Breathing pattern in intraspinal injection of autologous bone marrow mononuclear cells
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Breathing pattern in a phase I clinical trial of intraspinal injection of autologous bone marrow mononuclear cells in patients with amyotrophic lateral sclerosis via ScienceDirect Publication: Respiratory Physiology & Neurobiology Publication date: 15 January 2016 *Source:*Respiratory Physiology & Neurobiology, Volume 221 Author(s): Francisco José Ruiz-López, Julia Guardiola, Virginia Izura, Joaquín Gómez-Espuch, Francisca Iniesta, Miguel Blanquer, Javier López-San Román, Vicenta Saez, Pedro De Mingo, Salvador Martínez, Jose María Moraleda The safety of autologous bone marrow mononuclea... περισσότερα »
Loop gain in severely obese women with obstructive sleep apnoea
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Loop gain in severely obese women with obstructive sleep apnoea via ScienceDirect Publication: Respiratory Physiology & Neurobiology Publication date: 15 January 2016 *Source:*Respiratory Physiology & Neurobiology, Volume 221 Author(s): Plamen Bokov, Mohamed Essalhi, Christophe Delclaux Our objective was to assess whether obstructive sleep apnoea (OSA) patients were characterised by a reduced central CO2 controller gain (CG) and an enhanced plant gain (PG). We matched three groups of women (n=10 per group) enrolled in a previous study (Essalhi et al., J. Asthma. 50: 565–572, 2013): obes... περισσότερα »
Low dose cyclophosphamide: mechanisms of T cell modulation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Low dose cyclophosphamide: mechanisms of T cell modulation via ScienceDirect Publication: Europ... Publication date: Available online 22 November 2015 *Source:*Cancer Treatment Reviews Author(s): Mutsa Tatenda Madondo, Michael Quinn, Magdalena Plebanski Cyclophosphamide is considered one of the most successful chemotherapy drugs and is listed on the World Health Organisation’s List of Essential Medicines. Since its initial synthesis in 1958, it has been widely used to treat a range of cancers but its use has been declining due to the advent of platinum based and other chemotherapy agent...περισσότερα »
OX40 signaling in head and neck squamous cell carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
: Overcoming immunosuppression in the tumor microenvironment via Oral Oncology Publication date: Available online 21 November 2015 *Source:*Oral Oncology Author(s): R. Bryan Bell, Rom S. Leidner, Marka R. Crittenden, Brendan D. Curti, Zipei Feng, Ryan Montler, Michael J. Gough, Bernard A. Fox, Andrew D. Weinberg, Walter J. Urba OX40 is a member of the tumor necrosis factor (TNF) receptor family and a potent co-stimulatory pathway that when triggered can enhance T-cell memory, proliferation and anti-tumor activity in patients with metastatic cancer. Ongoing investigations at our institu...περισσότερα »
Inflammatory pseudotumor of the mandible
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Rare case report of huge via ScienceDirect Publication: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Publication date: Available online 21 November 2015 *Source:*Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Toshihisa Sato, Hideyuki Suenaga, Madoka Sugiyama, Kazuto Hoshi, Tsuyoshi Takato Inflammatory pseudotumor (IPT) is a rare benign non-neoplastic lesion. The etiology and the pathogenesis are yet to be understood. Aggressive progression, together with confusing radiological signs, is often mistaken as malignant. We report here a ...περισσότερα »
Clarithromycin-based triple therapy and bismuth-based quadruple therapy for eradicating H. pylori
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Quadruple therapy versus standard triple therapy for eradication of Helicobacter pylori in Kuwait via Gastroenterology Publication date: Available online 21 November 2015 *Source:*Arab Journal of Gastroenterology Author(s): Mohamed Alboraie, Motaz Saad, Jaber Al-Ali, Mohammad Malik, Noha Asem, Imre Schmidt, Ahmad A. Alfadhli Background and study aimsChronic infection caused by Helicobacter pylori (H. pylori) is associated with chronic gastritis, peptic ulcer disease, and gastric cancer. Eradication of H. pylori reduces morbidity of chronic gastritis and incidence of gastric cancer in h... περισσότερα »
Reconstruction after oral carcinoma resection : The medial sural artery perforator flap
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
The medial sural artery perforator flap aided by ultrasonic perforator-localization for reconstruction after oral carcinoma resection via Journal of Oral and Maxillofacial Surgery Publication date: Available online 22 November 2015 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Wenquan Zhao, Zhiyong Li, Lianjun Wu, Huiyong Zhu, Jianhua Liu, Huiming Wang PurposeTo evaluate the application of medial sural artery perforator flap (MSAP) aided by preoperative ultrasonic perforator-localization for post-surgical reconstruction of oral carcinoma.MethodsFrom November, 2013 to Au... περισσότερα »
Use of pedicled nasoseptal flap for pathologic oroantral fistula closure
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Use of pedicled nasoseptal flap for pathologic oroantral fistula closure via Journal of Oral and Maxillofacial Surgery Publication date: Available online 22 November 2015 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Julia Noel, Neville Teo, Vasu Divi, Jayakar V. Nayak Graphical abstract [image: image]
Peripheral blood monocyte and T cell subsets in children with specific polysaccharide antibody deficiency (SPAD).
