OtoRhinoLaryngology News: 05/20/16

Παρασκευή 20 Μαΐου 2016

[Development of improving speech perception of cochlear implants in noisy environment].

[Development of improving speech perception of cochlear implants in noisy environment].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):172-6

Authors: Pan H, Chen Z

Abstract
Cochlear implantation has been a standard therapy for treating severe deafness because patients who receive it have better speech perception. However, the hearing performance of cochlear implantation in noisy environment is far from satisfaction. Efforts have been made to reverse such condition, such as EAS, bimodal stimulation, environment-adaptive speech enhancement and multipolar stimulation, and patients who receive it get more or less better speech perception in noisy environment than traditional cochlear implantation.

PMID: 27192923 [PubMed - in process]

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[Treatment options of T1 glottic carcinoma].

[Treatment options of T1 glottic carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):166-72

Authors: Wang Q, Fan G

Abstract
T1 glottic carcinoma is part of early laryngeal carcinoma which involves the vocal cords, including anterior commissure or posterior commissure. We analyzed the treatment options of T1 glottic carcinoma by reviewing the related literatures about T1 glottic carcinoma treated by conservative surgery (open surgery and laser microsurgery), radiotherapy, robot surgery, photodynamic treatment.

PMID: 27192922 [PubMed - in process]

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[Progress of Th17 cells in chronic rhinosinusitis].

[Progress of Th17 cells in chronic rhinosinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):161-6

Authors: Wang Y, Tang Z, Yao D

Abstract
Chronic rhinosinusitis is a common disease and frequently encountered disease in otolaryngology, but the therapeutic effect is not ideal. While its pathogenesis is exploring in the continuously. Found in the recent years, Th17 cells are a new subset of T cells and closely related with inflammatory disorders, autoimmune diseases and cancer. Its differentiation, regulation and biological effects are widely noted as a hot area of research. This review explores the discovery of differentiation and regulation of Th17 cells, the relationship between related cytokines and chronic rhinosinusitis, in order to have a beteer knowledge of chronic rhinosinusitis. This review regards Th17 cells as the main clue, nevertheless, lacking consideration of the impacts of other factors on chronic rhinosinusitis.

PMID: 27192921 [PubMed - in process]

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[The diagnosis and treatment of one huge cystic lymphangioma in etropharyngeal space].

[The diagnosis and treatment of one huge cystic lymphangioma in etropharyngeal space].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):159-60

Authors: Zhang H, Song X, Jia C

Abstract
One child was hospitalized because of repeated cough and sputum. The biopsy diagnosis in local hospital was cystic lymphangioma in retropharyngeal space. We carried out transoral incision and drainage by catheter under general anesthesia. Put into the surgical cavity a suction drainage tube, and injected 5 mg dexamethasone and 8mg Bleomycin. He had nasogastric liquid diet after operation. We removed the suction drainage tube two weeks later. No recurrence was found following up over two years.

PMID: 27192920 [PubMed - in process]

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[One case report of nasal sinus ossification].

[One case report of nasal sinus ossification].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):157-8

Authors: Liu R, Wang C, Liu Z

Abstract
A 8-years-old male patient with a bulge of left eye ball for one mongth was hospitalized. The inspection of the patient showed the movement on the left side of the lateral nasal wall and a narrow nasal cavity. Orbital CT showed that the left orbital ethmoid sinus, maxillary sinus cyst, left orbital, sphenoid sinus, nasal cavity were damaged. A resection with the combination of approaches including the left maxillary sinus, the ethmoid sinus, and the sphenoid sinus osteofibroma was performed. 5 days after the operation, the nasal packing material was removed and 7 days after the operation the stiches were removed. The recovery of the patient was satisfied after the operation and no recurrence was observed during one and half years follow up.

PMID: 27192919 [PubMed - in process]

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[Maxillary sinus carcinoma combined with maxillary sinus fungal sinusitis: one case report].

[Maxillary sinus carcinoma combined with maxillary sinus fungal sinusitis: one case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):155-6

Authors: Peng Z, Xu X, Wei B

Abstract
A 70 years old male patient complained a sense of swelling on right facial, mild pain, and the obstruction of right nasal, no complain of facial numbness and toothache. Physical examination showed the slight bulging on right facial with mild tenderness, purulent nasal secretions on the right middle nasal meatus, and no significant neoplasm. CT scan showed that soft density tissue in the right maxillary sinus,and the high density tissue in some period. Postoperative diagnosis: carcinoma of maxillary sinus with fungal sinusitis.

PMID: 27192918 [PubMed - in process]

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[A case of large solitary fibrous tumor originated from the neck].

[A case of large solitary fibrous tumor originated from the neck].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):153-4

Authors: Luo Q, Zhang S, Zhang Z

Abstract
Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm that usually develops in the pleura and peritoneum. The head and the neck region is involved in only 6% of the cases. We described a rare case of large SFT originated from the right neck region in a 32-year-old man. Enhanced CT scan revealed two large completely resected masses in the carotid sheath region and the right thyroid gland. Immunohistochemical studies showed positive CD34, CD99, NSE and bcl-2, and negative Desmin, NF, S-100, CD31, F8, CK, MBP, indicating that the tumor was benign. It showed no evidence of recurrence on the patient during 9 years follow-up.

PMID: 27192917 [PubMed - in process]

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[A case of vocal cord contact granuloma after vocal cord polyp surgery].

[A case of vocal cord contact granuloma after vocal cord polyp surgery].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):152-3

Authors: Qiu Z, Jiang X, Yuan X

Abstract
The vocal cord polyp is easy to relapse after surgery, but if the patient has recurrence in a short term, it is necessary to consider it as postoperative vocal cord contact granuloma. If the patients with contact granuloma after surgical treatment had severe impact on the pronunciation, it is necessary to be operated and confirmed by pathology and given the treatment of acid suppression, in order to avoid postoperative recurrence.

PMID: 27192916 [PubMed - in process]

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[Analysis of 20 mutation sites in 4 genes in neonates in shaoguan city].

[Analysis of 20 mutation sites in 4 genes in neonates in shaoguan city].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):150-1

Authors: Lan P, Chen Y, Liu Y

PMID: 27192915 [PubMed - in process]

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[The observation of therapeutic effect of auricle keloid by the operation of through resection].

[The observation of therapeutic effect of auricle keloid by the operation of through resection].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):148-9

Authors: Li E, Tian Y, Guo Q

PMID: 27192914 [PubMed - in process]

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[Correlations between allergen skin prick tests and patients' symptoms and quality of life].

