An Unusual Case of a Pharyngeal Fistula to the Cervical Spine Causing Osteomyelitis

xlomafota13 shared this article with you from Inoreader An Unusual Case of a Pharyngeal Fistula to the Cervical Spine Causing Osteomyelitis Via ear nose throat Ear Nose Throat J. 2021 Jul 5:1455613211029773. doi: 10.1177/01455613211029773. Online ahead of print. ABSTRACT SIGNIFICANCE STATEMENT: Pharyngeal fistulas to the cervical spine resulting in vertebral osteomyelitis are a rare, yet clinically important, complication of total laryngectomy performed in conjunction with chemoradiotherapy or radiation therapy. This complication is likely underdiagnosed and can have a high mortality rate. It is very important that clinicians are a ware of this complication as early diagnosis and management may improve patient outcomes. PMID:34219496 | DOI:10.1177/01455613211029773 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Simultaneous Sudden Hearing Loss and Peripheral Facial Paralysis in a Patient With Covid-19

xlomafota13 shared this article with you from Inoreader Simultaneous Sudden Hearing Loss and Peripheral Facial Paralysis in a Patient With Covid-19 Via ear nose throat Ear Nose Throat J. 2021 Jul 5:1455613211028094. doi: 10.1177/01455613211028094. Online ahead of print. ABSTRACT Although peripheral facial paralysis and sudden sensorineural hearing loss are not as common as anosmia, they are reported neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We present a 62-year-old, serologically COVID-19 positive woman with seventh and eighth nerve involvement showed electrophysiologically with Auditory B rainstem Response and electroneurography and radiologically with internal acoustic canal magnetic resonance imaging. This single case report suggests a possible association between the SARS-CoV-2 infection with simultaneous sudden sensorineural hearing loss and isolated facial paralysis. However, further studies are needed to determine whether this relationship is coincidental or occasional. PMID:34219500 | DOI:10.1177/01455613211028094 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Atypical Carcinoid of the Larynx: A Case Report

xlomafota13 shared this article with you from Inoreader Atypical Carcinoid of the Larynx: A Case Report Via ear nose throat Ear Nose Throat J. 2021 Jul 5:1455613211024868. doi: 10.1177/01455613211024868. Online ahead of print. ABSTRACT Neuroendocrine carcinomas are a spectrum of rare and highly heterogeneous malignant tumors. Neuroendocrine carcinomas mainly arise from neuroendocrine cells scattered throughout the body. They mainly occur in the lung and gastrointestinal tract. Atypical carcinoid of the larynx is a rare type of neuroendocrine carcinoma, which is easily misdiagnosed as hemangioma i n appearance. We mainly feature the disease to you through the diagnosis and treatment of a case of atypical carcinoid of the larynx. PMID:34219499 | DOI:10.1177/01455613211024868 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effect of Methimazole Therapy on Thyroid Pathohistology That May Mimic Thyroid Malignancy

xlomafota13 shared this article with you from Inoreader Effect of Methimazole Therapy on Thyroid Pathohistology That May Mimic Thyroid Malignancy Via radioactive iodine Acta Clin Croat. 2020 Jun;59(Suppl 1):146-148. doi: 10.20471/acc.2020.59.s1.19. ABSTRACT Diffuse toxic goiter, as the most common cause of hyperthyroidism, is usually initially treated with thyrostatic drugs such as methimazole, followed by radioiodine therapy or surgery which may be indicated as definitive treatment. Radioactive iodine therapy has a known association with various histopathologic features including cytologic atypia, but herein we present a rare example of morpholog ical thyrocyte changes induced by long-term pharmacological treatment with methimazole that mimicked thyroid malignancy in a pathohistological sample. PMID:34219897 | PMC:PMC8212614 | DOI:10.20471/acc.2020.59.s1.19 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma

xlomafota13 shared this article with you from Inoreader Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma Via radioactive iodine Case Rep Endocrinol. 2021 Jun 11;2021:3024639. doi: 10.1155/2021/3024639. eCollection 2021. ABSTRACT Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy may exacerbate TAO. Here, we present the case of a 67-year-old-woman treated with RAI therapy for metastatic follicular thyroid carcinoma who presented with TAO during the course of sorafenib administration. Tg and TgAb levels were gradually decreased with sorafenib and lenvatinib treatment, and TAO was improved without any ophthalmologic treatment. PMID:34221517 | PMC:PMC8213507 | DOI:10.1155/2021/3024639 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extent of Surgery and the Prognosis of Unilateral Papillary Thyroid Microcarcinoma