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Peripheral blood monocyte and T cell subsets in children with specific polysaccharide antibody deficiency (SPAD).: Authors: Otero C, Díaz D, Uriarte I, Bezrodnik L, Finiasz MR, Fink S Abstract Specific polysaccharide antibody deficiency (SPAD) is a well reported immunodeficiency characterized by a failure to produce antibodies against polyvalent polysaccharide antigens, expressed by encapsulated microorganisms. The clinical presentation of these patients involves recurrent bacterial infections, being the most frequent agent Streptococcus (S.) pneumoniae. In SPAD patients few reports ... περισσότερα »
Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements: BACKGROUND AND OBJECTIVES: Children with atopic dermatitis (AD) have a higher risk for development of food allergies. The objective of this study was to examine incidence of food allergy development in infants with AD and the predictive value of food-antigen–specific immunoglobulin E measurements. METHODS: This trial examined the long-term safety and efficacy of pimecrolimus cream 1% in >1000 infants (3–18 months) with mild-to-severe AD without a history of food allergy. Food allergy deve... περισσότερα »
Stochastic resonance (SR),Apnea,Bradycardia,and Oxygenation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Stochastic Resonance Effects on Apnea, Bradycardia, and Oxygenation: A Randomized Controlled Trial: OBJECTIVE: To evaluate the effect of stochastic resonance (SR) stimulation on preterm infant oxygen desaturation, bradycardia, and apnea events. We hypothesized that SR stimulation will reduce these events. METHODS: This was a randomized crossover study conducted from April 2012 to July 2014. Eligible preterm infants were not receiving ventilation support and had at least 1 clinically documented apnea, bradycardia, and/or oxygen desaturation event. The 3 outcome variables were as fol...περισσότερα »
A novel cell-based assay for inhibitory anti-muscarinic type 3 receptor antibodies in primary sjögren's syndrome.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
A novel cell-based assay for inhibitory anti-muscarinic type 3 receptor antibodies in primary sjögren's syndrome.: Authors: Bastian I, Gordon TP, Jackson MW Abstract Inhibitory autoantibodies acting at the muscarinic acetylcholine receptor type 3 (M3R) are postulated to mediate autonomic dysfunction, including decreased salivary and lacrimal gland output and extra-glandular manifestations, in patients with primary Sjögren's syndrome. However, the contention that anti-M3R antibodies are pathogenic in patients remains untested, due to a lack of assays both sophisticated enough to detec... περισσότερα »
Peripheral blood antigen presenting cell responses in otitis-prone and non-otitis-prone infants.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
Peripheral blood antigen presenting cell responses in otitis-prone and non-otitis-prone infants.: Authors: Surendran N, Nicolosi T, Kaur R, Pichichero ME Abstract Stringently defined otitis-prone (sOP) children represent a new classification of the otitis-prone condition. Previous studies showed dysfunction in Ab, B-cell memory and T-cell memory responses. We sought to determine whether there are defects in numbers, phenotype and/or function of professional APC in the peripheral blood of sOP infants. APC phenotypic counts, MHC II expression and intracellular cytokine levels were dete... περισσότερα »
MicroRNA-125b suppresses the epithelial–mesenchymal transition and cell invasion by targeting ITGA9 in melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
MicroRNA-125b suppresses the epithelial–mesenchymal transition and cell invasion by targeting ITGA9 in melanoma: In this study, we aimed to investigate the role of miR-125b in melanoma progression and metastasis. We found that miR-125b expression is significantly downregulated in primary melanoma, and an even greater downregulation was observed in metastatic invasion. Restored expression of miR-125b in melanoma suppressed cell proliferation and invasion both in vitro and in vivo. Furthermore, our findings demonstrate that upregulating miR-125b significantly inhibits malignant phenot...περισσότερα »
Patients with Low-Risk Differentiated Thyroid Cancer Who Did Not Undergo Radioiodine Remnant Ablation after Total Thyroidectomy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
A Prospective Study Showing an Excellent Response of Patients with Low-Risk Differentiated Thyroid Cancer Who Did Not Undergo Radioiodine Remnant Ablation after Total Thyroidectomy: *Objectives:* To prospectively evaluate the outcome of patients with low-risk papillary thyroid carcinoma treated with total thyroidectomy (TT) who did not undergo radioiodine remnant ablation (RRA). *Study Design:* We prospectively followed up 57 patients; 3 months after TT, thyroglobulin (Tg) assessment and neck ultrasonography (US) were performed while patients were taking L-T4, presenting suppressed ...περισσότερα »
Risk Factors for Possible Dementia Using the Hopkins Verbal Learning Test and the Mini-Mental State Examination in Shanghai
Alexandros G. SfakianakisστοHead and NeckΠριν από 36 δευτερόλεπτα
Diagnostics, Vol. 5, Pages 487-496: Risk Factors for Possible Dementia Using the Hopkins Verbal Learning Test and the Mini-Mental State Examination in Shanghai: Using a combination of the Hopkins Verbal Learning Test (HVLT) and the Mini-Mental State Examination (MMSE), we investigated the prevalence of possible dementia (DEM) in community-dwelling elderly in Shanghai. Subsequently, we investigated significant risk factors for DEM and generated a DEM self-checklist for early DEM detection and case management. We found that among a total of 521 participants using a HVLT cut-off score ...περισσότερα »
HPV16/18 genotyping for the triage of HPV positive women in primary cervical cancer screening in Chile
Alexandros G. SfakianakisστοHead and NeckΠριν από 36 δευτερόλεπτα
HPV16/18 genotyping for the triage of HPV positive women in primary cervical cancer screening in Chile: Conclusions: HPV16/18 triage effectively stratified hrHPV positive women by their risk of high-grade lesions. HPV16/18 positive women must be referred immediately; referral could be deferred in HPV16/18 negative women given the slower progression of non-HPV16/18 lesions, however, they will require active follow-up. (Source: Infectious Agents and Cancer)
Cancer‐related hair loss
Alexandros G. SfakianakisστοHead and NeckΠριν από 36 δευτερόλεπτα
Cancer‐related hair loss: a selective review of the alopecia research literature: ConclusionsTreatment‐induced alopecia negatively affects millions of survivors each year in unique and nuanced ways. We hope that survivors' healthcare providers and loved ones may better appreciate the psychosocial challenges they experience related to hair loss, as well as the strategies they use to cope. Further research is much needed to better understand cancer‐related alopecia. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)
Comparison of African American Children's Performances on a Minimal Competence Core for Morphosyntax and the Index of Productive Syntax.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 41 δευτερόλεπτα
Comparison of African American Children's Performances on a Minimal Competence Core for Morphosyntax and the Index of Productive Syntax.: Conclusion: The MCC-MS has convergent criterion validity with the IPSyn. Although more research is warranted, both measures can be potentially used in oral language assessments of African American 3-year-olds. PMID: 26580135 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology) *MedWorm Sponsor Message:* Directory of the best January Sales in the UK. Find the best Christmas presents too.