[Correlations between allergen skin prick tests and patients' symptoms and quality of life].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):146-8

Authors: Zhang K, Zhu L, Zhang Y

PMID: 27192913 [PubMed - in process]

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[Value of high-resolution CT reconstruction technique in the assessment of patients with hearing problem after the ossicular chain reconstruction].

[Value of high-resolution CT reconstruction technique in the assessment of patients with hearing problem after the ossicular chain reconstruction].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):143-5

Authors: Lu Q, Guo Y, Liu Y

PMID: 27192912 [PubMed - in process]

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[The significance of keratinocyte in hyperproliferation of middle ear cholesteatoma].

[The significance of keratinocyte in hyperproliferation of middle ear cholesteatoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):139-43

Authors: Zhu Z, Hong Y, Wang Y, He G, Ye S

Abstract
OBJECTIVE: In order to investigate the interaction between the cytokines and keratinocyte and determine the role of cytokines in hyperproliferative of chronic otitis media with cholesteatoma, we observe the expression of matrix metalloproteinase 9 (MMP9), vascular endothelial growth factor (VEGF), keratinocyte growth factor (KGF) and its receptor (KGFR) in middle ear cholesteatoma.
METHOD: We examined the expression of MMP9, VEGF, KGF, KGFR and Ki-67 by immunohistochemistry in 50 specimens from chronic otitis media with cholesteatoma and 15 specimens from the normal skin of external auditory meatus. Ki-67 as an evaluation of cholesteatoma proliferation markers were used to detect the keratinocyte proliferative activity.
RESULT: (1) The expression of VEGF and MMP9 in cholesteatoma specimens was higher than normal skin, and the difference was statistically significant (t = 4.914, P < 0.01; t = 3.284, P < 0.01). (2) The expression of KGF and KGFR in middle ear tissues was higher than normal skin, and the difference was statistically significant (t = 4.814, P < 0.01; t = 3.104, P < 0.01); The expression of KGF and KGFR increased, and the expression of Ki-67 also correspondly increased in the cholesteatoma. (3) In the tissue MMP9 and VEGF were positive. Mean optical density increased as well. KGF expression also increased accordingly.
CONCLUSION: MMP9, VEGF, KGF and KGFR proteins played an important role in hyperproliferation of cholesteatoma tissues. VEGF, MMP9 and KGF had a synergistic effect in hyperproliferation of cholesteatoma tissues.

PMID: 27192911 [PubMed - in process]

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[The evaluation of curative effect of radiofrequency thermocoagulation on semilunar ganglion of aged patients with recurrent trigeminal neuralgia].

[The evaluation of curative effect of radiofrequency thermocoagulation on semilunar ganglion of aged patients with recurrent trigeminal neuralgia].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):135-8

Authors: Qu S, Zhu X, Wang T, Li D

Abstract
OBJECTIVE: To investigate curative effect and importance of radiofrequency thermocoagulation onsemilunar ganglion of aged patients with recurrent trigeminal neuralgia.
METHOD: 112 cases with recurrent trigeminal neuralgia were performed with radiofrequency thermocoagulation on semilunar ganglion by puncture through skin under local anesthesia.
RESULT: The maintaining effective duration in 112 cases was 7.3 ± 1.3 years after primary therapy. After the first thermocoagulation, 89.28% (100/112) patients got the relief from pain immediately, 8 (7.14%) cases also recieved the same effect after twice treatment. However two cases (2.6%) had no effects. The total effective rate was 98.21%. During five follow-up years, VAS scores, dose of carbamazepine and satisfaction were better than those before the treatment. The effective rate was still over 57.5% within three years after the treatment. The recurrent risk increased obviously from 40 months after the treatment by Kaplan-Meier method.
CONCLUSION: Semilunar ganglion of radiofrequency thermocoagulation was an ideal option for old-age patients with trigeminal neuralgia. It can be performed repeatedly.

PMID: 27192910 [PubMed - in process]

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[Construction and screening effective sequence of shRNA targeting human trefoil factor 3].

[Construction and screening effective sequence of shRNA targeting human trefoil factor 3].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):130-4

Authors: Wu J, Wang D, Xue G, Chen Y, Zhang W, Zhang J, Li S

Abstract
OBJECTIVE: Trefoil factor 3 plays a pivot role in oncogenic transformation, growth and metastatic extension of solid tumours besides mucosal protection. We screened the best siRNA sequence targeting human TFF3 by the transient-transfection of the lentiviral mediated shRNA into thyroid carcinoma K1 cells which secrete TFF3 themselves.
METHOD: Four siRNA transcription template hairpin structure target potential sites in human TFF3 mRNA sequence(132,170,258 and 537 bp,seperately) were selected and synthesized,as well as one negative shRNA(shRNAC). After annealing in vitro, insert pLVX-shRNA-puro construct recombinant plasmid, then enzyme digestion and sequencing analysis. The lentiviral-shRNAs were transient-transfected into K1 cells. TFF3 mRNA and protein levels were test by real-time PCR and western blot respectively in K1 cells at 48h post transient-transfected.
RESULT: Genetic mutations in two sequences of shRNA1~2, so the follow-up study terminated. The TFF3 expression were obviously inhibited in K1 cells at 48 hours post transient-transfected of shRNA3 and shRNA4. TFF3 (258-276) showed the highest silencing efficiency (TFF3 mRNA reduced 60.67% and TFF3 protein reduced 56.44%, P < 0.01) when the transfection efficiency was 76.83%.
CONCLUSION: pLVX-shRNA-puro-TFF3 expression plamid were successfully constructed and the highest efficiency sequences were screened. All these laid a foundation for further study about the function of TFF3 gene.

PMID: 27192909 [PubMed - in process]

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[Analysis on the clinical outcomes of idiopathic sudden sensorineural hearing loss using the EuroQol 5-Dimension 3-Level questionnaire].

[Analysis on the clinical outcomes of idiopathic sudden sensorineural hearing loss using the EuroQol 5-Dimension 3-Level questionnaire].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):126-9

Authors: Liu R, Zhao L, Chen Z, Zhang D, Hao Q, Li J, Zhao H, Yang S

Abstract
OBJECTIVE: To investigate the applicability of EuroQol 5-Dimension 3-Level questionnaire (Chinese Version 1.0) (EQ-5D-3L) in the assessment of life quality of patients with idopathic sudden hearing loss.
METHOD: In this retrospect study, the EQ-5D-3L was assigned to 60 patients with idopathic sudden hearing loss before and after drug therapy. Audiometry examinations were undertaken and concomitant symptoms were recorded. A Wilcoxon rank sum test was applicated to the comparisons of results of EQ-5D-3L before and after the treatment, a t-test for results of EQ-VAS and a Kappa measurement for the consistency of certain dimension correlated with the symptoms.
RESULT: Sixty patients completed the five questions and visual analog scale of the EQ-5D. A statistically significant changes of pain/discomfort, anxiety/depression before and after the treatment were observed (P < 0.05). The domains of mobility, self-care and usual activities did not show statistically significant different (P > 0.05). The dimension of pain/discomfort was in agreement with the concomitant symptoms. And the result of EQ-VAS was in agreement with the therapeutic outcome.
CONCLUSION: It is suitable for the EQ-5D to be a general health measure with sensitivity to clinical change in idiopathic sudden sensorineural hearing loss, which monitors the patients' outcomes.

