Brief Communication PD1-related Nephrotoxicity: Optimizing Its Clinical Management Through Histopathologic Features

alwin shared this article with you from Inoreader Brief Communication PD1-related Nephrotoxicity: Optimizing Its Clinical Management Through Histopathologic Features Via Journal of Immunotherapy Immune-related nephrotoxicity (ir-N) is a rare adverse event of immune-checkpoint(s) inhibitors (ICI) therapy and its clinical management is still debated. Among 501 consecutive ICI-treated patients at our Institution, 6 who developed an ir-N with clinical signs suggestive for an acute kidney injury underwent kidney biopsy. Histology showed an acute tubule-interstitial nephritis, simulating the scenario of acute T-cell–mediated kidney transplant rejection. Thus, the management of allograft kidney rejection routinely utilized at our clinic was implemented, leading to rapid renal function improvement. Histologic features supporting the definition of an immune-mediated acute kidney injury in ICI-treated patients may help optimizing the clinical management of ir-N. (Source: Journal of Immuno... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hyperbaric Oxygen as Adjunctive Therapeutic in Management of Craniocervical Necrotizing Fasciitis: Case Series and Treatment Protocol

alwin shared this article with you from Inoreader Hyperbaric Oxygen as Adjunctive Therapeutic in Management of Craniocervical Necrotizing Fasciitis: Case Series and Treatment Protocol Via Journal of Oral and Maxillofacial Surgery Odontogenic infections are commonly encountered in OMS practices. Rarely, odontogenic infections can progress into craniocervical necrotizing fasciitis (CCNF). CCNF of the head and neck is a rare, potentially lethal disease process involving infection and subsequent destruction of fascial planes. Mortality ranges from 33% to 50% if the mediastinum is involved.1,2 CCNF diagnosis is based on clinical suspicion. Typical findings include dishwater-like purulence and easy spread of fascial planes using fingers.3 Treatment for CCNF usually consists of aggressive surgical debridement, source control, and intravenous antibiotics. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Can Positioning an Oral Endotracheal Tube in the Retromolar Space Allow Maxillomandibular Fixation without Occlusal Interference?

alwin shared this article with you from Inoreader Can Positioning an Oral Endotracheal Tube in the Retromolar Space Allow Maxillomandibular Fixation without Occlusal Interference? Via Journal of Oral and Maxillofacial Surgery Traumatic maxillofacial injuries requiring maxillomandibular fixation (MMF) traditionally necessitate airway management via tracheostomy or submental intubation. The aim of this study is to understand whether the retromolar space can accommodate passage of a reinforced endotracheal tube (ETT) without interfering with establishing MMF, a technique previously described as retromolar intubation. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Improved Quality of Living following Simultaneous Condylectomy and Orthognathic Surgery: A Retrospective Analysis for Active Unilateral Condylar Hyperplasia

alwin shared this article with you from Inoreader Improved Quality of Living following Simultaneous Condylectomy and Orthognathic Surgery: A Retrospective Analysis for Active Unilateral Condylar Hyperplasia Via Journal of Oral and Maxillofacial Surgery The objective was to assess quality of life in patients who underwent simultaneous condylectomy and orthognathic surgery in conjunction with orthodontic treatment for active unilateral condylar (TMJ) hyperplasia. This pathologic process leads to the development of esthetic and functional concerns. High condylectomy (7-10mm of bone removed from condylar process) simultaneously performed with orthognathic surgery is the treatment studied1, but currently, there is no published literature that analyzes patient satisfaction. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Orbital fractures with concomitant ocular nerve palsy: An insidious and potentially misleading association in surgical decision-making.

alwin shared this article with you from Inoreader Orbital fractures with concomitant ocular nerve palsy: An insidious and potentially misleading association in surgical decision-making. Via Journal of Oral and Maxillofacial Surgery Orbital fractures (OFs) are common, but their association with concomitant traumatic ocular nerve palsy (TONP) is exceptional and may potentially cause confusing clinical pictures of oculomotor involvement. The purpose of the present study was to describe a series of patients with OFs and concomitant TONP following facial trauma and to evaluate clinical features, diagnostic pitfalls and final functional outcome. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Accuracy and precision of the CTA perforator localization technique for virtual surgical planning of composite osteocutaneous fibular free flaps in head and neck reconstruction.