Lenvatinib: Role in Thyroid Cancer and Other Solid Tumors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Lenvatinib: Role in Thyroid Cancer and Other Solid Tumors: The incidence of thyroid cancer is increasing in the United States [1]. Average annual percentage increases from 2006 to 2010 for thyroid cancers were 5.4% for men and 6.5% for women, some of the largest annual increases among cancers [1]. Thyroid cancer can be divided into 3 primary histologic types—differentiated, medullary, and anaplastic—and these histologic subtypes have different characteristics and prognoses. Differentiated thyroid cancers (DTCs) account for about 95% of all thyroid cancer cases and can be subdivided ... περισσότερα »
Human Frequency Following Response: Neural Representation of Envelope and Temporal Fine Structure in Listeners with Normal Hearing and Sensorineural Hearing Loss.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Human Frequency Following Response: Neural Representation of Envelope and Temporal Fine Structure in Listeners with Normal Hearing and Sensorineural Hearing Loss.: Objective: Listeners with sensorineural hearing loss (SNHL) typically experience reduced speech perception, which is not completely restored with amplification. This likely occurs because cochlear damage, in addition to elevating audiometric thresholds, alters the neural representation of speech transmitted to higher centers along the auditory neuroaxis. While the deleterious effects of SNHL on speech perception in humans...περισσότερα »
Qualities of Single Electrode Stimulation as a Function of Rate and Place of Stimulation with a Cochlear Implant.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Qualities of Single Electrode Stimulation as a Function of Rate and Place of Stimulation with a Cochlear Implant.: Objectives: Although it has been shown previously that changes in temporal coding produce changes in pitch in all cochlear regions, research has suggested that temporal coding might be best encoded in relatively apical locations. The authors hypothesized that although temporal coding may provide useable information at any cochlear location, low rates of stimulation might provide better sound quality in apical regions that are more likely to encode temporal information i...περισσότερα »
Within- and Across-Subject Variability of Repeated Measurements of Medial Olivocochlear-Induced Changes in Transient-Evoked Otoacoustic Emissions.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Within- and Across-Subject Variability of Repeated Measurements of Medial Olivocochlear-Induced Changes in Transient-Evoked Otoacoustic Emissions.: Objectives: Measurement of changes in transient-evoked otoacoustic emissions (TEOAEs) caused by activation of the medial olivocochlear reflex (MOCR) may have clinical applications, but the clinical utility is dependent in part on the amount of variability across repeated measurements. The purpose of this study was to investigate the within- and across-subject variability of these measurements in a research setting as a step toward determi...περισσότερα »
Craniopharyngioma and hypothalamic injury
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity.: Purpose of review: Hypothalamic alterations, pathological or treatment induced, have major impact on prognosis in craniopharyngioma patients mainly because of consequent hypothalamic obesity. Recent insight in molecular genetics, treatment strategies, risk factors and outcomes associated with hypothalamic obesity provide novel therapeutic perspectives. This review includes relevant publications since 2013. Recent findings: Recent findings confirm that alterations in posterior hy... περισσότερα »
Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer: *Conditions*: Human Papilloma Virus Infection; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVB Squamous Cell Carcinoma of the Oropharynx *Interventions*: Procedure: therapeutic conventional surgery; Radiation: intensity-modulated radiation therapy; Drug: cisplatin; Drug: carboplatin; Radiation: intensity-modulated radiation...περισσότερα »
Changes in Tumor Tissue and Serum Biomarkers Before and After Cetuximab Combined With Preoperative Radiotherapy in Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Changes in Tumor Tissue and Serum Biomarkers Before and After Cetuximab Combined With Preoperative Radiotherapy in Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma: *Condition*: Locally Advanced Thoracic Middle-lower Segment Esophageal Squamous Cell Carcinoma *Interventions*: Radiation: preoperative radiotherapy; Drug: cetuximab *Sponsors*: Sichuan Cancer Hospital and Research Institute; Daping Hospital and the Research Institute of Surgery of the Third Military Medical University; Affiliated Tumor Hospital of Guangzhou Medical University; Southwest Hospita...περισσότερα »
Concurrent Radiotherapy and Weekly Chemotherapy of PF for Postoperative Locoregional Recurrence of Esophageal Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Concurrent Radiotherapy and Weekly Chemotherapy of PF for Postoperative Locoregional Recurrence of Esophageal Cancer: *Condition*: Esophageal Squamous Cell Carcinoma *Interventions*: Drug: fluorouracil; Drug: Cisplatin; Radiation: Intensity-modulated radiation therapy *Sponsor*: Sun Yat-sen University ArmsAssigned InterventionsExperimental: Weekly PF with radiation 4 cycles of weekly cisplatin and fluorouracil (cisplatin 25mg/m2 on day 1, fluorouracil 1176mg/m2 on day 1-3, repeated weekly for 4 weeks) concurrently with Intensity-modulated radiation therapy (60Gy/28fr). D... περισσότερα »
National observational study to evaluate the “cleanyourhands” campaign (NOSEC): a questionnaire based study of national implementation
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
IntroductionThe number of national hand-hygiene campaigns has increased recently, following the World Health Organisation's (WHO) "Save Lives: clean your hands" initiative (2009), which offers hospitals a multi-component hand-hygiene intervention. The number of campaigns to be evaluated remains small. Most evaluations focus on consumption of alcohol hand rub (AHR). We are not aware of any evaluation reporting implementation of all campaign components. In a previously published report, we evaluated the effects of the English and Welsh cleanyourhands campaign (2004–8) on procurement... περισσότερα »
Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL/6 Mice Fed a Low-Fat Diet
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Background. This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5−/−), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice. Results. TLR5−/− and C57BL/6 male mice were divided into three subgroups: (1) control, mice were fed a standard AIN-76A (fat: 11.5 kcal%) diet for 12 weeks; (2) DIO, mice were fed a 58 kcal% high-fat diet (HFD) for 12 weeks; and (3) diet, mice were fed a HFD for 8 weeks to induce obesity and then switched to a 10.5 kcal% LFD for 4...περισσότερα »
