OtoRhinoLaryngology News: 02/06/16

Σάββατο 6 Φεβρουαρίου 2016

Response.

Response.

Ear Nose Throat J. 2015 Oct-Nov;94(10-11):E50

Authors: Wadhera R, Zafar N, Gulati SP, Kalra V, Ghai A

PMID: 26845781 [PubMed - in process]

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Response.

Response.

Ear Nose Throat J. 2015 Oct-Nov;94(10-11):E50

Authors: Wadhera R, Zafar N, Gulati SP, Kalra V, Ghai A

PMID: 26845781 [PubMed - in process]

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[Basal cell carcinoma of the face: about four cases reported in Madagascar].

[Basal cell carcinoma of the face: about four cases reported in Madagascar].

Pan Afr Med J. 2015;22:97

Authors: Razafindrakoto RM, Razafindranaivo MN, Schammirah MR, Randriamboavonjy R

PMID: 26848344 [PubMed - in process]

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[Intra-sinusal maxillary pleomorphic adenoma: a rare entity].

[Intra-sinusal maxillary pleomorphic adenoma: a rare entity].

Pan Afr Med J. 2015;22:81

Authors: Razafindrakoto RM, Schammirah MR

PMID: 26848328 [PubMed - in process]

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Endoscopic surgery for congenital basal meningoencephaloceles in children.

Endoscopic surgery for congenital basal meningoencephaloceles in children.

Acta Otolaryngol. 2016 Feb 5;:1-7

Authors: Wu X, Zhang J, Zhang H, Xie Z, Fan R, Liu Y, Wu B, Sun H, Jiang W

Abstract
Conclusions Endoscopic surgery is safe and effective for children with congenital basal meningoencephaloceles (CBMs); it provides an acceptable operative outcome with a short recovery time and fewer complications and may be considered as a primary approach. Objectives To explore the safety and effectiveness of using transnasal or transoral endoscopic surgery on children with CBMs. Methods The clinical data of eight CBMs children who underwent transnasal or transoral endoscopic surgery in a hospital from January 2011 to January 2015 were collected. The presenting symptoms, lesion locations, surgical outcomes, and complications were examined retrospectively. Results Of the eight children, five (62.5%) patients were male, and their ages ranged from 1 year and 6 months to 14 years (median of 9 years). Six patients presented with the transethmoidal sub-type, and two presented with the transsphenoidal sub-type. The average hospital stay of all patients was 8.6 ± 2.6 days. There were neither intra-operative nor post-operative complications observed in any of the cases during the follow-ups that occurred between 6-54 months (mean of 15.5 months).

PMID: 26848970 [PubMed - as supplied by publisher]

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Long-term follow-up after ESS and balloon sinuplasty: Comparison of symptom reduction and patient satisfaction.

Long-term follow-up after ESS and balloon sinuplasty: Comparison of symptom reduction and patient satisfaction.

Acta Otolaryngol. 2016 Feb 5;:1-5

Authors: Koskinen A, Myller J, Mattila P, Penttilä M, Silvola J, Alastalo I, Huhtala H, Hytönen M, Toppila-Salmi S

Abstract
Conclusion This is the first controlled study of balloon sinuplasty's long-term efficacy with the follow-up time over 5 years. The results are in accordance with a previous 2-year-follow-up study. Both techniques retained the efficacy and patient satisfaction on average 6 years after the surgery. Background Endoscopic sinus surgery (ESS) and balloon sinuplasty are considered as a treatment for chronic rhinosinusitis (CRS) after a failure of conservative therapy. High cost and lack of long-term follow-up studies restrain the use of balloon sinuplasty. Objective The aim of this study was to compare long-term efficacy and satisfaction in CRS patients who had undergone maxillary sinus operation with either balloon sinuplasty or ESS technique. Previous or additional sinonasal operations were exclusion criteria. Materials and methods Study patients were recruited from 208 CRS-patients who underwent either ESS or balloon sinuplasty. Patients with nasal polyposis (gradus ≥ 2), previous sinonasal surgery, unilateral disease, or immune deficiency were excluded. Altogether 45 patients in the ESS group and 40 patients in the balloon group were included. Of these, 30 and 28, respectively, answered to a phone interview held on average 6 years after primary surgery. Symptom reduction and long-term satisfaction were evaluated by using symptom scores of 19 parameters altogether. Results Both groups experienced improvement in symptoms and were equally satisfied with the operation. The number of patient-reported acute exacerbations was higher among the balloon dilated patients. Also, the reduction of thick nasal discharge was less evident in the balloon sinuplasty group. Four patients in the balloon sinuplasty group underwent revision surgery. There were no revisions in the ESS group.

