KRasG12D diffusion and trafficking. Elife. 2019 11 01;8: Authors: Lee Y, Phelps C, Huang T, Mostofian B, Wu L, Zhang Y, Tao K, Chang YH, Stork PJ, Gray JW, Zuckerman DM, Nan X Abstract Membrane nanodomains have been implicated in Ras signaling, but what these domains are and how they interact with Ras remain obscure. Here, using single particle tracking...
Thu May 28, 2020 13:51
Related ArticlesSET Domain-Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence. Cancer Res. 2019 Sep 15;79(18):4729-4743 Authors: Ye S, Ding YF, Jia WH, Liu XL, Feng JY, Zhu Q, Cai SL, Yang YS, Lu QY, Huang XT, Yang JS, Jia SN, Ding GP, Wang YH, Zhou JJ, Chen YD, Yang WJ Abstract Quiescent cancer stem cells (CSC) play important roles in tumorigenesis, relapse, and resistance to chemoradiotherapy. However, the determinants...
Thu May 28, 2020 13:51
Related ArticlesPterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies. Pharmacol Res. 2019 07;145:104265 Authors: Ma Z, Zhang X, Xu L, Liu D, Di S, Li W, Zhang J, Zhang H, Li X, Han J, Yan X Abstract Pterostilbene, a natural dimethylated analog of resveratrol, exerts pleiotropic anticancer effects against a variety of cancer types. Due to the better lipophilic and oral absorption, higher cellular uptake and a...
Thu May 28, 2020 13:51
Related ArticlesThe effect of prostatic tissue density on the perioperative outcomes of Holmium laser enucleation of prostate (HoLEP): a pilot study. World J Urol. 2020 Feb;38(2):455-461 Authors: Kaya E, Gazel E, Yalcın S, Tokas T, Aydogan TB, Aybal HC, Tunc L Abstract PURPOSE: To evaluate the effect of prostate tissue density (PTD) on perioperative Holmium laser enucleation of prostate (HoLEP) outcomes. METHODS: Two hundred fourteen patients...
Thu May 28, 2020 13:51
Publication date: Available online 27 May 2020Source: Archives of Oral BiologyAuthor(s): Kazuo Kato, Kiyomi Tamura, Yoshihiro Shimazaki
Thu May 28, 2020 13:50
The objective of this study was to determine the level of environmental contamination in hospitals in the Dutch/Belgian border area, using ATP measurements.
Thu May 28, 2020 03:00
Current guidelines advocate empirical antibiotic treatment (EAT) in haematological patients with febrile neutropenia. However, the optimal duration of EAT is unknown. In 2011, we have introduced a protocol, pr...
Wed May 27, 2020 03:00
Although Staphylococcus aureus bloodstream infections (SA-BSI) are a common and important infection, polymicrobial SA-BSI are infrequently reported. The aim of this study was to investigate the clinical character...
Wed May 27, 2020 03:00
A World Health Organization (WHO) guideline-based multimodal hand hygiene (HH) initiative was introduced hospital-wide to a nonteaching Japanese hospital for 5 years. The objective of this study was to assess ...
Wed May 27, 2020 03:00
Related ArticlesMultilevel genome typing: genomics-guided scalable resolution typing of microbial pathogens. Euro Surveill. 2020 May;25(20): Authors: Payne M, Kaur S, Wang Q, Hennessy D, Luo L, Octavia S, Tanaka MM, Sintchenko V, Lan R Abstract BackgroundBoth long- and short-term epidemiology are fundamental to disease control and require accurate bacterial typing. Genomic data resulting from implementation of whole genome sequencing in many public health...
Thu May 28, 2020 17:42
Related ArticlesLarge community-acquired Legionnaires' disease outbreak caused by Legionella pneumophila serogroup 1, Italy, July to August 2018. Euro Surveill. 2020 May;25(20): Authors: Faccini M, Russo AG, Bonini M, Tunesi S, Murtas R, Sandrini M, Senatore S, Lamberti A, Ciconali G, Cammarata S, Barrese E, Ceriotti V, Vitaliti S, Foti M, Gentili G, Graziano E, Panciroli E, Bosio M, Gramegna M, Cereda D, Perno CF, Mazzola E, Campisi D, Aulicino G, Castaldi S, Girolamo...