Timing of Resective Surgery After Neoadjuvant Chemoradiotherapy in Esophageal Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Timing of Resective Surgery After Neoadjuvant Chemoradiotherapy in Esophageal Cancer: *Condition*: Cancer of the Esophagus *Intervention*: Procedure: Resective surgery *Sponsors*: Karolinska University Hospital; Oslo University Hospital; Haukeland University Hospital; St. Olavs Hospital; Lund University Hospital; Sahlgrenska University Hospital, Sweden; Uppsala University Hospital; University Hospital, Linkoeping; University Hospital Orebro; University Hospital, Umeå This study compares outcomes with regard to the timing of resective surgery after neoadjuv... περισσότερα »
Intranasal Bevacizumab for HHT-Related Epistaxis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Intranasal Bevacizumab for HHT-Related Epistaxis: *Conditions*: HHT; Hereditary Hemorrhagic Telangiectasia; Epistaxis; Nose Bleeds; Nasal Bleeding *Interventions*: Drug: Bevacizumab; Drug: Placebo (Saline) *Sponsor*: Stanford University This is a randomized, controlled, double-blind, placebo-controlled trial of intranasal Avastin (bevacizumab) injection versus saline control for control of HHT-related epistaxis when used in conjunction with bipolar electrocautery. ConditionInterventionPhaseHHT Hereditary Hemorrhagic Telangiectasia Epistaxis Nose Bleeds Nasal Bleed... περισσότερα »
Chemoradiotherapy With or Without Enteral Nutrition Intervention for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Chemoradiotherapy With or Without Enteral Nutrition Intervention for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma: *Conditions*: Esophageal Squamous Cell Carcinoma; Enteral Nutrition Therapy; Chemoradiotherapy *Interventions*: Drug: nutrison; Radiation: radiotherapy; Drug: Docetaxel, cisplatin *Sponsors*: Sichuan Cancer Hospital and Research Institute; Wuhan University; Xiangya Hospital of Central South University; Shanxi Province Cancer Hospital; Shandong Tumor Hospital; Henan Cancer Hospital; Beijing Cancer Hospital; Hebei Medical Univ... περισσότερα »
IRX-2 Regimen in Patients With Newly Diagnosed Stage III or IVA Squamous Cell Carcinoma of the Oral Cavity
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
IRX-2 Regimen in Patients With Newly Diagnosed Stage III or IVA Squamous Cell Carcinoma of the Oral Cavity: *Condition*: Squamous Cell Carcinoma of the Oral Cavity *Interventions*: Biological: IRX-2; Drug: Cyclophosphamide; Drug: Indomethacin; Dietary Supplement: Zinc-containing multivitamin; Drug: Omeprazole *Sponsor*: IRX Therapeutics The purpose of this study is to determine whether a pre-operative regimen of the study drug, IRX-2, a human cell-derived biologic with multiple active cytokine components, plus a single dose of cyclophosphamide, followed by 21 days ... περισσότερα »
Neurobehavioral Outcomes and Quality of Life in Pediatric Patients With Brain or Head/Neck Tumors Receiving Proton or Photon Radiotherapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Neurobehavioral Outcomes and Quality of Life in Pediatric Patients With Brain or Head/Neck Tumors Receiving Proton or Photon Radiotherapy: *Condition*: Brain Tumor *Intervention*: Radiation: standard adjuvant local radiation therapy or cranial radiation therapy *Sponsor*: Chang Gung Memorial Hospital Background: Neurobehavioral functions and quality of life (QoL) are the important outcome measurements after radiotherapy in patients with brain tumors and even head/neckcancers. However, few studies have focused on neurobehavioral functions and QoL after anti-cancer treatment ... περισσότερα »
Pembrolizumab + Radiation for Locally Adv SCC of the Head and Neck (SCCHN) Not Eligible Cisplatin
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Pembrolizumab + Radiation for Locally Adv SCC of the Head and Neck (SCCHN) Not Eligible Cisplatin: *Condition*: Head and Neck Cancer *Interventions*: Drug: Pembrolizumab; Radiation: Intensity Modulated Radiation Theapy *Sponsor*: UNC Lineberger Comprehensive Cancer Center This study is being done to evaluate the efficacy of Pembrolizumab, concomitant with and following standard of care definitive radiation, for locally advanced squamous cell carcinoma of the head and neck patients who are not good candidates for Cisplatin. ConditionInterventionPhaseHead and Neck CancerDru... περισσότερα »
Intensity-modulated Radiotherapy With or Without Concurrent Chemotherapy for Stage II Nasopharyngeal Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Intensity-modulated Radiotherapy With or Without Concurrent Chemotherapy for Stage II Nasopharyngeal Carcinoma: *Condition*: Nasopharyngeal Carcinoma *Interventions*: Drug: Cisplatin; Radiation: Intensity-modulated radiotherapy *Sponsors*: Sun Yat-sen University; Affiliated Tumor Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangdong Pharmaceutical University A prior phase III randomized trial showed considerable survival benefit from the combined treatment of cisplatin-bas... περισσότερα »
Concurrent Docetaxel Plus Cisplatin or Cisplatin Alone With IMRT in High Risk Nasopharyngeal Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Concurrent Docetaxel Plus Cisplatin or Cisplatin Alone With IMRT in High Risk Nasopharyngeal Carcinoma: *Condition*: Nasopharyngeal Carcinoma *Interventions*: Drug: Cisplatin 2; Drug: Docetaxel; Drug: Cisplatin 1; Radiation: Intensity-modulated radiotherapy *Sponsors*: Sun Yat-sen University; Affiliated Tumor Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangdong Pharmaceutical University ArmsAssigned InterventionsExperimental: TP plus IMRT Concurrent chemotherapy: TP - D... περισσότερα »
Resectable Esophageal Adenocarcinoma and the Relevance of CTC
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Pilot Study: Resectable Esophageal Adenocarcinoma and the Relevance of CTC: *Condition*: Esophageal Adenocarcinoma *Intervention*: Procedure: Blood Test for CTC evaluation *Sponsor*: University Hospital Freiburg To investigate the feasibility of evaluation of prevalence and clinical significance and relevance of circulating tumor cells (CTC) in the blood of patients with resectable adenocarcinoma of the esophagus (EAC) treated with multimodal therapy. The primary hypothesis is that the number of CTC correlates with tumor burden and response to treatment. One established and ... περισσότερα »
Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid: *Condition*: Head and Neck Squamous Cell Carcinoma *Interventions*: Drug: Valproic Acid; Drug: Placebo *Sponsor*: Barretos Cancer Hospital This study evaluates the addition of valproic acid as a chemopreventive drug in head and neck squamous cell carcinoma (HNSCC) patients that do not have signs of recurrence or residual disease. The participants will be randomized 1:1 (valproic acid : placebo). The primary outcome is to document histone acetylation in saliva collected from participants wh...περισσότερα »
Intrathoracic Esophagogastric Anastomosis After Robot Assisted Minimally Invasive Esophagectomy Using STRATAFIX