PMID: 26848855 [PubMed - as supplied by publisher]

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Acknowledgement to referees 2015.

Acknowledgement to referees 2015.

Eur Arch Otorhinolaryngol. 2016 Feb 5;

Authors:

PMID: 26846486 [PubMed - as supplied by publisher]

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Reconstruction of nasal tip support in primary, open approach septorhinoplasty : A retrospective analysis between the tongue-in-groove technique and the columellar strut.

Reconstruction of nasal tip support in primary, open approach septorhinoplasty : A retrospective analysis between the tongue-in-groove technique and the columellar strut.

Eur Arch Otorhinolaryngol. 2016 Feb 4;

Authors: Karaiskakis P, Bromba M, Dietz A, Sand M, Dacho A

Abstract
The reconstruction of the nasal tip support is one of the most essential issues in septorhinoplasty. A comparison of the results after using the tongue-in-groove technique and the columellar strut technique was the target of this study. Thirty-three patients who underwent a primary, open approach septorhinoplasty using the above-mentioned techniques were retrospectively analyzed. The gain in tip rotation postoperatively, the sensitivity and the rigidity of the nasal tip and the aesthetic outcome after surgery were examined and evaluated. Both techniques led to an increase in nasal tip rotation postoperatively. The gain in rotation was higher in patients, treated with the tongue-in-groove technique (p = 0.0052). The sensitivity of the tip region in the tongue-in-groove group of patients was significantly lower than that in the columellar strut group of patients (p = 0.0424). Both techniques led to high percentages of tip rigidity after surgery with satisfactory aesthetic results though. The tongue-in-groove technique and the columellar strut technique are both reliable techniques for reconstructing the nasal tip support and correcting a droopy tip. Although the tongue-in-groove technique might result in a more significant increase in tip rotation, it leads to less sensitivity in the tip region.

PMID: 26846403 [PubMed - as supplied by publisher]

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Endoscopic surgery for congenital basal meningoencephaloceles in children.

Endoscopic surgery for congenital basal meningoencephaloceles in children.

Acta Otolaryngol. 2016 Feb 5;:1-7

Authors: Wu X, Zhang J, Zhang H, Xie Z, Fan R, Liu Y, Wu B, Sun H, Jiang W

PMID: 26848970 [PubMed - as supplied by publisher]

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Comparative analysis of the anterior transpetrosal approach with the endoscopic endonasal approach to the petroclival region.

Comparative analysis of the anterior transpetrosal approach with the endoscopic endonasal approach to the petroclival region.

J Neurosurg. 2016 Feb 5;:1-16

Authors: Muto J, Prevedello DM, Ditzel Filho LF, Tang IP, Oyama K, Kerr EE, Otto BA, Kawase T, Yoshida K, Carrau RL

Abstract
OBJECTIVE The endoscopic endonasal approach (EEA) offers direct access to midline skull base lesions, and the anterior transpetrosal approach (ATPA) stands out as a method for granting entry into the upper and middle clival areas. This study evaluated the feasibility of performing EEA for tumors located in the petroclival region in comparison with ATPA. METHODS On 8 embalmed cadaver heads, EEA to the petroclival region was performed utilizing a 4-mm endoscope with either 0° or 30° lenses, and an ATPA was performed under microscopic visualization. A comparison was executed based on measurements of 5 heads (10 sides). Case illustrations were utilized to demonstrate the advantages and disadvantages of EEA and ATPA when dealing with petroclival conditions. RESULTS Extradurally, EEA allows direct access to the medial petrous apex, which is limited by the petrous and paraclival internal carotid artery (ICA) segments laterally. The ATPA offers direct access to the petrous apex, which is blocked by the petrous ICA and abducens nerve inferiorly. Intradurally, the EEA allows a direct view of the areas medial to the cisternal segment of cranial nerve VI with limited lateral exposure. ATPA offers excellent access to the cistern between cranial nerves III and VIII. The quantitative analysis demonstrated that the EEA corridor could be expanded laterally with an angled drill up to 1.8 times wider than the bone window between both paraclival ICA segments. CONCLUSIONS The midline, horizontal line of the petrous ICA segment, paraclival ICA segment, and the abducens nerve are the main landmarks used to decide which approach to the petroclival region to select. The EEA is superior to the ATPA for accessing lesions medial or caudal to the abducens nerve, such as chordomas, chondrosarcomas, and midclival meningiomas. The ATPA is superior to lesions located posterior and/or lateral to the paraclival ICA segment and lesions with extension to the middle fossa and/or infratemporal fossa. The EEA and ATPA are complementary and can be used independently or in combination with each other in order to approach complex petroclival lesions.

