Management of oral Graft versus Host Disease with topical agents: A systematic review.

Management of oral Graft versus Host Disease with topical agents: A systematic review.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Albuquerque R, Khan Z, Poveda A, Higham J, Richards A, Monteiro L, Jané-Salas E, Lopez-Lopez J, Warnakulasuriya S

Abstract
BACKGROUND: Oral Graft-versus-Host Disease (oGvHD) is a common complication of haematopoietic stem cell transplantation. Choosing the right topical application to be used intra orally can be a challenge. Consequently, the aim of this work is to review the effectiveness and safety of topical agents currently used in the management of the inflammatory mucosal lesions encountered in oGVHD.
MATERIAL AND METHODS: We carried out electronic searches of publications up to May 2015 of the databases Pubmed, National Library of Medicine's Medline, Embase and the Cochrane Central Register of Controlled Clinical trials to identify potentially relevant studies (keywords: "oral", "graft", "versus", "host", "disease" and "treatment"). The main inclusion criterion was the reported use of a topical agent which was not intentionally swallowed when used for the treatment of oGVHD. A 3-point grading system, described by the Swedish Council on Technology Assessment in Health Care and the Centre for Reviews and Dissemination, University of York, was used to rate the methodological quality of the papers.
RESULTS: From the 902 entries identified in the search, 7 studies qualifying for inclusion were analysed. Overall, there is limited evidence with regards to the effectiveness of topical steroids for oGVHD. However, the studies showed some effect of Budesonide alone and when combined with dexamethasone. Topical tacrolimus also appears to have some effect and clobetasol propionate mouthwash had a significantly better clinical response than dexamethasone mouthwash in treating oGVHD.
CONCLUSIONS: As the number of clinical trials conducted is limited, there is little evidence to support the use of topical therapies to treat the inflammatory mucosal lesions found in oGVHD. High quality randomised control trials are needed in order to measure the effectiveness of any topical application for the treatment of the inflammatory mucosal lesions found in oGVHD.

PMID: 26615510 [PubMed - as supplied by publisher]

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Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.

Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Orozco-Solís M, García-Ávalos Y, Pichardo-Ramírez C, Tobías-Azúa F, Zapata-Morales JR, Aragon-Martínez OH, Isiordia-Espinoza MA

Abstract
BACKGROUND: Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for dental pain. The aim of this study was to compare the analgesic, anti-inflammatory and anti-trismus effect of a single dose of diclofenac and meloxicam after mandibular third molar extraction.
MATERIAL AND METHODS: A total of 36 patients were randomized into two treatment groups, each with 18 patients, using a series of random numbers: Group A, was administered 100 mg of diclofenac; and Group B, 15 mg of meloxicam. Drugs were administered orally 1 hour prior to surgery. We evaluated pain intensity, analgesic consumption, swelling, as well as trismus.
RESULTS: The results of this study showed that patients receiving 15 mg of meloxicam had less postoperative pain (P=0.04) and better aperture than those receiving 100 mg of diclofenac (P=0.03). The meloxicam group presented less swelling than diclofenac group; however, significant statistical differences were not observed.
CONCLUSIONS: Data of this double-blind, randomized, parallel-group clinical trial demonstrated that patients receiving 15 mg of preoperative meloxicam had a better postoperative analgesia and anti-trismus effect compared with who were given 100 mg of diclofenac after third molar extractions.

PMID: 26615509 [PubMed - as supplied by publisher]

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Prevalence of the different Axis I clinical subtypes in a sample of patients with orofacial pain and temporomandibular disorders in the Andalusian Healthcare Service.

Prevalence of the different Axis I clinical subtypes in a sample of patients with orofacial pain and temporomandibular disorders in the Andalusian Healthcare Service.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Blanco-Hungría A, Blanco-Aguilera A, Blanco-Aguilera E, Serrano-Del-Rosal R, Biedma-Velázquez L, Rodríguez-Torronteras A, Segura-Saint-Gerons R

Abstract
BACKGROUND: The main objective of this paper is to analyze the prevalence of each of the different clinical subtypes of temporomandibular disorders (TMD) in a sample of patients with this pathology. In addition, a second objective was to analyze their distribution according to gender.
MATERIAL AND METHODS: To this end, the results of 1603 patients who went to the Unit of Temporomandibular Disorders in the Córdoba Healthcare District because they suffered from this pathology were analyzed. In order to diagnose them, the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) were applied, analyzing the different Axis I subtypes (myopathy, discopathy and arthropathy) and obtaining the combined Axis I for each patient and the relation of all these variables according to gender. The null-hypothesis test confirmed the lack of connection between the gender variable and the different subtypes in the clinical analysis, and between the former and the combined Axis I of the RDC/TMD.
RESULTS: The prevalence was high for the muscle disorders subtype in general, showing an 88.7% prevalence, while the presence of discopathies or arthropathies was much lower. Among discopathies, the most frequent ones were disc displacements with reduction, with 39.7% and 42.8% for the left and right temporomandibular joints (TMJ), respectively, while the prevalence of arthropathies was 26.3% for the right TMJ and 32.9% for the left TMJ. The bivariate analysis on the connection with gender reveals a p≥ 0.05 value for the muscle and arthralgia subtypes.
CONCLUSIONS: The patients seen at the TMD Unit where mostly middle-aged women whose main clinical axis subtype was the muscle disorder subtype. For their part, both discopathies and arthropathies, although present, are much less prevalent.

PMID: 26615508 [PubMed - as supplied by publisher]

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Can palpation-induced muscle pain pattern contribute to the differential diagnosis among temporomandibular disorders, primary headaches phenotypes and possible bruxism?

Can palpation-induced muscle pain pattern contribute to the differential diagnosis among temporomandibular disorders, primary headaches phenotypes and possible bruxism?

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Costa YM, Porporatti AL, Calderon PS, Conti PC, Bonjardim LR

Abstract
BACKGROUND: The evaluation of possible differences in the distribution or characteristics of palpation-induced pain in the masticatory muscles could be valuable in terms of diagnostic assessment. The aim of this study was to evaluate the impact of different combinations of anterior temporalis (AT) and masseter palpation-induced pain in the diagnostic of temporomandibular disorder (TMD), primary headaches and bruxism.
MATERIAL AND METHODS: A total of 1200 dental records of orofacial pain adult patients were analyzed. The outcomes were dichotomously classified (presence/absence) as following: a) AT and/or masseter palpation-induced pain; b) myogenous TMD; c) temporomandibular joint (TMJ) arthralgia (arthrogenous TMD); d) migraine; e) tension-type headache (TTH); f) self-reported bruxism. Binomial logistic regression model (α = 5%) was applied to the data considering the palpation-induced muscle pain as the dependent variable.
RESULTS: Mean age (SD) were 35.7 years (13.4) for 635 included dental records (83% females). Myogenous and arthrogenous TMD, migraine, TTH and bruxism were mainly associated with, respectively, masseter palpation-induced pain (p<0.001 - OR=5.77, 95%CI 3.86-8.62), AT or masseter palpation-induced pain (p<0.001 - OR=2.39, 95%CI 1.57-3.63), bilateral AT palpation-induced pain (p<0.001 - OR=2.67, 95%CI 1.64-4.32), masseter and AT palpation-induced pain (p=0.009 - OR=1.62, 95%CI 1.12-2.33) and bilateral masseter palpation-induced pain (p=0.01 - OR=1.74, 95%CI 1.13-2.69).
CONCLUSIONS: Palpation-induced pain in the masticatory muscles may play a role in the differential diagnosis among painful TMD, primary headaches and bruxism.

PMID: 26615507 [PubMed - as supplied by publisher]

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Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry.

Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Cuevas-González JC, Vega-Memíje ME, García-Vázquez FJ, Rodríguez-Lobato E, Farfán-Morales JE

Abstract
BACKGROUND: Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway).
MATERIAL AND METHODS: Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. In H&E-stained slides, the diagnosis of AP was corroborated, and 1-µm-thick sections were processed for immunohistochemistry (IHC). A database was constructed with SPSS version 20, Inc., Chicago, IL, USA, and descriptive statistics were analyzed by X2 test and comparison of means.
RESULTS: A total of 64 cases were processed, of which 40 (62.5%) were cheilitis AP and 24 (37.5%) were AP in the skin. Of the 40 cheilitis samples, 27 were positive for Bcl-2 and caspase 3 (67.5%), p53 was expressed in 30 (75%). Of the skin lesions, p53 and caspase 3 were expressed in 18 of 24 cases (75%), and 13 were positive for Bcl-2 (54%).
CONCLUSIONS: We propose that apoptosis is the last step in the type IV subtype a-b hypersensitivity response-activation of the intrinsic pathway indicates that external factors, such as UV-A and -B are the trigger.

PMID: 26615506 [PubMed - as supplied by publisher]

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Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate.

Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Sá J, Araújo L, Guimarães L, Maranhão S, Lopes G, Medrado A, Coletta R, Reis S

Abstract
BACKGROUND: Individuals with nonsyndromic cleft lip with or without cleft palate (NSCL±P) present high frequency of dental anomalies, which may represent complicating factors for dental treatment. The aim of this study was to investigate the prevalence of dental anomalies inside cleft area in a group of Brazilians with NSCL±P.
MATERIAL AND METHODS: Retrospective analysis of 178 panoramic radiographs of patients aged from 12 to 45 years old and without history of tooth extraction or orthodontic treatment was performed. Association between cleft type and the prevalence of dental anomalies was assessed by chi-square test with a significance level set at p≤ 0.05.
RESULTS: Dental anomalies were found in 88.2% (n=157) of the patients. Tooth agenesis (47.1%), giroversion (20%) and microdontia (15.5%) were the most common anomalies. Individuals with unilateral complete cleft lip and palate (CLP, p<0.0001), bilateral complete CLP (p=0.0002) and bilateral incomplete CLP (p< 0.0001) were more affected by tooth agenesis than individuals with other cleft types. The maxillary lateral incisors were the most affected teeth (p<0.0001).
CONCLUSIONS: The present study revealed a high frequency of dental anomalies inside cleft region in NSCL±P patients, and further demonstrated that patients with unilateral complete CLP and bilateral incomplete CLP were frequently more affected by dental anomalies. Moreover, our results demonstrate that dental anomalies should be considered during dental treatment planning of individuals affected by NSCL±P.

PMID: 26615505 [PubMed - as supplied by publisher]

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Impact of crestal and subcrestal implant placement in peri-implant bone: A prospective comparative study.