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Intrathoracic Esophagogastric Anastomosis After Robot Assisted Minimally Invasive Esophagectomy Using STRATAFIX: *Condition*: Esophageal Cancer *Intervention*: Device: Stratafix PGA Suture *Sponsors*: Henry Ford Health System; Ethicon, Inc. ArmsAssigned InterventionsSTRATAFIX Anastomosis of esophagus to stomach Device: Stratafix PGA Suture Subject leak Stricture rates post procedure Detailed Description:The purpose of the proposed study is to demonstrate that a hand sewn anastomosis using STRATAFIX is safe and effective after minimally invasive esophagectomy and capture ana...περισσότερα »
Active Surveillance of Papillary Thyroid Microcarcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Active Surveillance of Papillary Thyroid Microcarcinoma: *Condition*: Papillary Thyroid Microcarcinoma *Intervention*: Other: Active Surveillance *Sponsor*: Cedars-Sinai Medical Center ArmsAssigned InterventionsActive Surveillance Active surveillance instead of standard of care immediate surgery. Patients will be closely monitored every six months until disease is stable for a two-year period and then annually thereafter. Other: Active Surveillance Subjects will be actively observed for disease progression (condition worsens) instead of receiving immediate surgery, considered... περισσότερα »
Evaluation of host Hsp(s) as potential biomarkers for the diagnosis of Tuberculous Meningitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Evaluation of host Hsp(s) as potential biomarkers for the diagnosis of Tuberculous Meningitis via Clinical Neurology and Neurosurgery Publication date: Available online 19 November 2015 *Source:*Clinical Neurology and Neurosurgery Author(s): Seema D. Shekhawat, Hemant J. Purohit, Girdhar M. Taori, Hatim F. Daginawala, Rajpal S. Kashyap ObjectivesDiagnosis of tuberculosis meningitis (TBM) remains challenging in tuberculosis (TB) endemic countries. The need for TB biomarkers arises, in part, from the difficulty of accurately diagnosing TBM with the available methods.Patients and Methods...περισσότερα »
Symptoms of Thyrotoxicosis, Bone Metabolism, and Occult Atrial Fibrillation in Older Women with Mild Endogenous Subclinical Hyperthyroidism
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Symptoms of Thyrotoxicosis, Bone Metabolism, and Occult Atrial Fibrillation in Older Women with Mild Endogenous Subclinical Hyperthyroidism: Summary Objective The objective of this study was to evaluate symptoms of thyrotoxicosis, bone turnover, bone mineral density (BMD), and occult atrial fibrillation (AF) in women ≥ 65 years with mild endogenous subclinical hyperthyroidism (SCH). Design Cross-sectional and case-control study. Patients Signs and symptoms of thyrotoxicosis, serum carboxyterminal telopeptide (CTx) and procollagen type I N-terminal propeptide (PINP), BMD, resting ele... περισσότερα »
Factors affecting parathyroid hormone levels in different types of primary aldosteronism
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Factors affecting parathyroid hormone levels in different types of primary aldosteronism: Abstract Background Recent studies have found that mild secondary hyperparathyroidism might be another clinical feature of patients with primary aldosteronims (PA), but whether serum parathyroid hormone level (PTH) is correlated with subtypes of PA and what contributes to the elevated PTH level remains unclear. Objective To illustrate the changes of PTH in PA and to partly explain the mechanism of how the effects of aldosterone regulating the secretion of PTH in PA. Methods We enrolled a total o...περισσότερα »
Taselisib (GDC-0032), a Potent {beta}-sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Taselisib (GDC-0032), a Potent {beta}-sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations: Purpose: Activating PIK3CA genomic alterations are frequent in head and neck squamous cell carcinoma (HNSCC) and there is an association between phosphoinositide 3-kinase (PI3K) signaling and radioresistance. Hence, we investigated the therapeutic efficacy of inhibiting PI3K with GDC-0032, a PI3K inhibitor with potent activity against p110α, with radiation in HNSCC. Experimental Design: The efficacy of GDC-0032 w...περισσότερα »
Bradykinin b2 receptor expression in the bronchial mucosa of allergic asthmatics: the role of NF-kB
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Bradykinin b2 receptor expression in the bronchial mucosa of allergic asthmatics: the role of NF-kB: Abstract Background Bradykinin (BK) mediates acute allergic asthma and airway remodeling. Nuclear factor-kappa B (NF-kB) is potentially involved in BK B2 receptor (B2R) regulation. Objective In this observational cross-sectional study B2R and NF-kB expression was evaluated in bronchial biopsies from mild asthmatics (after diluent/allergen challenge) and healthy controls examining the role of NF-kB in B2R expression in primary human fibroblasts from normal and asthmatic subjects (HNB...περισσότερα »
IgE responses to Ascaris and mite tropomyosins are risk factors for asthma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Comment on IgE responses to Ascaris and mite tropomyosins are risk factors for asthma: Abstract We read with great interest the paper by Ahumada et al. [1] on the association between asthma symptoms and IgE responses to *Ascaris* and mites in a population living in the tropics. They report for the first time in a nation-wide case control study performed in Columbia that IgE sensitization to housedust mite or *Ascaris* tropomyosin has clinical relevance. They also report that specific IgE to tropomyosins from *Ascaris* and mites strongly correlate, and speculate that co-exposure to ... περισσότερα »
Peanut allergic patients in the MIRABEL survey: characteristics, allergists’ dietary advice and lessons from real life
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Peanut allergic patients in the MIRABEL survey: characteristics, allergists’ dietary advice and lessons from real life: Abstract Background The MIRABEL survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyze the consumer behavior, to study the presence of peanut traces in pre-packed foods with/without precautionary allergen labeling (PAL), and to combine these data to quantify allergic risk and produce a cost/benefit analysis. This paper reports a real life observatory of 785 patients ... περισσότερα »
Randomized study of sinusoidal chronomodulated versus flat intermittent induction chemotherapy with cisplatin and 5-fluorouracil followed by traditional radiotherapy for locoregionally advanced nasopharyngeal carcinoma.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Randomized study of sinusoidal chronomodulated versus flat intermittent induction chemotherapy with cisplatin and 5-fluorouracil followed by traditional radiotherapy for locoregionally advanced nasopharyngeal carcinoma.: This study aimed to evaluate the toxic and therapeutic effects of sinusoidal chronomodulated infusion versus flat intermittent infusion of cisplatin (DDP) and 5-fluorouracil (5-FU) followed by radiotherapy in patients with locoregionally advanced NPC. Patients with biopsy-diagnosed untreated stages III and IV NPC (according to the 2002 UICC staging system) were rand... περισσότερα »
Spinocerebellar ataxia type 1