PMID: 26848916 [PubMed - as supplied by publisher]

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Classification and surgical approaches for transnasal endoscopic skull base chordoma resection: a 6-year experience with 161 cases.

Classification and surgical approaches for transnasal endoscopic skull base chordoma resection: a 6-year experience with 161 cases.

Neurosurg Rev. 2016 Feb 3;

Authors: Gui S, Zong X, Wang X, Li C, Zhao P, Cao L, Zhang Y

Abstract
The aim of this study is to retrospectively analyze 161 cases of surgically treated skull base chordoma, so as to summarize the clinical classification of this tumor and the surgical approaches for its treatment via transnasal endoscopic surgery. Between August 2007 and October 2013, a total of 161 patients (92 males and 69 females) undergoing surgical treatment of skull base chordoma were evaluated with regard to the clinical classification, surgical approach, and surgical efficacy. The tumor was located in the midline region of the skull base in 134 cases, and in the midline and paramedian regions in 27 cases (extensive type). Resection was performed via the transnasal endoscopic approach in 124 cases (77 %), via the open cranial base approach in 11 cases (6.8 %), and via staged resection combined with the transnasal endoscopic approach and open cranial base approach in 26 cases (16.2 %). Total resection was achieved in 38 cases (23.6 %); subtotal resection, 86 cases (53.4 %); partial resection of 80-95 %, 29 cases (18 %); and partial resection <80 %, 8 cases (5 %). The clinical classification method used in this study seems suitable for selection of transnasal endoscopic surgical approach which may improve the resection degree and surgical efficacy of skull base chordoma. Gross total resection of skull base chordoma via endoscopic endonasal surgery (with addition of an open approach as needed) is a safe and viable alternative to the traditional open approach.

PMID: 26846667 [PubMed - as supplied by publisher]

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Clinical and Electromyographic Characteristics of Unilateral Vocal Fold Paralysis With Lower Cranial Nerve Injury.

Clinical and Electromyographic Characteristics of Unilateral Vocal Fold Paralysis With Lower Cranial Nerve Injury.

J Voice. 2016 Feb 1;

Authors: Hu R, Li Y, Xu W, Cheng L, Ren H

Abstract
OBJECTIVES: The aim was to investigate the clinical and electromyographic characteristics of patients with unilateral vocal fold paralysis (UVFP) combined with lower cranial nerve injury.
STUDY DESIGN: This is a case series with chart review.
METHODS: Among 368 patients with idiopathic UVFP, 31 patients (8.4%) were eventually diagnosed with lower cranial nerve palsy after examinations of the head and neck, radiology, and electromyogram (EMG). The clinical and electromyographic characteristics of these patients were analyzed.
RESULTS: Of the 31 patients, 27 patients exhibited obvious abnormal lower cranial nerve injury physical signs, and 4 patients showed atypical physical signs, identified by EMG. Ultimately, 41.9% (13/31) were diagnosed with idiopathic causes, 38.7% (12/31) with intracranial or skull-base lesions on radiology, 12.9% (4/31) with lower cranial neuritis, and 6.4% (2/31) with radiation-induced lower cranial nerve palsy. Among the cranial lesions, lesions of the jugular foramen region were the most common (50%, 6/12). All 26 patients who underwent EMG tests were confirmed to have vagus nerve impairments (11 complete and 15 incomplete) and accessory nerve impairments (16 complete and 10 incomplete), whereas only 13 patients (50%) exhibited hypoglossal nerve injuries (5 complete and 8 incomplete).
CONCLUSIONS: For patients with clinically "idiopathic" UVFP, physical examinations of the lower cranial nerves are essential screening procedures. For patients with abnormal or suspicious physical signs, radiology should be performed to detect possible cranial or cervical lesions. EMG tests were strongly recommended to identify suspicious lower cranial nerve injury and its severity, and may help to predict the prognosis.

PMID: 26846541 [PubMed - as supplied by publisher]

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Outcome of hospital discharge on postoperative Day 1 following uncomplicated tethered spinal cord release.

Outcome of hospital discharge on postoperative Day 1 following uncomplicated tethered spinal cord release.