Impact of crestal and subcrestal implant placement in peri-implant bone: A prospective comparative study.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Pellicer-Chover H, Peñarrocha-Diago MA, Peñarrocha-Oltra D, Gomar-Vercher S, Agustín-Panadero R, Peñarrocha-Diago M

Abstract
BACKGROUND: To assess the influence of the crestal or subcrestal placement of implants upon peri-implant bone loss over 12 months of follow-up.
MATERIAL AND METHODS: Twenty-six patients with a single hopeless tooth were recruited in the Oral Surgery Unit (Valencia University, Valencia, Spain). The patients were randomized into two treatment groups: group A (implants placed at crestal level) or group B (implants placed at subcrestal level). Control visits were conducted by a trained clinician at the time of implant placement and 12 months after loading. A previously established standard protocol was used to compile general data on all patients (sex and age, implant length and diameter, and brushing frequency). Implant success rate, peri-implant bone loss and the treatment of the exposed implant surface were studied. The level of statistical significance was defined as 5% (α=0.05).
RESULTS: Twenty-three patients (8 males and 15 females, mean age 49.8±11.6 years, range 28-75 years) were included in the final data analyses, while three were excluded. All the included subjects were non-smokers with a brushing frequency of up to twice a day in 85.7% of the cases. The 23 implants comprised 10 crestal implants and 13 subcrestal implants. After implant placement, the mean bone position with respect to the implant platform in group A was 0.0 mm versus 2.16±0.88 mm in group B. After 12 months of follow-up, the mean bone positions were -0.06±1.11 mm and 0.95±1.50 mm, respectively - this representing a bone loss of 0.06±1.11 mm in the case of the crestal implants and of 1.22±1.06 mm in the case of the subcrestal implants (p=0.014). Four crestal implants and 5 subcrestal implants presented peri-implant bone levels below the platform, leaving a mean exposed treated surface of 1.13 mm and 0.57 mm, respectively. The implant osseointegration success rate at 12 months was 100% in both groups.
CONCLUSIONS: Within the limitations of this study, bone loss was found to be greater in the case of the subcrestal implants, though from the clinical perspective these implants presented bone levels above the implant platform after 12 months of follow-up.

PMID: 26615504 [PubMed - as supplied by publisher]

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Antibacterial suture vs silk for the surgical removal of impacted lower third molars. A randomized clinical study.

Antibacterial suture vs silk for the surgical removal of impacted lower third molars. A randomized clinical study.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Sala-Pérez S, López-Ramírez M, Quinteros-Borgarello M, Valmaseda-Castellón E, Gay-Escoda C

Abstract
suture (Monocryl® Plus) in the surgical removal of I3M.
MATERIAL AND METHODS: A "split-mouth", prospective pilot clinical study was designed involving 20 patients programmed for the surgical removal of I3M. Each side was randomly sutured with Monocryl® Plus or silk suture and removed for microbiological study 72 hours and 7 days after surgery. Presence of SSI, wound bleeding and the degree of discomfort associated with each type of suture material (scored by means of a visual analog scale) were evaluated. The level of contamination of each material was observed under the scanning electron microscope.
RESULTS: Wound bleeding upon suture removing was slightly greater after 72 hours and 7 days with black silk suture, though the differences were not statistically significant (p=0.752 and p=0.113, respectively). Patient discomfort was very similar with both types of suture material (p=0.861). Only one case of SSI was recorded with black silk suture after 72 hours. Microbiologically, the antibacterial suture showed a lesser presence of microorganisms (p<0.001, at 72h and p=0.033 at 7th day, respectively). The most common bacterial species included grampositive cocci (Streptococcus viridans group, Neisseria spp., Coagulasenegative Staphylococcus and Peptostreptococcus), gramnegative cocci (Veillonella), grampositive Bacilli (Lactobacillus), and gramnegative Bacilli (Prevotella).
CONCLUSIONS: The greatest antibacterial effect of Monocryl Plus suture was observed after 72 hours. According to most authors, there is no doubt that this antibacterial suture can provide little safety in the control of SSI.

PMID: 26615503 [PubMed - as supplied by publisher]

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Survey of Spanish dentists on the prescription of antibiotics and antiseptics in surgery for impacted lower third molars.

Survey of Spanish dentists on the prescription of antibiotics and antiseptics in surgery for impacted lower third molars.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Arteagoitia MI, Ramos E, Santamaría G, Álvarez J, Barbier L, Santamaría J

Abstract
BACKGROUND: This study explored the attitude of registered dentists in Biscay towards prescribing antibiotics and/or antiseptics to prevent potential infections after surgical extraction of completely bone-impacted third molars in otherwise healthy individuals, with no history of infection.
MATERIAL AND METHOD: We sent letters to 931 registered dentists in Biscay, with an explanation of the study objectives, description of a case of lower third molar impaction, including a panoramic radiograph, and a questionnaire. The questionnaire asked whether they would prescribe antibiotics and/or antiseptics, in the hypothetical case of lower third molar extraction surgery presented, and if so, when, what type, at what dose and how long for.
RESULTS: The questionnaire was completed by 261 dentists (28%), with a mean age of 44.3 years old (SD 11.05) and mean of 18.7 years working as a dentist (SD 9). A total of 216 dentists (82.7%) considered it necessary to prescribe antibiotics. Of these, 126 (58.3%) would prescribe amoxicillin and 74 (34.5%) amoxicillin/clavulanic acid, while 129 dentists (59%) would prescribe antibiotics both before and after surgery and 10 (4.6%) only after surgery. The most common doses were amoxicillin 500 mg or 750 mg every 8 hours, and amoxicillin/clavulanic acid 875/125 mg every 8 hours, in both cases for a mean of 7 days. Further, 74 dentists (28%) said they would use immediate post-extraction socket irrigation with chlorhexidine, while 211 (81%) would prescribe antiseptics in the postoperative period, of whom 97% recommended chlorhexidine. We did not find significant differences in the use of antibiotics or antiseptics by dentist age (ANOVA p=0.22 and p=0.53, respectively), or professional experience (ANOVA p=0.45 and p=0.62).
CONCLUSIONS: In our sample, the prophylactic prescription of antibiotics and/or chlorhexidine is widespread in clinical practice, in most cases amoxicillin and amoxicillin/clavulanic acid for a week, starting the treatment before surgery.

PMID: 26615502 [PubMed - as supplied by publisher]

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TlR expression profile of human gingival margin-derived stem progenitor cells.

TlR expression profile of human gingival margin-derived stem progenitor cells.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Fawzy-El-Sayed K, Mekhemar M, Adam-Klages S, Kabelitz D, Dorfer C

Abstract
BACKGROUND: Gingival margin-derived stem/progenitor cells (G-MSCs) show remarkable periodontal regenerative potential in vivo. During regeneration, G-MSCs may interact with their inflammatory environment via toll-like-receptors (TLRs). The present study aimed to depict the G-MSCs TLRs expression profile.
MATERIAL AND METHODS: Cells were isolated from free gingival margins, STRO-1-immunomagnetically sorted and seeded to obtain single colony forming units (CFUs). G-MSCs were characterized for CD14, CD34, CD45, CD73, CD90, CD105, CD146 and STRO-1 expression, and for multilineage differentiation potential. Following G-MSCs' incubation in basic or inflammatory medium (IL-1β, IFN-γ, IFN-α, TNF-α) a TLR expression profile was generated.
RESULTS: G-MSCs showed all stem/progenitor cells' characteristics. In basic medium G-MSCs expressed TLRs 1, 2, 3, 4, 5, 6, 7, and 10. The inflammatory medium significantly up-regulated TLRs 1, 2, 4, 5, 7 and 10 and diminished TLR 6 (p≤0.05, Wilcoxon-Signed-Ranks-Test).
CONCLUSIONS: The current study describes for the first time the distinctive TLRs expression profile of G-MSCs under uninflamed and inflamed conditions.

PMID: 26615501 [PubMed - as supplied by publisher]

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CCharacteristics of Traumatic Brain Injury among Accident and Falling Down Cases.

CCharacteristics of Traumatic Brain Injury among Accident and Falling Down Cases.

Acta Med Iran. 2015 Oct;53(10):652-655

Authors: Aghakhani K, Heidari M, Ameri M, Mehrpisheh S, Memarian A

Abstract
Motor vehicle and falling down are responsible for the most number of traumatic injuries. This study aimed to compare the characteristics of traumatic brain injury among accident and falling down cases. In this analytical cross- sectional study, data were collected from the records of cadavers who died due to accident or falling down and referred to Kahrizak dissection hall, Tehran forensic medicine organization during 2013. A total of 237 subjects (183 (77.2%) accident and 54 (22.8%) falling down) with a mean age of 35.62 (SD=15.75) were evaluated. A number of 213 (89.9%) were male. From accident group, scalp injury was seen in 146 (79.8%), scalp abrasion in 122 (66.7%), scalp laceration in 104 (56.8%), sub skull bruising in 176 (96.3%), skull fracture in 119 (65%), hemorrhage in 166 (90.7%), Subdural hemorrhage (SDH) in 155 (84.7%), Subarachnoid hemorrhage (SAH) in 161 (88%), Epidural hemorrhage (EDH) in 41 (22.4%), contusion in 140 (76.5%), and skull base fracture in 140 (76.5%) of cases. In falling down group scalp injury was seen in 42 (77.8%) cadavers, scalp abrasion in 38 (70.4%), scalp laceration in 30 (55.6%), sub skull bruising in 49 (90.7%), skull fracture in 39 (72.2%), Hemorrhage in 49 (90.7%), SDH in 43 (79.6%), SAH in 47 (87%), EDH in 10 (18.5%), contusion in 33 (61.1%), and skull base fracture in 39 (72.2%) of cases. There was no significant difference between these two groups (P Value> 0.05). Accident and falling down had no difference in terms of any injury or hemorrhage.

PMID: 26615380 [PubMed - as supplied by publisher]

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Management of oral Graft versus Host Disease with topical agents: A systematic review.

