OtoRhinoLaryngology News: 12/04/15

Παρασκευή 4 Δεκεμβρίου 2015

The Vicious Cycle: Pediatric Facial Trauma from Bicycling.

The Vicious Cycle: Pediatric Facial Trauma from Bicycling.

Otolaryngol Head Neck Surg. 2015 Dec 2;

Authors: Svider PF, Chen M, Burchhardt D, O'Brien PS, Shkoukani MA, Zuliani GF, Folbe AJ

Abstract
OBJECTIVES: Although prevention of head injuries through helmet use is widespread, there has been a paucity of inquiry and publicity regarding the potential for facial injury stemming from cycling. Our objectives included estimating the incidence of emergency department (ED) visits for bicycle-related facial trauma among the pediatric population and detailing injury patterns.
STUDY DESIGN AND SETTING: Analysis of a nationwide database.
METHODS: The National Electronic Injury Surveillance System, offered by the Consumer Product Safety Commission, was accessed for ED visits related to bicycle-related facial trauma among individuals 21 years old and younger. These data were used to estimate national incidence and examine patient demographics and injury characteristics.
RESULTS: From 2010 to 2014, there were 5420 entries extrapolating to an estimated 178,457 ED visits for pediatric bicycle-related facial trauma. Median age was 8 years, and 71.9% of patients were male. Lacerations (63.1%), abrasions/contusions (27%), and fractures (7%) were most common, with fractures dramatically increasing in prevalence with age. Nasal fractures were the most common fracture type. Injury patterns varied by age.
CONCLUSION: Bicycle-related facial trauma is prevalent among the pediatric population, with nearly 180,000 visits to EDs between 2010 and 2014. Soft tissue injuries predominated among all age groups, although fractures increased significantly with age. Knowledge of injury patterns described may be a useful adjunct assisting history, examination, and decision making regarding the use of medical imaging. There is a clear void in inquiry regarding the use of facial protection, reinforcing the need for further study into prevention and efforts to raise public awareness among youth.

PMID: 26631380 [PubMed - as supplied by publisher]

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The efficacy of individual treatment of subjective tinnitus with cognitive behavioural therapy.

The efficacy of individual treatment of subjective tinnitus with cognitive behavioural therapy.

Acta Otorrinolaringol Esp. 2015 Nov 26;

Authors: Canals P, Pérez Del Valle B, Lopez F, Marco A

Abstract
INTRODUCTION: It has been a long time since subjective tinnitus cases were described for the first time but they still lack a treatment with proven effectiveness. The main goal of this study was to evaluate the effectiveness of cognitive behavioural therapy in these patients.
PATIENTS AND METHOD: Between 2012 and 2013, 310 patients that suffered from subjective tinnitus were studied. Of these, 267 were included in treatment based on cognitive behavioural therapy. The monitoring period lasted 18 months for most cases, while it lasted 21 months for 11 patients.
RESULTS: Considering patients that interrupted their treatment as failures, the percentage of recovery was 95.7%.
CONCLUSION: Cognitive behavioural therapy should always be included in the treatment of people suffering from tinnitus.

PMID: 26632254 [PubMed - as supplied by publisher]

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Head and Neck Squamous Cell Carcinoma in Iran: Clinico-Pathological and Treatment-Related Factors Influencing Survival.

Head and Neck Squamous Cell Carcinoma in Iran: Clinico-Pathological and Treatment-Related Factors Influencing Survival.

Iran J Cancer Prev. 2015 Oct;8(5):e3842

Authors: Novin K, Ameri A, Faraji S, Torbati P, Mortazavi N

Abstract
BACKGROUND: Evidences about survival of the patients with head and neck squamous cell carsinoma (HNSCC) have been scant in our region.
OBJECTIVES: The aim of current study was to determine clinico-pathological and treatment-related factors, influencing outcome of these patients.
PATIENTS AND METHODS: We have reviewed all patients with a new diagnosis of HNSCC admitted between 2008 and 2014 in "Jorjani Cancer Center", Tehran, Iran. Overall survival (OS) and event free survival (EFS) of the patients, and their relation with demographic and clinico-pathological factors have been analyzed.
RESULTS: Among 119 included patients, 90 were male and 29 were female with mean age of 58 years. Larynx was the most common primary tumor site (55% of all patients). With a median follow-up period of 28 months, OS and EFS of the study patients was 61.2% and 52.4%, respectively. Tumor stage was the only parameter has significantly influenced the patients' OS. Patients with normal BMIs had significantly higher mean EFS compared with patients with bellow or above normal BMIs. Surgical treatment modalities have resulted in the same prognosis as non-surgical approaches.
CONCLUSIONS: Our study seems to be the first that investigated outcome of Iranian patients with head and neck cancer and its influencing factors.