J Neurosurg Pediatr. 2016 Feb 5;:1-6

Authors: Poonia S, Graber S, Corbett Wilkinson C, O'neill BR, Handler MH, Hankinson TC

Abstract
OBJECTIVE Postoperative management following the release of simple spinal cord-tethering lesions is highly variable. As a quality improvement initiative, the authors aimed to determine whether an institutional protocol of discharging patients on postoperative day (POD) 1 was associated with a higher rate of postoperative CSF leaks than the prior protocol of discharge on POD 2. METHODS This was a single-center retrospective review of all children who underwent release of a spinal cord-tethering lesion that was not associated with a substantial fascial or dural defect (i.e., simple spinal cord detethering) during 2 epochs: prior to and following the institution of a protocol for discharge on POD 1. Outcomes included the need for and timing of nonroutine care of the surgical site, including return to the operating room, wound suturing, and nonsurgical evaluation and management. RESULTS Of 169 patients identified, none presented with CSF-related complications prior to discharge. In the preintervention group (n = 113), the postoperative CSF leak rate was 4.4% (5/113). The mean length of stay was 2.3 days. In the postintervention group, the postoperative CSF leak rate was 1.9% (1/53) in the patients with postdischarge follow-up. The mean length of stay in that group was 1.3 days. CONCLUSIONS At a single academic children's hospital, a protocol of discharging patients on POD 1 following uncomplicated release of a simple spinal cord-tethering lesion was not associated with an increased rate of postoperative CSF leaks, relative to the previous protocol. The rates identified are consistent with the existing literature. The authors' practice has changed to discharge on POD 1 in most cases.

PMID: 26849810 [PubMed - as supplied by publisher]

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Digital subtraction myelography for the identification of spontaneous spinal CSF-venous fistulas.

Digital subtraction myelography for the identification of spontaneous spinal CSF-venous fistulas.

J Neurosurg Spine. 2016 Feb 5;:1-5

Authors: Schievink WI, Moser FG, Maya MM, Prasad RS

Abstract
OBJECTIVE In most patients with spontaneous intracranial hypotension, a spinal CSF leak can be found, but occasionally, no leak can be demonstrated despite extensive spinal imaging. Failure to localize a CSF leak limits treatment options. The authors recently reported the discovery of CSF-venous fistulas in patients with spontaneous intracranial hypotension and now report on the use of digital subtraction myelography in patients with spontaneous intracranial hypotension but no CSF leak identifiable on conventional spinal imaging (i.e., non-digital subtraction myelography). METHODS The patient population consisted of 53 consecutive patients with spontaneous intracranial hypotension who underwent digital subtraction myelography but in whom no spinal CSF leak (i.e., presence of extradural CSF) was identifiable on conventional spinal imaging. RESULTS The mean age of the 33 women and 20 men was 53.4 years (range 29-71 years). A CSF-venous fistula was demonstrated in 10 (19%) of the 53 patients. A CSF-venous fistula was found in 9 (27%) of the 33 women and in 1 (5%) of the 20 men (p = 0.0697). One patient was treated successfully with percutaneous injection of fibrin sealant. Nine patients underwent surgery for the fistula. Surgery resulted in complete resolution of symptoms in 8 patients (follow-up 7-25 months), and in 1 patient, symptoms recurred after 4 months. CONCLUSIONS In this study, the authors found a CSF-venous fistula in approximately one-fifth of the patients with recalcitrant spontaneous intracranial hypotension but no CSF leak identifiable on conventional spinal imaging. The authors suggest that digital subtraction myelography be considered in this patient population.

PMID: 26849709 [PubMed - as supplied by publisher]

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Is the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literature.

Is the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literature.

J Laryngol Otol. 2016 Feb 5;:1-6

Authors: Bitar MA, Nassar J, Dana R

Abstract
OBJECTIVES: To study and review the short- and long-term effects of intranasal steroids on obstructive adenoids.
METHODS: In this prospective cohort study, 19 children previously treated with mometasone furoate for 3 months were contacted at 3, 6 and 12 months after cessation of treatment. Main outcome measures included: change in severity of nasal obstruction, allergic rhinitis and obstructive symptoms. A systematic review of literature was also performed.
RESULTS: By one year, 25 per cent of patients required adenoidectomy; the remaining children had no significant change in clinical score (p = 0.464), obstruction severity (p = 0.191) or allergic symptoms (p = 0.284). Fourteen pertinent studies were identified; all but one study showed improvement in the patients' symptoms and/or degree of obstruction. Two studies with follow up reaching 25 months showed positive effects.
CONCLUSION: The short-term positive effect of some intranasal steroids on obstructive adenoids seems to persist in a significant number of patients after the cessation of treatment.

PMID: 26847580 [PubMed - as supplied by publisher]

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Transoral robotic resection of a large schwannoma in the retropharyngeal space.

Transoral robotic resection of a large schwannoma in the retropharyngeal space.

