Management of poor-risk metastatic renal cell carcinoma: current approaches, the role of temsirolimus and future directions
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1lkGUDB via IFTTT
Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy
Abstract Background Whole brain radiation therapy (WBRT) is widely used for the treatment of brain metastases. Cognitive decline and alopecia are recognized adverse effects of WBRT. Recently hippocampus sparing whole brain radiation therapy (HS-WBRT) has been shown to reduce the incidence of memory loss. In this study, we found that multi-field intensity modulated radiation therapy (IMRT), with strict constraints to the brain parenchyma and to the hippocampus, reduces follicular scalp dose and prevents alopecia. Methods Suitable patients befitting the inclusion criteria of the RTO...περισσότερα »
Prognostic indices in stereotactic radiotherapy of brain metastases of non-small cell lung cancer
Abstract Background Our purpose was to analyze the long-term clinical outcome and to identify prognostic factors after Linac-based stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) on patients with brain metastases (BM) from non-small cell lung cancer (NSCLC). Materials and Methods We performed a retrospective analysis of survival on 90 patients who underwent SRS or FSRT of intracranial NSCLC metastases between 04/2004 and 05/2014 that had not undergone prior surgery or whole brain radiotherapy (WBRT) for BM. Follow-up data was analyzed until May 201... περισσότερα »
A prospective study of nomogram-based adaptation of prostate radiotherapy target volumes
Abstract Background A prospective clinical trial was conducted to evaluate the feasibility of a novel approach to the treatment of patients with high risk prostate cancer (HRPC) through the use of a nomogram to tailor radiotherapy target volumes. Methods Twenty seven subjects with HRPC were treated with a mildly hypofractionated radiotherapy regimen using image-guided IMRT technique between Jun/2013-Jan/2015. A set of validated prognostic factors were inputted into the Memorial-Sloan-Kettering Cancer Center (MSKCC) prostate cancer nomogram to estimate risk of loco-regional spread...περισσότερα »
Non-invasive molecular imaging of inflammatory macrophages in allograft rejection
Abstract Background Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We therefore decided to image in vivo sialoadhesin (Sn, Siglec 1 or CD169) using anti-Sn mAb (SER-4) directly radiolabelled with 99mTc pertechnetate. Methods We used a heterotopic heart transplantation model where allogeneic or syngeneic heart grafts were trans... περισσότερα »
The Multidisciplinary Management of Cancer in Daily Clinical Practice: Towards a Community Hospital Comprehensive Cancer Center
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hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer
Abstract The objective of the study was to investigate the role of hcrcn81 gene in Wnt/β-catenin signaling pathway related to human colorectal cancer. A total of 30 pairs of human colorectal cancer tissues with control normal tissues were analyzed by qRT-PCR. The proliferation, apoptosis, cell cycle, cell colony and metastasis of LS174T−hcrcn81, HCT116−hcrcn81, LoVo+hcrcn81 and SMMC-7721+hcrcn81 cells were tested, of which hcrcn81 was knockdown in LS174T, HCT116 cells and hcrcn81 was overexpressed in LoVo, SMMC-7721 cells. Besides, the mRNA and protein levels of hcrcn81, β-catenin,...περισσότερα »
Cardiovascular medication after cancer at a young age in Finland: A nationwide registry linkage study
Abstract Despite improved survival rates, childhood and young adult (YA) cancer survivors face elevated risks for life-threatening morbidities, especially cardiovascular complications. Our nationwide Finnish registry study investigated the purchases of cardiovascular medication from 1993 to 2011 in patients diagnosed with cancer aged below 35 years (N=8,197) between 1993 and 2004 compared to siblings (N=29,974) via linkage to the drug purchase registry. The cumulative incidence for purchasing cardiovascular medications was higher in childhood and YA cancer patients compared to sib... περισσότερα »
Decreased expression of BRCA1-associated protein 1 predicts unfavorable survival in gastric adenocarcinoma
Abstract BRCA1-associated protein 1 (BAP1) has been reported as a novel tumor suppressor, while in gastric adenocarcinoma, the function of this protein was still await to be uncovered. Based on a large group of patients with gastric adenocarcinoma, our study aimed to have a further understanding about the correlation of BAP1 expression and patients' clinical outcomes. We performed quantitative PCR and Western blot to examine BAP1 expression in 38 cases of gastric adenocarcinoma samples and adjacent non-cancerous tissues. Immunochemistry was used to evaluate BAP1 expression in a lar... περισσότερα »
Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance
Abstract Long noncoding RNA (lncRNA) is a kind of RNA that is longer than 200 nucleotides with limited or no protein-coding potential. Studies have proved that lncRNAs play important regulatory roles in gene expression and contribute to oncogenesis and cancer metastasis. However, the expression level of lncRNAs and their clinicopathologic significance in papillary thyroid carcinoma (PTC) have not been well studied. In this study, we investigated the expression level of a novel lncRNA NONHSAT037832 in PTC and paired noncancerous thyroid tissues as well as some cell lines by quantit...περισσότερα »
Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma
Abstract The CXC chemokine receptor 4 (CXCR4) has been reported to be involved in the development and progression of nasopharyngeal carcinoma (NPC). However, the role of CXCR4 in clinical outcome and prognosis of NPC patients remains controversial. In the present study, we investigated and reviewed the expression of CXCR4 in NPC tissues and then analyzed the definitive role of CXCR4 in clinical outcome and prognosis. Here, we found that the expression level of CXCR4 was significantly higher in NPC cancer specimens (61/98) than that in paired non-tumor tissues (*p* < 0.001). Togethe...περισσότερα »
Anti-tumor angiogenesis effect of a new compound: B-9-3 through interference with VEGFR2 signaling
Abstract B-9-3, a derivative of harmine, was first synthesized in our laboratory. We have reported that B-9-3 has an anti-proliferative effect against human lung cancer cells via induction of apoptosis and inhibition of cell migration. In the present study, we first studied that the anti-tumor angiogenesis effect and the molecular mechanism of B-9-3-induced tumor vascular degrade and mortify in lung cancer. In vitro, the results showed that B-9-3 selectively inhibited the proliferation of endothelial cells IC50 = 6.16 μg/ml) and vascular fibroblasts (IC50 = 12.59 μg/ml) and induce... περισσότερα »
The immunobiology of myeloid-derived suppressor cells in cancer
Abstract The tumor microenvironment is a complex and heterogeneous milieu in which multiple interactions occur between tumor and host cells. Immunosuppressive cells which are present in this microenvironment, such as regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs), play an important role in tumor progression, via down-regulation of antitumor responses. MDSCs represent a heterogeneous group of cells originated from the myeloid lineage that are in the immature state. These cells markedly accumulate under pathologic conditions, such as cancer, infection, and in... περισσότερα »
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma
Abstract Primary thyroid lymphoma (PTL) is a rare malignant thyroid tumor; its pathogenesis is closely related to chronic lymphocytic thyroiditis. The different pathological subtypes and stages of PTL have distinct clinical characteristics and prognosis, but the specific reasons are not clear. Wnt5a is a representative protein of non-canonical Wnt signaling. It plays an important role in many different types of tumors. This study is to explore the changes of Wnt5a and its receptor Ror2 in PTL development process and the clinical significance of their represent. We collected 22 PTL... περισσότερα »
Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells
Abstract Norcantharidin (NCTD) is currently used as an anticancer drug for the treatment of some malignant cancers. However, whether it may have therapeutic effects on glioblastoma multiforme (GBM) remains unknown. Moreover, the underlying mechanisms have not been completely elucidated. Recently, SUMO-specific protease 6 (SENP6) has been shown as a tumor suppressor in some cancers. Nevertheless, whether it is involved in the pathogenesis of GBM has not been examined. Here, we studied the effects of NCTD on GBM cells. We found that NCTD dose-dependently increased SENP6 protein, but... περισσότερα »
Influence of the interaction between long noncoding RNAs and hypoxia on tumorigenesis