PMID: 26634109 [PubMed - as supplied by publisher]

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Five- and 10-Year Cause-Specific Survival Rates in Carcinoma of the Minor Salivary Gland.

Five- and 10-Year Cause-Specific Survival Rates in Carcinoma of the Minor Salivary Gland.

JAMA Otolaryngol Head Neck Surg. 2015 Dec 3;:1-7

Authors: Baddour HM, Fedewa SA, Chen AY

Abstract
Importance: Previous studies of prognostic factors of carcinoma of the minor salivary gland (MSG) have been limited to single-institution studies and small case series. Thus, limited data are available to guide the head and neck oncologist in counseling patients on the prognosis and management of these malignant neoplasms.
Objective: To examine 5- and 10-year cause-specific survival (CSS) rates of MSG carcinomas across all histologic subtypes and head and neck tumor subsites.
Design, Setting, and Patients: Retrospective, population-based study using National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) data from January 1, 1988, through December 31, 2009. The study included 5334 patients diagnosed as having MSG carcinoma and registered in the SEER database. Patients without follow-up, diagnostic confirmation, and/or race designation were excluded from the analysis (131 [2.4%]). Final follow-up was completed on December 31, 2009, and data were analyzed from August 5, 2013, to July 1, 2014.
Main Outcomes and Measures: Five- and 10-year CSS rates for US patients with MSG carcinoma. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% CIs.
Results: Among the 5334 patients with MSG carcinoma included, the most common histologic subtypes included mucoepidermoid carcinoma (1568 [29.4%]), adenoid cystic carcinoma (1228 [23.0%]), and adenocarcinoma (1313 [24.6%]). The most frequent sites of primary tumor were the oral cavity (3132 [58.7%]) and pharynx (1130 [21.2%]). Five-year CSS rate was significantly worse for MSG malignant neoplasms located in the larynx (HR, 2.42; 95% CI, 1.67-3.50) and nasal cavity and/or paranasal sinus (HR, 1.73; 95% CI, 1.29-2.32). Being older than 75 years was associated with a significantly worse 5-year CSS rate (HR, 2.88; 95% CI, 2.05-4.06). Compared with no surgery, local tumor destruction (HR, 0.44; 95% CI, 0.30-0.64), partial surgery (HR, 0.33; 95% CI, 0.23-0.47), and total surgery (HR, 0.55; 95% CI, 0.41-0.74) were each found to be a significant positive prognostic factor. No differences were observed in the 5-year hazard of death for race/ethnicity, sex, diagnosis year, or socioeconomic status, and 10-year adjusted HRs were similar to the 5-year patterns.
Conclusions and Relevance: This study, to date, represents the largest US survival analysis of carcinoma of the MSG. Prognosis is associated with histologic subtype, tumor subsite, age at diagnosis, grade, and surgical therapy.

PMID: 26632951 [PubMed - as supplied by publisher]

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Vestibulo-spinal and vestibulo-ocular reflexes are modulated when standing with increased postural threat.

Vestibulo-spinal and vestibulo-ocular reflexes are modulated when standing with increased postural threat.

J Neurophysiol. 2015 Dec 2;:jn.00626.2015

Authors: Naranjo EN, Cleworth TW, Allum JH, Inglis JT, Lea J, Westerberg BD, Carpenter MG