J Laryngol Otol. 2016 Feb 5;:1-3

Authors: Gungadeen A, Lisseter R, Manickavasagam J, Paleri V

Abstract
BACKGROUND: External approaches have been traditionally used for the complete excision of large retropharyngeal space lesions.
CASE REPORT: This paper describes a case of a large schwannoma of the retropharyngeal space excised transorally with the use of a robotic system. This lesion measured 2.7 × 1.2 cm in axial dimensions and over 5.8 cm in craniocaudal length. The lesion was delivered en bloc with an intact capsule. No peri- or post-operative complications were encountered. The procedure allowed quick resumption of an oral diet and a return to normal activity for the patient.
CONCLUSION: This is, to our knowledge, the first report of this technique used in the excision of a large retropharyngeal space mass.

PMID: 26847473 [PubMed - as supplied by publisher]

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Classification of vocal fold leukoplakia by clinical scoring.

Classification of vocal fold leukoplakia by clinical scoring.

Head Neck. 2016 Feb 5;

Authors: Fang TJ, Lin WN, Lee LY, Young CK, Lee LA, Chang KP, Liao CT, Li HY, Yen TC

Abstract
BACKGROUND: Vocal cord leukoplakia comprises a variety of lesions. The purpose of this study was to stratify vocal leukoplakias before surgery.
METHODS: Patients with an initial diagnosis of vocal leukoplakia who underwent surgical excision at a tertiary referral center in Taiwan were recruited for this study. Their clinical records, including age, sex, preoperative laryngoscopic images in the office setting, and final pathology reports were collected and analyzed.
RESULTS: Patient age (p = .010), nonhomogenous lesion texture (p = .001), and existence of hyperemia (p = .014) were identified as independent factors predicting malignancy. A predictive formula was established accordingly. The model showed an excellent discrimination role by receiver operating characteristic curve analysis (area under the curve = 0.86; p < .001).
CONCLUSION: This study confirmed the value of a scoring system based on laryngoscopic characteristics and patient age for predicting the histologic results in vocal leukoplakia. It is helpful for classifying vocal leukoplakia and pretreatment planning. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 26849206 [PubMed - as supplied by publisher]

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Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial.

Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial.

Head Neck. 2016 Feb 5;

Authors: Villani V, Zucchella C, Cristalli G, Galiè E, Bianco F, Giannarelli D, Carpano S, Spriano G, Pace A

Abstract
BACKGROUND: Few studies have investigated the effect of vitamin E in reducing the cisplatin (CDDP)-induced ototoxicity. This study evaluated vitamin E supplementation as a protecting agent against CDDP-induced ototoxicity.
METHODS: Patients who started CDDP were randomly assigned to receive vitamin E supplementation at 400 mg per day (group 1) or placebo (group 2). Audiograms and evoked brainstem responses were obtained at baseline, and after 1, 2, and 3 months.
RESULTS: Twenty-three patients affected by solid malignancies were enrolled (13 in group 1 and 10 in group 2). At 1 month, a significant hearing loss in group 2 at both 2000 HZ (right ear: p = .05; left ear: p = .04) and 8000 HZ (right ear: p = .04; left ear: p = .03) was detected when compared to baseline values. Audiograms did not show significant changes. At 1 month, evoked brainstem responses remained unchanged in both arms without significant differences between groups.
CONCLUSION: These preliminary findings confirm the neuroprotective properties of vitamin E against the CDDP-induced ototoxicity. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 26849799 [PubMed - as supplied by publisher]

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Human papillomavirus-associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association.

Human papillomavirus-associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association.

Head Neck. 2016 Feb 5;

Authors: Marzouki HZ, Biron VL, Harris J, O'Connell D, Seikaly H

Abstract
BACKGROUND: The purpose of this study was to investigate the possible epidemiological association between oropharyngeal carcinoma and anogenital tumors.
METHODS: Population-based demographic and pathologic data on all male patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC) and anogenital cancer between 1980 and 2011 in the province of Alberta was collected. The risk of association between anogenital cancers and OPSCCs was estimated.
RESULTS: Between 1980 and 2011, a total of 2105 male patients were diagnosed with OPSCC and 914 with anogenital cancers. Only 5 patients were diagnosed with both.
CONCLUSION: In our male population, there was no significant association between anogenital and OPSCCs. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 26849535 [PubMed - as supplied by publisher]

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Comparison of single photon emission CT (SPECT) with SPECT/CT imaging in preoperative localization of parathyroid adenomas: A cost-effectiveness analysis.

