Related ArticlesThe Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level. Cell Rep. 2020 May 26;31(8):107683 Authors: Jin Z, Chen J, Huang H, Wang J, Lv J, Yu M, Guo X, Zhang Y, Cai T, Xi R Abstract Balanced stem cell self-renewal and differentiation is essential for maintaining tissue homeostasis, but the underlying mechanisms are poorly understood. Here, we identified...
Thu May 28, 2020 14:37
Related ArticlesThe chemopreventive effect of 5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven colorectal carcinogenesis in mice is associated with its colonic metabolites. Food Funct. 2020 May 27;: Authors: Song M, Lan Y, Wu X, Han Y, Wang M, Zheng J, Li Z, Li F, Zhou J, Xiao J, Cao Y, Xiao H Abstract 5-Demethylnobiletin (5DN) is a unique flavonoid mainly found in citrus fruits. In this study, we determined the chemopreventive effects...
Thu May 28, 2020 14:37
Related ArticlesCytotoxic and Antimetastatic Activity of Hesperetin and Doxorubicin Combination Toward Her2 Expressing Breast Cancer Cells. Asian Pac J Cancer Prev. 2020 May 01;21(5):1259-1267 Authors: Nurhayati IP, Khumaira A, Ilmawati GPN, Meiyanto E, Hermawan A Abstract OBJECTIVE: This study aimed to explore Hesperetin (Hst) potency as a co-chemotherapeutics agent combined with Doxorubicin (Dox), particularly cytotoxic and antimetastasis effects...
Thu May 28, 2020 13:37
Related Articlesβ-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest. Front Bioeng Biotechnol. 2020;8:378 Authors: Zhang R, Pan T, Xiang Y, Zhang M, Feng J, Liu S, Duan T, Chen P, Zhai B, Chen X, Wang W, Chen B, Han X, Chen L, Yan L, Jin T, Liu Y, Li G, Huang X, Zhang W, Sun Y, Li Q, Zhang Q, Zhuo L, Xie T, Wu Q, Sui X Abstract Objective:...
Thu May 28, 2020 13:37
Related ArticlesInflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage. Front Immunol. 2020;11:734 Authors: Franzin R, Stasi A, Fiorentino M, Stallone G, Cantaluppi V, Gesualdo L, Castellano G Abstract The aberrant activation of complement system in several kidney diseases suggests that this pillar of innate immunity has a critical role in the pathophysiology of renal damage of different etiologies. A growing...
Thu May 28, 2020 13:37
Related ArticlesRegorafenib is effective against neuroblastoma in vitro and in vivo and inhibits the RAS/MAPK, PI3K/Akt/mTOR and Fos/Jun pathways. Br J Cancer. 2020 May 27;: Authors: Subramonian D, Phanhthilath N, Rinehardt H, Flynn S, Huo Y, Zhang J, Messer K, Mo Q, Huang S, Lesperance J, Zage PE Abstract BACKGROUND: Regorafenib is an inhibitor of multiple kinases with aberrant expression and activity in neuroblastoma tumours that have potential...
Thu May 28, 2020 13:37
Related ArticlesConidial Melanin of the Human-Pathogenic Fungus Aspergillus fumigatus Disrupts Cell Autonomous Defenses in Amoebae. mBio. 2020 May 26;11(3): Authors: Ferling I, Dunn JD, Ferling A, Soldati T, Hillmann F Abstract The human-pathogenic fungus Aspergillus fumigatus is a ubiquitous saprophyte that causes fatal lung infections in immunocompromised individuals. Following inhalation, conidia are ingested by innate immune cells and can arrest...
Thu May 28, 2020 13:37
Related ArticlesCarnosic acid exhibits antiproliferative and proapoptotic effects in tumoral NCI-H460 and nontumoral IMR-90 lung cells. J Toxicol Environ Health A. 2020 May 27;:1-10 Authors: Corveloni AC, Semprebon SC, Baranoski A, Biazi BI, Zanetti TA, Mantovani MS Abstract Carnosic acid (CA) is a phenolic diterpene with many important biological activities including antimicrobial, antioxidant, anti-inflammatory properties, and anti-proliferative...