Management of oral Graft versus Host Disease with topical agents: A systematic review.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Albuquerque R, Khan Z, Poveda A, Higham J, Richards A, Monteiro L, Jané-Salas E, Lopez-Lopez J, Warnakulasuriya S

Abstract
BACKGROUND: Oral Graft-versus-Host Disease (oGvHD) is a common complication of haematopoietic stem cell transplantation. Choosing the right topical application to be used intra orally can be a challenge. Consequently, the aim of this work is to review the effectiveness and safety of topical agents currently used in the management of the inflammatory mucosal lesions encountered in oGVHD.
MATERIAL AND METHODS: We carried out electronic searches of publications up to May 2015 of the databases Pubmed, National Library of Medicine's Medline, Embase and the Cochrane Central Register of Controlled Clinical trials to identify potentially relevant studies (keywords: "oral", "graft", "versus", "host", "disease" and "treatment"). The main inclusion criterion was the reported use of a topical agent which was not intentionally swallowed when used for the treatment of oGVHD. A 3-point grading system, described by the Swedish Council on Technology Assessment in Health Care and the Centre for Reviews and Dissemination, University of York, was used to rate the methodological quality of the papers.
RESULTS: From the 902 entries identified in the search, 7 studies qualifying for inclusion were analysed. Overall, there is limited evidence with regards to the effectiveness of topical steroids for oGVHD. However, the studies showed some effect of Budesonide alone and when combined with dexamethasone. Topical tacrolimus also appears to have some effect and clobetasol propionate mouthwash had a significantly better clinical response than dexamethasone mouthwash in treating oGVHD.
CONCLUSIONS: As the number of clinical trials conducted is limited, there is little evidence to support the use of topical therapies to treat the inflammatory mucosal lesions found in oGVHD. High quality randomised control trials are needed in order to measure the effectiveness of any topical application for the treatment of the inflammatory mucosal lesions found in oGVHD.

PMID: 26615510 [PubMed - as supplied by publisher]

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Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.

Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Orozco-Solís M, García-Ávalos Y, Pichardo-Ramírez C, Tobías-Azúa F, Zapata-Morales JR, Aragon-Martínez OH, Isiordia-Espinoza MA

Abstract
BACKGROUND: Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for dental pain. The aim of this study was to compare the analgesic, anti-inflammatory and anti-trismus effect of a single dose of diclofenac and meloxicam after mandibular third molar extraction.
MATERIAL AND METHODS: A total of 36 patients were randomized into two treatment groups, each with 18 patients, using a series of random numbers: Group A, was administered 100 mg of diclofenac; and Group B, 15 mg of meloxicam. Drugs were administered orally 1 hour prior to surgery. We evaluated pain intensity, analgesic consumption, swelling, as well as trismus.
RESULTS: The results of this study showed that patients receiving 15 mg of meloxicam had less postoperative pain (P=0.04) and better aperture than those receiving 100 mg of diclofenac (P=0.03). The meloxicam group presented less swelling than diclofenac group; however, significant statistical differences were not observed.
CONCLUSIONS: Data of this double-blind, randomized, parallel-group clinical trial demonstrated that patients receiving 15 mg of preoperative meloxicam had a better postoperative analgesia and anti-trismus effect compared with who were given 100 mg of diclofenac after third molar extractions.

PMID: 26615509 [PubMed - as supplied by publisher]

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Prevalence of the different Axis I clinical subtypes in a sample of patients with orofacial pain and temporomandibular disorders in the Andalusian Healthcare Service.

Prevalence of the different Axis I clinical subtypes in a sample of patients with orofacial pain and temporomandibular disorders in the Andalusian Healthcare Service.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Blanco-Hungría A, Blanco-Aguilera A, Blanco-Aguilera E, Serrano-Del-Rosal R, Biedma-Velázquez L, Rodríguez-Torronteras A, Segura-Saint-Gerons R

Abstract
BACKGROUND: The main objective of this paper is to analyze the prevalence of each of the different clinical subtypes of temporomandibular disorders (TMD) in a sample of patients with this pathology. In addition, a second objective was to analyze their distribution according to gender.
MATERIAL AND METHODS: To this end, the results of 1603 patients who went to the Unit of Temporomandibular Disorders in the Córdoba Healthcare District because they suffered from this pathology were analyzed. In order to diagnose them, the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) were applied, analyzing the different Axis I subtypes (myopathy, discopathy and arthropathy) and obtaining the combined Axis I for each patient and the relation of all these variables according to gender. The null-hypothesis test confirmed the lack of connection between the gender variable and the different subtypes in the clinical analysis, and between the former and the combined Axis I of the RDC/TMD.
RESULTS: The prevalence was high for the muscle disorders subtype in general, showing an 88.7% prevalence, while the presence of discopathies or arthropathies was much lower. Among discopathies, the most frequent ones were disc displacements with reduction, with 39.7% and 42.8% for the left and right temporomandibular joints (TMJ), respectively, while the prevalence of arthropathies was 26.3% for the right TMJ and 32.9% for the left TMJ. The bivariate analysis on the connection with gender reveals a p≥ 0.05 value for the muscle and arthralgia subtypes.
CONCLUSIONS: The patients seen at the TMD Unit where mostly middle-aged women whose main clinical axis subtype was the muscle disorder subtype. For their part, both discopathies and arthropathies, although present, are much less prevalent.

PMID: 26615508 [PubMed - as supplied by publisher]

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Can palpation-induced muscle pain pattern contribute to the differential diagnosis among temporomandibular disorders, primary headaches phenotypes and possible bruxism?

Can palpation-induced muscle pain pattern contribute to the differential diagnosis among temporomandibular disorders, primary headaches phenotypes and possible bruxism?

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Costa YM, Porporatti AL, Calderon PS, Conti PC, Bonjardim LR

Abstract
BACKGROUND: The evaluation of possible differences in the distribution or characteristics of palpation-induced pain in the masticatory muscles could be valuable in terms of diagnostic assessment. The aim of this study was to evaluate the impact of different combinations of anterior temporalis (AT) and masseter palpation-induced pain in the diagnostic of temporomandibular disorder (TMD), primary headaches and bruxism.
MATERIAL AND METHODS: A total of 1200 dental records of orofacial pain adult patients were analyzed. The outcomes were dichotomously classified (presence/absence) as following: a) AT and/or masseter palpation-induced pain; b) myogenous TMD; c) temporomandibular joint (TMJ) arthralgia (arthrogenous TMD); d) migraine; e) tension-type headache (TTH); f) self-reported bruxism. Binomial logistic regression model (α = 5%) was applied to the data considering the palpation-induced muscle pain as the dependent variable.
RESULTS: Mean age (SD) were 35.7 years (13.4) for 635 included dental records (83% females). Myogenous and arthrogenous TMD, migraine, TTH and bruxism were mainly associated with, respectively, masseter palpation-induced pain (p<0.001 - OR=5.77, 95%CI 3.86-8.62), AT or masseter palpation-induced pain (p<0.001 - OR=2.39, 95%CI 1.57-3.63), bilateral AT palpation-induced pain (p<0.001 - OR=2.67, 95%CI 1.64-4.32), masseter and AT palpation-induced pain (p=0.009 - OR=1.62, 95%CI 1.12-2.33) and bilateral masseter palpation-induced pain (p=0.01 - OR=1.74, 95%CI 1.13-2.69).
CONCLUSIONS: Palpation-induced pain in the masticatory muscles may play a role in the differential diagnosis among painful TMD, primary headaches and bruxism.

PMID: 26615507 [PubMed - as supplied by publisher]

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Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry.

Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Cuevas-González JC, Vega-Memíje ME, García-Vázquez FJ, Rodríguez-Lobato E, Farfán-Morales JE

Abstract
BACKGROUND: Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway).
MATERIAL AND METHODS: Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. In H&E-stained slides, the diagnosis of AP was corroborated, and 1-µm-thick sections were processed for immunohistochemistry (IHC). A database was constructed with SPSS version 20, Inc., Chicago, IL, USA, and descriptive statistics were analyzed by X2 test and comparison of means.
RESULTS: A total of 64 cases were processed, of which 40 (62.5%) were cheilitis AP and 24 (37.5%) were AP in the skin. Of the 40 cheilitis samples, 27 were positive for Bcl-2 and caspase 3 (67.5%), p53 was expressed in 30 (75%). Of the skin lesions, p53 and caspase 3 were expressed in 18 of 24 cases (75%), and 13 were positive for Bcl-2 (54%).
CONCLUSIONS: We propose that apoptosis is the last step in the type IV subtype a-b hypersensitivity response-activation of the intrinsic pathway indicates that external factors, such as UV-A and -B are the trigger.

PMID: 26615506 [PubMed - as supplied by publisher]

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Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate.

Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Sá J, Araújo L, Guimarães L, Maranhão S, Lopes G, Medrado A, Coletta R, Reis S

Abstract
BACKGROUND: Individuals with nonsyndromic cleft lip with or without cleft palate (NSCL±P) present high frequency of dental anomalies, which may represent complicating factors for dental treatment. The aim of this study was to investigate the prevalence of dental anomalies inside cleft area in a group of Brazilians with NSCL±P.
MATERIAL AND METHODS: Retrospective analysis of 178 panoramic radiographs of patients aged from 12 to 45 years old and without history of tooth extraction or orthodontic treatment was performed. Association between cleft type and the prevalence of dental anomalies was assessed by chi-square test with a significance level set at p≤ 0.05.
RESULTS: Dental anomalies were found in 88.2% (n=157) of the patients. Tooth agenesis (47.1%), giroversion (20%) and microdontia (15.5%) were the most common anomalies. Individuals with unilateral complete cleft lip and palate (CLP, p<0.0001), bilateral complete CLP (p=0.0002) and bilateral incomplete CLP (p< 0.0001) were more affected by tooth agenesis than individuals with other cleft types. The maxillary lateral incisors were the most affected teeth (p<0.0001).
CONCLUSIONS: The present study revealed a high frequency of dental anomalies inside cleft region in NSCL±P patients, and further demonstrated that patients with unilateral complete CLP and bilateral incomplete CLP were frequently more affected by dental anomalies. Moreover, our results demonstrate that dental anomalies should be considered during dental treatment planning of individuals affected by NSCL±P.

PMID: 26615505 [PubMed - as supplied by publisher]

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Impact of crestal and subcrestal implant placement in peri-implant bone: A prospective comparative study.