PMID: 27192908 [PubMed - in process]

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[Expression and significance of p-Stat3 and its downstream gene c-myc in laryngeal squamous cell carcinoma tissue and cell line].

[Expression and significance of p-Stat3 and its downstream gene c-myc in laryngeal squamous cell carcinoma tissue and cell line].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):123-5, 129

Authors: Liu L, Wang Y, Sang J

Abstract
OBJECTIVE: To detect the expressions of p-Stat3 and c-myc in human laryngeal squamous cell carcinoma (LSCC) tissue and Hep2 cell line, and to find the relationship between them.
METHOD: Immunohistochemistry was used to detect the expressions of p-Stat3 and c-myc in 60 cases of LSCC and 30 cases of vocal cord polyp tissue. The protein levels of p-Stat3 and c-myc in Hep2 cell line was determined by immunocytochemistry. Western blotting was used to determine the protein levels of p-Stat3 and c-myc in Hep2 after treating with different concentrations of Stattic.
RESULT: The positive rates of p-Stat3 and c-myc were 65% and 70% in the LSCC tissue, compared with that in the vocal cord polyp tissue, with significant difference (P < 0.05). The expression of p-Stat3 in LSCC tissue was associated with that of c-myc (r = 0.273, P < 0.05). The protein levels of p-Stat3 and c-myc were detected in the Hep2 cell line. Stattic inhibited Stat3 phosphorylation and c-myc in the Hep2 cell line in a concentration-dependent manner.
CONCLUSION: p-Stat and c-myc were up regulated in the tissue of laryngeal squamous cell carcinoma and the Hep2 cell line. Stattic inhibits the constitutively active p-Stat3 signaling pathway, and downregulats the expression of c-myc. The strong constitutive p-Stat3 signaling pathway in LSCC makes p-Stat3 a target for the development of novel therapeutic strategies.

PMID: 27192907 [PubMed - in process]

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[Value of thyroid imaging reporting and data system and shear wave elastography for diagnosis of thyroid microcarcinoma].

[Value of thyroid imaging reporting and data system and shear wave elastography for diagnosis of thyroid microcarcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):118-22

Authors: Lu X, Zhang Y, Liu Y, Zhang N, Zhang C

Abstract
OBJECTIVE: To investigate the value of each single and combined applications of ultrasound thyroid imaging reporting and data system (TI-RADS), ultrasonic shear wave elastography in the diagnosis of thyroid microcarcinoma (TMC).
METHOD: 323 patients with thyroid tiny nodules confirmed by surgery and pathology were analyzed prospectively. Then their TI-RADS and shear wave elastography features were summarized. SWE elasticity indices (mean, minimum and maximum value of interest) of nodules were measured. The surgical pathology results were regarded as the gold standard to calculate the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of TI-RADS, shear wave elastography and their combination in the diagnosis of TMC. The receiver operating characteristic (ROC) curve of TI-RADS, shear wave elastography and combined application of both were drawn. The area under the ROC curve were calculated. Furthermore, the value of combined application of both examinations in the diagnosis of thyroid microcarcinoma (TMC) was investigated.
RESULT: From 323 nodules,253 were thyroid carcinomas and 70 were benign. Areas under the ROC curves (AUC) of SWE parameters were 0. 648,0. 629 and 0. 605. For SWE, the optimal cut-off value according to ROC curve was SWE_max = 65.50 kPa and SWE_mean = 37.50 kPa. Generally, the sensitivity, specificity, accuracy, PPV and NPV were 88.14%, 82.86%, 87.00%, 94.89% and 65.91% for TI-RADS, and 49.01%, 74.29%, 54.49%, 87.32% and 28. 73% for SWE. There were statistically significant differences in the sensitivity, accuracy, PPV and no statistically significant differences in the specificity, and NPV. The sensitivity,specificity, accuracy, PPV and NPV were 95.26%, 67.14%, 89.16%, 91.29% and 79.66% for combined application of both. The area under the ROC curve of TI-RADS, shear wave elastography and their combination were 0.763, 0.616, 0.804. For nodules ≤ 5 mm, the sensitivity, specificity, accuracy, PPV and NPV were 91.67%, 66.67%, 87.07%, 92.44% and 64.29%. However, for nodules 5-10 mm,the sensitivity,specificity, accuracy, PPV and NPV were 98.50%, 67.44%, 90.91%, 90.34% and 93.55%.
CONCLUSION: The diagnose of TMC can be further improved by combined application of ultra-sonic TI-RADS and SWE.

PMID: 27192906 [PubMed - in process]

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[Distribution and drug sensitivity test of bacteria of patients on chronic rhinosinusitis with or without nasal polyps].

[Distribution and drug sensitivity test of bacteria of patients on chronic rhinosinusitis with or without nasal polyps].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):115-8

Authors: Li J, Wu Y, Li X, Di B, Wang L

Abstract
OBJECTIVE: To study the distribution and drug sensitivity test of bacteria of patients on chronic rhinosinusitis with or without nasal polyps.
METHOD: The purulent discharges were collected from sinus of 175 patients with chronic rhinosinusitis with or without nasal polyps during endoscopic sinus surgery. The results of germiculture and drug sensitivity test were analyzed.
RESULT: From 175 specimens, 118 (67%) showed positive results in germiculture. Among them, 79 strains of gram positive bacteria and 39 strains of gram negative bacteria were detected. Staphylococcus epidermidis, Staphylococcus aureus and Staphylococcus haemolyticus were the most common pathogens in gram positive bacteria. The most common pathogens of gram negative bacteria were P. Aeruginosa, Enterobacter aerogenes, Enterobacter cloacae. The sensitive antibiotic on gram positive bacteria were amikacin, Daptomycin, Linezolid, vancomycin, teicoplanin, amoxicillin and clavulanate potassium, cefuroxime, respectively. The sensitive antibiotics on Gram negative bacteria were amikacin, Cefoperazone/sulbactam and imipenem, ceftazidime ceftazidime, aztreonam, levofloxacin, respectively.
CONCLUSION: Bacterial infection was common happened in the sinus cavity of patients with chronic rhinosinusitis with or without nasal polyps. Gram positive bacteria were the main pathogenic bacteria and gram positive bacteria and gram negative bacteria have great differences in the sensitivity of antibiotics. For patients with chronic rhinosinusitis, the using of antibiotics should depend on the drug sensitivity test.

