Expression of MAGE-A1, -A9, -A11 in laryngeal squamous cell carcinoma and their prognostic significance: a retrospective clinical study.

Expression of MAGE-A1, -A9, -A11 in laryngeal squamous cell carcinoma and their prognostic significance: a retrospective clinical study.

Acta Otolaryngol. 2016 Jan 14;:1-8

Authors: Liu S, Sang M, Xu Y, Gu L, Liu F, Shan B

Abstract
Conclusion The melanoma-associated antigens A1, -A9, -A11 (MAGE-A1, -A9, -A11) are relatively tumor-specific in laryngeal squamous cell carcinoma (LSCC), and could be ideal antigens for LSCC immunotherapy. In addition, MAGE-A9 probably is a poor prognostic marker for LSCC patients. Objective The MAGE-A family belongs to Cancer/testis antigens (CTA). However, the expression pattern of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC is still unclear. This study aims to evaluate the expression and possible prognostic role of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC patients. Methods The expression of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC specimens was investigated by immunohistochemistry, and the association of their expression and the clinical parameters and the survival of LSCC patients were analyzed by chi-square test, Kaplan-Meier survival and Cox regression analysis. Results The expression rates of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC were 54.7%, 46.2%, and 51.9%, respectively. The expression of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC was correlated with clinical stage, lymph node metastasis, and tumor size. The overall survival of LSCC patients with positive MAGE-A1, MAGE-A9, or MAGE-A11 expression was lower than the patients without MAGE-A1, MAGE-A9, or MAGE-A11 expression. Cox's multivariable analysis showed that MAGE-A9 expression was an independently poor prognostic factor for LSCC patients.

PMID: 26766421 [PubMed - as supplied by publisher]

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Deafness gene mutations in newborns in Beijing.

Deafness gene mutations in newborns in Beijing.

Acta Otolaryngol. 2016 Jan 14;:1-5

Authors: Han S, Yang X, Zhou Y, Hao J, Shen A, Xu F, Chu P, Jin Y, Lu J, Guo Y, Shi J, Liu H, Ni X

Abstract
Objective To determine the incidence of congenital hearing loss (HL) in newborns by the rate of deafness-related genetic mutations. Design Clinical study of consecutive newborns in Beijing using allele-specific polymerase chain reaction-based universal array. Study sample This study tested 37 573 newborns within 3 days after birth, including nine sites in four genes: GJB2 (35 del G, 176 del 16, 235 del C, 299 del AT), SLC26A4 (IVS7-2 A > G, 2168 A > G), MTRNR1 (1555 A > G, 1494 C > T), and GJB3 (538 C > T). The birth condition of infants was also recorded. Results Of 37 573 newborns, 1810 carried pathogenic mutations, or 4.817%. The carrier rates of GJB2 (35 del G, 176 del 16, 235 del C, 299 del AT), GJB3 (538 C > T), SLC26A4 (IVS7-2 A > G, 2168 A > G), and MTRNR1 (1555 A > G, 1494 C > T) mutations were 0.005%, 0.104%, 1.924%, 0.551%, 0.295%, 0.253%, 1.387%, 0.024%, and 0.274%, respectively. Logistic regression analysis indicated no statistically significant relationship between mutations and infant sex, premature delivery, twin status, or birth weight. Conclusions The 235delC GJB2 mutation was the most frequent deafness-related mutation in the Chinese population. Genetic screening for the deafness gene will help detect more cases of newborn congenital HL than current screening practices.

PMID: 26766211 [PubMed - as supplied by publisher]

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[Surgical treatement by intracapsular enucleation of cervical peripheral neural sheath tumors].

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[Surgical treatement by intracapsular enucleation of cervical peripheral neural sheath tumors].