Comparison of single photon emission CT (SPECT) with SPECT/CT imaging in preoperative localization of parathyroid adenomas: A cost-effectiveness analysis.

Head Neck. 2016 Feb 5;

Authors: Barber B, Moher C, Côté D, Fung E, O'Connell D, Dziegielewski P, Harris J

Abstract
BACKGROUND: Controversy exists regarding the superiority of single photon emission CT (SPECT)/CT over SPECT for preoperative localization of parathyroid adenomas in primary hyperparathyroidism (PHPT), as well as the cost-effectiveness.
METHODS: A retrospective review was undertaken of patients undergoing surgery for PHPT from January 2009 to August 2014. Ultrasound and SPECT (ultrasound-SPECT) or SPECT/CT (ultrasound-SPECT/CT) were performed for each patient. Sensitivity and positive predictive value (PPV) of each modality were calculated. Cost-effectiveness was determined by an incremental cost-effectiveness ratio (ICER) analysis.
RESULTS: Two hundred fifty-nine patients with 266 parathyroid adenomas were included in the study. Lateralization sensitivity and PPV of ultrasound-SPECT were 85.1% and 98.2%, respectively. The lateralization sensitivity and PPV of ultrasound-SPECT/CT were 86.9% and 99.4%, respectively. A cost of $2499.22 (CAD) per additional parathyroid adenoma detection by ultrasound-SPECT/CT was determined from the ICER analysis.
CONCLUSION: Similar sensitivities and PPVs were observed between ultrasound-SPECT and ultrasound-SPECT/CT in preoperatively lateralizing parathyroid adenomas, with relatively equivalent cost-effectiveness. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 26849426 [PubMed - as supplied by publisher]

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Successful detection of a minute tonsillar cancer lesion on transoral examination with narrow band imaging: A report of 2 cases.

Successful detection of a minute tonsillar cancer lesion on transoral examination with narrow band imaging: A report of 2 cases.

Head Neck. 2016 Feb 5;

Authors: Ebisumoto K, Okami K, Sakai A, Sugimoto R, Iida M

Abstract
BACKGROUND: The improvement of optical enhancement devices, such as narrow band imaging (NBI), has enabled us to visualize lesions that cannot be seen upon macroscopic examination. NBI is useful for detecting subtle lesions, including the primary sites of occult primary cancer.
METHODS AND RESULTS: We describe 2 cases of tiny tonsillar cancer with positive p16 staining. Case 1 was as an occult primary cancer, and case 2 had a foreign body sensation of the pharynx. With transoral examination using a flexible video-laryngoscope with NBI, we successfully detected tonsillar cancer. These patients were treated with surgery, and the patients are currently alive with no evidence of disease more than 1 year posttreatment.
CONCLUSION: We detected a small primary lesion in the palatine tonsil through transoral examination with NBI, which is a simple and noninvasive method. This approach may be useful to detect subtle lesions, especially in patients with human papillomavirus (HPV)-related tonsillar cancer. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 26849351 [PubMed - as supplied by publisher]

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Classification of vocal fold leukoplakia by clinical scoring.

Classification of vocal fold leukoplakia by clinical scoring.

Head Neck. 2016 Feb 5;

Authors: Fang TJ, Lin WN, Lee LY, Young CK, Lee LA, Chang KP, Liao CT, Li HY, Yen TC

PMID: 26849206 [PubMed - as supplied by publisher]

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Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing.

Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing.

Head Neck. 2016 Feb 5;

Authors: Tillman BN, Yanik M, Birkeland AC, Liu CJ, Hovelson DH, Cani AK, Palanisamy N, Carskadon S, Carey TE, Bradford CR, Tomlins SA, McHugh JB, Spector ME, Chad Brenner J

Abstract
BACKGROUND: Targeted sequencing of patients with epidemiologically low-risk (ELR) head and neck squamous cell carcinoma (HNSCC) could help identify novel drivers or lost suppressors leading to precision medicine protocols and improved survival rates.
METHODS: A patient with ELR-HNSCC was selected for targeted sequencing. We then assessed next generation sequencing cohorts from the Oncomine Powertool Database, which contains pan-cancer data from The Cancer Genome Atlas (TCGA).
RESULTS: Targeted sequencing revealed fibroblast growth factor receptor-1 (FGFR1) amplifications as a putative driver of the patient's tumor. Patients with HNSCC from TCGA data demonstrated fibroblast growth factor (FGF) family mutations, rearrangements, or amplifications in over 35% of HNSCC cases, with a statistically significant higher frequency in African American populations. FGF alterations were unique from activating phosphatidylinositol 3-kinase (PIK3CA) mutations.
CONCLUSION: Together, these data suggest that FGF signaling may be critical for a subset of patients with HNSCC independent of other known pathways and provides rationale for leveraging patients with ELR-HNSCC to define molecular subsets of high-risk HNSCC. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 26849095 [PubMed - as supplied by publisher]

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Temporal course and predictive factors of analgesic opioid requirement for chemoradiation-induced oral mucositis in oropharyngeal cancer.