PMID: 27192905 [PubMed - in process]

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[Efficacy of combined modality therapy for intractable difficult-to-treat rhinosinusitis].

[Efficacy of combined modality therapy for intractable difficult-to-treat rhinosinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):111-4

Authors: Yang Q, Zhao K, Shen Y, Shen Z, Yu J

Abstract
OBJECTIVE: To investigate the clinical effects of the combined modality therapy for the patients with difficult-to-treat rhinosinusitis (DTRS).
METHOD: The clinical data involving 42 patients with DTRS were analyzed retrospectively. All patients received revision endoscopic sinus surgery (ESS) and combined modality therapy systematically and individually. The clinical effects of all patients were observed 6- and 12-month following revision ESS.
RESULT: Forty-two patients were followed up for 6 months, whereas 35 patients were followed for 12 months post operation. VAS scores of the patients significantly improved (P < 0.01) 6- and 12-month after revision ESS, but there was no statistic difference (P > 0.05) between 6- and 12-month post operation. Moreover, Lund-Kennedy scores by endoscopy significantly improved (P < 0.01) 6- and 12-month following ESS. Similarly, there was no statistic difference (P > 0.05) between 6- and 12-month postoperatively. Additionally, within 6 months follow-up, 16 of 42 patients (38.1%) were cured, 19 of 42 patients (45.2%) were improved, and 7 of 42 patients (16.7%) were ineffective. The total effective rate in all patients was 83.3% 6 months postoperatively. While within 12 months follow-up, 11 of 35 patients (31.4%) were cured, 15 of 35 patients (42.9%) were improved, and 9 of 35 patients (25.7%) were ineffective. Hence, the total effective rate in 35 patients was 74.3% after 12-month follow-up. There was no statistic difference (χ² = 1.019, P > 0.05) between 6- and 12-month postoperatively.
CONCLUSION: Appropriate revision ESS plus the combined modality therapy has been proven to be an effective method for the treatment of DTRS. The clinical effects in this study are significant and stable, and thus it is worthy of further clinical applications.

PMID: 27192904 [PubMed - in process]

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Hemangiopericytoma of the Cerebellopontine Angle: A Wolf in Sheep's Clothing.

Hemangiopericytoma of the Cerebellopontine Angle: A Wolf in Sheep's Clothing.

Brain Tumor Res Treat. 2016 Apr;4(1):8-12

Authors: Nsir AB, Badri M, Kassar AZ, Hammouda KB, Jemel H

Abstract
Primary meningeal hemangiopericytoma (HPC) is a rare, aggressive dura based tumor that remarkably mimics a meningioma clinically and radiologically. Its occurrence within the cerebellopontine angle (CPA) is exceptional, and establishing the exact diagnosis is of the utmost importance since total resection remains the cornerstone of treatment. A 42-year-old man presented with a three-month history of progressively worsening vertigo and difficulty in walking. On admission, his neurological examination revealed a right peripheral facial palsy, right abducens palsy and left hemiparesis, suggesting the diagnosis of Millard-Gubler syndrome. Computed tomography and magnetic resonance imaging demonstrated a homogeneously enhancing dura based lesion of the right CPA causing major brain stem compression. There was no widening of the ipsilateral internal auditory canal. A standard retrosigmoid craniotomy was performed to access the right CPA. Exposure of the lesion revealed a well-encapsulated, gray, fibrous lesion, which appeared to originate from the tentorium. Gross total resection was achieved and confirmed radiologically. The microscopic features and the immunohistochemical profile confirmed the diagnosis of a HPC, and adjuvant radiation therapy was administered. Ten years later, the patient presented with a severe neurological deficit due to a local recurrence, but at that time refused any second intervention. He died three months later. HPC can locate within the CPA and present as a Millard-Gubler syndrome. The diagnosis should be kept in mind in case of a CPA dura based tumor. Radical surgery plus radiation therapy can maximize the recurrence-free survival and close follow-up remains mandatory to spot recurrences early.

PMID: 27195255 [PubMed]

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Increased Intracranial Pressure in a Boy with Gorham-Stout Disease.

Increased Intracranial Pressure in a Boy with Gorham-Stout Disease.

Case Rep Neurol. 2016 Jan-Apr;8(1):66-71

Authors: Patel MK, Mittelstaedt BR, Valentin FE, Thomas LP, Carlson CL, Faux BM, Hsieh DT

Abstract
Gorham-Stout disease (GSD), also known as vanishing bone disease, is a rare disorder, which most commonly presents in children and young adults and is characterized by an excessive proliferation of lymphangiomatous tissue within the bones. This lymphangiomatous proliferation often affects the cranium and, due to the proximate location to the dura surrounding cerebrospinal fluid (CSF) spaces, can result in CSF leaks manifesting as intracranial hypotension with clinical symptoms to include orthostatic headache, nausea, and vertigo. We present the case of a boy with GSD and a known history of migraine headaches who presented with persistent headaches due to increased intracranial pressure. Although migraine had initially been suspected, he was eventually diagnosed with intracranial hypertension after developing ophthalmoplegia and papilledema. We describe the first known instance of successful medical treatment of increased intracranial pressure in a patient with GSD.

PMID: 27194986 [PubMed]

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Insertion characteristics and placement of the Mid-Scala electrode array in human temporal bones using detailed cone beam computed tomography.

Insertion characteristics and placement of the Mid-Scala electrode array in human temporal bones using detailed cone beam computed tomography.

Eur Arch Otorhinolaryngol. 2016 May 19;

Authors: Dietz A, Gazibegovic D, Tervaniemi J, Vartiainen VM, Löppönen H

Abstract
The aim of this study was to evaluate the insertion results and placement of the new Advanced Bionics HiFocus Mid-Scala (HFms) electrode array, inserted through the round window membrane, in eight fresh human temporal bones using cone beam computed tomography (CBCT). Pre- and post-insertion CBCT scans were registered to create a 3D reconstruction of the cochlea with the array inserted. With an image fusion technique both the bony edges of the cochlea and the electrode array in situ could accurately be determined, thus enabling to identify the exact position of the electrode array within the scala tympani. Vertical and horizontal scalar location was measured at four points along the cochlea base at an angular insertion depth of 90°, 180° and 270° and at electrode 16, the most basal electrode. Smooth insertion through the round window membrane was possible in all temporal bones. The imaging results showed that there were no dislocations from the scala tympani into the scala vestibule. The HFms electrode was positioned in the middle of the scala along the whole electrode array in three out of the eight bones and in 62 % of the individual locations measured along the base of the cochlea. In only one cochlea a close proximity of the electrode with the basilar membrane was observed, indicating possible contact with the basilar membrane. The results and assessments presented in this study appear to be highly accurate. Although a further validation including histopathology is needed, the image fusion technique described in this study represents currently the most accurate method for intracochlear electrode assessment obtainable with CBCT.