Rev Laryngol Otol Rhinol (Bord). 2015;136(1):45-7

Authors: Raguin T, Alhabib SF, Schultz P, Dupret-Bories A

Abstract
Schwannomas and neurofibromas are benign tumors of the peripheral neural sheath tumors (PNST), representing 5% of soft tissue tumors. Cervical PNST are mainly located on the vagus nerve or in the sympathetic nervous system. The treatment is based on a tumor resection with preservation of nerve function. Classical surgery consists in total tumor removal after dissection of the nerve and is frequently complicated by nerve paralysis. The authors describe a simpler surgical technique consisting in a resection of the intracapsular enucleation of PNST that can limit the risk of nerve injury without increasing recidivism. The description of this surgical technique is illustrated by its use in a type I neurofibromatosis patient with a large vagal nerve neurofibroma.

PMID: 26749606 [PubMed - in process]

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Recurrent mandibular ameloblastoma with anterior skull base invasion: Case report.

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Recurrent mandibular ameloblastoma with anterior skull base invasion: Case report.

Rev Laryngol Otol Rhinol (Bord). 2015;136(1):41-3

Authors: Santini L, Varoquaux A, Giovanni A, Dessi P, Michel J

Abstract
Recurrent ameloblastoma with skull base invasion is a rare clinical entity with poor prognosis. We report a case of a mandibular ameloblastoma recurrence involving the anterior skull base. The diagnostic and therapeutic processes are presented with emphasis on the radiologic features of ameloblastoma. Another aim of this case report is to underline the importance of close and long-term follow-up after resection. Ameloblastoma recurrences are frequent and mainly occur after incomplete surgical resection. These recurrences may be diagnosed late because of lack of symptoms in the mandibular area.

PMID: 26749605 [PubMed - in process]

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[The silent sinus syndrome: A reconstruction of the orbital floor with Medpor implant].

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[The silent sinus syndrome: A reconstruction of the orbital floor with Medpor implant].

Rev Laryngol Otol Rhinol (Bord). 2015;136(1):37-40

Authors: Clarós P, Ahmed H, Minka Ngom EG, Clarós A

Abstract
INTRODUCTION: The silent sinus syndrome (SSS) is a rare clinical entity in both ENT and ophthalmology. It is characterized by enophthalmos and ptosis associated with a reduction in pressure in the maxillary sinus caused by chronic hypoventilation. The objective of this study was to demonstrate the importance of maxillary hypoplasia whether congenital or acquired in this disease, and the use of Medpor implant for reconstruction of the orbital floor.
MATERIAL AND METHODS: We report 3 cases of silent sinus syndrome proved clinically and radiologically. The first is a 45 year old male patient complaining of enophthalmos which occurred gradually, without any medical history; the second case is that of a woman of 39 years with a gradual onset enophthalmos, with a history of sinusitis; the third case, a man of 25 years who had a history of nasal trauma and consults for enophthalmos and diplopia.
RESULTS: Endoscopic surgery is performed quickly allowing a disappearance of enophthalmos and diplopia. All patients underwent a reconstruction of the orbital floor with a Medpor implant fixed by miniplates without complications.

PMID: 26749604 [PubMed - in process]

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Audiological comparison between two different clips prostheses in stapes surgery.

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Audiological comparison between two different clips prostheses in stapes surgery.