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy: [image: F2.medium.gif] Spinocerebellar ataxia type 1 is one of nine polyglutamine expansion diseases and is characterized by cerebellar ataxia and neuronal degeneration in the cerebellum and brainstem. Currently, there are no effective therapies for this disease. Previously, we have shown that RNA interference mediated silencing of *ATXN1* mRNA provides therapeutic benefit in mouse models of the disease. Adeno-associated viral delivery of an engineered microRNA targeting *ATX... περισσότερα »
Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency: [image: F2.medium.gif] A long-standing mystery surrounding ataxia-telangiectasia is why it is mainly cerebellar neurons, Purkinje cells in particular, that appear vulnerable to ATM deficiency. Here we present data showing that 5-hydroxymethylcytosine (5hmC), a newly recognized epigenetic marker found at high levels in neurons, is substantially reduced in human ataxia-telangiectasia and *Atm*–/– mouse cerebellar Purkinje cells. We further show that TET1, a... περισσότερα »
Mitochondrial Complex IV [cytochrome c oxidase (COX)] deficiency is one of the most common respiratory chain defects
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
LRPPRC mutations cause early-onset multisystem mitochondrial disease outside of the French-Canadian population: [image: F2.medium.gif] Mitochondrial Complex IV [cytochrome *c* oxidase (COX)] deficiency is one of the most common respiratory chain defects in humans. The clinical phenotypes associated with COX deficiency include liver disease, cardiomyopathy and Leigh syndrome, a neurodegenerative disorder characterized by bilateral high signal lesions in the brainstem and basal ganglia. COX deficiency can result from mutations affecting many different mitochondrial proteins. The ... περισσότερα »
Risk of Stroke-Associated Pneumonia and Oral Hygiene
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Risk of Stroke-Associated Pneumonia and Oral Hygiene: *Background:* Pneumonia is a major complication of stroke, but effective prevention strategies are lacking. Since aspiration of oropharyngeal secretions is the primary mechanism for development of stroke-associated pneumonia, strategies that decrease oral colonization with pathogenic bacteria may help curtail pneumonia risk. We therefore hypothesized that systematic oral care protocols can help decrease pneumonia risk in hospitalized stroke patients. In this study, we investigated the impact of a systematic oral hygiene care (OHC...περισσότερα »
Growth-suppressive effect of suberoylanilide hydroxamic acid (SAHA) on human oral cancer cells
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Growth-suppressive effect of suberoylanilide hydroxamic acid (SAHA) on human oral cancer cells: Conclusions Our results indicate that the ERK signaling pathway may constitute a critical denominator of SAHA-induced apoptosis in OSCC-derived cells and that SAHA may have therapeutic potential for OSCC. (Source: Cellular Oncology) Abstract Purpose The histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) has been reported to exhibit anticancer activities in various cancer cell types, but as yet there are few reports on the anticancer effects of SAHA in oral squa... περισσότερα »
Frontiers of Nuclear Cardiology.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Frontiers of Nuclear Cardiology.* Cardiol Clin. 2016 Feb;34(1):xiii Authors: Dorbala S, Slomka P PMID: 26590790 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1MMMohu via IFTTT
Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula: Abstract Use of high-flow oxygen via nasal cannula (HFO2-NC) is increasingly common in intensive care unit (ICU) settings. Despite the critical interface between respiration and swallowing, and the high acuity of patients in ICUs, the impact of HFO2-NC on feeding and swallowing is unknown. The present prospective, single-center, cohort study investigated the impact of HFO2-NC use on oral alimentation in neonatal and adult ICU patients. Oral alimentation status was evaluated in 100 consec... περισσότερα »
Dysphagia in Parkinson’s Disease
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Dysphagia in Parkinson’s Disease: Abstract More than 80 % of patients with Parkinson’s disease (PD) develop dysphagia during the course of their disease. Swallowing impairment reduces quality of life, complicates medication intake and leads to malnutrition and aspiration pneumonia, which is a major cause of death in PD. Although the underlying pathophysiology is poorly understood, it has been shown that dopaminergic and non-dopaminergic mechanisms are involved in the development of dysphagia in PD. Clinical assessment of dysphagia in PD patients is challenging and often delivers unre...περισσότερα »
The evolving spectrum of the PRRT2 (proline-rich transmembrane protein 2)-associated paroxysmal diseases
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The evolving spectrum of PRRT2-associated paroxysmal diseases: [image: F2.medium.gif] Next-generation sequencing has identified mutations in the *PRRT2* (proline-rich transmembrane protein 2) gene as the leading cause for a wide and yet evolving spectrum of paroxysmal diseases. *PRRT2* mutations are found in the majority of patients with benign familial infantile epilepsy, infantile convulsions and choreoathetosis and paroxysmal kinesigenic dyskinesia, confirming a common disease spectrum that had previously been suggested based on gene linkage analyses and shared clinical featu... περισσότερα »
The visual perception of natural motion
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The visual perception of natural motion: abnormal task-related neural activity in DYT1 dystonia: [image: F2.medium.gif] Although primary dystonia is defined by its characteristic motor manifestations, non-motor signs and symptoms have increasingly been recognized in this disorder. Recent neuroimaging studies have related the motor features of primary dystonia to connectivity changes in cerebello-thalamo-cortical pathways. It is not known, however, whether the non-motor manifestations of the disorder are associated with similar circuit abnormalities. To explore this possibility,... περισσότερα »
The parietal lobe is thought to play in the processing of corollary discharges for saccadic eye movements
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Refuting the hypothesis that a unilateral human parietal lesion abolishes saccade corollary discharge: [image: F2.medium.gif] This paper questions the prominent role that the parietal lobe is thought to play in the processing of corollary discharges for saccadic eye movements. A corollary discharge copies the motor neurons’ signal and sends it to brain areas involved in monitoring eye trajectories. The classic double-step saccade task has been used extensively to study these mechanisms: two targets (T1 and T2) are quickly (40–150 ms) flashed sequentially in the periphery. After... περισσότερα »
