Stratification of SNOT-22 scores into mild, moderate or severe and relationship with other subjective instruments.

Related Articles

Stratification of SNOT-22 scores into mild, moderate or severe and relationship with other subjective instruments.

Rhinology. 2016 Mar 27;

Authors: Toma S, Hopkins C

Abstract
AIMS AND OBJECTIVES: The European Position Paper on Rhinosinusitis and Nasal Polyps provides treatment algorithms based on the mild/moderate/severe (MMS) classification. To date there has been no statistically validated stratification of the SNOT-22 score according to this classification.
METHODS: 65 consecutive patients diagnosed with CRS completed a SNOT-22, VAS and rated their symptoms according to MMS and impact on quality of life.
RESULTS: The median SNOT 22 scores varied between the 3 MMS categories. The interquartile ranges for the respective MMS groups were: Mild 8-17, Moderate 22.5-48, Severe 54-83. Median values for the respective MMs groups were: Mild 12, Moderate 36 and Severe 66. 15.38 % of patients in the Mild category, 95.24% in the Moderate category and 100% in the Severe category feel their QoL is affected. There was a strongly positive correlation between the SNOT-22 and VAS scores.
CONCLUSION: We propose a statistically validated definition for stratification of the SNOT-22, with Mild being defined on the SNOT-22 score as 8-20 inclusive, Moderate as between 20-50 and Severe as over 50.

PMID: 27017484 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Mn4Hzr
via IFTTT

Long term e ects of olfactory training in patients with post-infectious olfactory loss.

Related Articles

Long term e ects of olfactory training in patients with post-infectious olfactory loss.

Rhinology. 2016 Mar 27;

Authors: Konstantinidis I, Tsakiropoulou E, Constantinidis J

Abstract
BACKGROUND: There is evidence of the effectiveness of repeated exposure to odours on short-term olfactory function. The aim of this study was to assess the long-term effects of olfactory training.
METHODS: We conducted a prospective study of 111 patients with post-infectious olfactory dysfunction. Two groups of patients performed olfactory training for 16 and 56 weeks, respectively, and were compared with a control group. The training was performed twice daily using four odours (phenyl ethyl alcohol, eucalyptol, citronellal, eugenol). Olfactory testing was performed by means of the Sniffin Sticks test as a baseline assessment and then every 8 weeks for 56 weeks. Subjective ratings were performed using a visual analogue scale (0-100).
RESULTS: Both training groups presented significantly higher scores than the controls. The long-term group had better results than the short-term group. Short-term training patients sustained their improvement within the follow-up period. Subsets analysis showed that training patients mainly increased identification and discrimination. Subjective ratings were in accordance with the olfactory test results.
CONCLUSION: Long-term olfactory training seems to be associated with better results in patients with post-infectious olfactory loss than a short-term scheme. Short-term training provides sustainable results at 56 weeks follow-up assessment.

PMID: 27017331 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Mn4FaK
via IFTTT

The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model.

Related Articles

The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model.

Rhinology. 2016 Mar 27;

Authors: Tatar A, Yayla M, Kose D, Halici Z, Yoruk O, Polat E

Abstract
OBJECTIVE: Desloratadine is a biologically active metabolite of loratadine which is indicated for the treatment of allergic rhinitis. Bosentan is a dual endothelin receptor antagonist used to treatment of pulmonary artery hypertension (PAH). In this study, we aimed to determine the role of endothelins in allergic rhinitis (AR) and the effects of endothelin receptor antagonists in AR rat models through comparison with desloratadine.
METHODS: In total, 20 adult Sprague-Dawley rats were used in this study. An ovalbumin-induced allergic rhinitis model was formed in three study groups except for the control group. Bosentan (100 mg/kg/day) was given to the bosentan-treated group for 7 days and desloratadine (10 mg/kg/day) was administered to the antihistaminic-treated group for 7 days. Nasal symptom scorings and histopathological examinations of the nasal tissues were carried out. Serum IgE levels and ET-1 and TNF-alpha mRNA expression levels were analysed. Between group comparisons for nasal symptoms, histopathological analysis, and molecular analyses were performed with a one-way ANOVA and Duncans multiple comparison tests. Significance was accepted at p smaller than 0.05.
RESULTS: Bosentan inhibited nasal symptom more significantly than desloratadine. The IgE level, ET-1 and TNF-alpha mRNA expression levels statistically increased in the allergic rhinitis group when compared to other groups. Conversely, the bosentan-treatment group showed a significant recovery from the same parameters. The deterioration in histopathological parameters reached the highest levels in the allergic rhinitis group. The histopathological findings were close to those of the control group in the bosentan and antihistaminic-treated group.
CONCLUSIONS: ET-1 is one of the mediators that impact AR development and ET-1 antagonists can be useful for symptom control and for decreasing allergic inflammation in AR patients.

PMID: 27016898 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/21OOswG
via IFTTT

Pharyngeal Electrical Stimulation in Dysphagia Poststroke: A Prospective, Randomized Single-Blinded Interventional Study.

Pharyngeal Electrical Stimulation in Dysphagia Poststroke: A Prospective, Randomized Single-Blinded Interventional Study.

Neurorehabil Neural Repair. 2016 Apr 6;

Authors: Vasant DH, Michou E, O'Leary N, Vail A, Mistry S, Hamdy S, Greater Manchester Stroke Research Network

Abstract
Background Pharyngeal electrical stimulation (PES) appears to promote cortical plasticity and swallowing recovery poststroke.Objective We aimed to assess clinical effectiveness with longer follow-up.Methods Dysphagic patients (n = 36; median = 71 years; 61% male) recruited from 3 trial centers within 6 weeks of stroke, received active or sham PES in a single-blinded randomized design via an intraluminal pharyngeal catheter (10 minutes, for 3days). The primary outcome measure was the Dysphagia Severity Rating (DSR) scale (<4, no-mild; ≥4, moderate-severe). Secondary outcomes included unsafe swallows on the Penetration-Aspiration Scale (PAS ≥ 3), times to hospital discharge, and nasogastric tube (NGT) removal. Data were analyzed using logistic regression. Odds/hazard ratios (ORs/HRs) >1 for DSR <4, hospital discharge, and NGT removal and OR <1 for PAS ≥3, indicated favorable outcomes for active PES.Results Two weeks post-active PES, 11/18 (61%) had DSR <4: OR (95% CI) = 2.5 (0.52, 14). Effects of active versus sham for secondary outcomes included the following: PAS ≥3 at 2 weeks, OR (95% CI) = 0.61 (0.27, 1.4); times to hospital discharge, 39 days versus 52 days, HR (95% CI) = 1.2 (0.55, 2.5); NGT removal 8 versus 14 days, HR (95% CI) = 2.0 (0.51, 7.9); and DSR <4 at 3 months, OR (95% CI) = 0.97 (0.13, 7.0). PES was well tolerated, without adverse effects or associations with serious complications (chest infections/death).Conclusions Although the direction of observed differences were consistent with PES accelerating swallowing recovery over the first 2 weeks postintervention, suboptimal recruitment prevents definitive conclusions. Our study design experience and outcome data are essential to inform a definitive, multicenter randomized trial.

PMID: 27053641 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/22hpshV
via IFTTT

Effect of dysphagia rehabilitation on oral intake in elderly patients with aspiration pneumonia.

Related Articles

Effect of dysphagia rehabilitation on oral intake in elderly patients with aspiration pneumonia.