Rev Laryngol Otol Rhinol (Bord). 2015;136(1):33-6

Authors: Potena M, Portmann D, Guindi S

Abstract
OBJECTIVES: To compare audiometric results and complications of stapes surgery with two different types of piston prosthesis, the Portmann Clip Piston (Medtronic) (PCP) and the Soft Clip Piston (Kurz) (SCP).
MATERIAL AND METHODS: Study conducted on 64 patients who underwent primary stapedotomy from 2008 to 2011. We matched for each case of stapedotomy with the PCP (Medtronic Xomed Inc. Portmann Clip Piston Stainless Steel/Fluoroplastic) a case with the SCP (Heinz Kurz GmbH Medizintechnik Soft Piston Clip Titanium). Each group consisted of 32 patients, and patients in both groups were matched with respect to gender, age, bilateral or unilateral otosclerosis, otological symptoms (tinnitus, vertigo or dizziness), family history, operated side and the Portmann grading for otosclerosis. The length of the prosthesis used was reported. Post-operative complications such as tinnitus, vertigo, hearing loss and altered taste were documented. Each patient was subjected to a preoperative and postoperative audiogram (follow-up at the second month after the surgery). We used the Student test for statistical analysis. Statistical significance was set at < 0.01.
RESULTS: None of the patients experienced a post-operative hearing loss and none required a later revision surgery. No statistically significant difference was found between the two populations regarding demographic data (age, sex, side, bilaterality, family history, stage and lenght of piston) and hearing level (> 0.01) in the air, bone conduction and air-bone gap (ABG). Postoperative complications did not result to be significantly different between the two groups. Also, both groups showed a significant improvement (< 0.01) in the post-operative air, bone conduction and air-bone gap. There was no statistically significant difference (> 0.01) between the post-operative hearing results (bone conduction, air conduction, air-bone gap) using the two pistons. The mean ABG improvement was respectively 16.63 dB in the SCP group and 20.59 dB in the PCP group.
CONCLUSION: The titanium Soft clip piston (SCP) is a good alternative to the Portmann clip piston (PCP). Nevertheless there are some differences in the surgical fixing of these two pistons in the correct position.

PMID: 26749603 [PubMed - in process]

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Vestibular disorders in Bell's palsy: A prospective study.

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Vestibular disorders in Bell's palsy: A prospective study.

Rev Laryngol Otol Rhinol (Bord). 2015;136(1):29-31

Authors: Santos MA, Vianna MF, Nishino LK, Lazarini PR

Abstract
OBJECTIVES: To ascertain the prevalence of vestibular abnormalities in individuals with Bell's palsy (BP) compared with a normal population and to correlate these findings with clinical evolution.
METHOD: A prospective study involving 120 individuals submitted to computerized vector-electronystagmography (VENG) was conducted. The sample included 60 BP patients and 60 control subjects, matched for gender and age.
RESULTS: Twenty-five percent of the Bell's palsy patients had results consistent with deficient peripheral vestibular syndrome. All exams were normal in the control group (p< 0.001). No relationship between vestibular abnormalities and degree of palsy improvement was observed.
CONCLUSION: Patients with Bell's palsy exhibited 25% vestibular abnormalities on vector- electronystagmography exams. Vestibular abnormalities were more frequent in patients with BP compared to normal control individuals. No relationship between vestibular abnormalities and degree of palsy improvement was observed.

PMID: 26749602 [PubMed - in process]

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Vestibular neuritis: Evaluation and effect of vestibular rehabilitation.

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Vestibular neuritis: Evaluation and effect of vestibular rehabilitation.