musical hallucinations and their relationship to neurological disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Minds on replay: musical hallucinations and their relationship to neurological disease: [image: F2.medium.gif] The phenomenon of musical hallucinations, in which individuals perceive music in the absence of an external auditory stimulus, has been described sparingly in the literature through small case reports and series. Musical hallucinations have been linked to multiple associated conditions, including psychiatric and neurologic disease, brain lesions, drug effect, and hearing impairment. This study aimed to review the demographics of subjects with musical hallucinations and... περισσότερα »
Patterns and predictors of failure following tri-modality therapy for locally advanced esophageal cancer.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Patterns and predictors of failure following tri-modality therapy for locally advanced esophageal cancer.: CONCLUSION: Tumor and treatment factors may predict for failure in patients undergoing tri-modality therapy for locally advanced esophageal cancer. Further data is needed to identify patterns of failure in these patients. PMID: 26581671 [PubMed - as supplied by publisher] (Source: Acta Oncologica) Acta Oncol. 2015 Nov 19:1-6. [Epub ahead of print] Patterns and predictors of failure following tri-modality therapy for locally advanced esophageal cancer. Shaikh T1, Zaki MA2, Do...περισσότερα »
Swallowing Kinematics and Factors Associated with Laryngeal Penetration and Aspiration in Stroke Survivors with Dysphagia.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Swallowing Kinematics and Factors Associated with Laryngeal Penetration and Aspiration in Stroke Survivors with Dysphagia.* Dysphagia. 2015 Nov 21; Authors: Seo HG, Oh BM, Han TR Abstract The purpose of this study was to investigate swallowing kinematics and explore kinematic factors related with penetration-aspiration in patients with post-stroke dysphagia. Videofluoroscopic images of 68 patients with post-stroke dysphagia and 34 sex- and age-matched healthy controls swallowing a thin liquid were quantitatively analyzed using two-dimensional motion digitization. The measuremen... περισσότερα »
Swallowing Kinematics and Factors Associated with Laryngeal Penetration and Aspiration in Stroke Survivors with Dysphagia.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Swallowing Kinematics and Factors Associated with Laryngeal Penetration and Aspiration in Stroke Survivors with Dysphagia.* Dysphagia. 2015 Nov 21; Authors: Seo HG, Oh BM, Han TR Abstract The purpose of this study was to investigate swallowing kinematics and explore kinematic factors related with penetration-aspiration in patients with post-stroke dysphagia. Videofluoroscopic images of 68 patients with post-stroke dysphagia and 34 sex- and age-matched healthy controls swallowing a thin liquid were quantitatively analyzed using two-dimensional motion digitization. The measuremen... περισσότερα »
Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula.* Dysphagia. 2015 Nov 21; Authors: Leder SB, Siner JM, Bizzarro MJ, McGinley BM, Lefton-Greif MA Abstract Use of high-flow oxygen via nasal cannula (HFO2-NC) is increasingly common in intensive care unit (ICU) settings. Despite the critical interface between respiration and swallowing, and the high acuity of patients in ICUs, the impact of HFO2-NC on feeding and swallowing is unknown. The present prospective, single-center, cohort study investigated the impact of HFO2-NC use on oral...περισσότερα »
Regression of advanced solid tumors in patients receiving placebo or no anti-cancer therapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
anti-angiogenic drug Meta-analysis of regression of advanced solid tumors in patients receiving placebo or no anti-cancer therapy in prospective trials Saturday, November 21, 2015, 16:38 Publication date: Available online 9 November 2015 *Source:*Critical Reviews in Oncology/Hematology Author(s): Pooja Ghatalia, Charity J. Morgan, Guru Sonpavde Background A meta-analysis of prospective trials systematically investigated regression of advanced solid tumors in patients receiving placebo or no anticancer therapy to inform on spontaneous regressions. Patient and methods Arms of randomized c... περισσότερα »
Metastatic melanoma treatment
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
anti-angiogenic drug : Combining old and new therapies Saturday, November 21, 2015, 16:38 Publication date: Available online 17 November 2015 *Source:*Critical Reviews in Oncology/Hematology Author(s): Ryan J. Davey, Andre van der Westhuizen, Nikola A. Bowden Metastatic melanoma is an aggressive form of cancer characterised by poor prognosis and a complex etiology. Until 2010, the treatment options for metastatic melanoma were very limited. Largely ineffective dacarbazine, temozolamide or fotemustine were the only agents in use for 35 years. In recent years, the development of molecular... περισσότερα »
Microbiology and Biofilm Trends of Silicone Lacrimal Implants
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Ophthalmic Plastic & Reconstructive Surgery - Published Ahead-of-Print : Comparing Infected Versus Routinely Removed Stents. Samimi, David B.; Ediriwickrema, Lilangi S.; Bielory, Brett P.; Miller, Darlene; Lee, Wendy; Johnson, Thomas E. · Saturday, November 21, 2015, 16:30 Purpose: To investigate the pathogens and biofilms responsible for clinically significant infection of silicone stents implanted within the lacrimal system. Methods: Retrospective review of culture results and patient demographics for all silicone lacrimal stents removed early for clinically significant infection and...περισσότερα »
Decompression for Thyroid-Related Compressive Optic Neuropathy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Ophthalmic Plastic & Reconstructive Surgery - Published Ahead-of-Print Simultaneous Versus Staged Balanced Decompression for Thyroid-Related Compressive Optic Neuropathy. Wu, Chris Y.; Stacey, Andrew W.; Kahana, Alon · Saturday, November 21, 2015, 16:30 Purpose: To compare the visual and exophthalmometry outcomes of simultaneous versus staged balanced decompression in patients with thyroid-related compressive optic neuropathy (CON). Methods: All consecutive patients who underwent simultaneous or staged balanced decompressions for clinically diagnosed thyroid-related CON performed by 4... περισσότερα »
Secondary Orbital Reconstruction
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Ophthalmic Plastic & Reconstructive Surgery - Published Ahead-of-Print Secondary Orbital Reconstruction in Patients with Prior Orbital Fracture Repair. Kim, Jane S.; Lee, Bradford W.; Scawn, Richard L.; Korn, Bobby S.; Kikkawa, Don O. ·Saturday, November 21, 2015, 16:30 Purpose: To evaluate clinical characteristics, preoperative imaging findings, pre- and post-operative outcomes, and satisfaction of patients requiring secondary reconstruction after inadequate primary orbital fracture repair. Methods: Retrospective review of 13 patients requiring secondary orbital reconstruction follow... περισσότερα »
T-shape double fascia graft for lower lip deformity from facial paralysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