Abstract The interaction between cancer and its microenvironment is crucial for survival and development of cancerous cells. Tumor microenvironment is usually under hypoxia, which promotes tumor aggressiveness like growth, angiogenesis, and metastasis. How cancer cells respond to hypoxia and the resultant impact on tumorigenesis are not yet fully explored. Long noncoding RNAs (lncRNAs) have been attracting more and more attention since their functions in regulating gene expression at chromatic, transcriptional, and posttranscriptional levels were found. lncRNAs are dysregulated in...περισσότερα »
Postoperative permanent pressure alopecia
Abstract A 49-year-old Chinese female underwent elective laparoscopic assisted Whipple's surgery lasting 12 h. This was complicated by postoperative pressure alopecia at the occipital area of the scalp. Pressure-induced hair loss after general anaesthesia is uncommon and typically temporary, but may be disconcerting to the patient. We report this case of postoperative permanent pressure alopecia due to its rarity in the anaesthesia/local literature, and review the risk factors for its development. from Anaesthesia via ola Kala on Inoreader http://ift.tt/1Nf2tAf via IFTTT
Pediatric anesthesia: current status and future directions
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Confirmation of tracheal intubation time in adult patients
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Justicia adhatoda L. (Acanthacées)
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Étude ethnobotanique, pharmacologique et phytochimique de quelques plantes médicinales congolaises à potentialité antitussive
Résumé Ce travail a permis d'ajouter au répertoire congolais les plantes à potentialités antitussives. L'enquête sur le terrain auprès des personnes ressources nous a permis de recenser 17 plantes dont le *Chenopodium ambrosioides* Lin (Chenoponaceae) et le *Erigeron floribundus* Kunth. qui ont été les plus citées. Les feuilles de *Chenopodium ambrosioides* Lin (Chenoponaceae) et de *Erigeron floribundus* Kunth. (Asteraceae) possèdent une activité antitussive. L'activité de ces plantes a été évaluée chez le cobaye en utilisant le modèle classique d'acide citrique. Le décocté de *Er...περισσότερα »
Phyto-aromathérapie de la bronchite chronique (BPCO)
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Complicated Intra-Abdominal Infections: The Old Antimicrobials and the New Players
Abstract Complicated intra-abdominal infections (cIAIs) are an important cause of morbidity and mortality worldwide. They are diagnosed when the initial abdominal organ infection has spread into the peritoneal space. Successful treatment relies on adequate source control and appropriate empiric antimicrobial therapy. Inappropriate antimicrobial therapy may result in poor patient outcomes and increases in healthcare costs. Current guidelines recommend several single and combination antimicrobial regimens; however, empiric antimicrobial treatment has been complicated by the increasin... περισσότερα »
Lacosamide: A Review in Focal Seizures in Patients with Epilepsy
Abstract Lacosamide (Vimpat®) is a functionalized amino acid available orally (as a solution or tablets) and as an intravenous infusion for use as monotherapy (only in the USA) or adjunctive therapy for the treatment of focal seizures in adult and adolescent (aged ≥17 years in the USA) patients with epilepsy. As adjunctive therapy to other antiepileptic drugs (AEDs), lacosamide provided effective seizure control and was generally well tolerated in adults and adolescents (aged ≥16 years) in randomized clinical trials and in the real-world setting. In clinical trials, adjunctive laco... περισσότερα »
Insulin Aspart in the Management of Diabetes Mellitus: 15 Years of Clinical Experience
Abstract Limiting excessive postprandial glucose excursions is an important component of good overall glycemic control in diabetes mellitus. Pharmacokinetic studies have shown that insulin aspart, which is structurally identical to regular human insulin except for the replacement of a single proline amino acid with an aspartic acid residue, has a more physiologic time–action profile (i.e., reaches a higher peak and reaches that peak sooner) than regular human insulin. As expected with this improved pharmacokinetic profile, insulin aspart demonstrates a greater glucose-lowering eff... περισσότερα »
Regulatory effects of ΔFosB on proliferation and apoptosis of MCF-7 breast cancer cells
Abstract Matrix metalloproteinase-9 (MMP-9) plays a vital role in tumor angiogenesis, cell migration, and invasiveness because it can degrade almost all basement membrane and extracellular matrix components. MMP-9 has been reported in many cancers including breast cancer, lung cancer, and colon cancer. ΔFosB in mammary epithelial cells has been shown to regulate cell proliferation, differentiation, and death. We found that ΔFosB increased the expression of MMP-9 in MCF-7 breast cancer cells. ΔFosB overexpression in MCF-7 cells increased cellular viability and decreased cell apopto...περισσότερα »
