Sophisticated devices for remote-controlled medical interventions require an electrogenetic interface that uses digital electronic input to directly program cellular behavior. We present a cofactor-free bioelectronic interface that directly links wireless-powered electrical stimulation of human cells to either synthetic promoter–driven transgene expression or rapid secretion of constitutively expressed protein therapeutics from vesicular stores. Electrogenetic control was achieved by coupling ectopic...
Thu May 28, 2020 20:40
Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the...
Thu May 28, 2020 20:40
Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19 (coronavirus disease 2019), which was first reported in Wuhan, China, in December 2019. Despite extensive efforts to control the disease, COVID-19 has now spread to more than 100 countries and caused a global pandemic. SARS-CoV-2 is thought to have originated in bats; however, the intermediate animal sources of the virus are unknown. In this study, we investigated the susceptibility of ferrets and...
Thu May 28, 2020 20:40
Cytotoxic lymphocyte–mediated immunity relies on granzymes. Granzymes are thought to kill target cells by inducing apoptosis, although the underlying mechanisms are not fully understood. Here, we report that natural killer cells and cytotoxic T lymphocytes kill gasdermin B (GSDMB)–positive cells through pyroptosis, a form of proinflammatory cell death executed by the gasdermin family of pore-forming proteins. Killing results from the cleavage of GSDMB by lymphocyte-derived granzyme A (GZMA), which...
Thu May 28, 2020 20:40
Forest dynamics arise from the interplay of environmental drivers and disturbances with the demographic processes of recruitment, growth, and mortality, subsequently driving biomass and species composition. However, forest disturbances and subsequent recovery are shifting with global changes in climate and land use, altering these dynamics. Changes in environmental drivers, land use, and disturbance regimes are forcing forests toward younger, shorter stands. Rising carbon dioxide, acclimation, adaptation,...
Thu May 28, 2020 20:40
Human mesenchymal stem cells (MSCs), a promising source of stem cells for regenerative medicine, have different morphological and functional characteristics. Carbohydrate moieties on the cell surface play an important role, including cell-cell interaction and cell recognition. The objective of this study was to determine possible differences in glycoconjugate distribution patterns of MSCs derived from various sources. MSCs were isolated from adipose tissue, bone marrow, Wharton’s jelly, and cord...
Thu May 28, 2020 12:48
Much of the current understanding on molecular and cellular events of adipose developmental biology comes from monolayer cell culture models using preadipocyte cell lines, although in vivo adipose tissue consists of a much more complex three-dimensional microenvironment of diverse cell types, extracellular network, and tissue-specific morphological and functional features. Added to this fact, the preadipocytes, on which the adipogenesis mechanisms are mostly explored, possess some serious limitations...
Thu May 28, 2020 12:04
British Journal of Nursing, Volume 29, Issue 10, Page 546-546, May 2020.
Thu May 28, 2020 08:14
British Journal of Nursing, Volume 29, Issue 10, Page S22-S29, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page S6-S13, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page 566-569, May 2020.
Thu May 28, 2020 08:14
British Journal of Nursing, Volume 29, Issue 10, Page 557-560, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page 561-565, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page 553-556, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page 578-579, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page 577-577, May 2020.
Thu May 28, 2020 08:14
British Journal of Nursing, Volume 29, Issue 10, Page S3-S3, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page 545-545, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page 582-583, May 2020.
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British Journal of Nursing, Volume 29, Issue 10, Page 580-581, May 2020.
Thu May 28, 2020 08:14
British Journal of Nursing, Volume 29, Issue 10, Page S4-S4, May 2020.
Thu May 28, 2020 08:14
British Journal of Nursing, Volume 29, Issue 10, Page 585-585, May 2020.
Thu May 28, 2020 08:14
British Journal of Nursing, Volume 29, Issue 10, Page 584-584, May 2020.
Thu May 28, 2020 08:14
Presented here is a protocol for whole-mount in situ RNA hybridization analysis in zebrafish and tube formation assay in patient-derived induced pluripotent stem cell-derived endothelial cells to study the role of endoglin in vascular formation.
Thu May 28, 2020 20:12
Publication date: Available online 27 May 2020Source: Cancer EpidemiologyAuthor(s): Siamak Sabour
Thu May 28, 2020 19:58
The world is facing a frightening pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with thousands of infections and fatalities. After 15 days of hard working in the intensive care unit managing patients with COVID-19, three nurses simultaneously complained about a red eye with painless eyelid swelling and tearing. Ophthalmological examination revealed similar single non-tender inflammatory nodules located in the middle of the lower eyelid, accompanied by conjunctival...
Thu May 28, 2020 19:01
ObjectivesWomen have a higher incidence of mental health problems compared with men. Psychosocial stressors at work are associated with mental health problems. However, few prospective studies have examined the association between these stressors and objectively measured outcomes of mental health. Moreover, evidence regarding potential differences between women and men in this association is scarce and inconsistent. This study investigates whether psychosocial stressors at work are associated with...
Thu May 28, 2020 19:01
BackgroundIncreased mammographic density is one of the strongest risk factors for breast cancer. Night shiftwork and its related factors, which include light at night, phase shift and sleep disruption, are believed to increase breast cancer risk however, their effects on mammographic density have barely been studied.MethodsThis study included 1821 women enrolled in the Breast Cancer Environment and Employment Study between 2009 and 2011. Mammographic density was measured using the Cumulus software...
Thu May 28, 2020 19:01
Mucosal Immunology, Published online: 28 May 2020; doi:10.1038/s41385-020-0302-xThe RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis
Thu May 28, 2020 03:00
Thu May 28, 2020 03:00
Thu May 28, 2020 03:00
Mucosal Immunology, Published online: 28 May 2020; doi:10.1038/s41385-020-0297-3Intestinal epithelium-derived BATF3 promotes colitis-associated colon cancer through facilitating CXCL5-mediated neutrophils recruitment
Thu May 28, 2020 03:00
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