Impact of crestal and subcrestal implant placement in peri-implant bone: A prospective comparative study.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Pellicer-Chover H, Peñarrocha-Diago MA, Peñarrocha-Oltra D, Gomar-Vercher S, Agustín-Panadero R, Peñarrocha-Diago M

Abstract
BACKGROUND: To assess the influence of the crestal or subcrestal placement of implants upon peri-implant bone loss over 12 months of follow-up.
MATERIAL AND METHODS: Twenty-six patients with a single hopeless tooth were recruited in the Oral Surgery Unit (Valencia University, Valencia, Spain). The patients were randomized into two treatment groups: group A (implants placed at crestal level) or group B (implants placed at subcrestal level). Control visits were conducted by a trained clinician at the time of implant placement and 12 months after loading. A previously established standard protocol was used to compile general data on all patients (sex and age, implant length and diameter, and brushing frequency). Implant success rate, peri-implant bone loss and the treatment of the exposed implant surface were studied. The level of statistical significance was defined as 5% (α=0.05).
RESULTS: Twenty-three patients (8 males and 15 females, mean age 49.8±11.6 years, range 28-75 years) were included in the final data analyses, while three were excluded. All the included subjects were non-smokers with a brushing frequency of up to twice a day in 85.7% of the cases. The 23 implants comprised 10 crestal implants and 13 subcrestal implants. After implant placement, the mean bone position with respect to the implant platform in group A was 0.0 mm versus 2.16±0.88 mm in group B. After 12 months of follow-up, the mean bone positions were -0.06±1.11 mm and 0.95±1.50 mm, respectively - this representing a bone loss of 0.06±1.11 mm in the case of the crestal implants and of 1.22±1.06 mm in the case of the subcrestal implants (p=0.014). Four crestal implants and 5 subcrestal implants presented peri-implant bone levels below the platform, leaving a mean exposed treated surface of 1.13 mm and 0.57 mm, respectively. The implant osseointegration success rate at 12 months was 100% in both groups.
CONCLUSIONS: Within the limitations of this study, bone loss was found to be greater in the case of the subcrestal implants, though from the clinical perspective these implants presented bone levels above the implant platform after 12 months of follow-up.

PMID: 26615504 [PubMed - as supplied by publisher]

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Antibacterial suture vs silk for the surgical removal of impacted lower third molars. A randomized clinical study.

Antibacterial suture vs silk for the surgical removal of impacted lower third molars. A randomized clinical study.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Sala-Pérez S, López-Ramírez M, Quinteros-Borgarello M, Valmaseda-Castellón E, Gay-Escoda C

Abstract
suture (Monocryl® Plus) in the surgical removal of I3M.
MATERIAL AND METHODS: A "split-mouth", prospective pilot clinical study was designed involving 20 patients programmed for the surgical removal of I3M. Each side was randomly sutured with Monocryl® Plus or silk suture and removed for microbiological study 72 hours and 7 days after surgery. Presence of SSI, wound bleeding and the degree of discomfort associated with each type of suture material (scored by means of a visual analog scale) were evaluated. The level of contamination of each material was observed under the scanning electron microscope.
RESULTS: Wound bleeding upon suture removing was slightly greater after 72 hours and 7 days with black silk suture, though the differences were not statistically significant (p=0.752 and p=0.113, respectively). Patient discomfort was very similar with both types of suture material (p=0.861). Only one case of SSI was recorded with black silk suture after 72 hours. Microbiologically, the antibacterial suture showed a lesser presence of microorganisms (p<0.001, at 72h and p=0.033 at 7th day, respectively). The most common bacterial species included grampositive cocci (Streptococcus viridans group, Neisseria spp., Coagulasenegative Staphylococcus and Peptostreptococcus), gramnegative cocci (Veillonella), grampositive Bacilli (Lactobacillus), and gramnegative Bacilli (Prevotella).
CONCLUSIONS: The greatest antibacterial effect of Monocryl Plus suture was observed after 72 hours. According to most authors, there is no doubt that this antibacterial suture can provide little safety in the control of SSI.

PMID: 26615503 [PubMed - as supplied by publisher]

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Survey of Spanish dentists on the prescription of antibiotics and antiseptics in surgery for impacted lower third molars.

Survey of Spanish dentists on the prescription of antibiotics and antiseptics in surgery for impacted lower third molars.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Arteagoitia MI, Ramos E, Santamaría G, Álvarez J, Barbier L, Santamaría J

Abstract
BACKGROUND: This study explored the attitude of registered dentists in Biscay towards prescribing antibiotics and/or antiseptics to prevent potential infections after surgical extraction of completely bone-impacted third molars in otherwise healthy individuals, with no history of infection.
MATERIAL AND METHOD: We sent letters to 931 registered dentists in Biscay, with an explanation of the study objectives, description of a case of lower third molar impaction, including a panoramic radiograph, and a questionnaire. The questionnaire asked whether they would prescribe antibiotics and/or antiseptics, in the hypothetical case of lower third molar extraction surgery presented, and if so, when, what type, at what dose and how long for.
RESULTS: The questionnaire was completed by 261 dentists (28%), with a mean age of 44.3 years old (SD 11.05) and mean of 18.7 years working as a dentist (SD 9). A total of 216 dentists (82.7%) considered it necessary to prescribe antibiotics. Of these, 126 (58.3%) would prescribe amoxicillin and 74 (34.5%) amoxicillin/clavulanic acid, while 129 dentists (59%) would prescribe antibiotics both before and after surgery and 10 (4.6%) only after surgery. The most common doses were amoxicillin 500 mg or 750 mg every 8 hours, and amoxicillin/clavulanic acid 875/125 mg every 8 hours, in both cases for a mean of 7 days. Further, 74 dentists (28%) said they would use immediate post-extraction socket irrigation with chlorhexidine, while 211 (81%) would prescribe antiseptics in the postoperative period, of whom 97% recommended chlorhexidine. We did not find significant differences in the use of antibiotics or antiseptics by dentist age (ANOVA p=0.22 and p=0.53, respectively), or professional experience (ANOVA p=0.45 and p=0.62).
CONCLUSIONS: In our sample, the prophylactic prescription of antibiotics and/or chlorhexidine is widespread in clinical practice, in most cases amoxicillin and amoxicillin/clavulanic acid for a week, starting the treatment before surgery.

PMID: 26615502 [PubMed - as supplied by publisher]

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TlR expression profile of human gingival margin-derived stem progenitor cells.

TlR expression profile of human gingival margin-derived stem progenitor cells.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Fawzy-El-Sayed K, Mekhemar M, Adam-Klages S, Kabelitz D, Dorfer C

Abstract
BACKGROUND: Gingival margin-derived stem/progenitor cells (G-MSCs) show remarkable periodontal regenerative potential in vivo. During regeneration, G-MSCs may interact with their inflammatory environment via toll-like-receptors (TLRs). The present study aimed to depict the G-MSCs TLRs expression profile.
MATERIAL AND METHODS: Cells were isolated from free gingival margins, STRO-1-immunomagnetically sorted and seeded to obtain single colony forming units (CFUs). G-MSCs were characterized for CD14, CD34, CD45, CD73, CD90, CD105, CD146 and STRO-1 expression, and for multilineage differentiation potential. Following G-MSCs' incubation in basic or inflammatory medium (IL-1β, IFN-γ, IFN-α, TNF-α) a TLR expression profile was generated.
RESULTS: G-MSCs showed all stem/progenitor cells' characteristics. In basic medium G-MSCs expressed TLRs 1, 2, 3, 4, 5, 6, 7, and 10. The inflammatory medium significantly up-regulated TLRs 1, 2, 4, 5, 7 and 10 and diminished TLR 6 (p≤0.05, Wilcoxon-Signed-Ranks-Test).
CONCLUSIONS: The current study describes for the first time the distinctive TLRs expression profile of G-MSCs under uninflamed and inflamed conditions.

PMID: 26615501 [PubMed - as supplied by publisher]

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Management of oral Graft versus Host Disease with topical agents: A systematic review.

Management of oral Graft versus Host Disease with topical agents: A systematic review.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Albuquerque R, Khan Z, Poveda A, Higham J, Richards A, Monteiro L, Jané-Salas E, Lopez-Lopez J, Warnakulasuriya S

Abstract
BACKGROUND: Oral Graft-versus-Host Disease (oGvHD) is a common complication of haematopoietic stem cell transplantation. Choosing the right topical application to be used intra orally can be a challenge. Consequently, the aim of this work is to review the effectiveness and safety of topical agents currently used in the management of the inflammatory mucosal lesions encountered in oGVHD.
MATERIAL AND METHODS: We carried out electronic searches of publications up to May 2015 of the databases Pubmed, National Library of Medicine's Medline, Embase and the Cochrane Central Register of Controlled Clinical trials to identify potentially relevant studies (keywords: "oral", "graft", "versus", "host", "disease" and "treatment"). The main inclusion criterion was the reported use of a topical agent which was not intentionally swallowed when used for the treatment of oGVHD. A 3-point grading system, described by the Swedish Council on Technology Assessment in Health Care and the Centre for Reviews and Dissemination, University of York, was used to rate the methodological quality of the papers.
RESULTS: From the 902 entries identified in the search, 7 studies qualifying for inclusion were analysed. Overall, there is limited evidence with regards to the effectiveness of topical steroids for oGVHD. However, the studies showed some effect of Budesonide alone and when combined with dexamethasone. Topical tacrolimus also appears to have some effect and clobetasol propionate mouthwash had a significantly better clinical response than dexamethasone mouthwash in treating oGVHD.
CONCLUSIONS: As the number of clinical trials conducted is limited, there is little evidence to support the use of topical therapies to treat the inflammatory mucosal lesions found in oGVHD. High quality randomised control trials are needed in order to measure the effectiveness of any topical application for the treatment of the inflammatory mucosal lesions found in oGVHD.

PMID: 26615510 [PubMed - as supplied by publisher]

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Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.

Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Orozco-Solís M, García-Ávalos Y, Pichardo-Ramírez C, Tobías-Azúa F, Zapata-Morales JR, Aragon-Martínez OH, Isiordia-Espinoza MA

Abstract
BACKGROUND: Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for dental pain. The aim of this study was to compare the analgesic, anti-inflammatory and anti-trismus effect of a single dose of diclofenac and meloxicam after mandibular third molar extraction.
MATERIAL AND METHODS: A total of 36 patients were randomized into two treatment groups, each with 18 patients, using a series of random numbers: Group A, was administered 100 mg of diclofenac; and Group B, 15 mg of meloxicam. Drugs were administered orally 1 hour prior to surgery. We evaluated pain intensity, analgesic consumption, swelling, as well as trismus.
RESULTS: The results of this study showed that patients receiving 15 mg of meloxicam had less postoperative pain (P=0.04) and better aperture than those receiving 100 mg of diclofenac (P=0.03). The meloxicam group presented less swelling than diclofenac group; however, significant statistical differences were not observed.
CONCLUSIONS: Data of this double-blind, randomized, parallel-group clinical trial demonstrated that patients receiving 15 mg of preoperative meloxicam had a better postoperative analgesia and anti-trismus effect compared with who were given 100 mg of diclofenac after third molar extractions.