Rev Laryngol Otol Rhinol (Bord). 2015;136(1):21-7

Authors: Lorin P, Donnard M, Foubert F

Abstract
UNLABELLED: Vestibular neuritis (VN) is a caloric vestibular areflexia that occurs suddenly, and whose compensation can take several weeks, sometimes several months. Usually these patients are rehabilitated, but the most affected patients (cervical vestibular evoked myogenic potential (cVEMP) absent) have a worse prognosis of vestibulo-ocular compensation. Thanks to symptomatic, videographic and posturographic evaluation tools, we objectify and quantify which factors influence the recovery or more accurately the compensation of this type of disorder. EQUIPMENT AND METHOD: We have colligated 34 observations of VN whose beginning could be precisely dated. These 34 unilateral caloric areflexic patients had a symptomatic evaluation (SE) with scales (vertigo symptom scale, dizziness handicap inventory, short form 36), an evaluation of the vestibulo-ocular reflex (VOR) (spontaneous nystagmus, head shaking test, mastoid bone skull vibration test, and finally an evaluation of the vestibulo-spinal function (VSF) on a dynamic posturography platform (DPY). On the other hand were evaluated eight elements supposed to influence (influence factors FI) the care and/or the outcome of the treatment (age, cVEMP absent, duration of deficiency, sports and walk practice, rehabilitation of VOR, rehabilitation of VSF, waiting period before application of rehabilitation, vertigo medications treatment).
RESULTS: By comparing averages and with a Fischer's exact test, we can show here that the medical treatment, the waiting period before the application of the rehabilitation, the number of rehabilitation sessions or the type of rehabilitation influence only partially the state of health of neuritis. The age of the patients and absent cVEMP don't have a major influence either. However, patients with the most important physical activity feel better from a symptomatic point of view, over a long period after the episode. The effect of rehabilitation might be temporary if daily activity is minimal.
CONCLUSION: The evaluation of the vestibulo-ocular reflex has long remained the main element for the evaluation of the state of health of vestibular neuritis. But if you use in addition posturography and symptomatic scales to assess the state of health, the neuritis considered to be compensated with the VOR will not always be symptomatically compensated. Estimating the functional recovery of neuritis can't be limited to estimating or quantifying the VOR. Rehabilitating neuritis can't be limited to rehabilitating the VOR. Finally we show here that physical activity is probably more necessary than any type of rehabilitation.

PMID: 26749601 [PubMed - in process]

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[Functional comparison of the voice quality after either open conservative surgery or only radiotherapy for early glottic carcinoma].

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[Functional comparison of the voice quality after either open conservative surgery or only radiotherapy for early glottic carcinoma].

Rev Laryngol Otol Rhinol (Bord). 2015;136(1):17-20

Authors: El Ouakif F, Veresezan O

Abstract
OBJECTIVES: The aim of this article is to compare the functional results after open conservative surgery versus radiotherapy alone in the management of early glottic carcinoma using the Voice Handicap Index questionnaire (VHI).
METHODS: Retrospective study was done using VHI for evaluation of 37 patients treated either by open conservative surgery or radiotherapy in T1-T2N0M0 glottic laryngeal carcinoma.
RESULTS: 19 patients were treated with radiotherapy. The overall survival rate and disease free after 5 years were 91.3%. The functional result was mild in 89%. 18 patients were treated surgically. The overall survival rate and disease free after 5 years were 93.1% and 95.4% respectively. The functional result was mild in 61% after surgery.
CONCLUSION: Radiotherapy alone seems to provide better functional results than partial surgery in T1-T2 glottic tumors.

PMID: 26749600 [PubMed - in process]

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[Covering of parotid and cervical lymph nodes metastasis of cutaneous squamous cell carcinoma of the head, about 18 cases].

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[Covering of parotid and cervical lymph nodes metastasis of cutaneous squamous cell carcinoma of the head, about 18 cases].

Rev Laryngol Otol Rhinol (Bord). 2015;136(1):9-15

Authors: Vatin L, Morvan JB, Rivière D, Okremchouk I, Abed S, Verdalle P

Abstract
AIM: To describe 18 cases of patients treated for advanced cutaneous squamous cell carcinoma (CSCC) of the head metastasing to cervical lymph nodes and parotid gland. To estimate their survival and the risk factors of metastases.
PATIENTS AND METHODS: 18 cases of patients affected by CSCC of the head, metastatic to parotid and cervical lymph nodes were afterward analyzed. Two populations were differentiated: the patients already treated for their CSCC, with secondary appearance of metastases in the Population A, the patients by whom the metastase is concomitantly discovered to the CSCC in the Population B.
RESULTS: The treatment consisted of a parotidectomy and neck dissection, possibly associated with excision of the primary tumour. Adjuvant radiotherapy was systematic. Metastatic progression was on lungs most of the time (57%), in patients of the population B (80%), or of whom primitive CSCC was of bad forecast (group 2) (78%). The mortality was bound to the complications induced by distant metastases (63%), at 5 years it was superior in the population B (100%) than in the population A (77%).
CONCLUSION: CSCC of the head, metastatic to parotid and cervical lymph nodes have a severe prognosis for survival in spite of an optimal curative treatment applied to fragile old patients.

