[The clinical aspects of HPV-positive cancer of the oral cavity and oropharynx].

Related Articles

[The clinical aspects of HPV-positive cancer of the oral cavity and oropharynx].

Vestn Otorinolaringol. 2016;81(1):72-7

Authors: Dvoryaninova OY, Chainzonov EL, Litvyakov NV

Abstract
This review was designed to focus on the prevalence and the magnitude of infection with human papilloma virus (HPV) among healthy subjects and patients presenting with cancer of the oral cavity and oropharynx. We compare the data on the relative frequency of HPV-positive and HPV-negative cancer of the oral cavity and oropharynx in different populations, peculiarities of the clinical course of this pathology, and methods of its treatment. Much emphasis is placed on the specific clinical and morphological features of HPV-positive cancer of the oral cavity and oropharynx. The general and relapse-free survival rates are considered with special reference to the outcome and prognosis of this disease. The currently accepted approaches to the treatment of HPV-positive cancer of the oral cavity and oropharynx are discussed. It is concluded that HPV-positive cancer of the oral cavity and oropharynx should be regarded as an autonomous pathological condition requiring specific approaches to its management, such as the application of adequate treatment schemes and algorithms.

PMID: 27166483 [PubMed - in process]

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[The methods for the treatment and prevention of cicatricalstenoses of tracheal].

Related Articles

[The methods for the treatment and prevention of cicatricalstenoses of tracheal].

Vestn Otorinolaringol. 2016;81(1):66-71

Authors: Kurgansky IS, Makhutov VN, Lepekhova SA

Abstract
The objective of the present study was to analyze the current literature concerning mechanisms underlying the development of tracheal stenosis, new methods for the treatment and prevention of this condition. The main cause behind the formation of cicatrical stenosis of trachea is believed to be long-term artificial lung ventilation whereas the principal factors responsible for the injury to the tracheal wall include the impact of the cuff and the free end of the endotracheal tube, reflux of duodenal and gastric contents, concomitant infection, and the involvement of the autoimmune component. These pathogenic factors produce morphological changes in all layers of the tracheal wall with the formation of the granulation tissue the appearance of which serves as a forerunner of irreversible changes leading to tracheal stenosis. The biomedical technologies including auto- and allo-transplantation, tissue engineering, gene and cell-based therapy are considered to be the most promising methods for the treatment and prevention of this condition likely to improve the outcome of the management of cicatrical tracheal stenosis.

PMID: 27166482 [PubMed - in process]

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