PMID: 27194346 [PubMed - as supplied by publisher]

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Idiosyncratic phenomena during the spontaneous healing of traumatic tympanic membrane perforations.

Idiosyncratic phenomena during the spontaneous healing of traumatic tympanic membrane perforations.

Eur Arch Otorhinolaryngol. 2016 May 19;

Authors: Jian-Yang

PMID: 27194345 [PubMed - as supplied by publisher]

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Is it effective to use the crushing technique in all types of concha bullosa.

Is it effective to use the crushing technique in all types of concha bullosa.

Eur Arch Otorhinolaryngol. 2016 May 18;

Authors: Koçak İ, Gökler O, Doğan R

Abstract
A prospective study to evaluate long term results of crushing technique in concha bullosa surgery with radiographic and endoscopic methods and to determine the type of concha bullosa in which crushing technique is more effective. 71 patients who underwent concha bullosa surgery with septoplasty were included in the study. All concha bullosa were divided into three groups according to their types (Group 1 lamellar type, Group 2 bulbous type, Group 3 extensive type). Crushing of the pneumatized middle turbinate was done under endoscopic view. All the patients had an endoscopic nasal examination and middle turbinates were photographed and axial and coronal paranasal computed tomography (CT) scans were taken before the surgery and approximately 2 years after the surgery. Preoperative and postoperative measurements were compared using paired t test and One-way ANOVA. Mean age of the 71 patients were as follows: 38 males, mean age 30.2 (range 20-44) years; 33 females, mean age 27.6 (range 18-40) years. The patients were followed for 22.7 (range 20-26) months. In all groups, the postoperative endoscopic grading scores and CT volumes were significantly reduced (p < 0.0001). Comparison between groups showed significant post operative reduction in both CT volumes and in endoscopic scoring for group 2 (bulbous type) (p < 0.0001). Crushing is a simple and safe method in concha bullosa surgery. There was no recurrance in long-term outcomes. This method can be used in all types of concha bullosa effectively and provides more volume reduction in bulbous type concha bullosa.

PMID: 27194152 [PubMed - as supplied by publisher]

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Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments.

Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments.

Int J Audiol. 2016 May 19;:1-9

Authors: Aazh H, Moore BC, Lammaing K, Cropley M

Abstract
OBJECTIVE: To assess patients' judgements of the effectiveness of the tinnitus and hyperacusis therapies offered in a specialist UK National Health Service audiology department.
DESIGN: Cross-sectional service evaluation questionnaire survey. Patients were asked to rank the effectiveness of the treatment they received on a scale from 1 to 5 (1 = no effect, 5 = very effective).
STUDY SAMPLE: The questionnaire was sent to all patients who received treatment between January and March 2014 (n = 200) and 92 questionnaires were returned.
RESULTS: The mean score was greatest for counselling (Mean = 4.7, SD = 0.6), followed by education (Mean = 4.5, SD = 0.8), cognitive behavioural therapy - CBT (Mean = 4.4, SD = 0.7), and hearing tests (Mean = 4.4, SD = 0.9). Only 6% of responders rated counselling as 3 or below. In contrast, bedside sound generators, hearing aids, and wideband noise generators were rated as 3 or below by 25%, 36%, and 47% of participants, respectively.
CONCLUSION: The most effective components of the tinnitus and hyperacusis therapy interventions were judged by the patients to be counselling, education, and CBT.

PMID: 27195947 [PubMed - as supplied by publisher]

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Validating self-reporting of hearing-related symptoms against pure-tone audiometry, otoacoustic emission, and speech audiometry.

Validating self-reporting of hearing-related symptoms against pure-tone audiometry, otoacoustic emission, and speech audiometry.

Int J Audiol. 2016 May 19;:1-9

Authors: Fredriksson S, Hammar O, Magnusson L, Kähäri K, Persson Waye K

Abstract
OBJECTIVE: To validate self-reported hearing-related symptoms among personnel exposed to moderately high occupational noise levels at an obstetrics clinic.
DESIGN: Sensitivity, specificity, and predictive values were calculated for questionnaire items assessing hearing loss, tinnitus, sound sensitivity, poor hearing, difficulty perceiving speech, and sound-induced auditory fatigue. Hearing disorder was diagnosed by pure-tone audiometry, distortion product otoacoustic emissions, and HINT (Hearing In Noise Test).
STUDY SAMPLE: Fifty-five female obstetrics personnel aged 22-63 participated; including 26 subjects reporting hearing loss, poor hearing, tinnitus, or sound sensitivity, and 29 randomly selected subjects who did not report these symptoms.
RESULTS: The questionnaire item assessing sound-induced auditory fatigue had the best combination of sensitivity ≥85% (95% CIs 56 to 100%) and specificity ≥70% (95% CIs 55 to 84%) for hearing disorder diagnosed by audiometry or otoacoustic emission. Of those reporting sound-induced auditory fatigue 71% were predicted to have disorder diagnosed by otoacoustic emission. Participants reporting any hearing-related symptom had slightly worse measured hearing.
CONCLUSIONS: We suggest including sound-induced auditory fatigue in questionnaires for identification of hearing disorder among healthcare personnel, though larger studies are warranted for precise estimates of diagnostic performance. Also, more specific and accurate hearing tests are needed to diagnose mild hearing disorder.

PMID: 27195802 [PubMed - as supplied by publisher]

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Small Compartment Toxicity: CN VIII and Quality of Life: Hearing Loss, Tinnitus, and Balance Disorders.

Small Compartment Toxicity: CN VIII and Quality of Life: Hearing Loss, Tinnitus, and Balance Disorders.