Thu May 28, 2020 17:42
Related ArticlesContributing to health security in Europe since 2005 - ECDC's 15th anniversary. Euro Surveill. 2020 May;25(20): Authors: Ammon A PMID: 32458792 [PubMed - in process]
Thu May 28, 2020 17:42
Related ArticlesCross-border spread of bla NDM-1- and bla OXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019. Euro Surveill. 2020 May;25(20): Authors: Ludden C, Lötsch F, Alm E, Kumar N, Johansson K, Albiger B, Huang TD, Denis O, Hammerum AM, Hasman H, Jalava J, Räisänen K, Dortet L, Jousset AB, Gatermann S, Haller S, Cormican M, Brennan W, Del Grosso M, Monaco M, Schouls L, Samuelsen...
Thu May 28, 2020 17:42
Related ArticlesClinical characteristics and fetal outcomes in women with epilepsy with planned and unplanned pregnancy: A retrospective study. Seizure. 2020 May 15;79:97-102 Authors: Zhang YY, Song CG, Wang X, Jiang YL, Zhao JJ, Yuan F, Yang XA, Yang F, Jiang W Abstract PURPOSE: To compare the antiepileptic drug (AED) treatment patterns, seizure control, and folic acid supplementation between planned and unplanned pregnancy in women with epilepsy (WWE)...
Thu May 28, 2020 16:36
Related ArticlesEpilepsy and Its Interaction With Sleep and Circadian Rhythm. Front Neurol. 2020;11:327 Authors: Jin B, Aung T, Geng Y, Wang S Abstract Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and epilepsy. Comprehending how these interact with each other may help to advance our understanding of the pathophysiology of epilepsy and develop new treatment strategies to improve seizure control by reducing the...
Thu May 28, 2020 13:47
Related ArticlesPossible Genetic Determinants of Response to Phenytoin in a Group of Colombian Patients With Epilepsy. Front Pharmacol. 2020;11:555 Authors: Calderon-Ospina CA, Galvez JM, López-Cabra C, Morales N, Restrepo CM, Rodríguez J, Aristizábal-Gutiérrez FA, Velez-van-Meerbeke A, Laissue P, Fonseca-Mendoza DJ Abstract Background: Epilepsy is a serious health problem worldwide. Despite the introduction of new antiepileptic drugs (AEDs) almost 30%...
Thu May 28, 2020 13:47
Related ArticlesGAD antibodies in neurological disorders - insights and challenges. Nat Rev Neurol. 2020 May 26;: Authors: Graus F, Saiz A, Dalmau J Abstract Antibodies to glutamic acid decarboxylase (GAD) have been associated with several neurological syndromes, including stiff-person syndrome, cerebellar ataxia and epilepsy. These antibodies were first described in 1988, but several controversies about GAD autoimmunity still remain. No criteria exist...
Thu May 28, 2020 13:47
Related ArticlesNeurological Syndromes Associated with Anti-GAD Antibodies. Int J Mol Sci. 2020 May 24;21(10): Authors: Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre JY, Psimaras D, Alentorn A Abstract Glutamic acid decarboxylase (GAD) is an intracellular enzyme whose physiologic function is the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter within the central nervous system. GAD antibodies...
Thu May 28, 2020 13:47
Related ArticlesPharmacometric Bridging Approach for U.S. Food and Drug Administration Approval and Identification of Topiramate Dosing Regimen for Pediatric Patients 2-9 Years of Age With Epilepsy. J Pharm Sci. 2019 04;108(4):1598-1603 Authors: Marathe A, Liu C, Kapcala LP, Hershkowitz N, Men A, Uppoor R, Mehta M, Wang Y Abstract This study was performed to identify an efficacious dosing regimen for U.S. Food and Drug Administration approval of topiramate...
Thu May 28, 2020 13:47
Related ArticlesNeuronal phase consistency tracks dynamic changes in acoustic spectral regularity. Eur J Neurosci. 2019 05;49(10):1268-1287 Authors: Gifford AM, Sperling MR, Sharan A, Gorniak RJ, Williams RB, Davis K, Kahana MJ, Cohen YE Abstract The brain parses the auditory environment into distinct sounds by identifying those acoustic features in the environment that have common relationships (e.g., spectral regularities) with one another and then...
Thu May 28, 2020 13:47
Abstract The food enzyme with 4‐α‐d ‐{(1‐>4)‐α‐d ‐glucano}trehalose trehalohydrolase ((4‐α‐d ‐[(1,4‐α‐d ‐glucano]trehalose glucanohydrolase (trehalose‐producing)), EC 3.2.1.141) and (1‐>4)‐α‐d ‐glucan 1‐α‐d ‐glucosylmutase ((1,4)‐α‐d ‐glucan 1‐α‐d ‐glucosylmutase, EC 5.4.99.15) activities is produced with a non‐genetically modified microorganism Gryllotalpicola ginsengisoli (formally Arthrobacter ramosus ) by Hayashibara Co., Ltd. The applicant states that the food enzyme will not be placed...