PMID: 26615509 [PubMed - as supplied by publisher]

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Prevalence of the different Axis I clinical subtypes in a sample of patients with orofacial pain and temporomandibular disorders in the Andalusian Healthcare Service.

Prevalence of the different Axis I clinical subtypes in a sample of patients with orofacial pain and temporomandibular disorders in the Andalusian Healthcare Service.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Blanco-Hungría A, Blanco-Aguilera A, Blanco-Aguilera E, Serrano-Del-Rosal R, Biedma-Velázquez L, Rodríguez-Torronteras A, Segura-Saint-Gerons R

Abstract
BACKGROUND: The main objective of this paper is to analyze the prevalence of each of the different clinical subtypes of temporomandibular disorders (TMD) in a sample of patients with this pathology. In addition, a second objective was to analyze their distribution according to gender.
MATERIAL AND METHODS: To this end, the results of 1603 patients who went to the Unit of Temporomandibular Disorders in the Córdoba Healthcare District because they suffered from this pathology were analyzed. In order to diagnose them, the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) were applied, analyzing the different Axis I subtypes (myopathy, discopathy and arthropathy) and obtaining the combined Axis I for each patient and the relation of all these variables according to gender. The null-hypothesis test confirmed the lack of connection between the gender variable and the different subtypes in the clinical analysis, and between the former and the combined Axis I of the RDC/TMD.
RESULTS: The prevalence was high for the muscle disorders subtype in general, showing an 88.7% prevalence, while the presence of discopathies or arthropathies was much lower. Among discopathies, the most frequent ones were disc displacements with reduction, with 39.7% and 42.8% for the left and right temporomandibular joints (TMJ), respectively, while the prevalence of arthropathies was 26.3% for the right TMJ and 32.9% for the left TMJ. The bivariate analysis on the connection with gender reveals a p≥ 0.05 value for the muscle and arthralgia subtypes.
CONCLUSIONS: The patients seen at the TMD Unit where mostly middle-aged women whose main clinical axis subtype was the muscle disorder subtype. For their part, both discopathies and arthropathies, although present, are much less prevalent.

PMID: 26615508 [PubMed - as supplied by publisher]

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Can palpation-induced muscle pain pattern contribute to the differential diagnosis among temporomandibular disorders, primary headaches phenotypes and possible bruxism?

Can palpation-induced muscle pain pattern contribute to the differential diagnosis among temporomandibular disorders, primary headaches phenotypes and possible bruxism?

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Costa YM, Porporatti AL, Calderon PS, Conti PC, Bonjardim LR

Abstract
BACKGROUND: The evaluation of possible differences in the distribution or characteristics of palpation-induced pain in the masticatory muscles could be valuable in terms of diagnostic assessment. The aim of this study was to evaluate the impact of different combinations of anterior temporalis (AT) and masseter palpation-induced pain in the diagnostic of temporomandibular disorder (TMD), primary headaches and bruxism.
MATERIAL AND METHODS: A total of 1200 dental records of orofacial pain adult patients were analyzed. The outcomes were dichotomously classified (presence/absence) as following: a) AT and/or masseter palpation-induced pain; b) myogenous TMD; c) temporomandibular joint (TMJ) arthralgia (arthrogenous TMD); d) migraine; e) tension-type headache (TTH); f) self-reported bruxism. Binomial logistic regression model (α = 5%) was applied to the data considering the palpation-induced muscle pain as the dependent variable.
RESULTS: Mean age (SD) were 35.7 years (13.4) for 635 included dental records (83% females). Myogenous and arthrogenous TMD, migraine, TTH and bruxism were mainly associated with, respectively, masseter palpation-induced pain (p<0.001 - OR=5.77, 95%CI 3.86-8.62), AT or masseter palpation-induced pain (p<0.001 - OR=2.39, 95%CI 1.57-3.63), bilateral AT palpation-induced pain (p<0.001 - OR=2.67, 95%CI 1.64-4.32), masseter and AT palpation-induced pain (p=0.009 - OR=1.62, 95%CI 1.12-2.33) and bilateral masseter palpation-induced pain (p=0.01 - OR=1.74, 95%CI 1.13-2.69).
CONCLUSIONS: Palpation-induced pain in the masticatory muscles may play a role in the differential diagnosis among painful TMD, primary headaches and bruxism.

PMID: 26615507 [PubMed - as supplied by publisher]

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Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry.

Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Cuevas-González JC, Vega-Memíje ME, García-Vázquez FJ, Rodríguez-Lobato E, Farfán-Morales JE

Abstract
BACKGROUND: Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway).
MATERIAL AND METHODS: Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. In H&E-stained slides, the diagnosis of AP was corroborated, and 1-µm-thick sections were processed for immunohistochemistry (IHC). A database was constructed with SPSS version 20, Inc., Chicago, IL, USA, and descriptive statistics were analyzed by X2 test and comparison of means.
RESULTS: A total of 64 cases were processed, of which 40 (62.5%) were cheilitis AP and 24 (37.5%) were AP in the skin. Of the 40 cheilitis samples, 27 were positive for Bcl-2 and caspase 3 (67.5%), p53 was expressed in 30 (75%). Of the skin lesions, p53 and caspase 3 were expressed in 18 of 24 cases (75%), and 13 were positive for Bcl-2 (54%).
CONCLUSIONS: We propose that apoptosis is the last step in the type IV subtype a-b hypersensitivity response-activation of the intrinsic pathway indicates that external factors, such as UV-A and -B are the trigger.

PMID: 26615506 [PubMed - as supplied by publisher]

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Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate.

Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Sá J, Araújo L, Guimarães L, Maranhão S, Lopes G, Medrado A, Coletta R, Reis S

Abstract
BACKGROUND: Individuals with nonsyndromic cleft lip with or without cleft palate (NSCL±P) present high frequency of dental anomalies, which may represent complicating factors for dental treatment. The aim of this study was to investigate the prevalence of dental anomalies inside cleft area in a group of Brazilians with NSCL±P.
MATERIAL AND METHODS: Retrospective analysis of 178 panoramic radiographs of patients aged from 12 to 45 years old and without history of tooth extraction or orthodontic treatment was performed. Association between cleft type and the prevalence of dental anomalies was assessed by chi-square test with a significance level set at p≤ 0.05.
RESULTS: Dental anomalies were found in 88.2% (n=157) of the patients. Tooth agenesis (47.1%), giroversion (20%) and microdontia (15.5%) were the most common anomalies. Individuals with unilateral complete cleft lip and palate (CLP, p<0.0001), bilateral complete CLP (p=0.0002) and bilateral incomplete CLP (p< 0.0001) were more affected by tooth agenesis than individuals with other cleft types. The maxillary lateral incisors were the most affected teeth (p<0.0001).
CONCLUSIONS: The present study revealed a high frequency of dental anomalies inside cleft region in NSCL±P patients, and further demonstrated that patients with unilateral complete CLP and bilateral incomplete CLP were frequently more affected by dental anomalies. Moreover, our results demonstrate that dental anomalies should be considered during dental treatment planning of individuals affected by NSCL±P.

PMID: 26615505 [PubMed - as supplied by publisher]

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Impact of crestal and subcrestal implant placement in peri-implant bone: A prospective comparative study.

Impact of crestal and subcrestal implant placement in peri-implant bone: A prospective comparative study.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Pellicer-Chover H, Peñarrocha-Diago MA, Peñarrocha-Oltra D, Gomar-Vercher S, Agustín-Panadero R, Peñarrocha-Diago M

Abstract
BACKGROUND: To assess the influence of the crestal or subcrestal placement of implants upon peri-implant bone loss over 12 months of follow-up.
MATERIAL AND METHODS: Twenty-six patients with a single hopeless tooth were recruited in the Oral Surgery Unit (Valencia University, Valencia, Spain). The patients were randomized into two treatment groups: group A (implants placed at crestal level) or group B (implants placed at subcrestal level). Control visits were conducted by a trained clinician at the time of implant placement and 12 months after loading. A previously established standard protocol was used to compile general data on all patients (sex and age, implant length and diameter, and brushing frequency). Implant success rate, peri-implant bone loss and the treatment of the exposed implant surface were studied. The level of statistical significance was defined as 5% (α=0.05).
RESULTS: Twenty-three patients (8 males and 15 females, mean age 49.8±11.6 years, range 28-75 years) were included in the final data analyses, while three were excluded. All the included subjects were non-smokers with a brushing frequency of up to twice a day in 85.7% of the cases. The 23 implants comprised 10 crestal implants and 13 subcrestal implants. After implant placement, the mean bone position with respect to the implant platform in group A was 0.0 mm versus 2.16±0.88 mm in group B. After 12 months of follow-up, the mean bone positions were -0.06±1.11 mm and 0.95±1.50 mm, respectively - this representing a bone loss of 0.06±1.11 mm in the case of the crestal implants and of 1.22±1.06 mm in the case of the subcrestal implants (p=0.014). Four crestal implants and 5 subcrestal implants presented peri-implant bone levels below the platform, leaving a mean exposed treated surface of 1.13 mm and 0.57 mm, respectively. The implant osseointegration success rate at 12 months was 100% in both groups.
CONCLUSIONS: Within the limitations of this study, bone loss was found to be greater in the case of the subcrestal implants, though from the clinical perspective these implants presented bone levels above the implant platform after 12 months of follow-up.

PMID: 26615504 [PubMed - as supplied by publisher]

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Antibacterial suture vs silk for the surgical removal of impacted lower third molars. A randomized clinical study.