Thu May 28, 2020 13:37
Related ArticlesHeme Oxygenase-1 in Central Nervous System Malignancies. J Clin Med. 2020 May 21;9(5): Authors: Sferrazzo G, Di Rosa M, Barone E, Li Volti G, Musso N, Tibullo D, Barbagallo I Abstract Central nervous system tumors are the most common pediatric solid tumors and account for 20%-25% of all childhood malignancies. Several lines of evidence suggest that brain tumors show altered redox homeostasis that triggers the activation of various...
Thu May 28, 2020 13:37
Antitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer Cells.
Related ArticlesAntitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer Cells. Molecules. 2020 May 21;25(10): Authors: Chang KF, Chang JT, Huang XF, Lin YL, Liao KW, Huang CW, Tsai NM Abstract Colorectal cancer (CRC) is the third most common type of cancer and the second most common cause of cancer-related death in the world. N-Butylidenephthalide (BP), a natural compound, inhibits several cancers, such as hepatoma,...
Thu May 28, 2020 13:37
Related ArticlesCu(ii)-TACN complexes selectively induce antitumor activity in HepG-2 cells via DNA damage and mitochondrial-ROS-mediated apoptosis. Dalton Trans. 2020 Jan 07;49(1):114-123 Authors: Liu M, Song XQ, Wu YD, Qian J, Xu JY Abstract A new 1,4,7-triazacyclononane derivative, 4-benzyloxy-benzyl-1,4,7-triazacyclononane (btacn), and three associated cyclen complexes, Cu(btacn)Cl2, Zn(btacn)Cl2 and [Cu(btacn)2]·(ClO4)2, were prepared to serve...
Thu May 28, 2020 13:37
Related ArticlesCellular Senescence: Defining a Path Forward. Cell. 2019 10 31;179(4):813-827 Authors: Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M Abstract Cellular senescence is a cell state implicated in...
Thu May 28, 2020 13:37
Related ArticlesFoxO1 controls the expansion of pre-B cells by regulating the expression of interleukin 7 receptor α chain and its signal pathway. Immunol Lett. 2019 12;216:28-35 Authors: Li Z, Zhang N, Hui F, Zahid D, Zheng W, Xu X, Li W Abstract Forkhead box O1 (FoxO1) has a crucial role in the early B cell development. To understand the functional importance of FoxO1 gene in the early B cell expansion, we established a FoxO1 knockdown model using...
Thu May 28, 2020 13:37
Related ArticlesInterference with the bromodomain epigenome readers drives p21 expression and tumor senescence. Cancer Lett. 2019 Oct 01;461:10-20 Authors: Webber LP, Yujra VQ, Vargas PA, Martins MD, Squarize CH, Castilho RM Abstract Head and neck cancer (HNSCC) are one of the most common solid malignancies of the world, being responsible for over 350,000 deaths every year. Much of the complications in managing and treating HNSCC advent from the complex...
Thu May 28, 2020 13:37
Related ArticlesLeucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation. Cell Cycle. 2019 05;18(9):963-975 Authors: Skalka G, Hall H, Somers J, Bushell M, Willis A, Malewicz M Abstract Common hallmarks of cancer include the dysregulation of cell cycle progression and the acquisition of genome instability. In tumors, G1 cell cycle checkpoint induction is often lost. This increases the...
Thu May 28, 2020 13:37
Related ArticlesFission yeast cells grow approximately exponentially. Cell Cycle. 2019 04;18(8):869-879 Authors: Pickering M, Hollis LN, D'Souza E, Rhind N Abstract How the rate of cell growth is influenced by cell size is a fundamental question of cell biology. The simple model that cell growth is proportional to cell size, based on the proposition that larger cells have proportionally greater synthetic capacity than smaller cells, leads to the prediction...