Int J Toxicol. 2016 May 18;

Authors: Gauvin DV, Yoder JD, Tapp RL, Baird TJ

Abstract
Life experiences, industrial/environmental exposures, and administration of Food and Drug Administration (FDA)-approved drugs may have unintended but detrimental effects on peripheral and central auditory pathways. Most relevant to the readership of this journal is the role that drug treatments approved by the FDA as safe and effective appear to interact with 3 independent modes of toxicity within the small compartment of the ear. What may seem to be trivial drug-induced toxicity has the potential to change important measures of quality of life and functional capacity of mid- to late-life patients. Drugs meant to treat can become the source of interference in the activities of daily living, and as a result, treatment compliance may be jeopardized. Ototoxicity has been defined as the tendency of certain therapeutic agents and other chemical substances to cause functional impairments and cellular degeneration of the tissues of the inner ear resulting in hearing loss. However, one of the largest contributors to hospitalizations is fall-related injuries in the elderly patients associated with disorders of vestibular function linked to progressive and drug-induced toxicities. Tinnitus affects 35 to 50 million adults representing approximately 25% of the US population, with 12 million seeking medical care and 2 to 3 million reporting symptoms that were severely debilitating. This review is intended to highlight these targets of neurotoxicity that threaten the usefulness of drug treatments deemed safe and effective prior to access by the general public.

PMID: 27194512 [PubMed - as supplied by publisher]

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Identification of a Circadian Clock in the Inferior Colliculus and Its Dysregulation by Noise Exposure.

Identification of a Circadian Clock in the Inferior Colliculus and Its Dysregulation by Noise Exposure.

J Neurosci. 2016 May 18;36(20):5509-19

Authors: Park JS, Cederroth CR, Basinou V, Meltser I, Lundkvist G, Canlon B

Abstract
UNLABELLED: Circadian rhythms regulate bodily functions within 24 h and long-term disruptions in these rhythms can cause various diseases. Recently, the peripheral auditory organ, the cochlea, has been shown to contain a self-sustained circadian clock that regulates differential sensitivity to noise exposure throughout the day. Animals exposed to noise during the night are more vulnerable than when exposed during the day. However, whether other structures throughout the auditory pathway also possess a circadian clock remains unknown. Here, we focus on the inferior colliculus (IC), which plays an important role in noise-induced pathologies such as tinnitus, hyperacusis, and audiogenic seizures. Using PER2::LUC transgenic mice and real-time bioluminescence recordings, we revealed circadian oscillations of Period 2 protein in IC explants for up to 1 week. Clock genes (Cry1, Bmal1, Per1, Per2, Rev-erbα, and Dbp) displayed circadian molecular oscillations in the IC. Averaged expression levels of early-induced genes and clock genes during 24 h revealed differential responses to day or night noise exposure. Rev-erbα and Dbp genes were affected only by day noise exposure, whereas Per1 and Per2 were affected only by night noise exposure. However, the expression of Bdnf was affected by both day and night noise exposure, suggesting that plastic changes are unlikely to be involved in the differences in day or night noise sensitivity in the IC. These novel findings highlight the importance of circadian responses in the IC and emphasize the importance of circadian mechanisms for understanding central auditory function and disorders.
SIGNIFICANCE STATEMENT: Recent findings identified the presence of a circadian clock in the inner ear. Here, we present novel findings that neurons in the inferior colliculus (IC), a central auditory relay structure involved in sound processing, express a circadian clock as evidenced at both the mRNA and protein levels. Using a reporter mouse that expresses a luciferase protein coupled to the core clock protein PERIOD2 (PER2::LUC), we could observe spontaneous circadian oscillations in culture. Furthermore, we reveal that the mRNA profile of clock-related genes in the IC is altered differentially by day or night noise exposure. The identification of a clock in the IC is relevant for understanding the mechanisms underlying dysfunctions of the IC such as tinnitus, hyperacusis, or audiogenic seizures.

PMID: 27194331 [PubMed - in process]

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[The value of lidocaine through different routes of administration in the treatment of tinnitus: a Meta-analysis].

[The value of lidocaine through different routes of administration in the treatment of tinnitus: a Meta-analysis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(2):101-5

Authors: Li H, Li M, Zhang J, Li X, Tan J, Ji B

Abstract
OBJECTIVE: To evaluate the clinical value of lidocain in the treatment of tinnitus through three routes of administration (intravenous, intratympanic and acupoint injection) by analyzing literatures.
METHOD: Articles were collected through Hownet, Wanfang, VIP, Pubmed, SciVerse ScienceDirect, Springer and OVID, etc. The articles were strictly evaluated based on their quality. The Meta-analysis was performed to evaluate the outcomes by RevMan 5. 2 software.
RESULT: A total of 16 articles with 1203 patients were enrolled in the analysis. Their tinnitus history ranged from 7 hours to 20 years. Assessment methods include tinnitus loudness levels, severity scales and subjective feelings. None of articles refer to maintaining time, instead of "short-term", "short" and so on. A total of 133 cases received intravenous injection and the effective rate was 73.4% (98 cases). 50 cases and 332 cases received intratympanic and acupoint injection respectively and their effective rates were 74.0% and 87.7%, respectively. The effective rate ranged from 42.4% to 58.3% in control group. Meta-analysis results indicate that all three routes of lidocaine administrations are more effective than conventional methods (P < 0.05).
CONCLUSION: Different routes of lidocaine administration have a good but short time effects on the tinnitus control. It can effectively reduce the time of tinnitus habituation as a complementary treatment. But its value still needs further evaluation.

PMID: 27192902 [PubMed - in process]

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Epithelioid hemangioendothelioma of the mandibular gingiva: A rare case of metastasis 4 years after radical excision and literature review.

Epithelioid hemangioendothelioma of the mandibular gingiva: A rare case of metastasis 4 years after radical excision and literature review.

J Oral Maxillofac Pathol. 2016 Jan-Apr;20(1):137-41

Authors: Salgarelli AC, Bellini P, Maccio L, Setti G

Abstract
Malignant epithelioid hemangioendothelioma (MEH), or high-risk epithelioid hemangioendothelioma, is a low- to intermediate-grade vascular malignancy. A few cases of MEH have been documented in the head and neck region, including the neck, thyroid gland, larynx and scalp. MEHs are extremely rare in the oral cavity. Only 31 cases of MEH in the oral cavity were described in English literature between 1975 and 2014. Further, only eleven cases were referred to MEH of the maxillary or mandibular gingiva. No gingival MEH metastases have been described in literature. We report a literature review and a case of MEH with a metastatic occurrence 4 years after surgical excision.

PMID: 27194877 [PubMed]

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Tongue Size and Posterior Airway Space Changes in Class III Malocclusion After Maxillomandibular Surgery: A Retrospective Study.

Tongue Size and Posterior Airway Space Changes in Class III Malocclusion After Maxillomandibular Surgery: A Retrospective Study.