Antibacterial suture vs silk for the surgical removal of impacted lower third molars. A randomized clinical study.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Sala-Pérez S, López-Ramírez M, Quinteros-Borgarello M, Valmaseda-Castellón E, Gay-Escoda C

Abstract
suture (Monocryl® Plus) in the surgical removal of I3M.
MATERIAL AND METHODS: A "split-mouth", prospective pilot clinical study was designed involving 20 patients programmed for the surgical removal of I3M. Each side was randomly sutured with Monocryl® Plus or silk suture and removed for microbiological study 72 hours and 7 days after surgery. Presence of SSI, wound bleeding and the degree of discomfort associated with each type of suture material (scored by means of a visual analog scale) were evaluated. The level of contamination of each material was observed under the scanning electron microscope.
RESULTS: Wound bleeding upon suture removing was slightly greater after 72 hours and 7 days with black silk suture, though the differences were not statistically significant (p=0.752 and p=0.113, respectively). Patient discomfort was very similar with both types of suture material (p=0.861). Only one case of SSI was recorded with black silk suture after 72 hours. Microbiologically, the antibacterial suture showed a lesser presence of microorganisms (p<0.001, at 72h and p=0.033 at 7th day, respectively). The most common bacterial species included grampositive cocci (Streptococcus viridans group, Neisseria spp., Coagulasenegative Staphylococcus and Peptostreptococcus), gramnegative cocci (Veillonella), grampositive Bacilli (Lactobacillus), and gramnegative Bacilli (Prevotella).
CONCLUSIONS: The greatest antibacterial effect of Monocryl Plus suture was observed after 72 hours. According to most authors, there is no doubt that this antibacterial suture can provide little safety in the control of SSI.

PMID: 26615503 [PubMed - as supplied by publisher]

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Survey of Spanish dentists on the prescription of antibiotics and antiseptics in surgery for impacted lower third molars.

Survey of Spanish dentists on the prescription of antibiotics and antiseptics in surgery for impacted lower third molars.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Arteagoitia MI, Ramos E, Santamaría G, Álvarez J, Barbier L, Santamaría J

Abstract
BACKGROUND: This study explored the attitude of registered dentists in Biscay towards prescribing antibiotics and/or antiseptics to prevent potential infections after surgical extraction of completely bone-impacted third molars in otherwise healthy individuals, with no history of infection.
MATERIAL AND METHOD: We sent letters to 931 registered dentists in Biscay, with an explanation of the study objectives, description of a case of lower third molar impaction, including a panoramic radiograph, and a questionnaire. The questionnaire asked whether they would prescribe antibiotics and/or antiseptics, in the hypothetical case of lower third molar extraction surgery presented, and if so, when, what type, at what dose and how long for.
RESULTS: The questionnaire was completed by 261 dentists (28%), with a mean age of 44.3 years old (SD 11.05) and mean of 18.7 years working as a dentist (SD 9). A total of 216 dentists (82.7%) considered it necessary to prescribe antibiotics. Of these, 126 (58.3%) would prescribe amoxicillin and 74 (34.5%) amoxicillin/clavulanic acid, while 129 dentists (59%) would prescribe antibiotics both before and after surgery and 10 (4.6%) only after surgery. The most common doses were amoxicillin 500 mg or 750 mg every 8 hours, and amoxicillin/clavulanic acid 875/125 mg every 8 hours, in both cases for a mean of 7 days. Further, 74 dentists (28%) said they would use immediate post-extraction socket irrigation with chlorhexidine, while 211 (81%) would prescribe antiseptics in the postoperative period, of whom 97% recommended chlorhexidine. We did not find significant differences in the use of antibiotics or antiseptics by dentist age (ANOVA p=0.22 and p=0.53, respectively), or professional experience (ANOVA p=0.45 and p=0.62).
CONCLUSIONS: In our sample, the prophylactic prescription of antibiotics and/or chlorhexidine is widespread in clinical practice, in most cases amoxicillin and amoxicillin/clavulanic acid for a week, starting the treatment before surgery.

PMID: 26615502 [PubMed - as supplied by publisher]

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TlR expression profile of human gingival margin-derived stem progenitor cells.

TlR expression profile of human gingival margin-derived stem progenitor cells.

Med Oral Patol Oral Cir Bucal. 2015 Nov 30;:0

Authors: Fawzy-El-Sayed K, Mekhemar M, Adam-Klages S, Kabelitz D, Dorfer C

Abstract
BACKGROUND: Gingival margin-derived stem/progenitor cells (G-MSCs) show remarkable periodontal regenerative potential in vivo. During regeneration, G-MSCs may interact with their inflammatory environment via toll-like-receptors (TLRs). The present study aimed to depict the G-MSCs TLRs expression profile.
MATERIAL AND METHODS: Cells were isolated from free gingival margins, STRO-1-immunomagnetically sorted and seeded to obtain single colony forming units (CFUs). G-MSCs were characterized for CD14, CD34, CD45, CD73, CD90, CD105, CD146 and STRO-1 expression, and for multilineage differentiation potential. Following G-MSCs' incubation in basic or inflammatory medium (IL-1β, IFN-γ, IFN-α, TNF-α) a TLR expression profile was generated.
RESULTS: G-MSCs showed all stem/progenitor cells' characteristics. In basic medium G-MSCs expressed TLRs 1, 2, 3, 4, 5, 6, 7, and 10. The inflammatory medium significantly up-regulated TLRs 1, 2, 4, 5, 7 and 10 and diminished TLR 6 (p≤0.05, Wilcoxon-Signed-Ranks-Test).
CONCLUSIONS: The current study describes for the first time the distinctive TLRs expression profile of G-MSCs under uninflamed and inflamed conditions.

PMID: 26615501 [PubMed - as supplied by publisher]

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OtoRhinoLaryngology & Medicine,New Articles,November 30th,2015,a

Metastatic cardiac tumor from urothelial carcinoma detected by transthoracic echocardiography: a case report

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

IntroductionCardiac metastasis of urothelial carcinoma is a very rare but clinically important complication. Most cardiac metastases are asymptomatic; symptoms from cardiac metastasis were seen in advanced stage and many of these cases were reported to have a poor prognosis. So it is important to find asymptomatic cardiac metastasis and to start chemotherapy early in order to improve the patient's prognosis.Case presentationA 73-year-old Asian man was referred to our hospital because of a right ventricular tumor. He had a history of left ureteral cancer 9 years ago. In screening e...περισσότερα »

Clinicopathological characteristics of tumours of the intraoral minor salivary glands

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

in 170 Brazilian patients via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 28 November 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Aline Corrêa Abrahão, Juliana de Noronha Santos Netto, Fábio Ramôa Pires, Teresa Cristina Ribeiro Bartholomeu dos Santos, Márcia Grillo Cabral Tumours of the minor salivary glands are relatively uncommon, and publications from around the world normally include tumours of both the minor and major salivary glands, making it difficult to assess their prevalence and distribution. Our aim wa... περισσότερα »

α-synuclein aggregation in the olfactory bulb

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

of middle-aged common marmoset via ScienceDirect Publication: Neuroscience Research Publication date: Available online 28 November 2015 *Source:*Neuroscience Research Author(s): Reona Kobayashi, Junko Takahashi-Fujigasaki, Seiji Shiozawa, Chikako Hara-Miyauchi, Takashi Inoue, Hirotaka James Okano, Erika Sasaki, Hideyuki Okano The synaptic protein α-synuclein has been identified as a major component of Lewy bodies, a pathological hallmark of Parkinson's disease (PD). Prior to the formation of Lewy bodies, mislocalization and aggregation of the α-synuclein in brain tissue is frequently ... περισσότερα »

Mediastinal Tuberculosis with an Isolated Prepontine Cistern Tuberculoma : Right Gaze Palsy and Hoarseness

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Right Gaze Palsy and Hoarseness: A Rare Presentation of Mediastinal Tuberculosis with an Isolated Prepontine Cistern Tuberculoma: We describe a previously healthy young man who presented with headaches, diplopia with right lateral gaze palsy, dysphagia, and hoarseness over a 2-month period. Magnetic resonance imaging of the brain revealed a small enhancing mass at the prepontine cistern and chest CT showed a left mediastinal mass. Mediastinoscopy and lymph node biopsy were performed. DNA probe and culture of the biopsy specimen were confirmed to be Mycobacterium tuberculosis complex... περισσότερα »

Diagnosis of the resistance of Helicobacter pylori to quinolone-based antibiotics

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

An integrated microfluidic system for via Biosensors and Bioelectronics [image: S09565663.gif] Publication date: 15 April 2016 *Source:*Biosensors and Bioelectronics, Volume 78 Author(s): Chih-Yu Chao, Chih-Hung Wang, Yu-Jui Che, Cheng-Yen Kao, Jiunn-Jong Wu, Gwo-Bin Lee Helicobacter pylori (H. pylori) is a species of bacteria that can colonize the human stomach mucosa. It is closely associated with gastric diseases such as ulcer and inflammation. Recently, some H. pylori strains were found to express resistance to a family of antibiotics known as quinolones due to single-point muta... περισσότερα »

An amplified immunosensor for detection of influenza

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

A nanohybrid of platinum nanoparticles-porous ZnO–hemin with electrocatalytic activity to construct an amplified immunosensor for detection of influenza via Biosensors and Bioelectronics [image: S09565663.gif] Publication date: 15 April 2016 *Source:*Biosensors and Bioelectronics, Volume 78 Author(s): Zhe-Han Yang, Ying Zhuo, Ruo Yuan, Ya-Qin Chai In this work, a nanohybrid of platinum nanoparticles-porous ZnO spheres-hemin (Pt–pZnO–hemin) was synthesized for construction of alkaline phosphatase-based immunosensor for detection of influenza. Briefly, porous ZnO spheres (pZnO) were pr... περισσότερα »

Endoscopic transnasal approach for orbital tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

: A report of four cases via Auris Nasus Larynx Publication date: Available online 28 November 2015 *Source:*Auris Nasus Larynx Author(s): Yasuhiro Arai, Nobutaka Kawahara, Takaakira Yokoyama, Nobuhiko Oridate Endoscopic transnasal approach is an excellent technique for resecting orbital tumors located inferiorly and/or medially to the optic nerve. The aim of this study was to present four cases of orbital tumor which were, at least in part, resected by an endoscopic transnasal approach and to discuss both indications and limitations of this approach through a comparison of the locati... περισσότερα »

The Charlson comorbidity index score (CCIS),The Elixhauser comorbidity index score (ECIS)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Comparison of different comorbidity measures for oral cancer patients with surgical intervention: A longitudinal study from a single cancer center via Auris Nasus Larynx Publication date: Available online 28 November 2015 *Source:*Auris Nasus Larynx Author(s): Ching-Chih Lee, Hsu-Chueh Ho, Yu-Chieh Su, Po-Chun Chen, Chia-Hui Yu, Ching-Chieh Yang ObjectiveSeveral comorbid measures have been developed and demonstrated the predictive ability for cancer mortality. We conducted a retrospective study on oral squamous cell carcinoma (OSCC) patients to compare the Charlson comorbidity index sc... περισσότερα »