Thu May 28, 2020 13:37
Related Articlesp21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775. Cell Cycle. 2019 04;18(8):834-847 Authors: Hauge S, Macurek L, Syljuåsen RG Abstract The Wee1 inhibitor MK1775 (AZD1775) is currently being tested in clinical trials for cancer treatment. Here, we show that the p53 target and CDK inhibitor p21 protects against MK1775-induced DNA damage during S-phase. Cancer and normal cells deficient for p21 (HCT116 p21-/-, RPE p21-/-,...
Thu May 28, 2020 13:37
Related ArticlesDynamics of protein synthesis and degradation through the cell cycle. Cell Cycle. 2019 04;18(8):784-794 Authors: Alber AB, Suter DM Abstract Protein expression levels depend on the balance between their synthesis and degradation rates. Even quiescent (G0) cells display a continuous turnover of proteins, despite protein levels remaining largely constant over time. In cycling cells, global protein levels need to be precisely doubled at...
Thu May 28, 2020 13:37
Related ArticlesBi-modal reprogramming of cell cycle by MiRNA-4673 amplifies human neurogenic capacity. Cell Cycle. 2019 04;18(8):848-868 Authors: Farahani R, Rezaei-Lotfi S, Simonian M, Hunter N Abstract Molecular mechanisms that inform heterochronic adaptations of neurogenesis in Homo sapiens remain largely unknown. Here, we uncover a signature in the cell cycle that amplifies the proliferative capacity of human neural progenitors by input from microRNA4673...
Thu May 28, 2020 13:37
Related ArticlesA checkpoint-oriented cell cycle simulation model. Cell Cycle. 2019 04;18(8):795-808 Authors: Bernard D, Mondesert O, Gomes A, Duthen Y, Lobjois V, Cussat-Blanc S, Ducommun B Abstract Modeling and in silico simulations are of major conceptual and applicative interest in studying the cell cycle and proliferation in eukaryotic cells. In this paper, we present a cell cycle checkpoint-oriented simulator that uses agent-based simulation...
Thu May 28, 2020 13:37
Related ArticlesSimultaneous Midface Advancement and Orthognathic Surgery: A Powerful Technique for Managing Midface Hypoplasia and Malocclusion. Plast Reconstr Surg. 2020 Jun;145(6):1067e-1072e Authors: Hammoudeh JA, Goel P, Wolfswinkel EM, Fahradyan A, Vartanian E, Garg R, Williams MS, Khansa I, Urata MM Abstract BACKGROUND: Midface hypoplasia dramatically affects the normative facial cascade. Simultaneous Le Fort III and Le Fort I procedures (Le Fort...
Thu May 28, 2020 17:40
Related ArticlesEfficacy and Safety of Intraoperative Lumbar Drain in Endoscopic Skull Base Tumor Resection: A Meta-Analysis. Front Oncol. 2020;10:606 Authors: Guo X, Zhu Y, Hong Y Abstract Objectives: This study aims to evaluate the efficacy and safety of lumbar drainage (LD) in preventing cerebrospinal fluid (CSF) leaks after endoscopic skull base tumor resection. Methods: A systematic online search was conducted using PubMed, Embase, Scopus, Web of...
Thu May 28, 2020 13:36
Related ArticlesRobot-based assistance in middle ear surgery and cochlear implantation: first clinical report. Eur Arch Otorhinolaryngol. 2020 May 26;: Authors: Vittoria S, Lahlou G, Torres R, Daoudi H, Mosnier I, Mazalaigue S, Ferrary E, Nguyen Y, Sterkers O Abstract PURPOSE: Middle ear surgery may benefit from robot-based assistance to hold micro-instruments or an endoscope. However, the surgical gesture performed by one hand may perturb surgeons accustomed...