PMID: 26749599 [PubMed - in process]

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INCREASING THE UPPER AIRWAY SPACE USING ORAL APPLIANCES IN PATIENTS WITH MILD SLEEP APNOEA CAUSED BY STOMATOGNATHIC DYSFUNCTIONS.

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INCREASING THE UPPER AIRWAY SPACE USING ORAL APPLIANCES IN PATIENTS WITH MILD SLEEP APNOEA CAUSED BY STOMATOGNATHIC DYSFUNCTIONS.

Ann Acad Med Stetin. 2014;60(2):74-9

Authors: Ey-Chmielewska H, Teul I, Lorkowski J

Abstract
INTRODUCTION: Abnormal breathing can be caused by developmental malformations or anatomical variations in the upper airways. Stomatognathic diseases may significantly impair the patency of the upper respiratory tract. Treatment of advanced stomatognathic dysfunctions is difficult due to their multifactorial aetiology, and often involves many phases. Sleep apnoea is one of the most bothersome complications. The mainstay therapeutic strategy relies on modifying the position of the mandible against the maxilla, achieved by using different types of oral appliances.
MATERIAL AND METHODS: The study was carried out in 2006-2010 on 92 patients (mean age 42.5 years) with diagnosed advanced dysfunction of the stomatognathic system. The treatment relied on the use of an orthodontic appliance (54 patients) or combined multi-phase therapy with splints used in the first phase (22 patients). Two different appliances were used (one of them was modified by the authors). Parameters assessed in the study included time to resolution of pain, reduction in the incidence of sleep apnoea, and improvement in nasal breathing.
RESULTS: Change in the protrusion of the mandible not only relieved problems with the stomatognathic system, but also improved breathing in patients. The use of modified oral appliances reduced treatment duration and improved patients' comfort. Therefore, it may be useful in the treatment of patients with mild sleep apnoea.

PMID: 26591113 [PubMed - indexed for MEDLINE]

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Characteristics of a Dysphonic Population Referred for Voice Assessment and/or Voice Therapy.

Characteristics of a Dysphonic Population Referred for Voice Assessment and/or Voice Therapy.

Folia Phoniatr Logop. 2016 Jan 15;67(4):178-186

Authors: De Bodt M, Van den Steen L, Mertens F, Raes J, Van Bel L, Heylen L, Pattyn J, Gordts F, van de Heyning P

Abstract
OBJECTIVE: The aim of this study was to define patient characteristics of a dysphonic population in terms of voice disorder, gender, age, and subjective and objective vocal parameters and to explore the relevant characteristics of the most frequent groups of voice disorders.
PATIENTS AND METHODS: Patient records from 4,447 subjects referred for voice assessment and/or voice therapy were analyzed.
RESULTS: Significantly more cases of dysphonia were structural as compared to nonstructural. This significant difference was found in almost all age groups. Significantly more women were diagnosed with dysphonia than men. The most common symptom was light-to-moderate hoarseness. The average voice handicap index was 31 and the average dysphonia severity index was -0.6. Vocal fold nodules (VFN), functional voice disorders (FVD) and vocal fold paralysis (VFP) were the three most frequently diagnosed vocal pathologies and were analyzed in detail. Women were found to be significantly more vulnerable to FVD, VFN and cysts, whereas men were significantly more often diagnosed with carcinoma, hyperkeratosis, laryngitis, papillomatosis, presbyphonia, puberphonia and VFP.
CONCLUSIONS: The results of this study allow a better estimation of the clinical needs and costs for a specific dysphonic population looking for help and highlight the gender-related risks of specific voice disorders.

PMID: 26766133 [PubMed - as supplied by publisher]

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