Int J Orthod Milwaukee. 2015;26(4):37-43

Authors: Uslu-Akcam O, Gokalp H

Abstract
The purpose of this study was to evaluate the changes in the airway space after surgical correction of Class III skeletal dentofacial deformity and to determine if orthognathic surgery alters the airway space and improves obstructive sleep apnea. Twenty-four Class III adults treated with orthognathic surgery were divided into two groups as Mandibular set-back (Bilateral Sagittal Split Osteotomy-BSSO, 10 patients) and two jaw surgery (Bilateral Sagittal Split Osteotomy combined with Le Fort I maxillary advancement, 14 patients). Lateral cephalometric radiographs were traced before (T0) and 6 months after surgery (T1). Steiner and McNamara analysis, linear pharyngeal airway measurements (PNS-PPW1, SPT-PPW2, E-PPW3, PNS-SPT), tongue volume measurements (TH, Tt-Eb) and pharyngeal area measurements (nasopharyngeal, upper oropharyngeal, lower oropharyngeal, epiglottis area) were performed. The data obtained was analyzed statistically by repeated measurement ANOVA and Duncan's test. The increase of PNS-PPW1 was important in two jaw surgery group (p < 0.05). The nasopharyngeal area was statistically different between T0 and T1 (p < 0.01), and the lower oropharyngeal area was statistically significant between BSSO and two jaw surgery groups (p < 0.05). Surgical correction of Class III skeletal dentofacial deformity alters posterior airway dimensions. Two jaw surgery is advantageous considering the risk for obstructive sleep apnea, because it evokes an increase in the upper pharyngeal airway dimensions. Keywords: Tongue size, posterior airway space, maxillomandibular surgery.

PMID: 27029091 [PubMed - indexed for MEDLINE]

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Blood supply of the terminal part of the external branch of the superior laryngeal nerve.

http:--production.springer.de-OnlineReso

Blood supply of the terminal part of the external branch of the superior laryngeal nerve.

Surg Today. 2015 Sep;45(9):1160-5

Authors: Yalcin B, Develi S, Tubbs RS, Poyrazoglu Y, Yazar F

Abstract
PURPOSE: The external laryngeal nerve (ELN) carries motor fibers to the cricothyroid and inferior pharyngeal muscles. Damage to the nerve may cause symptoms such as a monotone voice. One reason for these symptoms may be nerve injury due to inadvertent stretching, ligation or transaction of the nerve during the dissection of the superior pole of the thyroid gland. We hypothesized a new reason for the symptoms, an insufficient arterial blood supply to the nerve, and investigated this hypothesis.
METHODS: From 36 larynges, 52 sides (26 right and 26 left) were dissected under a surgical Zeiss-OpM1 microscope.
RESULTS: The arterial branch to the external branch of the superior laryngeal nerve originated from the posterior glandular branch of the superior thyroid artery in 26 (50%) sides, from the anterior glandular branch in 23 (44.23%) sides, from its trunk on one (1.92%) side, from the infrahyoid branch on one (1.92%) side and from the bifurcation of the superior thyroid artery at the level of separation of the anterior and posterior glandular branches on one (1.92%) side.
CONCLUSION: Devascularization of the ELN may lead to dysfunction, so this nerve's varied blood supply should be kept in mind when invasive procedures are performed in this region.

PMID: 25326251 [PubMed - indexed for MEDLINE]

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Educating teenagers about hearing health by training them to educate children.

Educating teenagers about hearing health by training them to educate children.

Int J Audiol. 2016 May 19;:1-8

Authors: Welch D, Reddy R, Hand J, Devine IM

Abstract
OBJECTIVE: We investigated the change in hearing-health behaviour amongst teenagers trained to deliver the Dangerous Decibels programme to younger children.
DESIGN: The Dangerous Decibels programme uses a two-stage process to train 8-12 year-old children to protect their hearing from noise: (1) a team of experts train 'Educators' who (2) give classroom training to children in schools. Training teenagers as Educators may add a second level of benefit if teenagers internalize the hearing-health messages that they present and thus protect their own hearing better. They were assessed before training, immediately after, and three months later (after all had presented the classroom training) using a questionnaire. In addition, a focus group was conducted with a subgroup of the Educators to assess their subjective experience.
STUDY SAMPLE: We trained 44 Educators aged 14-17 years.
RESULTS: Results were generally positive: there were significant and sustained improvements in knowledge, self-reported behaviour, and perceived supports towards protecting hearing, and trends but not significant changes in attitudes or perceived barriers to hearing protection.
CONCLUSIONS: Providing training to teenagers had benefits beyond the delivery of training to younger children, but improvements in the delivery model may increase the uptake and impact on the teenagers.

PMID: 27196113 [PubMed - as supplied by publisher]

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Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments.

Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments.

Int J Audiol. 2016 May 19;:1-9

Authors: Aazh H, Moore BC, Lammaing K, Cropley M

PMID: 27195947 [PubMed - as supplied by publisher]

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Validating self-reporting of hearing-related symptoms against pure-tone audiometry, otoacoustic emission, and speech audiometry.

Validating self-reporting of hearing-related symptoms against pure-tone audiometry, otoacoustic emission, and speech audiometry.

Int J Audiol. 2016 May 19;:1-9

Authors: Fredriksson S, Hammar O, Magnusson L, Kähäri K, Persson Waye K

PMID: 27195802 [PubMed - as supplied by publisher]

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Educating teenagers about hearing health by training them to educate children.

Educating teenagers about hearing health by training them to educate children.

Int J Audiol. 2016 May 19;:1-8

Authors: Welch D, Reddy R, Hand J, Devine IM

PMID: 27196113 [PubMed - as supplied by publisher]

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Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments.

Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments.

Int J Audiol. 2016 May 19;:1-9

Authors: Aazh H, Moore BC, Lammaing K, Cropley M

PMID: 27195947 [PubMed - as supplied by publisher]

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Validating self-reporting of hearing-related symptoms against pure-tone audiometry, otoacoustic emission, and speech audiometry.

Validating self-reporting of hearing-related symptoms against pure-tone audiometry, otoacoustic emission, and speech audiometry.

Int J Audiol. 2016 May 19;:1-9

Authors: Fredriksson S, Hammar O, Magnusson L, Kähäri K, Persson Waye K

PMID: 27195802 [PubMed - as supplied by publisher]

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[The Interdisciplinary Conference on Lacrimal System Disorders of ophthalmic and ENT surgeons at the University Hospital Halle : An analysis of present patient material].

[The Interdisciplinary Conference on Lacrimal System Disorders of ophthalmic and ENT surgeons at the University Hospital Halle : An analysis of present patient material].