alwin shared this article with you from Inoreader Accuracy and precision of the CTA perforator localization technique for virtual surgical planning of composite osteocutaneous fibular free flaps in head and neck reconstruction. Via Journal of Oral and Maxillofacial Surgery Virtual surgical planning (VSP), computer aided design/computer aided modeling (CAD/CAM), and three-dimensional (3D) printing technology have been shown to improve surgical accuracy and efficiency in head and neck reconstruction. However, persisting criticism of the technology is that it does not adequately address the soft-tissue related aspects of the reconstructive surgery. Prior publication on the computed tomographic angiography (CTA) perforator localization technique has demonstrated how soft tissue planning can be incorporated directly into existing VSP workflows. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Are Incisional Biopsies Reliable to Select Definitive Treatment in Patients with Ameloblastoma of the Jaws? A 15-year Interdisciplinary Retrospective Study

alwin shared this article with you from Inoreader Are Incisional Biopsies Reliable to Select Definitive Treatment in Patients with Ameloblastoma of the Jaws? A 15-year Interdisciplinary Retrospective Study Via Journal of Oral and Maxillofacial Surgery Ameloblastomas are tumors of odontogenic epithelium that, although benign, can have a locally aggressive course causing significant morbidity. WHO classifies ameloblastomas as 1 of 3 variants: solid/multicystic, unicystic, and peripheral. Resection, the standard treatment, is deemed curative, but can be debilitating to the patient. Unicystic subtype is considered less aggressive and could be treated with enucleation and curettage. The mercurial presentation of ameloblastomas makes the chosen treatment modality essential in decreasing the recurrence rates and associated morbidity. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Modified Lip Revision Surgery For The Severe Whistle Lip Deformity In Bilateral Cleft Lip

alwin shared this article with you from Inoreader Modified Lip Revision Surgery For The Severe Whistle Lip Deformity In Bilateral Cleft Lip Via Journal of Oral and Maxillofacial Surgery Whistle deformity is a sequela of primary surgical repair of the bilateral cleft lip that leads to a vertical tissue deficiency and a non-functional orbicularis oris muscle in the medial portion of the upper lip. This sequel is significantly limiting functionally and esthetically. We propose a complete labial revision with a secondary cheiloplasty of Mulliken and a submucosal inferiorly based flap in the central tubercle to increase the volume at this usually deficient area. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Intraoperative flap warming: The novel use of a sterile cardiac forced warm air blanket for maintaining optimal flap perfusion.

alwin shared this article with you from Inoreader Intraoperative flap warming: The novel use of a sterile cardiac forced warm air blanket for maintaining optimal flap perfusion. Via Journal of Oral and Maxillofacial Surgery The two-team approach in major head and neck/reconstructive surgery can occasionally lead to delays between flap harvest and detachment, due to the complexity and length of the ablative procedure. In order to minimize the potential for flap cooling and the adverse impact on microcirculation, active warming can be beneficial.(1) Intraoperative flap warming to either maintain or improve circulation during free flap harvesting has been performed with a variety of passive and active techniques,(2) however limitations such as a lack of consistent temperature regulation, lack of sterility, inability to directly visualise the flap or the need for acquisition of new equipment for a niche area meant that an ideal solution was lacking. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Training the pronunciation of L2 vowels under different conditions: the use of non-lexical materials and masking noise

alwin shared this article with you from Inoreader Training the pronunciation of L2 vowels under different conditions: the use of non-lexical materials and masking noise Via Phonetica Phonetica. 2022 Apr 15. doi: 10.1515/phon-2022-2018. Online ahead of print.ABSTRACTThe current study extends traditional perceptual high-variability phonetic training (HVPT) in a foreign language learning context by implementing a comprehensive training paradigm that combines perception (discrimination and identification) and production (immediate repetition) training tasks and by exploring two potentially enhancing training conditions: the use of non-lexical training stimuli and the presence of masking noise during production training. We assessed training effects on L1-Spanish/Catalan bilingual EFL learners' production of a difficult English vowel contrast (/æ/-/ʌ/). The participants (N = 62) were randomly assigned to either non-lexical (N = 24) or lexical (N = 24) training and were fu... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.