Geriatr Gerontol Int. 2015 Jun;15(6):694-9

Authors: Momosaki R, Yasunaga H, Matsui H, Horiguchi H, Fushimi K, Abo M

Abstract
AIM: To clarify the effects of dysphagia rehabilitation on oral intake after aspiration pneumonia in older adults.
METHODS: The present retrospective observational study used data from the Japanese Diagnosis Procedure Combination inpatient database. We identified patients who were admitted to acute care hospitals with aspiration pneumonia. Patients were subdivided into those with and without dysphagia rehabilitation. The main outcome variable was total oral intake on discharge. We carried out multivariate logistic regression analysis to assess the effect of dysphagia rehabilitation on the outcome, with adjustment for patient backgrounds. We also carried out analyses based on pneumonia severity, and the timing and duration of dysphagia rehabilitation.
RESULTS: We identified 22,819 patients with dysphagia rehabilitation and 75,555 patients without dysphagia rehabilitation. The rates of total oral intake on discharge were 78.0 and 75.2%, respectively. The multivariate regression model showed that the dysphagia rehabilitation group had a significantly higher proportion of total oral intake on discharge (odds ratio 1.32; P < 0.001). Mild pneumonia patients had a higher odds ratio for total oral intake associated with dysphagia rehabilitation than patients with moderate and severe pneumonia (odds ratio 2.27; P < 0.001). Among patients who underwent a short period of dysphagia rehabilitation, those with early rehabilitation were more likely to achieve total oral intake at discharge than those with late rehabilitation.
CONCLUSION: The data suggest that dysphagia rehabilitation had a positive effect on total oral intake in elderly patients with aspiration pneumonia. Dysphagia rehabilitation showed greater benefit in patients with mild pneumonia than with more severe pneumonia.

PMID: 25109319 [PubMed - indexed for MEDLINE]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qxEPH5
via IFTTT

Diagnosis of amblyaudia in children referred for auditory processing assessment.

Diagnosis of amblyaudia in children referred for auditory processing assessment.

Int J Audiol. 2016 Apr 8;:1-13

Authors: Moncrieff D, Keith W, Abramson M, Swann A

Abstract
Children (n = 141) referred to 5 clinical sites for auditory processing disorder assessment were tested with two dichotic listening tests, one with word pairs and the other with pairs of digits, as part of a comprehensive diagnostic battery. Scores from the Randomized Dichotic Digits Test and the Dichotic Words Test were compared to age-appropriate norms and used to place children into one of four diagnostic categories (normal, dichotic dysaudia, amblyaudia, or amblyaudia plus) or to identify them as undiagnosed. Results from the two dichotic tests led to diagnosis of 56% of the children tested, leaving 44% undiagnosed. When results from a third dichotic listening test were used as a tie-breaker among originally undiagnosed children, a total of 79% of the children's scores were placed into diagnostic categories (13% normal, 19% dichotic dysaudia, 35% amblyaudia, 12% amblyaudia plus). Amblyaudia, a binaural integration deficit evident only from dichotic listening test results, was most prevalent (35% + 12% = 47%) in this population of children suspected of auditory processing weaknesses. Since amblyaudia responds to treatment with Auditory Rehabilitation for Interaural Asymmetry (ARIA), clinicians are guided through the protocol for identifying diagnostic categories so that they can make appropriate referrals for rehabilitation.

PMID: 27058650 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1YkMOSt
via IFTTT

The contrast between cueing and/or observation in therapy for verb retrieval in post-stroke aphasia.

Related Articles

The contrast between cueing and/or observation in therapy for verb retrieval in post-stroke aphasia.

J Commun Disord. 2015 Mar-Apr;54:43-55

Authors: Routhier S, Bier N, Macoir J

Abstract
BACKGROUND: Studies measuring treatment efficacy for post-stroke verb anomia are scarce. These studies mainly assessed the efficacy of three strategies: semantic, phonological and sensorimotor. Following these previous treatments, the performance of most participants improved on treated verbs, while improvement on untreated stimuli and tasks was inconsistent.
AIMS: This study aimed to measure the effectiveness of a semantic-phonological strategy and a sensorimotor strategy for verb anomia in post-stroke aphasia.
METHODS: A multiple baseline single-subject experimental study was conducted with two participants (9-37 years post-stroke). Four phases were completed: (1) background assessment, (2) baselines, (3) therapy, and (4) follow-up. Three equivalent lists of verbs were created for each participant and two of them were trained with a different strategy: action observation+semantic-phonological cues, action observation alone. The stimuli of the third list (control list) were not treated.
RESULTS: The semantic-phonological cueing strategy led to a significant improvement. No improvement was observed after action observation. No generalization to untreated verbs was found.
CONCLUSIONS: Verb naming can be enhanced by semantic/phonological cueing. In addition, other studies (clinical, neuroimaging, etc.) are needed to document the effect of action observation for the treatment of verb anomia.
LEARNING OUTCOMES: The reader will be able to (1) describe semantic-phonological therapies used in post-stroke verb anomia, (2) describe sensorimotor therapies used in post-stroke verb anomia, and (3) identify factors contributing to the efficacy of therapies to improve action naming in aphasia.

PMID: 25638465 [PubMed - indexed for MEDLINE]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1YlmrMj
via IFTTT

CSF leak after coccyx fracture.

CSF leak after coccyx fracture.

Spine J. 2016 Apr 4;

Authors: Cawley D, Power F, Murphy M

PMID: 27058288 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1oLhT5R
via IFTTT

Clinical evaluation of balloon dilation eustachian tuboplasty surgery in adult otitis media with effusion.

Clinical evaluation of balloon dilation eustachian tuboplasty surgery in adult otitis media with effusion.

Acta Otolaryngol. 2016 Apr 8;:1-4

Authors: Dai S, Guan GF, Jia J, Li H, Sang Y, Chang D, Hou L, Zhang W, Wen LJ, Zhang DJ

Abstract
CONCLUSION: BDET might be effective for the patients with OME, and proved to be an efficacious and mini-invasive treatment for OME.
OBJECTIVES: To evaluate the therapeutic benefits of balloon dilation eustachian tuboplasty (BDET) in the treatment of adult patients with otitis media with effusion (OME) caused by eustachian tube dysfunction (ETD).
METHODS: After informed consent, eight adult patients with OME were included in this study. After investigated patients' case history and oto-function, all patients underwent BDET treatment. Then four criteria including tympanic membrane, pure tone audiometry (PTA), tympanometry, and subjective symptoms were adopted to evaluate the therapeutic benefits of BDET.
RESULTS: None of the involved patients complained of problems or complications during the post-operative period, or with absence of pain and bleeding after the operation. Prominent post-operative improvement was observed in tympanic membrane and otoscopic appearance. In addition, cure rates after 3 months and 6 months post-operatively were gradually increased.

PMID: 27056263 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qdZFea
via IFTTT

Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings.

Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings.

Acta Otolaryngol. 2016 Apr 8;:1-4

Authors: Marunaka H, Orita Y, Tachibana T, Miki K, Makino T, Gion Y, Nishizaki K, Yoshino T, Sato Y

Abstract
CONCLUSION: In Kikuchi-Fujimoto disease (KFD), a low ratio of blastic cells (<70%) in lymph node specimens and absence of atypical lymphocytes in peripheral blood are predictive of a protracted clinical course.
OBJECTIVES: Since KFD is a self-limiting disorder that does not require any specific management, prognostic factors have received little attention. The present study identified clinical and pathological factors that may affect the period from onset to cure of KFD.
METHODS: This retrospective study investigated 43 KFD patients who underwent lymph node biopsy diagnosed by immunohistochemical staining at Okayama University Hospital and Okayama Medical Center from January 2001 to December 2013.
RESULTS: Mean total period from onset to cure was 6 months (median =9.4 months; range =1-37 months). Low ratios of blastic cell proliferation area (<70%) in lymph node specimens (p = 0.011) and absence of atypical lymphocytes in peripheral blood (p = 0.026) were associated with a relatively long duration of KFD.

PMID: 27056102 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qCZlqj
via IFTTT

Outcome comparison of two methods of pharyngeal cavity reconstruction in uvulopalatopharyngoplasty.

Outcome comparison of two methods of pharyngeal cavity reconstruction in uvulopalatopharyngoplasty.