Wed May 27, 2020 14:10
Abstract In 2015, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP ) issued an opinion on the safety and efficacy of ammonium, calcium and sodium formate when used as a technological additive (preservative) for all animal species. Sodium formate was considered safe for all animal species at a maximum concentration of 10,000 mg formic acid equivalents/kg complete feed (with the exception of pigs, for which a maximum concentration of 12,000 mg formic acid equivalents/kg...
Wed May 27, 2020 14:10
Abstract In 2014, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP ) issued an opinion on the safety and efficacy of calcium formate when used as a technological additive (preservative) for all animal species. Calcium formate was considered safe for all animal species at a maximum concentration of 10,000 mg formic acid equivalents/kg complete. Calcium formate was also considered safe for the consumer and the environment. The Panel also concluded that calcium formate...
Wed May 27, 2020 14:10
Abstract Selenium‐enriched yeast produced by Saccharomyces cerevisiae CNCM I‐3399 (selenised yeast inactivated) (SELSAF ) is characterised as organic selenium mainly containing selenomethionine (Se‐Met, ≥ 63%). The applicant requested for the renewal of the authorisation for selenium‐enriched yeast produced by S. cerevisiae CNCM I‐3399 when used as a feed additive for all animal species. The applicant has provided evidence that the additive in the market complies with the conditions of the authorisation....
Wed May 27, 2020 14:09
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP ) was asked to deliver a scientific opinion on the safety and efficacy of ProEquo® as a feed additive for horses. This additive is a preparation single strain of Lactobacillus plantarum intended for use as a zootechnical additive in feed for horses. The identity of the bacterial strain was not established. Consequently, the qualified presumption of safety approach...
Wed May 27, 2020 14:09
Abstract The food enzyme is a lysophospholipase (2‐lysophosphatidylcholine acylhydrolase; EC 3.1.1.5) produced with a genetically modified Aspergillus niger strain NZYM ‐LP by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA . The lysophospholipase food enzyme is intended to be used in starch processing for glucose syrups production, and for degumming of fats and oils. Residual amounts...
Wed May 27, 2020 14:08
Abstract Following a request from the European Commission, the Panel on Additives and Products or substances used in Animal Feed (FEEDAP ) was asked to deliver a scientific opinion on the safety and efficacy of disodium 5′‐inosinate (IMP ) produced by fermentation using Corynebacterium stationis KCCM 80161 when used as a sensory additive (flavouring compound) in feed and water for drinking for all animal species. The production strain is not genetically modified. Viable cells of the production...
Wed May 27, 2020 14:08
Abstract The food enzyme α‐amylase (1,4‐α‐d ‐glucan glucanohydrolase; EC 3.2.1.1) is produced with a non‐genetically modified Parageobacillus thermoglucosidasius strain DP ‐Gzb47 by Danisco US Inc. The α‐amylase food enzyme is intended to be used in brewing processes and distilled alcohol production. Since residual amounts of the food enzyme are removed by distillation, dietary exposure was only calculated for brewing processes. Based on the maximum use levels recommended for brewing processes,...
Wed May 27, 2020 14:07
Related ArticlesNeratinib for the treatment of early-stage, hormone receptor-positive, HER2-overexpressed breast cancer. Future Oncol. 2020 May 27;: Authors: Jerez Y, Herrero B, Arregui M, Morón B, Martín M, Echavarría I Abstract HER2-positive breast cancer accounts for 18-20% of all breast cancers. Despite significant advances and the currently available adjuvant treatments for management of the disease, approximately 25% of HER2-positive early-stage...
Thu May 28, 2020 17:44
Related ArticlesDorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections. Brain Struct Funct. 2020 May 26;: Authors: Radtke-Schuller S, Town SM, Yin P, Elgueda D, Schuller G, Bizley JK, Shamma SA, Fritz JB Abstract Recent studies of the neurobiology of the dorsal frontal cortex (FC) of the ferret have illuminated its key role in the attention network, top-down cognitive control of sensory...
Thu May 28, 2020 13:45
Related ArticlesRepair of large traumatic tympanic membrane perforation using ofloxacin otic solution and gelatin sponge. Braz J Otorhinolaryngol. 2020 May 05;: Authors: Li X, Zhang H, Zhang Y Abstract INTRODUCTION: Traumatic large tympanic membrane perforations usually fail to heal and require longer healing times. Few studies have compared the healing and hearing outcomes between gelatin sponge patching and ofloxacin otic solution. OBJECTIVES:...
Thu May 28, 2020 13:44
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