British Association of Plastic Surgeons Assessment of T-shape double fascia graft for lower lip deformity from facial paralysis: A questionnaire survey Saturday, November 21, 2015, 16:40 Publication date: Available online 19 November 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Ayato Hayashi, Hidekazu Yoshizawa, Yuhei Natori, Shunichi Suda, Mariko Mochizuki, Yuri Nishimuta, Rica Tanaka, Hiroshi Mizuno Introduction There are two main methods to treat lower lip deformity (LLD) in facial paralysis. First is surgical intervention on the side of the par...περισσότερα »
ESCC : Aberrant methylation of the TERT promoter
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Aberrant methylation of the TERT promoter in esophageal squamous cell carcinoma via Cancer Genetics Publication date: Available online November 2015 *Source:*Cancer Genetics Author(s): Jiaying Deng, Daizhan Zhou, Junhua Zhang, Yun Chen, Chunyu Wang, Yun Liu, Kuaile Zhao Recent study indicated that upstream of the transcription start site (UTSS)hypermethylation of the telomerase reverse transcriptase (TERT)gene was associated with tumor progression and poor prognosis in pediatric brain tumors. The potential for methylation-mediated regulation of the UTSS region of the TERT gene in esop... περισσότερα »
Tumor-Infiltrating Lymphocyte Therapy: Addressing Prevailing Questions.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Tumor-Infiltrating Lymphocyte Therapy: Addressing Prevailing Questions.: Authors: Radvanyi LG Abstract Autologous adoptive T-cell therapies have made tremendous strides over the last few years with excitement currently being generated by technologies that can reprogram T-cell specificities toward any desired antigen including chimeric antigen receptors and recombinant T-cell receptors. Time will tell whether these new genetically engineered T-cell technologies will be effective as advertised, especially in solid tumors, considering the limited availability of specific antigens and th... περισσότερα »
Chimeric Antigen Receptor T-Cells
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Chimeric Antigen Receptor T-Cells: New Approaches to Improve Their Efficacy and Reduce Toxicity.: Authors: Maus MV, Powell DJ Abstract The durable remission of B-cell leukemia and lymphoma following chimeric antigen receptor (CAR) T-cell therapy has brought this new form of adoptive immunotherapy to center stage with the expectation that CAR T-cell therapy may provide similar efficacy in other hematologic and solid cancers. Herein, we review recent advances in the areas of CAR design that improve CAR T-cell proliferation, engraftment, and efficacy, as well as clinical application str... περισσότερα »
Natural Killer Cell Adoptive Transfer Therapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Natural Killer Cell Adoptive Transfer Therapy: Exploiting the First Line of Defense Against Cancer.: Authors: Davis ZB, Felices M, Verneris MR, Miller JS Abstract Natural killer (NK) cells constitute an important component of the initial immunological response against transformed cells. However, chronic exposure to the tumor microenvironment can fundamentally alter the ability of NK cells to sufficiently control tumor progression. Thus, the adoptive transfer of healthy, functional NK cells as an interventional therapy has been an area of great interest for improving patient outcomes....περισσότερα »
MicroRNA-125b suppresses the epithelial–mesenchymal transition and cell invasion by targeting ITGA9 in melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
MicroRNA-125b suppresses the epithelial–mesenchymal transition and cell invasion by targeting ITGA9 in melanoma: In this study, we aimed to investigate the role of miR-125b in melanoma progression and metastasis. We found that miR-125b expression is significantly downregulated in primary melanoma, and an even greater downregulation was observed in metastatic invasion. Restored expression of miR-125b in melanoma suppressed cell proliferation and invasion both in vitro and in vivo. Furthermore, our findings demonstrate that upregulating miR-125b significantly inhibits malignant phenot...περισσότερα »
Cranial irradiation significantly reduces beta amyloid plaques in the brain and improves cognition in a murine model of Alzheimer’s Disease (AD)
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 23 November 2015 *Source:*Radiotherapy and Oncology Author(s): Brian Marples, Mackenzie McGee, Sean Callan, Scott E. Bowen, Bryan J. Thibodeau, Daniel B. Michael, George D. Wilson, Michael E. Maddens, James Fontanesi, Alvaro A. Martinez Background and purposeTo investigate if cranial X-irradiation reduces amyloid-β (Aβ) plaques and influences cognitive function in a transgenic mouse model of AD.Methods and materialsB6.Cg-Tg (APPswePSEN1dE9)85Dbo/J AD-prone mice were given cranial X-irradiation. The number of Aβ plaques, along with expression of AD ... περισσότερα »
Machine Learning Approaches for Predicting Radiation Therapy Outcomes
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Machine Learning Approaches for Predicting Radiation Therapy Outcomes: A Clinician's Perspective.: Authors: Kang J, Schwartz R, Flickinger J, Beriwal S Abstract Radiation oncology has always been deeply rooted in modeling, from the early days of isoeffect curves to the contemporary Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) initiative. In recent years, medical modeling for both prognostic and therapeutic purposes has exploded thanks to increasing availability of electronic data and genomics. One promising direction that medical modeling is moving toward is...περισσότερα »
Wheat Allergy and Intolerence
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Recent Updates and Perspectives pp. 13-24(12) Authors: *Pasha, Imran; Saeed, Farhan; Sultan, Muhammad Tauseef; Batool, Rizwana; Aziz, Mahwash; Ahmed, Waqas* Abstract:The current review paper highlights the complicacies associated with communities relying on wheat as their dietary staple. Although, wheat is an important source of nutrients but is also linked with allergenic responses in genetically susceptible subjects. The wheat proteins especially α-amylase inhibitors, ω-5 gliadins, prolamins, nonprolamin, glucoprotein, and profilins are of significance importance. The allergenic ...περισσότερα »
Palisaded neutrophilic and granulomatous dermatitis(PNGD) : dark red plaques, nodules, annular erythema, papules and indurated bands
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Palisaded neutrophilic and granulomatous dermatitis *Author(s):* LIAO Wen-jun, FU Meng, LUAN Qi, LIU Yu, Department of Dermatology, Xijing Hospital, the Fourth Military Medical University *Pages:* 665-669 *Year:* 2015 *Issue:* 10 *Journal:* *Journal of Clinical Dermatology* *Keyword:* dermatitis; palisaded neutrophilic and granulomatous; dermatitis interstitial granulomatous; *Abstract:* Objective: To analyze the clinical and histopathological characteristics of palisaded neutrophilic and granulomatous dermatitis(PNGD). Methods: The clinical and histopathologic characteristics of 9 ... περισσότερα »