Acta Otolaryngol. 2016 Apr 8;:1-5

Authors: Wu H, Yin Y, Ma H, Wang Q, Da P, Yue H

Abstract
CONCLUSIONS: The efficacy of uvulopalatopharyngoplasty (UPPP) can be achieved without application of an apposition suture of the palatopharyngeal arch and the palatoglossal arch.
OBJECTIVE: To compare the outcomes of two different methods of pharyngeal cavity reconstruction in UPPP.
METHODS: Forty-eight patients with obstructive sleep apnoea syndrome (OSAS) underwent UPPP (uvula-preserving). A classical pharyngeal cavity reconstruction was performed in 24 patients in group one, with plastic suture of the inferior nasopharynx and exposure of the tonsillar fossa in 24 patients in group two. The parameters evaluated were the subjective symptom score, the Epworth Sleepiness Scale (ESS), and polysomnography result. The mean operating times and complications of the post-operative pharyngeal cavity were investigated.
RESULTS: No significant difference was observed in surgical success (p = 0.54), subjective syndromes (snoring, sleep apnoea, morning headache, daytime sleepiness) (p = 0.16, 0.36, 0.79 and 0.52), ESS (p = 0.41), apnoea-hypopnoea index (AHI) (p = 0.32), and minimum SaO2 (p = 0.13) between the two groups. In group one, the mean operating time was 54.72 ± 6.52 min, 11 suture dehiscence (45.8%), and five scar hypertrophy of the pharyngeal wall (20.8%) were observed post-operatively; while in group two was 38.78 ± 5.75 min, no suture dehiscence resulting from suture cutting of tissue, three scar hypertrophy were observed (12.5%).

PMID: 27055923 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qdZEH6
via IFTTT

Cochlin-tomoprotein test and hearing outcomes in surgically treated true idiopathic perilymph fistula.

Cochlin-tomoprotein test and hearing outcomes in surgically treated true idiopathic perilymph fistula.

Acta Otolaryngol. 2016 Apr 8;:1-4

Authors: Komori M, Yamamoto Y, Yaguchi Y, Ikezono T, Kojima H

Abstract
CONCLUSION: Approximately 50% of patients with sPLF based on the clinical diagnosis criteria were definitively diagnosed with CTP-positive sPLF. These results suggest that early surgery within 7 days of the disease onset contributes to improvements in the therapeutic response of hearing loss.
OBJECTIVES/HYPOTHESIS: Idiopathic spontaneous perilymph fistula (sPLF) cannot be diagnosed reliably. It is speculated that this condition occurs in patients with vertigo-accompanied acute sensorineural hearing loss that progresses rapidly in spite of steroid therapy. This study herein evaluated cochlin-tomoprotein (CTP) test results in patients with sPLF who underwent exploratory tympanotomy and considered surgical outcomes with true sPLF.
STUDY DESIGN: Retrospective study.
METHODS: Twenty-three patients diagnosed with sPLF based on the clinical diagnosis criteria who underwent exploratory tympanotomy were included.
RESULTS: CTP test results were positive in 11 cases. In CTP-positive cases, the mean hearing level was 66.5 dB pre-operatively and 42.3 dB post-operatively. The hearing level post-operatively completely recovered in four cases, markedly recovered in three cases, slightly recovered in one case and showed no response in three cases. Hearing level improvements were significantly better in CTP-positive patients who underwent surgery within 7 days of the disease onset than in those treated 8 or more days after the disease onset.

PMID: 27055739 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/25QOBV2
via IFTTT

Transarterial embolization in the management of intractable epistaxis: the angiographic findings and results based on etiologies.

Transarterial embolization in the management of intractable epistaxis: the angiographic findings and results based on etiologies.

Acta Otolaryngol. 2016 Apr 8;:1-5

Authors: Wang B, Zu QQ, Liu XL, Zhou CG, Xia JG, Zhao LB, Shi HB, Liu S

Abstract
CONCLUSIONS: Transarterial embolization (TAE) appears to be a safe and effective treatment for patients with intractable epistaxis, despite different etiologies or angiography findings. Idiopathic epistaxis is prone to present with negative angiographic findings.
OBJECTIVE: To retrospectively evaluate the safety and effectiveness of TAE for intractable epistaxis, and focus on the factors of etiology and angiographic findings.
MATERIALS AND METHODS: From March 2008 to December 2014, the data of 43 patients with intractable bleeding undergoing TAE were reviewed. The outcomes of interventional therapy were assessed according to different etiology (malignant or benign disease) and angiographic finding (positive or negative angiogram).
RESULTS: Positive angiographic findings were found in 11 of 12 cases with malignant diseases and 22 of 31 cases with benign diseases, respectively (p = 0.237). Among the 10 cases with negative angiographic findings, the negative angiography rate of idiopathic epistaxis was higher than that of epistaxis with definite etiology (p = 0.003). Bleeding was controlled successfully in all of the 43 patients after embolization. During the mean follow-up period of 24.0 ± 16.7 months, five patients relapsed. No significant difference was found in recurrence rates between malignant and benign diseases or between positive and negative angiography (p = 0.241, p = 0.704, respectively).

PMID: 27055585 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Sm8I3s
via IFTTT

Symptomatic vallecular cysts: diagnosis and management with the KTP laser.

Symptomatic vallecular cysts: diagnosis and management with the KTP laser.

Eur Arch Otorhinolaryngol. 2016 Apr 7;

Authors: Zalvan CH, Reilly E

Abstract
The objective of this study is to discuss the evaluation and treatment of patients with vallecular cysts removed via potassium titanyl phosphate (KTP) laser therapy. This is a retrospective cohort study with longitundinal follow-up. Clinical records were reviewed for demographic information, symptoms, and findings on laryngoscopy of nine patients having had KTP laser surgery for vallecular cysts. Nine patients (six female, three male) had vallecular cysts removed via KTP laser. The average age at the time of removal was 61, with a range of 34-95 years. The most common preoperative symptom was dysphagia, present in two-thirds of patients. The most common physical exam finding was a smooth, rounded vallecular cyst with reproduction of symptoms upon palpation of the lesion. More than half of the patients had a history of laryngopharyngeal reflux disease and were being treated with acid-reducing medication. Only, patient #1 had a history of trauma. All but two patients had a vallecular cyst located on the right side. Four of the patients underwent treatment in the office procedure room and five in the operating room. The average age of those treated in the office was 71 and 53 in the operating room. 89 % of patients had complete resolution of symptoms post operatively. Patient #4, treated in the office, continued to experience the symptoms but was lost to follow-up. No complications or adverse events were noted. KTP laser removal of vallecular cysts is a successful treatment option for symptomatic patients. Furthermore, the ability to remove such lesions in an office setting is advantageous, cost-effective, and convenient.
LEVEL OF EVIDENCE: Level 4.

PMID: 27056198 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qzLksW
via IFTTT

IgG4-related disease presenting with destructive sinonasal lesion mimicking malignancy.

IgG4-related disease presenting with destructive sinonasal lesion mimicking malignancy.

Eur Arch Otorhinolaryngol. 2016 Apr 7;

Authors: Chen BN

Abstract
IgG4-related disease is a newly recognized systemic fibroinflammatory disorder. We report a 36-year-old man who presented with intractable right nasal pain and frontal headache for 1 month. Computed tomography revealed an ill-defined lesion with bony erosion over the right anterior ethmoid sinus and middle turbinate. The lesion was resected through endoscopic anterior ethmoidectomy and middle turbinectomy. IgG4-related disease was definitively diagnosed according to histopathological features. Prednisolone was administered postoperatively. IgG4-related disease presenting with destructive sinonasal lesion mimicking malignancy is rare. Awareness is essential to avoid delayed diagnosis or unnecessary invasive intervention, because the disorder responds to glucocorticoid and immunosuppressant therapy.

PMID: 27056197 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qCZlGT
via IFTTT

Pleomorphic adenoma in the nasal cavity: a clinicopathological study of ten cases in Finland.

Pleomorphic adenoma in the nasal cavity: a clinicopathological study of ten cases in Finland.

