Barretts Esophagus and Esophageal Adenocarcinoma Biomarkers.
Cancer Epidemiol Biomarkers Prev. 2020 Oct 22;:
Authors: Grady WM, Yu M, Markowitz SD, Chak A
Abstract
Esophageal adenocarcinoma (EAC) is a major cause of cancer related morbidity and mortality in Western countries. The incidences of EAC and its precursor Barrett's esophagus (BE) have increased substantially in the last four decades. Current care guidelines recommend that endoscopy be used for the early detection and monitoring of patients with BE, however, the efficacy of this approach is unclear. In order to prevent the increasing morbidity and mortality from EAC, there is a need for early detection and surveillance biomarker assays that are accurate, low-cost, and clinically feasible to implement. The last decade has seen remarkable advances in the development of minimally invasive molecular biomarkers, an effort led in large part by the Early Detection Research Network (EDRN). Advances in multi-omics analysis, the development of swallowable cytology collection devices, and emerging technology have led to promising assays that are likely to be implemented into clinical care in the next decade, with the most promising markers to date being methylated VIM and CCNA1. In this review, an updated overview of the molecular pathology of BE and EAC and emerging molecular biomarker assays, as well as the role of EDRN in biomarker discovery and validation, will be discussed.
PMID: 33093162 [PubMed - as supplied by publisher]