HNO. 2016 May 19;

Authors: Struck HG, Glien A, Herzog M, Sandner A, Plontke SK, Heichel J

Abstract
BACKGROUND AND AIM: The lacrimal system (LS) crosses regions of ocular adnexa, the nose, and the paranasal sinuses. Surgery of disorders requires a targeted ophthalmologic and otolaryngologic examination. Since 2013, an Interdisciplinary Conference on Lacrimal System Disorders (ICLSD) has existed at the University Hospital Halle. First results of our experiences with this cooperation between ophthalmic and ENT surgeons are presented.
METHODS: In a retrospective study at the Department of Ophthalmology, University Hospital Halle, all patients aged 22-80 years (n = 43, 10 with bilateral manifestation; mean age 65.1 years) having had a consultation in ICLSD between February 2013 and May 2015 were analyzed. Thereby, 53 LS were included in the descriptive evaluation.
RESULTS: The main relevant pathology in terms of ophthalmologic manifestation was chronic dacryocystitis and its complications (n = 42), whereas nasal septum deviation (n = 11) and chronic rhinosinusitis (n = 10) were the most frequent otorhinolaryngologic pathologies. Prior to consultation, ENT (n = 34) and/or ophthalmic surgery (n = 40) had been performed. During ICLSD, an individualized therapeutic regime for each patient was developed. Surgery was required in 43 out of 53 LS. Of these, 32 were mainly ophthalmic, 11 mainly ENT interventions. At the time of evaluation (median 3 months; range 1 to 24 months), 29 out of 38 patients (76.3 %) were free of complaints.
CONCLUSION: Since 2013, competences of ophthalmic and ENT surgeons have been integrated in ICLSD for advanced diagnosis and therapy of lacrimal disorders at the University Hospital Halle. Encouraging functional results are shown in this study, as most patients have had a long and complicated history of lacrimal system disorders. ICLSD enables interdisciplinary patient care.

PMID: 27193235 [PubMed - as supplied by publisher]

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Schnarchen und obstruktive Schlafapnoe.

Schnarchen und obstruktive Schlafapnoe.

HNO. 2016 May 18;

Authors:

PMID: 27193140 [PubMed - as supplied by publisher]

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Management of isolated cricopharyngeal dysfunction: systematic review.

Management of isolated cricopharyngeal dysfunction: systematic review.

J Laryngol Otol. 2016 May 19;:1-5

Authors: Ashman A, Dale OT, Baldwin DL

Abstract
OBJECTIVE: A systematic review was performed to evaluate the safety and efficacy of different therapeutic interventions available for the management of isolated cricopharyngeal dysfunction.
METHODS: Studies were identified using the following databases: Ovid (Medline, Embase), the Cochrane Library, PubMed and Google Scholar. An initial search identified 339 articles. All titles and abstracts were reviewed. Fifty-six relevant articles were inspected in more detail; of these, 47 were included in the qualitative analysis.
RESULTS: No relevant randomised trials were found. A range of case series were used to perform a qualitative analysis. Botulinum toxin A injection and cricopharyngeal dilatation were associated with a higher risk of recurrence, but appear to be more suitable in elderly and co-morbid patients. In those patients requiring formal myotomy, endoscopic approaches appear to be as effective but less morbid when compared with classical open surgery.
CONCLUSION: There is good evidence for the safety and efficacy of the different therapeutic options for isolated cricopharyngeal dysfunction. However, further studies are required to compare the efficacy of the various treatment modalities.

PMID: 27194375 [PubMed - as supplied by publisher]

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Regenerative therapy for vestibular disorders using human induced pluripotent stem cells (iPSCs): neural differentiation of human iPSC-derived neural stem cells after in vitro transplantation into mouse vestibular epithelia.

Regenerative therapy for vestibular disorders using human induced pluripotent stem cells (iPSCs): neural differentiation of human iPSC-derived neural stem cells after in vitro transplantation into mouse vestibular epithelia.

Acta Otolaryngol. 2016 May 19;:1-7

Authors: Taura A, Nakashima N, Ohnishi H, Nakagawa T, Funabiki K, Ito J, Omori K

Abstract
OBJECTIVES: Vestibular ganglion cells, which convey sense of motion from vestibular hair cells to the brainstem, are known to degenerate with aging and after vestibular neuritis. Thus, regeneration of vestibular ganglion cells is important to aid in the recovery of balance for associated disorders.
METHODS: The present study derived hNSCs from induced pluripotent stem cells (iPSCs) and transplanted these cells into mouse utricle tissues. After a 7-day co-culture period, histological and electrophysiological examinations of transplanted hNSCs were performed.
RESULTS: Injected hNSC-derived cells produced elongated axon-like structures within the utricle tissue that made contact with vestibular hair cells. A proportion of hNSC-derived cells showed spontaneous firing activities, similar to those observed in cultured mouse vestibular ganglion cells. However, hNSC-derived cells around the mouse utricle persisted as immature neurons or occasionally differentiated into putative astrocytes. Moreover, electrophysiological examination showed hNSC-derived cells around utricles did not exhibit any obvious spontaneous firing activities.
CONCLUSIONS: Injected human neural stem cells (hNSCs) showed signs of morphological maturation including reconnection to denervated hair cells and partial physiological maturation, suggesting hNSC-derived cells possibly differentiated into neurons.

PMID: 27196942 [PubMed - as supplied by publisher]

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[III. An update on drug therapy for chordoma].

[III. An update on drug therapy for chordoma].

Gan To Kagaku Ryoho. 2016 Mar;43(3):317-21

Authors: Endo M

PMID: 27192740 [PubMed - in process]

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[II. The evidence of local treatments for malignant bone tumors in pelvis and spine].

[II. The evidence of local treatments for malignant bone tumors in pelvis and spine].

Gan To Kagaku Ryoho. 2016 Mar;43(3):313-6

Authors: Akiyama T

PMID: 27192739 [PubMed - in process]

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[I. Management of giant cell tumor of the spine and pelvis--current perspective].

[I. Management of giant cell tumor of the spine and pelvis--current perspective].

Gan To Kagaku Ryoho. 2016 Mar;43(3):307-12

Authors: Susa M, Horiuchi K, Morioka H

PMID: 27192738 [PubMed - in process]

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[Musculoskeletal tumor. Update therapeutic strategies for bone sarcomas of spine and pelvis].

[Musculoskeletal tumor. Update therapeutic strategies for bone sarcomas of spine and pelvis].

Gan To Kagaku Ryoho. 2016 Mar;43(3):305-6

Authors: Chuman H

PMID: 27192737 [PubMed - in process]

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Αρχειοθήκη ιστολογίου

Παρασκευή 20 Μαΐου 2016