Eur Arch Otorhinolaryngol. 2016 Apr 7;

Authors: Vento SI, Numminen J, Kinnunen I, Rautiainen M, Tarkkanen J, Hagström J, Mäkitie AA

Abstract
The objective of the study was to investigate the nationwide occurrence of sinonasal pleomorphic adenoma in Finland. A retrospective study was conducted at The Departments of Otorhinolaryngology-Head and Neck Surgery, and Pathology at the five university hospitals in Finland. Data were obtained by searching for sinonasal pleomorphic adenoma cases in the clinical and histopathological registries at these institutions for the past two to four decades. All patients who had had a histologically proven pleomorphic adenoma in the sinonasal area were included as participants. Ten cases with pleomorphic adenoma of the nasal cavity were found. The majority of these tumours originated in the septum, and there were no malignant transformations. Pleomorphic adenomas of the nasal cavity were found to be extremely rare in this nationwide investigation.

PMID: 27056196 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qdZDmt
via IFTTT

Endoscopic endonasal control of the paraclival internal carotid artery by Fogarty balloon catheter inflation: an anatomical study.

Endoscopic endonasal control of the paraclival internal carotid artery by Fogarty balloon catheter inflation: an anatomical study.

J Neurosurg. 2016 Apr 8;:1-8

Authors: Ruggeri A, Enseñat J, Prats-Galino A, Lopez-Rueda A, Berenguer J, Cappelletti M, De Notaris M, d'Avella E

Abstract
OBJECTIVE Neurosurgical management of many vascular and neoplastic lesions necessitates control of the internal carotid artery (ICA). The aim of this study was to investigate the feasibility of achieving control of the ICA through the endoscopic endonasal approach by temporary occlusion with a Fogarty balloon catheter. METHODS Ten endoscopic endonasal paraseptal approaches were performed on cadaveric specimens. A Fogarty balloon catheter was inserted through a sellar bony opening and pushed laterally and posteriorly extraarterially along the paraclival carotid artery. The balloon was then inflated, thus achieving temporary occlusion of the vessel. The position of the catheter was confirmed with CT scans, and occlusion of the ICA was demonstrated with angiography. The technique was performed in 2 surgical cases of pituitary macroadenoma with cavernous sinus invasion. RESULTS Positioning the Fogarty balloon catheter at the level of the paraclival ICA was achieved in all cadaveric dissections and surgical cases through a minimally invasive, quick, and safe approach. Inflation of the Fogarty balloon caused interruption of blood flow in 100% of cases. CONCLUSIONS Temporary occlusion of the paraclival ICA performed through the endoscopic endonasal route with the aid of a Fogarty balloon catheter may be another maneuver for dealing with intraoperative ICA control. Further clinical studies are required to prove the efficacy of this method.

PMID: 27058202 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Smf9Dv
via IFTTT

Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma.

Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma.

J Neurosurg. 2016 Apr 8;:1-11

Authors: Nanda A, Bir SC, Maiti TK, Konar SK, Missios S, Guthikonda B

Abstract
OBJECTIVE The clinical significance of the Simpson system for grading the extent of meningioma resection and its role as a predictor of the recurrence of World Health Organization (WHO) Grade I meningiomas have been questioned in the past, echoing changes in meningioma surgery over the years. The authors reviewed their experience in resecting WHO Grade I meningiomas and assessed the association between extent of resection, as evaluated using the Simpson classification, and recurrence-free survival (RFS) of patients after meningioma surgery. METHODS Clinical and radiological information for patients with WHO Grade I meningiomas who had undergone resective surgery over the past 20 years was retrospectively reviewed. Simpson and Shinshu grading scales were used to evaluate the extent of resection. Statistical analysis was conducted using Kaplan-Meier curves and Cox proportional-hazards regression. RESULTS Four hundred fifty-eight patients were eligible for analysis. Overall tumor recurrence rates for Simpson resection Grades I, II, III, and IV were 5%, 22%, 31%, and 35%, respectively. After Cox regression analysis, Simpson Grade I (extensive resection) was revealed as a significant predictor of RFS (p = 0.003). Patients undergoing Simpson Grade I and II resections showed significant improvement in RFS compared with patients undergoing Grade III and IV resections (p = 0.005). Extent of resection had a significant effect on recurrence rates for both skull base (p = 0.047) and convexity (p = 0.012) meningiomas. Female sex and a Karnofsky Performance Scale score > 70 were also identified as independent predictors of RFS after resection of WHO Grade I meningioma. CONCLUSIONS In this patient cohort, a significant association was noted between extent of resection and rates of tumor recurrence. In the authors' experience the Simpson grading system maintains its relevance and prognostic value and can serve an important role for patient education. Even though complete tumor resection is the goal, surgery should be tailored to each patient according to the risks and surgical morbidity.

PMID: 27058201 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1RKrB4a
via IFTTT

[Sinunasal Tumors].

[Sinunasal Tumors].

Laryngorhinootologie. 2016 Apr;95(4):270-291

Authors: Arens C

Abstract
Sinunasal tumors represent a rare and very heterogeneous group of lesions of the nose, sinuses and skull base with a broad spectrum of different biological activities and clinical behavior, which require an individual and primarily surgical treatment strategy. Despite of mild improvement in the overall survival of patients with sinunasal malignancies (SNM) over the last decade, treatment outcome remains stable on a moderate to low level. This analysis brings up the necessity of a more effective local as well as systemic treatment. Especially new concepts in surgery, chemo radiation as well as antibody treatment offer multimodal treatment strategies that may improve quality of life and overall survival in patients with sinunasal tumors.

PMID: 27058141 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1RX6oAH
via IFTTT

[Multidisciplinary collaboration of skull base surgery in China: past, present and future].

[Multidisciplinary collaboration of skull base surgery in China: past, present and future].

Zhonghua Yi Xue Za Zhi. 2016 Mar 8;96(9):673-675

Authors: Zhang LW, Xue Z

PMID: 27055502 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Smf9n6
via IFTTT

In Response.

Related Articles

In Response.

Anesth Analg. 2016 Jan;122(1):293-4

Authors: Eloy JD, Svider PF, Radvansky BM, Farver WT, Gubenko YA, Eloy JA

PMID: 26678480 [PubMed - indexed for MEDLINE]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1RKrB46
via IFTTT

[Injection of Lipotransplants for Wound Healing Complications after Radiotherapy].

[Injection of Lipotransplants for Wound Healing Complications after Radiotherapy].

Laryngorhinootologie. 2016 Apr;95(4):242-244

Authors: Haubner F, Gassner HG, Pérez Álvarez JC

Abstract
Wound healing complications in irradiated tissues represent a major clinical challenge. Fistula or even major vessel rupture may occur. The injection of adipose tissue derived stem cells seem to be a promising therapeutical strategy. The article describes the clinical case of a patient suffering from a pharyngo-cutaneous fistula after laryngectomy and radiotherapy. The patient was successfully treated by the injection of fat tissue.

PMID: 27058137 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1RX6ok4
via IFTTT

[Editor's Comment].

[Editor's Comment].

Laryngorhinootologie. 2016 Apr;95(4):233

Authors: Guntinas-Lichius O

PMID: 27058136 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qzLb97
via IFTTT

[From the Expert's Office: Whistle-Attack by Phone-Call].

[From the Expert's Office: Whistle-Attack by Phone-Call].

Laryngorhinootologie. 2016 Mar;95(3):202-204

Authors: Brusis T, Delank KW

PMID: 27057963 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1RX6los
via IFTTT

Dysphagia, dysphonia and sore throat following cerebral infarction: an unexpected cause.

Related Articles

Dysphagia, dysphonia and sore throat following cerebral infarction: an unexpected cause.

BMJ Case Rep. 2015;2015

Authors: Slade PM, Larsen MP

Abstract
A 75-year-old woman presented with left-sided weakness. There was no speech disturbance or reported swallowing difficulties. CT of the head revealed infarction in the territory of the right middle cerebral artery. The patient was transferred to the acute stroke unit and a nasogastric tube was placed following a failed swallow screening test. The following day, on assessment, there was considerable pain on swallowing. The tone and quality of the patient's voice had deteriorated and there was significant dysphagia. Seven days later a plastic item, later identified as the patient's denture, was expectorated. Following this, the dysphagia, dysphonia and sore throat rapidly resolved. The case highlights the importance of considering foreign body in the differential, and oral cavity examination in the assessment of a patient with dysphagia and sore throat is essential.

