Frequency and distribution of H1N1 influenza A viruses with oseltamivir‐resistant mutations worldwide before and after the 2009 pandemic

alexandrossfakianakis shared this article with you from Inoreader Frequency and distribution of H1N1 influenza A viruses with oseltamivir‐resistant mutations worldwide before and after the 2009 pandemic via Journal of Medical Virology Abstract H1N1 influenza has brought serious threats to people's health and a high socio-economic burden to society. Oseltamivir, a kind of neuraminidase (NA) inhibitor, is the second-generation specific drug that is broadly used currently. However, H1N1 influenza viruses have exhibited oseltamivir resistance in the past decades, which might be a hidden danger. To understand the frequency and distribution laws of oseltamivir-resistant viruses, we conducted a thorough and deep analysis of the available NA protein sequences of H1N1 influenza viruses worldwide from 1918 to 2020. The differences and similarities before and after 2009 were also considered since the dominant viruses changed in this period. Results showed that 3.76% of H1N1 viruses harbored oseltamivir resistance currently. Among various significative mutations, H274Y had the highest frequency of 3.30%, while the frequencies of the other mutations were far below this whether before or after 2009. The oseltam ivir resistance was mainly found in three hosts, human, swine, and avian. Different mutation sites could exhibit different distributions in each host. Our results showed that the resistance level reached a peak during the 2007-2008 influenza season and then quickly decreased in 2009. The resistance also displayed a global distribution. The densely populated countries usually had a high resistance level. However, frequent significative mutations were also found in some small countries. Our findings indicated the necessity of monitoring oseltamivir resistance around the world. The study could provide a unique perspective towards the cognition of viruses and facilitate the future study of both pandemic and drug development. This article is protected by copyright. All rights reserved. View on Web

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Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta‐analysis

alexandrossfakianakis shared this article with you from Inoreader Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta‐analysis via Head & Neck Abstract It is important to define the accuracy of fine-needle aspiration cytology (FNAC) in the diagnosis of Warthin tumor (WT). This systematic review and meta-analysis evaluated the accuracy of FNAC in the diagnosis of WT in the parotid gland and WT growth rate. For determination of FNAC accuracy, 17 studies, encompassing 1710 cases, were included. Pulled random model estimates of sensitivity, specificity, PPV, and NPV were 93.7% (95%CI: 92.1, 95.3), 97.9% (95%CI: 97, 98.9), 93.3% (95%CI: 91.5, 95.1), and 97.4% (95%CI: 96.4, 98.4), respectively. FNAC is highly reliable for the diagnosis of WT of the parotid. The high PPV value suggests that patients with a cytological diagnosis of WT of the parotid may be assigned to active surveillance. View on Web

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Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells

alexandrossfakianakis shared this article with you from Inoreader Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells via ScienceDirect Publication: Experimental Cell Research Publication date: Available online 18 May 2022 Source: Experimental Cell Research Author(s): Li Ding, Chenhong Zhao, Yujie Xu, Zhiping Zhang, Yesen Nie, Kai Liao, Yuerou Chen, Beibei Tu, Xinyue Zhang View on Web

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Endoscopic modified transseptal bi-nostril approach for pituitary tumors. Efficacy of complex preservation of every turbinate and olfaction: A STROBE analysis

alexandrossfakianakis shared this article with you from Inoreader Endoscopic modified transseptal bi-nostril approach for pituitary tumors. Efficacy of complex preservation of every turbinate and olfaction: A STROBE analysis via ScienceDirect Publication: European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 18 May 2022 Source: European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): T. Takeda, K. Omura, E. Mori, R. Mori, Y. Ishii, N. Otori View on Web

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PD-L1 expression in 117 sinonasal mucosal melanomas and its association with clinical outcome

alexandrossfakianakis shared this article with you from Inoreader PD-L1 expression in 117 sinonasal mucosal melanomas and its association with clinical outcome via Annals of Diagnostic Pathology Publication date: Available online 18 May 2022 Source: Annals of Diagnostic Pathology Author(s): Lining Wang, Honggang Liu View on Web

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Posterior tibial artery flap versus radial forearm flap in oral cavity reconstruction and donor site morbidity

alexandrossfakianakis shared this article with you from Inoreader Posterior tibial artery flap versus radial forearm flap in oral cavity reconstruction and donor site morbidity via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The repair of soft tissue defects after oral cavity cancer resection is challenging. The aim of this study was to compare the outcomes and donor site morbidity of the radial forearm free flap (RFF) and posterior tibial artery perforator flap (PTAF) for oral cavity reconstruction after cancer ablation. All patients who underwent oral cavity reconstruction with a RFF or PTAF between January 2017 and December 2019 were included retrospectively in this study. All flaps were harvested with a long adipofascial extension. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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