Antiviral Activity of Resveratrol

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

against Human and Animal Viruses via Advances in Virology Resveratrol is a potent polyphenolic compound that is being extensively studied in the amelioration of viral infections both in vitro and in vivo. Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF-κβ pathway, while its antiviral effects are associated with inhibitions of viral replication, protein synthesis, gene expression, and nucleic acid synthesis. Although the beneficial roles of resveratrol in several viral diseases have been well documented, a few adverse effects have b... περισσότερα »

Fluorescence guided resection (FGR)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

: A primer for oncology via ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy Publication date: Available online 28 November 2015 *Source:*Photodiagnosis and Photodynamic Therapy Author(s): Ron R. Allison Curative treatment for most cancer patients requires surgical removal of the tumor. Often though, residual disease is left behind negatively impacting tumor control and survival. Florescent Guided resection (FGR) is one type of Image Guided Surgery that offers the potential to improve outcomes for these patients. Currently, during FGR, a probe is preoperatively applie...περισσότερα »

Unilateral temporomandibular disorders pain : Simultaneously recorded occlusion contact and surface electromyographic activity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

An investigation on the simultaneously recorded occlusion contact and surface electromyographic activity for patients with unilateral temporomandibular disorders pain via Journal of Electromyography and Kinesiology Publication date: Available online 28 November 2015 *Source:*Journal of Electromyography and Kinesiology Author(s): Bao-Yong Li, Li-Juan Zhou, Shao-Xiong Guo, Yuan Zhang, Lei Lu, Mei-Qing Wang The present study examined if unilateral pain from temporomandibular disorders (TMD) was associated with the occlusion contacts and surface electromyographic (SEMG) activities of jaw-c...περισσότερα »

QT Interval Variability Index and QT Interval Duration in Different Sleep Stages: Analysis of Polysomnographic Recordings in Nonapneic Male Patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

QT Interval Variability Index and QT Interval Duration in Different Sleep Stages: Analysis of Polysomnographic Recordings in Nonapneic Male Patients: The aim of the study was to determine whether different sleep stages, especially REM sleep, affect QT interval duration and variability in male patients without obstructive sleep apnea (OSA). Polysomnographic recordings of 30 patients were analyzed. Beat-to-beat QT interval variability was calculated using QTV index (QTVI) formula. For QTc interval calculation, in addition to Bazett’s formula, linear and parabolic heart rate correction ... περισσότερα »

Surgical Management of Recurrent Tracheocarotid Fistula following Endovascular Stent Placement

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Surgical Management of Recurrent Tracheocarotid Fistula following Endovascular Stent Placement: We report the case of a 25-year-old woman who developed a tracheocarotid fistula secondary to an infected endovascular stent placed in the right carotid artery after the patient experienced hemorrhage on her first tracheostomy change. The patient originally had the tracheostomy placed at an outside hospital in September 2014, due to prolonged intubation after a motor vehicle accident. The patient presented to the otolaryngology service with an acute tracheal hemorrhage. This necessitated ... περισσότερα »

Deep Neck Infection and Descending Mediastinitis as a Complication of Propionibacterium acnes Odontogenic Infection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Deep Neck Infection and Descending Mediastinitis as a Complication of Propionibacterium acnes Odontogenic Infection: Propionibacterium acnes is an anaerobic, Gram-positive bacterium which causes numerous types of infections. Isolated Propionibacterium acnes deep neck infections are very rare. We present an interesting case of deep neck infection complicated by descending mediastinitis of isolated Propionibacterium acnes infection. Propionibacterium acnes is an anaerobic, Gram-positive bacterium, comprising a large part of the skin flora of healthy individuals [1]. Propionibacteri...περισσότερα »

Ant venom proteins causing hypersensitivity reactions

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Current advances in ant venom proteins causing hypersensitivity reactions in the Asia-Pacific region via ScienceDirect Publication: Molecular Immunology Publication date: January 2016 *Source:*Molecular Immunology, Volume 69 Author(s): Hathairat Srisong, Sakda Daduang, Andreas L. Lopata The main insects causing allergy reactions to stinging insect in humans are Apidae (bees), Vespidae (wasps, yellow jackets and hornets) and Formicidae (ants). Their venom stings are composed of various biologically active peptides and protein components, some of which can cause toxicity or anaphylaxis i... περισσότερα »

Recurrent Guillain–Barré syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

presenting stereotypic manifestations, positive antiganglioside antibodies, and rapid recovery via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): So Young Pyun, Jin-Ho Jeong, Jong Seok Bae ObjectiveRecurrent Guillain–Barré syndrome (rGBS) has been described as a rare entity with distinct characteristics. However, little is known about rGBS in Asian group. The aim of this study was to identify the incidence and clinical course of rGBS, and to determine... περισσότερα »

Factors associated with the severity of childhood rhinoconjunctivitis

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες

Factors associated with the severity of childhood rhinoconjunctivitis via Allergology International Publication date: Available online 29 November 2015 *Source:*Allergology International Author(s): Koichi Yoshida, Mari Sasaki, Yuichi Adachi, Toshiko Itazawa, Hiroshi Odajima, Hirohisa Saito, Akira Akasawa BackgroundAllergic rhinitis is one of the most common chronic diseases in children. Although it has a large impact on the patient's quality of life, little is known about the factors associated with its severity. The aim of this study was to assess the factors associated with the sever... περισσότερα »

Hen's egg (HE) allergy develops during infancy

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες

Natural history of immediate-type hen&#39;s egg allergy in Japanese children via Allergology International Publication date: Available online 28 November 2015 *Source:*Allergology International Author(s): Kiyotaka Ohtani, Sakura Sato, Akinori Syukuya, Tomoyuki Asaumi, Kiyotake Ogura, Yumi Koike, Katsuhito Iikura, Noriyuki Yanagida, Takanori Imai, Motohiro Ebisawa BackgroundHen&#39;s egg (HE) allergy develops during infancy. We investigated tolerance acquisition in Japanese children allergic to HE aging &lt;6 years.MethodsIn this retrospective study, 226 children born in 2005 with a history of im... περισσότερα »

Orienting versus inhibition in the Concealed Information Test: Different cognitive processes drive different physiological measures

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες

Abstract The Concealed Information Test (CIT) provides a valid tool for psychophysiological detection of concealed knowledge. However, its precise theoretical underpinnings remain a matter of debate. The differential physiological responses elicited by concealed, relevant items, relative to control items, were traditionally explained as reflecting an orienting response (OR). According to an alternative account, these responses reflect attempts to inhibit arousal. The present study examined whether and to what extent CIT detection efficiency is affected by instructions aimed at man...περισσότερα »

Volatile Organic Compounds in Plasma for the Diagnosis of Esophageal Adenocarcinoma

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες

Volatile Organic Compounds in Plasma for the Diagnosis of Esophageal Adenocarcinoma: A Pilot Study: A non-invasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for diagnosis of EAC has not been previously studied. Abstract Background &amp; Aims A non-invasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for d... περισσότερα »

Task oriented program and balance training on postural stability in stroke patients

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες

Comparison between the effects of task oriented program and balance training on postural stability in stroke patients: 2015-11-29T17-03-15Z *Source:* International Journal of Therapies and Rehabilitation Research Hosam Magdy Metwally, Waleed Talat Mansour, Amal Sayed Ashour, Islam Hasan Fayed. Background: Sensorimotor cortex is responsive to peripheral and central stimulation by mechanisms that are important for learning motor tasks. The purpose of this study was to investigate difference between the effect of task oriented program and balance exercises on postural stability in str... περισσότερα »

The anterior horn cells control all voluntary movement: motor activity, respiratory, speech, and swallowing functions are dependent upon signals from the anterior horn cells

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες

Anterior Horn Cell Diseases: 2015-11-29T18-03-41Z *Source:* Archives Medical Review Journal Merve Fırıncıoğulları, Burak Yavuz, Filiz Koç. The anterior horn cells control all voluntary movement: motor activity, respiratory, speech, and swallowing functions are dependent upon signals from the anterior horn cells. Diseases that damage the anterior horn cells, therefore, have a profound impact. Symptoms of anterior horn cell loss (weakness, falling, choking) lead patients to seek medical attention. In this article, anterior horn disease were reviewed, diagnostic criteria and manageme... περισσότερα »

Microvascular decompression and MRI findings in trigeminal neuralgia and hemifacial spasm

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

. A single center experience via Clinical Neurology and Neurosurgery Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Patrick W. Hitchon, Mario Zanaty, Toshio Moritani, Ergun Uc, Connie L. Pieper, Wenzhuan He, Jennifer Noeller ObjectiveFor patients with medically unresponsive trigeminal neuralgia (TIC) and hemifacial spasm (HS), surgical microvascular decompression (MVD) is the procedure of choice. The authors of this report sought to review their outcomes with MVD in patients with TIC and HS, and the success of preoperative magnetic ...περισσότερα »

Autonomic symptoms in hypertensive patients with post-acute minor ischemic stroke

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Autonomic symptoms in hypertensive patients with post-acute minor ischemic stroke via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Juan Idiaquez, Hector Farias, Francisco Torres, Jorge Vega, David A. Low BackgroundMost studies regarding autonomic dysfunction in ischemic stroke are limited to heart rate and blood pressure changes during the acute phase. However, there are few data on quantitative assessment of autonomic symptoms. We sought to assess ... περισσότερα »

Festination in patients with Parkinson's disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Festination in Chinese patients with Parkinson's disease via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Ruwei Ou, Xiaoyan Guo, Qianqian Wei, Bei Cao, Jing Yang, Wei Song, Na Shao, Bi Zhao, Xueping Chen, Huifang Shang ObjectiveTo investigate the occurrence and clinical associations of festination in Chinese patients with Parkinson's disease (PD).MethodsA total of 480 PD patients were recruited in this cross-sectional study. Assessments scales includ...περισσότερα »

BacterioFiles 240 - Water Worms Make (carbon) Monoxide Meals

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 2 ώρες

This episode: Marine worms and their microbial symbionts can live on the toxic gas carbon monoxide! Reminder: this is the last episode for at least a few weeks while I am wrapping up my PhD. See you again when I'm done! (11.1 MB, 12.1 minutes) from Infection via ola Kala on Inoreader http://ift.tt/1PmEtxm via IFTTT

Soil moisture and chemistry influence diversity of ectomycorrhizal fungal communities associating with willow along an hydrologic gradient