PMID: 26150638 [PubMed - indexed for MEDLINE]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UPFi46
via IFTTT

Clinical evaluation of balloon dilation eustachian tuboplasty surgery in adult otitis media with effusion.

Clinical evaluation of balloon dilation eustachian tuboplasty surgery in adult otitis media with effusion.

Acta Otolaryngol. 2016 Apr 8;:1-4

Authors: Dai S, Guan GF, Jia J, Li H, Sang Y, Chang D, Hou L, Zhang W, Wen LJ, Zhang DJ

Abstract
CONCLUSION: BDET might be effective for the patients with OME, and proved to be an efficacious and mini-invasive treatment for OME.
OBJECTIVES: To evaluate the therapeutic benefits of balloon dilation eustachian tuboplasty (BDET) in the treatment of adult patients with otitis media with effusion (OME) caused by eustachian tube dysfunction (ETD).
METHODS: After informed consent, eight adult patients with OME were included in this study. After investigated patients' case history and oto-function, all patients underwent BDET treatment. Then four criteria including tympanic membrane, pure tone audiometry (PTA), tympanometry, and subjective symptoms were adopted to evaluate the therapeutic benefits of BDET.
RESULTS: None of the involved patients complained of problems or complications during the post-operative period, or with absence of pain and bleeding after the operation. Prominent post-operative improvement was observed in tympanic membrane and otoscopic appearance. In addition, cure rates after 3 months and 6 months post-operatively were gradually increased.

PMID: 27056263 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qdZFea
via IFTTT

Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings.

Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings.

Acta Otolaryngol. 2016 Apr 8;:1-4

Authors: Marunaka H, Orita Y, Tachibana T, Miki K, Makino T, Gion Y, Nishizaki K, Yoshino T, Sato Y

Abstract
CONCLUSION: In Kikuchi-Fujimoto disease (KFD), a low ratio of blastic cells (<70%) in lymph node specimens and absence of atypical lymphocytes in peripheral blood are predictive of a protracted clinical course.
OBJECTIVES: Since KFD is a self-limiting disorder that does not require any specific management, prognostic factors have received little attention. The present study identified clinical and pathological factors that may affect the period from onset to cure of KFD.
METHODS: This retrospective study investigated 43 KFD patients who underwent lymph node biopsy diagnosed by immunohistochemical staining at Okayama University Hospital and Okayama Medical Center from January 2001 to December 2013.
RESULTS: Mean total period from onset to cure was 6 months (median =9.4 months; range =1-37 months). Low ratios of blastic cell proliferation area (<70%) in lymph node specimens (p = 0.011) and absence of atypical lymphocytes in peripheral blood (p = 0.026) were associated with a relatively long duration of KFD.

PMID: 27056102 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qCZlqj
via IFTTT

Outcome comparison of two methods of pharyngeal cavity reconstruction in uvulopalatopharyngoplasty.

Outcome comparison of two methods of pharyngeal cavity reconstruction in uvulopalatopharyngoplasty.

Acta Otolaryngol. 2016 Apr 8;:1-5

Authors: Wu H, Yin Y, Ma H, Wang Q, Da P, Yue H

Abstract
CONCLUSIONS: The efficacy of uvulopalatopharyngoplasty (UPPP) can be achieved without application of an apposition suture of the palatopharyngeal arch and the palatoglossal arch.
OBJECTIVE: To compare the outcomes of two different methods of pharyngeal cavity reconstruction in UPPP.
METHODS: Forty-eight patients with obstructive sleep apnoea syndrome (OSAS) underwent UPPP (uvula-preserving). A classical pharyngeal cavity reconstruction was performed in 24 patients in group one, with plastic suture of the inferior nasopharynx and exposure of the tonsillar fossa in 24 patients in group two. The parameters evaluated were the subjective symptom score, the Epworth Sleepiness Scale (ESS), and polysomnography result. The mean operating times and complications of the post-operative pharyngeal cavity were investigated.
RESULTS: No significant difference was observed in surgical success (p = 0.54), subjective syndromes (snoring, sleep apnoea, morning headache, daytime sleepiness) (p = 0.16, 0.36, 0.79 and 0.52), ESS (p = 0.41), apnoea-hypopnoea index (AHI) (p = 0.32), and minimum SaO2 (p = 0.13) between the two groups. In group one, the mean operating time was 54.72 ± 6.52 min, 11 suture dehiscence (45.8%), and five scar hypertrophy of the pharyngeal wall (20.8%) were observed post-operatively; while in group two was 38.78 ± 5.75 min, no suture dehiscence resulting from suture cutting of tissue, three scar hypertrophy were observed (12.5%).

PMID: 27055923 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qdZEH6
via IFTTT

Cochlin-tomoprotein test and hearing outcomes in surgically treated true idiopathic perilymph fistula.

Cochlin-tomoprotein test and hearing outcomes in surgically treated true idiopathic perilymph fistula.

Acta Otolaryngol. 2016 Apr 8;:1-4

Authors: Komori M, Yamamoto Y, Yaguchi Y, Ikezono T, Kojima H

Abstract
CONCLUSION: Approximately 50% of patients with sPLF based on the clinical diagnosis criteria were definitively diagnosed with CTP-positive sPLF. These results suggest that early surgery within 7 days of the disease onset contributes to improvements in the therapeutic response of hearing loss.
OBJECTIVES/HYPOTHESIS: Idiopathic spontaneous perilymph fistula (sPLF) cannot be diagnosed reliably. It is speculated that this condition occurs in patients with vertigo-accompanied acute sensorineural hearing loss that progresses rapidly in spite of steroid therapy. This study herein evaluated cochlin-tomoprotein (CTP) test results in patients with sPLF who underwent exploratory tympanotomy and considered surgical outcomes with true sPLF.
STUDY DESIGN: Retrospective study.
METHODS: Twenty-three patients diagnosed with sPLF based on the clinical diagnosis criteria who underwent exploratory tympanotomy were included.
RESULTS: CTP test results were positive in 11 cases. In CTP-positive cases, the mean hearing level was 66.5 dB pre-operatively and 42.3 dB post-operatively. The hearing level post-operatively completely recovered in four cases, markedly recovered in three cases, slightly recovered in one case and showed no response in three cases. Hearing level improvements were significantly better in CTP-positive patients who underwent surgery within 7 days of the disease onset than in those treated 8 or more days after the disease onset.

PMID: 27055739 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/25QOBV2
via IFTTT

Transarterial embolization in the management of intractable epistaxis: the angiographic findings and results based on etiologies.

Transarterial embolization in the management of intractable epistaxis: the angiographic findings and results based on etiologies.

Acta Otolaryngol. 2016 Apr 8;:1-5

Authors: Wang B, Zu QQ, Liu XL, Zhou CG, Xia JG, Zhao LB, Shi HB, Liu S

Abstract
CONCLUSIONS: Transarterial embolization (TAE) appears to be a safe and effective treatment for patients with intractable epistaxis, despite different etiologies or angiography findings. Idiopathic epistaxis is prone to present with negative angiographic findings.
OBJECTIVE: To retrospectively evaluate the safety and effectiveness of TAE for intractable epistaxis, and focus on the factors of etiology and angiographic findings.
MATERIALS AND METHODS: From March 2008 to December 2014, the data of 43 patients with intractable bleeding undergoing TAE were reviewed. The outcomes of interventional therapy were assessed according to different etiology (malignant or benign disease) and angiographic finding (positive or negative angiogram).
RESULTS: Positive angiographic findings were found in 11 of 12 cases with malignant diseases and 22 of 31 cases with benign diseases, respectively (p = 0.237). Among the 10 cases with negative angiographic findings, the negative angiography rate of idiopathic epistaxis was higher than that of epistaxis with definite etiology (p = 0.003). Bleeding was controlled successfully in all of the 43 patients after embolization. During the mean follow-up period of 24.0 ± 16.7 months, five patients relapsed. No significant difference was found in recurrence rates between malignant and benign diseases or between positive and negative angiography (p = 0.241, p = 0.704, respectively).