Thu May 28, 2020 13:34
Related ArticlesExamination of the possible relation of the superior semicircular canal morphology with the roof thickness of the glenoid fossa and bone changes of the temporomandibular joint. Eur Arch Otorhinolaryngol. 2020 May 26;: Authors: Akay G, Karataş MS, Karadağ Ö, Üçok CÖ, Güngör K Abstract PURPOSE: This study sought to assess the relationships between a morphological characteristic of the superior semicircular canal (SSC) and both the roof...
Thu May 28, 2020 13:34
Related ArticlesIndications and timing for tracheostomy in patients with SARS CoV2-related. Eur Arch Otorhinolaryngol. 2020 May 26;: Authors: Ferri E, Boscolo Nata F, Pedruzzi B, Campolieti G, Scotto di Clemente F, Baratto F, Cristalli G Abstract BACKGROUND: The indications and timing for tracheostomy in patients with SARS CoV2-related are controversial. PURPOSE: In a recent issue published in the European Archives of Otorhinolaryngology, Mattioli...
Thu May 28, 2020 13:34
Related ArticlesLetter to the editor "Surgical resection of oral cancer: en‑bloc versus discontinuous approach". Eur Arch Otorhinolaryngol. 2020 May 26;: Authors: Luo MS PMID: 32458120 [PubMed - as supplied by publisher]
Thu May 28, 2020 13:34
Related ArticlesNew frontiers in precision medicine for sepsis-induced immunoparalysis. Expert Rev Clin Immunol. 2019 03;15(3):251-263 Authors: Bruse N, Leijte GP, Pickkers P, Kox M Abstract INTRODUCTION: In the last decade, the sepsis research field has shifted focus from targeting hyperinflammation to reversing sepsis-induced immunoparalysis. Sepsis-induced immunoparalysis is very heterogeneous: the magnitude and the nature of the underlying immune...
Thu May 28, 2020 13:33
Publication date: Available online 27 May 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): A.H. Friedlander, P.H. Couto-Souza, S.A. Berti-Couto
Thu May 28, 2020 13:30
Abstract Objectives To investigate the full publication proportion (FPP) of abstracts presented at the 2010 and 2011 EAO Congresses, analyse the discrepancies between abstracts and their full publications, and explore potential predictors of FPP and discrepancies. Methods Abstracts presented at the 2010 and 2011 EAO Congresses were retrieved. Associated full publications were identified by searching PubMed, Embase and Google Scholar. Discrepancies between abstracts and full publications...
Wed May 27, 2020 13:02
Abstract Objectives To investigate the effect of defined versus undefined periodontal maintenance after implant therapy on the prevalence of peri‐implant complications. Material and Methods Two hundred patients who underwent dental implant therapy in the National Dental Centre Singapore (NDCS) from 2005 to 2012 were recruited. One hundred patients had regular periodontal maintenance (defined maintenance programme group, DMP) and the other 100 patients had no documentation of periodontal...
Wed May 27, 2020 11:51
Abstract Objectives The objective of this in vitro study was to assess the accuracy of fully guided implant placement following virtual implant planning based on MRI. Material and Methods 16 human cadaver hemimandibles with single missing teeth (n=3), partially edentulous (n=6) and edentulous situations (n=7) were imaged using MRI. MRI and optical scans obtained with an intraoral scanner, were imported into an implant planning software. Virtual prosthetic and implant planning were performed...
Wed May 27, 2020 11:27
Related ArticlesPygmy mouse songs reveal anatomical innovations underlying acoustic signal elaboration in rodents. J Exp Biol. 2020 May 26;: Authors: Riede T, Pasch B Abstract Elaborate animal communication displays are often accompanied by morphological and physiological innovations. In rodents, acoustic signals used in reproductive contexts are produced by two distinct mechanisms, but the underlying anatomy that facilitates such divergence is poorly...