Temporal course and predictive factors of analgesic opioid requirement for chemoradiation-induced oral mucositis in oropharyngeal cancer.

Head Neck. 2016 Feb 5;

Authors: Alfieri S, Ripamonti CI, Marceglia S, Orlandi E, Iacovelli NA, Granata R, Cavallo A, Pozzi P, Boffi R, Bergamini C, Imbimbo M, Pala L, Resteghini C, Mirabile A, Locati LD, Licitra L, Bossi P

Abstract
BACKGROUND: Oral mucositis (OM)-related pain affects most patients with head and neck cancer during treatments, but its management is not standardized.
METHODS: We retrospectively collected data about the opioid therapy used for OM-induced pain in all patients with oropharyngeal cancer treated with chemoradiotherapy (CRT) between 2009 and 2013. To compare the different opioids, a conversion into oral morphine equivalent daily dose (OMEDD) was performed. The highest OMEDD (h-OMEDD) and the opioids' weekly increase were associated with patient, tumor, or treatment-related characteristics in order to identify predictive factors of opioid consumption.
RESULTS: Ninety-seven percent of patients received opioids. The h-OMEDD was significantly correlated with a higher OM-grade and a lower smoking history. The weekly opioids' increase was higher in patients with lower smoking history and human papillomavirus (HPV) positivity.
CONCLUSION: Opioid therapy remains the mainstay for OM-related pain management during CRT. The role of previous smoking and HPV on opioid use needs further confirmations. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 26849016 [PubMed - as supplied by publisher]

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Book review.

Book review.

Int J Audiol. 2015 Dec;54(12):997

Authors: Honaker J

PMID: 26848999 [PubMed - as supplied by publisher]

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Book review.

Book review.

Int J Audiol. 2015 Dec;54(12):997

Authors: Honaker J

PMID: 26848999 [PubMed - as supplied by publisher]

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Endoscopic surgery for congenital basal meningoencephaloceles in children.

Endoscopic surgery for congenital basal meningoencephaloceles in children.

Acta Otolaryngol. 2016 Feb 5;:1-7

Authors: Wu X, Zhang J, Zhang H, Xie Z, Fan R, Liu Y, Wu B, Sun H, Jiang W

PMID: 26848970 [PubMed - as supplied by publisher]

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Long-term follow-up after ESS and balloon sinuplasty: Comparison of symptom reduction and patient satisfaction.

Long-term follow-up after ESS and balloon sinuplasty: Comparison of symptom reduction and patient satisfaction.

Acta Otolaryngol. 2016 Feb 5;:1-5

Authors: Koskinen A, Myller J, Mattila P, Penttilä M, Silvola J, Alastalo I, Huhtala H, Hytönen M, Toppila-Salmi S

PMID: 26848855 [PubMed - as supplied by publisher]

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Balance Disorders in the Elderly: Does Instability Increase Over Time?

Balance Disorders in the Elderly: Does Instability Increase Over Time?

Ann Otol Rhinol Laryngol. 2016 Feb 4;

Authors: Soto-Varela A, Rossi-Izquierdo M, Faraldo-García A, Vaamonde-Sánchez-Andrade I, Gayoso-Diz P, Del-Río-Valeiras M, Lirola-Delgado A, Santos-Pérez S

Abstract
OBJECTIVES: To analyze the equilibriometric differences between 2 populations of elderly patients (young elderly and very elderly) with instability induced solely by age.
METHODS: Cross-sectional study, with 2 study groups classified according to patient age (cut-points in twenty-fifth and seventy-fifth percentiles of the age of the sample).
POPULATION: 64 patients aged 65 years or more. Two groups of 32 subjects were established: group A (people 65 years of age or older but less than 72.6, twenty-fifth percentile) and group B (patients 82.5 years, seventh-fifth percentile, or older). Main analyzed variables: timed up-and-go test, sensory organization test of the computerized dynamic posturography, Dizziness Handicap Inventory (DHI), and Short Falls Efficacy Scale-International (FES-I) questionnaires. Student's t test or the Mann-Whitney test were used.
RESULTS: The older patients obtain poorer scores in the equilibriometric tests but not in all of them. In the sensory organization test, the older patients make poorer use of visual and vestibular information; they also require more time and steps for the timed up-and-go. With regards to the questionnaires, fear of falling is greater (higher Short FES-I scores) but not subjective perception of disability (DHI scores without differences).
CONCLUSIONS: There is a need to establish aged subgroups of elderly patients with instability, adapting therapeutic strategies.