PMID: 27055585 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Sm8I3s
via IFTTT

Efficacy and acceptability of oxcarbazepine vs. carbamazepine with betahistine mesilate tablets in treating vestibular paroxysmia: a retrospective review.

Efficacy and acceptability of oxcarbazepine vs. carbamazepine with betahistine mesilate tablets in treating vestibular paroxysmia: a retrospective review.

Postgrad Med. 2016 Apr 8;

Authors: Yi C, Wenping X, Hui X, Xin H, Xiue L, Jun Z, Shangyong G

Abstract
OBJECTIVES: Vestibular paroxysmia (VP) is a rare episodic peripheral vestibular disorder that can cause acute short attacks of vertigo. This study aimed to compare the efficacy and acceptability of carbamazepine (CBZ), CBZ plus betahistine mesilate tablets (BMT) and oxcarbazepine (OXC) plus BMT in treating VP within 12 weeks.
METHODS: A retrospective analysis of data from 196 VP patients treated in our hospital was conducted. There were 73 patients receiving CBZ, 65 patients receiving CBZ+BMT and 58 patients receiving OXC+BMT. The frequency of vertigo, vertigo duration, vertigo score, response rate (RR) and side effects were compared between groups to assess efficacy and acceptability at the end of 12(th) week.
RESULTS: After 12 weeks' treatment, the CBZ+BMT group had a greater reduction in the frequency of vertigo, vertigo duration and vertigo score than the other two groups. The RR was highest in the CBZ+BMT group, second in the OXC+BMT group and lowest in the CBZ group. The incidence of side-effects was highest in the CBZ group, second in the CBZ+BMT group and lowest in the OXC+BMT group. Two patients in the CBZ group were withdrawn.
CONCLUSION: These results indicated that using BMT as an augmentation for CBZ or OXC might be a good choice in treating VP.

PMID: 27056408 [PubMed - as supplied by publisher]

from Hearing and Balance via ola Kala on Inoreader http://ift.tt/1qzLdxM
via IFTTT

Cochlin-tomoprotein test and hearing outcomes in surgically treated true idiopathic perilymph fistula.

Cochlin-tomoprotein test and hearing outcomes in surgically treated true idiopathic perilymph fistula.

Acta Otolaryngol. 2016 Apr 8;:1-4

Authors: Komori M, Yamamoto Y, Yaguchi Y, Ikezono T, Kojima H

Abstract
CONCLUSION: Approximately 50% of patients with sPLF based on the clinical diagnosis criteria were definitively diagnosed with CTP-positive sPLF. These results suggest that early surgery within 7 days of the disease onset contributes to improvements in the therapeutic response of hearing loss.
OBJECTIVES/HYPOTHESIS: Idiopathic spontaneous perilymph fistula (sPLF) cannot be diagnosed reliably. It is speculated that this condition occurs in patients with vertigo-accompanied acute sensorineural hearing loss that progresses rapidly in spite of steroid therapy. This study herein evaluated cochlin-tomoprotein (CTP) test results in patients with sPLF who underwent exploratory tympanotomy and considered surgical outcomes with true sPLF.
STUDY DESIGN: Retrospective study.
METHODS: Twenty-three patients diagnosed with sPLF based on the clinical diagnosis criteria who underwent exploratory tympanotomy were included.
RESULTS: CTP test results were positive in 11 cases. In CTP-positive cases, the mean hearing level was 66.5 dB pre-operatively and 42.3 dB post-operatively. The hearing level post-operatively completely recovered in four cases, markedly recovered in three cases, slightly recovered in one case and showed no response in three cases. Hearing level improvements were significantly better in CTP-positive patients who underwent surgery within 7 days of the disease onset than in those treated 8 or more days after the disease onset.

PMID: 27055739 [PubMed - as supplied by publisher]

from Hearing and Balance via ola Kala on Inoreader http://ift.tt/25QOBV2
via IFTTT

Description of spatio-temporal gait parameters in elderly people and their association with history of falls: results of the population-based cross-sectional KORA-Age study.

Related Articles

Description of spatio-temporal gait parameters in elderly people and their association with history of falls: results of the population-based cross-sectional KORA-Age study.

BMC Geriatr. 2015;15:32

Authors: Thaler-Kall K, Peters A, Thorand B, Grill E, Autenrieth CS, Horsch A, Meisinger C

Abstract
BACKGROUND: In this epidemiological study we described the characteristics of spatio-temporal gait parameters among a representative, population-based sample of 890 community-dwelling people aged 65 to 90 years. In addition, we investigated the associations between certain gait parameters and a history of falls in study participants.
METHODS: In descriptive analyses spatio-temporal gait parameters were assessed according to history of falls, frailty, multimorbidity, gender, multiple medication use, disability status, and age group. Logistic regression models were calculated to examine the association between gait velocity and stride length with a history of falls (at least one fall in the last 12 month). Data on gait were collected on an electronic walkway on which participants walked at their usual pace.
RESULTS: We found significant differences within gait parameters when stratifying by frailty, multimorbidity, disability and multiple medication use as well as age (cut point 75 years) and sex, with p < 0.05 for all gait parameters (velocity, cadence, time, stride duration, stride length, step width). After stratification by history of falls, only stride length showed a significant difference (p < 0.05) between the groups of fallers and non-fallers. Logistic regression models showed that a decreased stride length was independently associated with falls in men aged older than 74 years (OR 1.34 (CI: 1.05-1.70 per 10 cm decrease)), while this was neither the case for women of similar age nor for men or women aged 65 to 74 years. A decreased walking speed was not associated with falls.
CONCLUSION: Age, frailty, multimorbidity, disability, history of falls, sex, and multiple medication use show an association with different gait parameters measured during gait assessment on an electronic walkway in elderly people. Furthermore, stride length is a good indicator to differentiate fallers from non-fallers in older men from the general population.

PMID: 25880255 [PubMed - indexed for MEDLINE]

from Hearing and Balance via ola Kala on Inoreader http://ift.tt/1RX6kkj
via IFTTT

Is NBI-Guided Resection a Breakthrough for Achieving Adequate Resection Margins in Oral and Oropharyngeal Squamous Cell Carcinoma?

Is NBI-Guided Resection a Breakthrough for Achieving Adequate Resection Margins in Oral and Oropharyngeal Squamous Cell Carcinoma?

Ann Otol Rhinol Laryngol. 2016 Apr 7;

Authors: Tirelli G, Piovesana M, Gatto A, Torelli L, Boscolo Nata F

Abstract
OBJECTIVES: Obtaining free resection margins is the main goal of oncological surgeons. Narrow-band imaging (NBI) has been recently used to help define resection margins in transoral laser microsurgery for laryngeal carcinoma. The aim of this study was to evaluate the effect of intraoperative NBI in defining the surgical resection margins of oral and oropharyngeal cancers.
METHODS: Between January 2014 and March 2015, NBI was used intraoperatively after an initial definition of resection margins with white light in 26 patients (group A). The rate of superficial positive margins at definitive histology was compared with that of a historical cohort of 44 patients (group B) previously managed without the use of intraoperative NBI.
RESULTS: A statistically significant reduction in the rate of positive superficial margins was observed at definitive histology in group A (P = .028). NBI helped to identify the presence of dysplasia and cancer around the visible tumor not otherwise detectable with visual examination alone.
CONCLUSIONS: NBI could be a useful tool for obtaining free resection margins in oral and oropharyngeal carcinoma.

PMID: 27056557 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Ng52Ph
via IFTTT

Next Generation Sequencing and the Microbiome of Chronic Rhinosinusitis: A Primer for Clinicians and Review of Current Research, Its Limitations, and Future Directions.