Thu May 28, 2020 13:30
Related ArticlesInsight toward the MicroRNA Profiling of Laryngeal Cancers: Biological Role and Clinical Impact. Int J Mol Sci. 2020 May 24;21(10): Authors: Takeuchi T, Kawasaki H, Luce A, Cossu AM, Misso G, Scrima M, Bocchetti M, Ricciardiello F, Caraglia M, Zappavigna S Abstract Head and neck squamous cell carcinoma (HNSCC), a heterogeneous disease arising from various anatomical locations including the larynx, is a leading cause of death worldwide....
Thu May 28, 2020 13:30
Related ArticlesDifferences in laryngeal movements during exercise in healthy and dyspnoeic adolescents. Int J Pediatr Otorhinolaryngol. 2020 Feb;129:109765 Authors: Norlander K, Johansson H, Emtner M, Janson C, Nordvall L, Nordang L Abstract OBJECTIVES: To compare glottic and supraglottic movements in healthy adolescents and adolescents experiencing dyspnoea during strenuous exercise. METHODS: Using the continuous laryngoscopy exercise (CLE)-test...
Thu May 28, 2020 13:30
Related ArticlesSedation withdrawal following single stage laryngotracheal reconstruction: Does dexmedetomidine help? Int J Pediatr Otorhinolaryngol. 2020 Feb;129:109758 Authors: Li L, Strum D, Pestieau SR, Zalzal G, Preciado D Abstract OBJECTIVES: Single-stage laryngotracheal reconstruction (SS-LTR) requires a period of post-operative intubation, during which time adequate sedation is needed to ensure graft healing. Commonly used agents include benzodiazepines,...
Thu May 28, 2020 13:30
Related ArticlesTransoral robotic tongue base reduction and supraglottoplasty combined with maxillomandibular advancement: a new option for selected sleep apnea patients? Preliminary report. Eur Arch Otorhinolaryngol. 2019 Dec;276(12):3543-3548 Authors: Dallan I, Cristofani-Mencacci L, Seccia V, Cambi C, Fiacchini G, Berrettini S, Brevi B Abstract PURPOSE: Transoral robotic surgery (TORS) and maxillo-mandibular advancement (MMA) are effective options...
Thu May 28, 2020 13:30
Related ArticlesLong-term changes in vocal function after supracricoid partial laryngectomy with cricohyoidoepiglottopexy for laryngeal cancer. Head Neck. 2019 01;41(1):139-145 Authors: Miyamaru S, Minoda R, Kodama N Abstract BACKGROUND: The purpose of this study was to assess changes in vocal function over time following supracricoid partial laryngectomy with cricohyoidoepiglottopexy (SCL-CHEP). METHODS: A total of 17 patients who underwent...
Thu May 28, 2020 13:30
Related ArticlesSclerosis of the arytenoid cartilage and glottic carcinoma: A clinical-pathological study. Head Neck. 2019 01;41(1):72-78 Authors: Lucioni M, Lionello M, Machin P, Sovran F, Canal F, Bertolin A, Rizzotto G Abstract BACKGROUND: Given the relevance of any tumor invasion of the arytenoid cartilage or crico-arytenoid unit to the planning open partial horizontal laryngectomy (OPHL) for laryngeal squamous cell carcinoma (LSCC), it is important...
Thu May 28, 2020 13:30
Intramuscular Corticosteroids for Acute Upper Respiratory Infections Affects Healthcare Utilization.
Related ArticlesIntramuscular Corticosteroids for Acute Upper Respiratory Infections Affects Healthcare Utilization. Ann Otol Rhinol Laryngol. 2020 May 26;:3489420929717 Authors: Parsel SM, Mohammed AE, Fort D, Barton BM, McCoul ED Abstract OBJECTIVE: To examine the use of intramuscular corticosteroid (IMCS) injections for treatment of acute upper respiratory infections (URI) and the influence on healthcare utilization. METHODS: This retrospective...
Thu May 28, 2020 13:29
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