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 2 ώρες

Influences of soil environment and willow host species on ectomycorrhizal fungi communities was studied across an hydrologic gradient in temperate North America. Soil moisture, organic matter and pH strongly predicted changes in fungal community composition. In contrast, increased fungal richness strongly correlated with higher plant-available phosphorus. The 93 willow trees sampled for ectomycorrhizal fungi included seven willow species. Host identity did not influence fungal richness or community composition, nor was there strong evidence of willow host preference for fungal spe... περισσότερα »

Pre-operative image-based segmentation of the cranial nerves and blood vessels in microvascular decompression

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

: Can we prevent unnecessary explorations? via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Parviz Dolati, Alexandra Golby, Daniel Eichberg, Mohamad Abolfotoh, Ian F. Dunn, Srinivasan Mukundan, Mohamed M. Hulou, Ossama Al-Mefty ObjectivesThis study was conducted to validate the accuracy of image-based pre-operative segmentation using the gold standard endoscopic and microscopic findings for localization and pre-operative diagnosis of the offensive v... περισσότερα »

High coincidence of pituitary adenoma in patients with ruptured Rathke's cleft cyst

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Demonstration of high coincidence of pituitary adenoma in patients with ruptured Rathke's cleft cyst: Results of a prospective study via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Hidetoshi Ikeda, Genichiro Ohhashi ObjectiveRepeated chronic inflammation, such as under circumstances of ruptured Rathke's cleft cyst (RCC), is known as the fundamental basis of various pathological changes including neoplastic change, therefore to examine accurate incid... περισσότερα »

Spinal Ependymomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Genetic and molecular distinctions in spinal ependymomas: A review via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Ian D. Connolly, Rohaid Ali, Yingmei Li, Melanie Hayden Gephart While gross total resection of spinal ependymomas prevents recurrence, this surgical result is not always possible. Increasing evidence suggests that ependymomas occurring in the spine are genetically distinct from those originating in the brain. Herein we review the most re... περισσότερα »

Spinal fractures in patients with ankylosing spondylitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Management of via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Najib E. El Tecle, Kingsley O. Abode-Iyamah, Patrick W. Hitchon, Nader S. Dahdaleh Ankylosing spondlylitis is a seronegative spondyloarthropathy that primarily affects the spinal column and sacroiliac joints. With disease progression autofusion of the spinal column takes place. This combined with the brittle bone quality make patients prone to fractures and spinal cord injury. The typic... περισσότερα »

Prognostic markers for craniopharyngioma recurrence : Increased expression of HIF-1α and VEGF correlates with recurrence

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Important via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Aatman Shah, Henry Jung Highlights • Craniopharyngioma markers that predict recurrence have not been identified. • Larger size and adherence to the hypothalamus correlated with recurrence. • Increased expression of HIF-1α and VEGF correlates with recurrence.

Invasion-related molecules in the peritumoral brain

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Expression pattern of via Clinical Neurology and Neurosurgery [image: S03038467.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Álmos Klekner, Gábor Hutóczki, József Virga, Judit Reményi-Puskár, Judit Tóth, Beáta Scholtz, Éva Csősz, Gergő Kalló, László Steiner, Tibor Hortobágyi, László Bognár ObjectiveThe effectiveness of therapy of intracerebral neoplasms is mainly influenced by the invasive behaviour of the tumour. The peritumoral invasion depends on the interaction between the tumour cells and the extracellular matrix (ECM)... περισσότερα »

Intracerebral hemorrhages in Deep brain stimulation surgeries

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

A detailed analysis of via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Mehmet Tonge, Linda Ackermans, Ersoy Kocabicak, Vivianne van Kranen-Mastenbroek, Mark Kuijf, Mayke Oosterloo, Pieter Kubben, Yasin Temel ObjectivesDeep brain stimulation is nowadays a frequently performed surgery in patients with movement disorders, intractable epilepsy, and severe psychiatric disorders. The most feared complication of this surgery is an intracerebral hemorrhage...περισσότερα »

Surgical management of ventrally based lower cervical (subaxial) meningiomas through the lateral approach

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

: Report on 16 cases via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Hisham Adel Aboul-Enein, Wael Mahmoud Khidr, Khaled Mohamed Abdeen, Aly Abo Madawi ObjectivesSpinal meningiomas are benign and relatively rare tumors. These tumors present about only 25% of primary spinal tumors. Although spinal meningiomas are considered as slowly growing benign tumors, yet they may cause devastating neurological deficits rendering patients crippled. This study d...περισσότερα »

The risk of meningitis in patients undergoing endoscopic endonasal transsphenoidal surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Efficacy of ultra-short single agent regimen antibiotic chemo-prophylaxis in reducing the risk of meningitis in patients undergoing endoscopic endonasal transsphenoidal surgery via Clinical Neurology and Neurosurgery [image: 1-s2.0-S0303846715X00114-cov150h.gif] Publication date: December 2015 *Source:*Clinical Neurology and Neurosurgery, Volume 139 Author(s): Teresa Somma, Alberto Enrico Maraolo, Felice Esposito, Luigi Maria Cavallo, Grazia Tosone, Raffaele Orlando, Paolo Cappabianca ObjectivesThe study aims to evaluate the incidence of infectious complications (namely meningitis) wi... περισσότερα »

Effects of mandibular advancement surgery on the temporomandibular joint and muscular and articular adaptive changes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

—a systematic review via Oral and Maxillofacial Surgery Publication date: Available online 28 November 2015 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): A. Bermell-Baviera, C. Bellot-Arcís, J.M. Montiel-Company, J.M. Almerich-Silla The objective of this study was to assess the anatomical changes to the condyle and articular disc following mandibular advancement surgery, the adaptation of the masticatory muscles, and the improvement or worsening of temporomandibular disorders (TMD) in patients with pre-existing disorders and those who developed them follo... περισσότερα »

Factors associated with the severity of childhood rhinoconjunctivitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Factors associated with the severity of childhood rhinoconjunctivitis via Allergology International Publication date: Available online 29 November 2015 *Source:*Allergology International Author(s): Koichi Yoshida, Mari Sasaki, Yuichi Adachi, Toshiko Itazawa, Hiroshi Odajima, Hirohisa Saito, Akira Akasawa BackgroundAllergic rhinitis is one of the most common chronic diseases in children. Although it has a large impact on the patient's quality of life, little is known about the factors associated with its severity. The aim of this study was to assess the factors associated with the severi... περισσότερα »

Hen's egg (HE) allergy develops during infancy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Natural history of immediate-type hen&#39;s egg allergy in Japanese children via Allergology International Publication date: Available online 28 November 2015 *Source:*Allergology International Author(s): Kiyotaka Ohtani, Sakura Sato, Akinori Syukuya, Tomoyuki Asaumi, Kiyotake Ogura, Yumi Koike, Katsuhito Iikura, Noriyuki Yanagida, Takanori Imai, Motohiro Ebisawa BackgroundHen&#39;s egg (HE) allergy develops during infancy. We investigated tolerance acquisition in Japanese children allergic to HE aging &lt;6 years.MethodsIn this retrospective study, 226 children born in 2005 with a history of imm... περισσότερα »

Volatile Organic Compounds in Plasma for the Diagnosis of Esophageal Adenocarcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Volatile Organic Compounds in Plasma for the Diagnosis of Esophageal Adenocarcinoma: A Pilot Study: A non-invasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for diagnosis of EAC has not been previously studied. AbstractBackground &amp; Aims A non-invasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for dia... περισσότερα »

Orienting versus inhibition in the Concealed Information Test: Different cognitive processes drive different physiological measures

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 3 ώρες

Abstract The Concealed Information Test (CIT) provides a valid tool for psychophysiological detection of concealed knowledge. However, its precise theoretical underpinnings remain a matter of debate. The differential physiological responses elicited by concealed, relevant items, relative to control items, were traditionally explained as reflecting an orienting response (OR). According to an alternative account, these responses reflect attempts to inhibit arousal. The present study examined whether and to what extent CIT detection efficiency is affected by instructions aimed at man...περισσότερα »

Orienting versus inhibition in the Concealed Information Test: Different cognitive processes drive different physiological measures

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Abstract The Concealed Information Test (CIT) provides a valid tool for psychophysiological detection of concealed knowledge. However, its precise theoretical underpinnings remain a matter of debate. The differential physiological responses elicited by concealed, relevant items, relative to control items, were traditionally explained as reflecting an orienting response (OR). According to an alternative account, these responses reflect attempts to inhibit arousal. The present study examined whether and to what extent CIT detection efficiency is affected by instructions aimed at man...περισσότερα »

Anesthesia Management in Diabetic Patients witht Cardiovascular Autonomic Neuropathy

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες

Anesthesia Management in Diabetic Patients witht Cardiovascular Autonomic Neuropathy: 2015-11-29T18-03-41Z *Source:* Archives Medical Review Journal Feride Karacaer. Cardiovascular autonomic neuropathy is frequently observed in patients with diabetes mellitus and encompasses damage to the autonomic nerve fibers, resulting in abnormalities in heart rate control and vascular dynamics. There is an increased mortality and morbidity rate among these patients. A series of cardiovascular reflex tests known as Ewings battery tests are used for diagnosis cardiac autonomic neuropathy and pr...περισσότερα »

Superoxide anions produced by Streptococcus pyogenes group A-stimulated keratinocytes are responsible for cellular necrosis and bacterial growth inhibition

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες

Superoxide anions produced by Streptococcus pyogenes group A-stimulated keratinocytes are responsible for cellular necrosis and bacterial growth inhibition: Gram-positive *Streptococcus pyogenes* (group A *Streptococcus* or GAS) is a major skin pathogen and interacts with keratinocytes in cutaneous tissues. GAS can cause diverse suppurative and inflammatory infections, such as cellulitis, a common acute bacterial dermo-hypodermitis with a high morbidity. Bacterial isolation yields from the lesions are low despite the strong local inflammation observed, raising numerous questions abo...περισσότερα »

Making a Good (Ear) Impression: Setting Up a Successful Impression-Taking Protocol

Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες

Making a Good (Ear) Impression: Setting Up a Successful Impression-Taking Protocol: There is a need to be skilled at taking impressions for a number of reasons. One of those is the opportunity that lies in being able to be proficient at making ear impressions. The opportunity to provide custom solutions for your patient in a non-custom world is one of the key benefits of being skilled and proficient at making ear impressions. The opportunity to demonstrate your professionalism through the care and effort that it takes to provide the best impression of anatomy, ear texture, and desire... περισσότερα »