Next Generation Sequencing and the Microbiome of Chronic Rhinosinusitis: A Primer for Clinicians and Review of Current Research, Its Limitations, and Future Directions.

Ann Otol Rhinol Laryngol. 2016 Apr 7;

Authors: Jervis Bardy J, Psaltis AJ

Abstract
OBJECTIVE: Microbiomics in chronic diseases, including chronic rhinosinusitis (CRS), have undergone rapid advances in recent times. The introduction of Next Generation Sequencing (NGS) technology has produced significant clinical insights regarding the bacteriology of these conditions. We review studies that have used 16S rRNA sequencing to specifically investigate the microbiota profiles of patients with CRS in a variety of contexts.
METHODS: Literature review using the CINAHL, MEDLINE, PUBMED, and the Cochrane databases. Papers utilizing 16S-sequencing technology on CRS specimens published between January 1, 1995, and October 31, 2015, were included. Studies limited to only healthy controls were excluded.
RESULTS: Consistent with published studies using non-NGS techniques, the main genera commonly identified from the sinuses of CRS patients included Staphylococcus, Propionibacterium, and Corynebacterium. The microbiome of CRS patients had lower bacterial diversity compared to controls in a number of studies. Also consistent with non-NGS-based studies, Staphylococcus was implicated as an important genus, with highly colonized patients having worse surgical outcomes. Conflicting reports of antibiotic effects on the CRS microbiome were observed. Sampling methods were well investigated, many of the studies reviewed failed to include important methodological detail.
CONCLUSION: While 16S sequencing is a novel microbiological laboratory method, current studies have confirmed our existing understanding of bacteriology of CRS without providing significant additional clinical insight. Complementing 16S studies with more complex NGS methods while developing robust clinical studies aimed at shifting the disrupted CRS microbiome will provide researches with the opportunity to derive further clinical insight and develop new therapeutic targets.

PMID: 27056556 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Sm2MYc
via IFTTT

[A rare complication of necrotizing enterocolitis in newborn].

Related Articles

[A rare complication of necrotizing enterocolitis in newborn].

Khirurgiia (Mosk). 2016;(1):78-9

Authors: Solov'ov AE, Anikin IA, Kokorkin AD, Pakhol'chuk AP, Mariev GS

PMID: 26977616 [PubMed - indexed for MEDLINE]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UPA3Bv
via IFTTT

Submucosal nodule in buccal mucosa.

Submucosal nodule in buccal mucosa.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb 17;

Authors: Daroit NB, Maraschin BJ, Carrard VC, Rados PV, Visioli F

PMID: 27055736 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UPA5t3
via IFTTT

Synchronous presentation of trigeminal, glossopharyngeal and geniculate neuralgias in a single patient.

Synchronous presentation of trigeminal, glossopharyngeal and geniculate neuralgias in a single patient.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb 23;

Authors: Homeida L, Elmuradi S, Sollecito TP, Stoopler ET

Abstract
Orofacial pain disorders can present as a diagnostic and therapeutic challenge for oral health care providers. Odontogenic and nonodontogenic sources of orofacial pain should be considered and cranial neuralgias may be included in the differential diagnosis. Synchronous presentation of multiple cranial neuralgias is a rare occurrence. We report a case of a patient with a synchronous presentation of trigeminal, glossopharyngeal, and geniculate neuralgias. To our knowledge, this is the first case of a synchronous presentation of these conditions reported to date.

PMID: 27055735 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/22jE93L
via IFTTT

Nodular swelling of the buccal mucosa.

Nodular swelling of the buccal mucosa.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb 17;

Authors: Almeida LY, Fernandes D, Ferrisse TM, Ortega RM, Travassos DC, Ribeiro-Silva A, León JE, Bufalino A

PMID: 27055734 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UPA4FF
via IFTTT

Novel incision design and primary flap closure reduces the incidence of alveolar osteitis and infection in impacted mandibular third molar surgery.

Novel incision design and primary flap closure reduces the incidence of alveolar osteitis and infection in impacted mandibular third molar surgery.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb 13;

Authors: Elo JA, Sun HB, Dong F, Tandon R, Singh HM

Abstract
OBJECTIVE: To measure the influence of flap design on alveolar osteitis (AO) and postoperative complications following mandibular third molar surgery.
STUDY DESIGN: This study was designed as a randomized single-blind, split-mouth clinical trial. The predictor variable was flap type. Envelope flap, modified triangular flap (MTF), and two related experimental flaps (second molar mesial papilla-sparing marginal incision with distobuccal release with double-pass single-layered primary closure [MPMI-2 X] and single-pass single-layered primary closure [MPMI-1 X]) were used. The primary outcome variable was AO. The secondary outcome variables were wound dehiscence and infection. Bivariate and logistic analyses were computed. P value < .05 was considered to be statistically significant.
RESULTS: One hundred ninety-six patients with symmetric bilateral partial bony or full bony impacted mandibular third molars participated. No sites (0 of 196) treated with MPMI-2 X developed AO, and only two sites (2 of 196) treated with MPMI-2 X developed postoperative infection. Both MPMI-1 X and MPMI-2 X were associated with decreased odds of complications compared with MTF and envelope flap. MPMI-2 X sites were significantly less likely than MTF sites to experience complications for both sides.
CONCLUSIONS: MPMI-2 X is a reliable technique to reduce complications, such as AO, wound dehiscence, and infection in mandibular third molar surgery.

PMID: 27055733 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/22jE8Nf
via IFTTT

Osteoporosis, osteoporotic fractures, and carotid artery calcification detected on panoramic radiographs in Japanese men and women.

Osteoporosis, osteoporotic fractures, and carotid artery calcification detected on panoramic radiographs in Japanese men and women.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb 23;

Authors: Iwamoto Y, Uchida K, Sugino N, Kuroiwa H, Kitamura Y, Udagawa N, Shinohara A, Higashi Y, Taguchi A

Abstract
OBJECTIVES: We investigated the association among diagnosed osteoporosis, osteoporotic fractures, and carotid artery calcification (CAC) detected on panoramic radiographs. Additionally, we assessed whether osteoporosis or fractures could be predicted by an incidental finding of CAC.
STUDY DESIGN: One thousand twenty-one patients participated in this study. Patients completed a structured questionnaire. Logistic regression analysis adjusted for covariates was used to calculate the odds ratio (95% confidence interval) for diagnosed osteoporosis or fractures according to the presence of CAC. Extended receiver operating characteristic (ROC) curve analysis was used to clarify whether osteoporosis or fractures were predicted by the detection of CAC.
RESULTS: The odds ratios for diagnosed osteoporosis or fracture associated with CAC were 1.82 (1.02-3.24) and 0.77 (0.33-1.77), respectively. The areas under the ROC curves for identifying patients with osteoporosis or fractures according to the detection of CAC were 0.54 and 0.50, respectively.
CONCLUSIONS: CAC may not be useful for identifying Japanese individuals with osteoporosis or those at risk of fracture, although the presence of CAC was significantly associated with a history of diagnosed osteoporosis without osteoporotic fractures.

PMID: 27055732 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UPA2NS
via IFTTT

Surgical management of traumatic cerebrospinal fluid fistulas with associated lesions.

Surgical management of traumatic cerebrospinal fluid fistulas with associated lesions.

Ulus Travma Acil Cerrahi Derg. 2015 Nov;21(6):450-456

Authors: Alagöz F, Dağlıoğlu E, Korkmaz M, Yıldırım AE, Uçkun ÖM, Divanlıoğlu D, Polat Ö, Dalgıç A, Ösün A, Yılmaz F, Sönmez M, Belen AD

Abstract
BACKGROUND: Head trauma is associated with a significant risk of cerebrospinal fluid (CSF) fistula.
METHODS: In this study, it was aimed to report twenty-two cases subjected to operative intervention for otorrhea, rhinorrhea and oculorrhea with associated traumatic lesions. Majority of the cases had moderate to severe head trauma with a Glascow Coma Scale (GCS) score under 14. The study group included eleven cases with depression fractures, 6 with epidural hematomas and 4 with tension pneumocephalus.
RESULTS: Rhinorrhea was the most common presenting symptom encountered in fifteen cases; whereas, otorrhea was prominent in 7 and oculorrhea in 2 cases. Two patients having rhinorrhea also had oculorrhea and otorrhea. The patients were operated with unilateral approaches in twelve and bifrontal approaches in ten of the cases.
CONCLUSION: Early surgical intervention should be performed in cases presenting with CSF fistula and associated traumatic lesions without considering conservative management to provide an effective control of associated complications due to CSF fistulas.