xlomafota13 shared this article with you from Inoreader Extent of Surgery and the Prognosis of Unilateral Papillary Thyroid Microcarcinoma Via radioactive iodine Front Endocrinol (Lausanne). 2021 Jun 16;12:655608. doi: 10.3389/fendo.2021.655608. eCollection 2021. ABSTRACT It remains controversial whether patients with papillary thyroid microcarcinoma (PTMC) benefit from total thyroidectomy (TT) or thyroid lobectomy (TL). We aimed to investigate the impact of extent of surgery on the prognosis of patients with unilateral PTMC. Patients were obtained from the Surveillance, Epidemiology, and End Results database from 2004 to 2015. Cancer-speci fic survival (CSS) and overall survival (OS) were evaluated by Cox regression and Kaplan-Meier curves with propensity score matching. Of 31167 PTMC patients enrolled, 22.2% and 77.8% of which underwent TL and TT, respectively. Patients with TT were more likely to be younger, females, present tumors of multifocality, extrathyroidal extension, cervical lymph node metastasis (CLNM), distant metastasis, and receive radioactive iodine (RAI) compared with those receiving TL. The multivariate Cox regression model showed that TT was not associated with an improved CSS and OS compared with TL with hazard ratio (HR) and 95% confidence interval (CI) of 0.53 (0.25-1.12) and 0.86 (0.72-1.04), respectively. In addition, the Kaplan-Meier curves further confirmed the similar survival between TL and TT after propensity score matching. The subgroup analysis showed that TT was associated with better CSS for patients < 55 years, those with tumors of gross extrathyroidal extension, CLNM (N1b), and ca ses not receiving RAI with HR 95% CI of 0.13 (0.02-0.81), 0.12 (0.02-0.66), 0.11 (0.02-0.64) and 0.36 (0.13-0.90), respectively. TT predicted a trend of better OS for patients with N1b and distant metastasis after adjustment. In addition, TT was associated with better CSS than TL for patients with risk factors like N1b combined with gross extrathyroidal extension, and/or multifocality after matching. In conclusion, TL may be enough for low-risk PTMC patients. TT may improve the prognosis of unilateral PTMC patients with 2 or more risk clinicopathologic factors like CLNM, multifocality, extrathyroidal extension and a younger age compared with TL. PMID:34220708 | PMC:PMC8242954 | DOI:10.3389/fendo.2021.655608 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

PVR-AFM: A Pathological Voice Repair System based on Non-linear Structure

xlomafota13 shared this article with you from Inoreader PVR-AFM: A Pathological Voice Repair System based on Non-linear Structure Via Journal of Voice Speech signal processing has become an important technique to ensure that the voice interaction system communicates accurately with the user by improving the clarity or intelligibility of speech signals. However, most existing works only focus on whether to process the voice of average human but ignore the communication needs of individuals suffering from voice disorder, including voice-related professionals, older people, and smokers. To solve this demand, it is essential to design a non-invasive repair system that processes pathological voices. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Risk stratification in differentiated thyroid cancer with RAI-avid lung metastases

xlomafota13 shared this article with you from Inoreader Risk stratification in differentiated thyroid cancer with RAI-avid lung metastases Via radioactive iodine Endocr Connect. 2021 Jul 1:EC-21-0215.R1. doi: 10.1530/EC-21-0215. Online ahead of print. ABSTRACT OBJECTIVE: Radioactive iodine (RAI) therapy is effective for differentiated thyroid cancer (DTC) patients with lung metastasis. However, some patients have poor prognosis despite the RAI accumulation. The utility of inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), has been reported as a prognostic factor for many carcinomas. This study aimed to investigate the risk factors related to DTC patient survival with RAI-avid lung metastasis and to attempt risk stratification. DESIGN AND METHODS: This retrospective study included 123 patients with RAI-accumulating lung metastatic DTC. The cause-specific survival (CSS) rate from the time of detection of lung metastasis was tested using the Kaplan-Meier log-rank test, and the multivariate analysis was calculated using the Cox proportional hazards model. NLR was retrospectively calculated using the blood sample collected before initial RAI treatment. The NLR cutoff value was 2.6 on the ROC curve. RESULTS: Age ≥55 years at time of operative treatment, follicular carcinoma, lung metastasis tumor ≥10 mm in diameter, age ≥55 years at the time of detection of lung metastasis, age ≥55 years at the time of RAI treatment, and NLR ≥2.6 at the initial RAI treatment were predictive of decreased CSS. Multivariate analysis identified that the independent prognostic factors were lung metasta tic tumor ≥10 mm in diameter and NLR ≥2.6. Patients in the high-risk group with both factors had significantly lower CSS rates than those in the low- and intermediate-risk groups with one or none of these factors. CONCLUSIONS: The high-risk group patients had significantly poorer survival, and these patients could be considered as future candidates for tyrosine kinase inhibitor therapy. PMID:34223823 | DOI:10.1530/EC-21-0215 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cochlear Implant in Klippel-Feil Syndrome: Challenges and Concerns