PMID: 26848036 [PubMed - as supplied by publisher]

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Improved Gustatory Sensitivity in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy.

Improved Gustatory Sensitivity in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy.

Ann Otol Rhinol Laryngol. 2016 Feb 4;

Authors: Altun H, Hanci D, Altun H, Batman B, Serin RK, Karip AB, Akyuz U

Abstract
INTRODUCTION: The reduction in the preferences for sweet and fat containing tastes in obese patients who underwent bariatric surgery was relatively well shown; however, there are only limited data on the changes in the sensitivity of other tastes like sour, salty, and bitter.
METHODS: We investigated the changes in gustatory sensitivity of 52 morbidly obese patients (M/F, 22/30; age range, 19-60 years; BMI range, 32.5-63.0 kg/m(2)) after laparoscopic sleeve gastrectomy. The surgery was performed by the same surgeon using 5 ports technique. Gustatory sensitivity was tested preoperatively and 1 and 3 months after the surgery using standardized Taste Strips test.
RESULTS: There was a statistically significant improvement in the taste acuity to sweet, sour, salty, and bitter tastants in morbidly obese patients after the laparoscopic sleeve gastrectomy during the follow-up period of 3 months. Median whole test scores of the patients were increased from 11.5 preoperatively to 14 in the first and third months.
CONCLUSION: In this study, we were able to show the significant improvement in gustatory sensitivity of morbidly obese patients after laparoscopic sleeve gastrectomy for the first time in literature.

PMID: 26848035 [PubMed - as supplied by publisher]

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Book Review: Review of The Performer's Voice.

Book Review: Review of The Performer's Voice.

Ann Otol Rhinol Laryngol. 2016 Feb 4;

Authors: Sadoughi B

PMID: 26848034 [PubMed - as supplied by publisher]

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OtoRhinoLaryngology News

Αρχειοθήκη ιστολογίου

Αναφορά κατάχρησης

Σάββατο 6 Φεβρουαρίου 2016

Response.

Response.

[Basal cell carcinoma of the face: about four cases reported in Madagascar].

[Intra-sinusal maxillary pleomorphic adenoma: a rare entity].

Endoscopic surgery for congenital basal meningoencephaloceles in children.

Long-term follow-up after ESS and balloon sinuplasty: Comparison of symptom reduction and patient satisfaction.

Acknowledgement to referees 2015.

Reconstruction of nasal tip support in primary, open approach septorhinoplasty : A retrospective analysis between the tongue-in-groove technique and the columellar strut.

Endoscopic surgery for congenital basal meningoencephaloceles in children.

Comparative analysis of the anterior transpetrosal approach with the endoscopic endonasal approach to the petroclival region.

Classification and surgical approaches for transnasal endoscopic skull base chordoma resection: a 6-year experience with 161 cases.

Clinical and Electromyographic Characteristics of Unilateral Vocal Fold Paralysis With Lower Cranial Nerve Injury.

Outcome of hospital discharge on postoperative Day 1 following uncomplicated tethered spinal cord release.

Digital subtraction myelography for the identification of spontaneous spinal CSF-venous fistulas.

Is the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literature.

Transoral robotic resection of a large schwannoma in the retropharyngeal space.

Classification of vocal fold leukoplakia by clinical scoring.

Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial.

Human papillomavirus-associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association.

Comparison of single photon emission CT (SPECT) with SPECT/CT imaging in preoperative localization of parathyroid adenomas: A cost-effectiveness analysis.

Successful detection of a minute tonsillar cancer lesion on transoral examination with narrow band imaging: A report of 2 cases.

Classification of vocal fold leukoplakia by clinical scoring.

Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing.

Temporal course and predictive factors of analgesic opioid requirement for chemoradiation-induced oral mucositis in oropharyngeal cancer.

Book review.

Book review.

Endoscopic surgery for congenital basal meningoencephaloceles in children.

Long-term follow-up after ESS and balloon sinuplasty: Comparison of symptom reduction and patient satisfaction.

Balance Disorders in the Elderly: Does Instability Increase Over Time?

Improved Gustatory Sensitivity in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy.

Book Review: Review of The Performer's Voice.

Antitumor therapy for breast cancer: Focus on tumor‐associated macrophages and nanosized drug delivery systems