PMID: 27054635 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1S8qUn5
via IFTTT

Empowering the family during the first months after identification of permanent hearing impairment in children.

Empowering the family during the first months after identification of permanent hearing impairment in children.

Acta Otorhinolaryngol Ital. 2016 Feb;36(1):64-70

Authors: Ciciriello E, Bolzonello P, Marchi R, Falzone C, Muzzi E, Orzan E

Abstract
The latest international guidelines highlight the importance of involving the family in the diagnositic and rehabilitation process of children affected by permanent hearing impairment. This emphasises how meaningful this approach is for the development of the deaf child. So far, there is very little evidence about this approach in Italy, and there are still some barriers to its practical management. The aim of this paper is to report the results of a strategic analysis, which identifies the strengths, weaknesses, opportunities and threats of the family empowerment process during early auditory diagnosis and rehabilitation. The audiology programme should have the goal to offer information and support to families in order to achieve a conscious decision about the use and type of auditory prosthesis and rehabilitation choice within three months after audiologic diagnosis. Within the framework of the Ministry of Health project CCM 2013 "Preventing Communication Disorders: a Regional Program for Early Identification, Intervention and Care of Hearing Impaired Children", a group of professionals identified three main recommendations that can be useful to foster the natural communicative development of the child by strengthening the therapeutic alliance and empowerment of the family. The recommendations obtained with this analysis can help to develop new Italian guidelines with the aim to foster natural communicative development of the child by strengthening the therapeutic alliance and empowerment of the family.

PMID: 27054393 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Whn7E5
via IFTTT

Follow-up of permanent hearing impairment in childhood.

Follow-up of permanent hearing impairment in childhood.

Acta Otorhinolaryngol Ital. 2016 Feb;36(1):60-63

Authors: Della Volpe A, De Lucia A, Pastore V, Bracci Laudiero L, Buonissimo I, Ricci G

Abstract
Programmes for early childhood childhood hearing impairment identification allows to quickly start the appropriate hearing aid fitting and rehabilitation process; nevertheless, a large number of patients do not join the treatment program. The goal of this article is to present the results of a strategic review of the strengths, weaknesses, opportunities and threats connected with the audiologic/prosthetic/language follow-up process of children with bilateral permanent hearing impairment. Involving small children, the follow-up includes the involvement of specialised professionals of a multidisciplinary team and a complex and prolonged multi-faced management. Within the framework of the Italian Ministry of Health project CCM 2013 "Preventing Communication Disorders: a Regional Program for Early Identification, Intervention and Care of Hearing Impaired Children", the purpose of this analysis was to propose recommendations that can harmonise criteria for outcome evaluation and provide guidance on the most appropriate assessment methods to be used in the follow-up course of children with permanent hearing impairment.

PMID: 27054392 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UOKOUG
via IFTTT

Early care in children with permanent hearing impairment.

Early care in children with permanent hearing impairment.

Acta Otorhinolaryngol Ital. 2016 Feb;36(1):51-59

Authors: Giuntini G, Forli F, Nicastro R, Ciabotti A, Bruschini L, Berrettini S

Abstract
The implementation of regional protocols for newborn hearing screening and early audiologic diagnosis represent the first step of the entire diagnostic, rehabilitative and prosthetic programme for children with permanent hearing impairment. The maximum benefit of early diagnosis can indeed be obtained only by prompt rehabilitation aimed at fostering the child's communicative, linguistic and cognitive development. Within the framework of the CMM 2013 project of the Ministry of Health entitled "Preventing Communication Disorders: a Regional Program for Early Identification, Intervention and Care of Hearing Impaired Children", the problems concerning the promotion of the global development of children with PHI throughan early rehabilitation project based on shared knowledge and scientific evidence. In this project, our specific aim was to define the features and modes of access to a precise and specialised rehabilitation project for the small hearing-impaired child within three months from audiologic diagnosis. Three main recommendations relative to assessment and rehabilitation aspects of early care emerged from the study.

PMID: 27054391 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1SVK5gQ
via IFTTT

Achieving early functional auditory access in paediatric cochlear implantation.

Achieving early functional auditory access in paediatric cochlear implantation.

Acta Otorhinolaryngol Ital. 2016 Feb;36(1):45-50

Authors: Orzan E, Muzzi E, Marchi R, Falzone C, Battelino S, Ciciriello E

Abstract
Cochlear implantation (CI) is a viable option for providing access to auditory stimulation in severe-to-profound hearing loss/impairment of cochlear origin. It has been demonstrated that CI is safe and effective for deaf children. Younger age at activation after CI is linked with better outcomes. It is important to study variables and issues that can interfere with an early fitting and access to sound after CI. They range from patient characteristics, family compliance and support, to technical, medical or organisational problems. A SWOT analysis and a subsequent TOWS matrix was conducted to discuss issues and propose recommendations to be considered when operating an early switch on of the CI.

PMID: 27054390 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1oIeLaO
via IFTTT

Achieving effective hearing aid fitting within one month after identification of childhood permanent hearing impairment.

Achieving effective hearing aid fitting within one month after identification of childhood permanent hearing impairment.

Acta Otorhinolaryngol Ital. 2016 Feb;36(1):38-44

Authors: Bastanza G, Gallus R, De Carlini M, Picciotti PM, Muzzi E, Ciciriello E, Orzan E, Conti G

Abstract
Diagnosis of child permanent hearing impairment (PHI) can be made with extreme timeliness compared to the past thanks to improvements in PHI identification through newborn hearing screening programmes. It now becomes essential to provide an effective amplification as quickly as possible in order to restore auditory function and favour speech and language development. The early fitting of hearing aids and possible later cochlear implantation indeed prompts the development of central auditory pathways, connections with secondary sensory brain areas, as well as with motor and articulatory cortex. The aim of this paper is to report the results of a strategic analysis that involves identification of strengths, weaknesses, opportunities and threats regarding the process of achieving early amplification in all cases of significant childhood PHI. The analysis is focused on the Italian situation and is part of the Italian Ministry of Health project CCM 2013 "Preventing Communication Disorders: a Regional Program for Early Identification, Intervention and Care of Hearing Impaired Children".

PMID: 27054389 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qxFI2t
via IFTTT

Aetiologic diagnosis of hearing loss in children identified through newborn hearing screening testing.

Aetiologic diagnosis of hearing loss in children identified through newborn hearing screening testing.

Acta Otorhinolaryngol Ital. 2016 Feb;36(1):29-37

Authors: Forli F, Giuntini G, Bruschini L, Berrettini S

Abstract
With the implementation of universal newborn hearing screening (UNHS) programmes and early diagnosis and treatment of hearing problems, the need has clearly emerged to implement and carry out a systematic and coordinated protocol for the aetiological diagnosis of permanent hearing impairment (PHI). Within the framework of the Italian Ministry of Health project CCM 2013 "Preventing Communication Disorders: a Regional Program for early Identification, Intervention and Care of Hearing Impaired Children", it has been decided to consider the problems relative to aetiological diagnosis of child PHI within UNHS programmes. The specific objective was to apply a shared diagnostic protocol that can identify the cause in at least 70% of cases of PHI. For this part of the project, four main recommendations were identified that can be useful for an efficient aetiological diagnosis in children affected by PHI and that can offer valid suggestions to optimise resources and produce positive changes for third-level audiologic centres.

PMID: 27054388 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UOKOUx
via IFTTT