xlomafota13 shared this article with you from Inoreader Cochlear Implant in Klippel-Feil Syndrome: Challenges and Concerns Via Otolaryngology Indian Abstract Cochlear implantation (CI) can be safely performed in patients with syndromic hearing loss. Here we present a case of CI in a child with Klippel-Feil syndrome with various skeletal, extraskeletal, cochleovestibular and Arnold-Chiari malformations. Multidisciplinary approach and good preoperative imaging play a key role in planning for surgery. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A single centre's experience of 23 cases of total rhinectomy for the treatment of squamous cell carcinoma involving the nasal vestibule

xlomafota13 shared this article with you from Inoreader A single centre's experience of 23 cases of total rhinectomy for the treatment of squamous cell carcinoma involving the nasal vestibule Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Jul 5. doi: 10.1007/s00405-021-06972-6. Online ahead of print. ABSTRACT PURPOSE: This study aims to analyse the oncological outcomes of total rhinectomy (TR) for squamous cell carcinomas (SCCs) involving the nasal vestibule, and to identify prognostic factors for disease recurrence. METHODS: A retrospective single-centre study was conducted between September 2003 and February 2021 including all patients who underwent a TR for a SCC involving the nasal vestibule. RESULTS: 23 patients were included in the study. Tumours originated from the anterior septum (n = 12), vestibule (n = 8) or skin (n = 3). Six TRs (26.1%) were salvage procedures, after primary radiotherapy or partial rhinectomy. Seven patients had a concurrent neck dissection and 17 patients (73.9%) received adjuvant treatment (14 patients had radiotherapy and 3 had chemoradiotherapy). After a median follow-up of 32 months, six patien ts (26.1%) presented with tumour recurrence. Three patients (13%) had nodal-only recurrence. The estimated 5-year overall survival, disease-free survival and disease-specific survival were 67.5%, 66.3% and 80.7%, respectively. Positive excision margins were a predictive factor for tumour recurrence (p = 0.0401). CONCLUSION: For SCCs involving the nasal vestibule that are not amenable to limited surgical resection, TR along with adjuvant radiotherapy provide good oncological outcomes and should be considered the main treatment option. PMID:34223976 | DOI:10.1007/s00405-021-06972-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

JianpiQinghua granule reduced PPI dosage in patients with nonerosive reflux disease: A multicenter, randomized, double-blind, double-dummy, noninferiority study

xlomafota13 shared this article with you from Inoreader JianpiQinghua granule reduced PPI dosage in patients with nonerosive reflux disease: A multicenter, randomized, double-blind, double-dummy, noninferiority study Via Traditional dysphagia therapy Phytomedicine. 2021 Jul 15;88:153584. doi: 10.1016/j.phymed.2021.153584. Epub 2021 May 3. ABSTRACT BACKGROUND: Proton pump inhibitors (PPIs) play an important role in the treatment of nonerosive reflux disease (NERD), but their long-term and excessive uses have been associated with safety concerns. Chinese herbal medicine (CHM) has become a popular alternative treatment for this condition. METHODS: A total of 204 patients were randomly assigned to the combination group or PPI group (1:1 ratio). They were given JianpiQinghua (JQ) granules (34.8 g) plus omeprazole (10 mg) plus dummy omeprazole (10 mg) or dummy JQ granules (34.8 g) plus omeprazole (20 mg) daily for 4 weeks. The primary endpoints were the rate of sufficient relief and complete resolution of GERD Q at week 4. Metabonomics and the gut microbiota were also assessed. RESULTS: Complete resolution was observed in 40.8% of patients in the combination group and 26.8% of patie nts in the PPI group after 4 weeks (FAS analysis, OR, 1.88; 95% CI, 1.03-3.44; p = 0.039). Sufficient relief was observed in 50% of patients in the combination group and 43.30% of patients in the PPI group after 4 weeks (FAS analysis, OR, 1.31; 95% CI, 0.74-2.30; p = 0.35). Three patients had liver dysfunction, one of whom had a mild case and 2 of whom had moderate-to-severe cases in the combination group. Patients in the combination group showed a significant increase in richness and diversity of their gut microbiota compared with those in the PPI group. Metabonomics showed that the combination therapy could correct the glutamate metabolism pathway. CONCLUSION: Our findings demonstrate the superior efficacy of JQ granules combined with omeprazole (10 mg) vs. omeprazole (20 mg) in terms of symptom relief in patients with NERD. TRIAL REGISTRATION: ClinicalTrials.gov number NCT02892357. Registered on 14 February 2019. PMID:34119741 | DOI:10.1016/j.phymed.2021.153584 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.