CD24 promotes HCC progression via triggering Notch-related EMT and modulation of tumor microenvironment
Abstract CD24 is known as a cell surface molecule in hematopoiesis and also described as a diagnostic marker for tumors. Previous studies suggested the important role of CD24 in hepatocellular carcinoma (HCC) pathogenesis. However, precise functions of CD24 in HCC are still unknown. Here, we found that CD24 is highly expressed in HCC both in mRNA and protein levels. Further, the epithelial-mesenchymal transition (EMT) and Notch1 signaling activations mediated by CD24 were elucidated as potential mechanisms of HCC promotion in Hepa1-6/Hepa1-6-CD24 cell models. Additionally, possible...περισσότερα »
MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation
Abstract Acute myeloid leukemia (AML) is a hematological malignant disorder. AML cells are not susceptible to chemotherapeutic drugs because of their multidrug resistance (MDR). Antitubulin agents are currently employed in cancer treatments; however, drug resistance results in treatment failures because of MDR1 expressing cancer cells. We previously synthesized a new tubulin inhibitor, 2-dimethylamino-*N*-[1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-acetamide (MPT0B169), which inhibits AML cell proliferation by arresting cell cycle at the G2/M phase. In this study, we ...περισσότερα »
The involvement of anterior gradient 2 in the stromal cell-derived factor 1-induced epithelial-mesenchymal transition of glioblastoma
Abstract In recent years, it has been widely identified that the stromal cell-derived factor 1 (SDF-1) and anterior gradient 2 (AGR2) were implicated in the development of epithelial-mesenchymal transition (EMT) in a variety of cancers. However, the involvement of SDF-1-AGR2 pathway in the EMT of glioblastoma has not been investigated. In the present study, the in vitro assays were used to investigate the role of AGR2 in cell cycle, migration, and invasion. We found that the expressions of AGR2 and chemokine (C-X-C motif) receptor 4 (CXCR4) were obviously upregulated in glioblasto... περισσότερα »
An extra-virgin olive oil rich in polyphenolic compounds has antioxidant effects in meat-type broiler chickens
Abstract The aim of this study was to extend the knowledge on the antioxidant effect of extra-virgin olive oil (EVOO) in the liver of broiler chickens not subjected to any form of insult. A total of 120 male broiler chickens (Hubbard strain) were divided into three groups and fed ad libitum with three isoenergetic diets from hatching until slaughter age (49 days) on a completely randomized design. The dietary treatments consisted of 2.5 % added oil or fat from three sources as follows: diet containing sunflower oil (SFO); diet containing lard (LRD), and diet containing extra-virgin... περισσότερα »
Évaluation d’un protocole de ré-introduction médicamenteuse chez l’enfant
Publication date: December 2015 *Source:*Annales de Dermatologie et de Vénéréologie, Volume 142, Issue 12, Supplement Author(s): A. Baron, A. Pipet, H. Colas, A. Magnan, C. Bernier IntroductionL'étiquette d'allergie médicamenteuse est très souvent posée chez l'enfant présentant une éruption cutanée en contexte infectieux. Le plus souvent, l'origine est virale. L'expérience montre qu'après bilan allergologique [tests cutanés puis test de provocation orale (TPO)], seul un faible pourcentage d'enfants s'avère réellement allergique. Il est donc important d'éliminer rapidement ce diagnos... περισσότερα »
EMMPRIN/CD147 est un biomarqueur pronostique indépendant dans le mélanome cutané
Publication date: December 2015 *Source:*Annales de Dermatologie et de Vénéréologie, Volume 142, Issue 12, Supplement Author(s): A. Caudron, M. Battistella, J.-P. Feugeas, C. Pages, N. Basset-Seguin, A. Sadoux, M.-P. Podgorniak, A. Janin, C. Lebbé, S. Mourah IntroductionEMMPRIN (Extracellular Matrix MetalloPRoteinase INducer) est un membre de la superfamille des immunoglobulines connu pour stimuler la dégradation des composants de la membrane basale en induisant la synthèse des MMPs (métalloproteinases matricielles). Il a été démontré que la protéine EMMPRIN est impliquée dans l'inv... περισσότερα »
Journées dermatologiques de Paris 2015
Publication date: December 2015 *Source:*Annales de Dermatologie et de Vénéréologie, Volume 142, Issue 12, Supplement Author(s): F. Caux from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1NewgZO via IFTTT
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