Abstract
OBJECTIVE: to investigate how vestibulo-spinal reflexes (VSR) and vestibulo-ocular reflexes (VOR) measured through vestibular evoked myogenic potentials (VEMP) and video head impulse test (vHIT) outcomes, respectively, are modulated when standing under conditions of increased postural threat.
METHODS: 25 healthy young adults stood quietly at low (0.8m from the ground) and high (3.2m) surface height conditions in two experiments. For the first experiment (n=25) VEMPs were recorded with surface EMG from inferior oblique (IO), sternocleidomastoid (SCM), trapezius (TRP) and soleus (SOL) muscles in response to 256 air-conducted short tone bursts (125 dB SPL; 500Hz; 4 ms) delivered via headphones. A sub-set of subjects (n=19) also received horizontal and vertical head thrusts (approx. 150 °/s) at each height in a separate session, comparing eye and head velocities by using a vHIT system for calculating the functional VOR gains.
RESULTS: VEMP amplitudes (IO, TRP, SOL) and horizontal and vertical vHIT gains all increased with high surface height conditions (p<0.05). Changes in IO and SCM VEMP amplitudes, as well as horizontal vHIT gains were correlated with changes in electrodermal activity (Rho=0.44 to 0.59, p<0.05). VEMP amplitude for the IO also positively correlated with fear (Rho = 0.43, p = 0.03).
CONCLUSION: Threat-induced anxiety, fear and arousal have significant effects on VSR and VOR gains that can be observed in both physiological and functional outcome measures. These findings provide support for a potential central modulation of the vestibular nuclei complex through excitatory inputs from neural centers involved in processing fear, anxiety, arousal and vigilance.

PMID: 26631147 [PubMed - as supplied by publisher]

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A Case of Spontaneous Intracranial Hypotension: The Role of Dynamic CT Myelography and Epidural Blood Patch in Diagnosis and Treatment.

A Case of Spontaneous Intracranial Hypotension: The Role of Dynamic CT Myelography and Epidural Blood Patch in Diagnosis and Treatment.

Conn Med. 2015 Oct;79(9):547-9

Authors: Kumar Y, Hooda K, Li S, Karol I, Muro GJ

Abstract
Spontaneous intracranial hypotension (SIH) most commonly results from cerebrospinal fluid (CSF) leaks in the upper spinal canal. Alterations in the equilibrium between the volumes of intracranial blood and CSF lead to compensatory dilatation of the vascular spaces, mostly on the venous side. Dynamic computerized tomogram (CT) myelography can be very helpful in diagnosing the site of a CSF leak in the spinal canal. Subsequently, the site of the leak can be sealed with epidural blood patch (EBP).

PMID: 26630707 [PubMed - in process]

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Response to Letter to the Editor by Bakshi et al.

Response to Letter to the Editor by Bakshi et al.

Ann Otol Rhinol Laryngol. 2015 Dec 1;

Authors: Ulualp S, Liu C

PMID: 26631765 [PubMed - as supplied by publisher]

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Revisiting Place-Pitch Match in CI Recipients Using 3D Imaging Analysis.

Revisiting Place-Pitch Match in CI Recipients Using 3D Imaging Analysis.

Ann Otol Rhinol Laryngol. 2015 Dec 1;

Authors: Devocht EM, Dees G, Arts RA, Smits JJ, George EL, van Hoof M, Stokroos RJ

Abstract
OBJECTIVE: To improve the estimation of the perceived pitch in a single-sided deaf cochlear implant (CI) listener by using accurate 3-dimensional (3D) image analysis of the cochlear electrode positions together with the predicted tonotopical function for humans.
METHODS: An SSD CI user underwent a Cone-Beam computed tomography (CBCT) scan. Electrode contacts were marked in 3D space in relation to the nearest point on the cochlear lateral wall. Distance to the base of the lateral wall was calculated and plotted against the place-pitch function for humans. An adaptive procedure was used to elicit the perceived pitch of electrically evoked stimulation by matching it with a contralateral acoustic pitch.
RESULTS: The electrically evoked pitch percept matched well with the calculated frequency. The median mismatch in octaves was 0.12 for our method in comparison to 0.69 using the conventional Stenvers view.
CONCLUSION: A method of improved image analysis is described that can be used to predict the pitch percept on corresponding cochlear electrode positions. This method shows the potential of 3D imaging in CI fitting optimization.

PMID: 26631764 [PubMed - as supplied by publisher]

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Malleus to Stapes Bone Cement Rebridging Ossiculoplasty: Why Don't We Perform Frequently?

Malleus to Stapes Bone Cement Rebridging Ossiculoplasty: Why Don't We Perform Frequently?

Ann Otol Rhinol Laryngol. 2015 Dec 1;

Authors: Edizer DT, Durna YM, Hamit B, Demirhan H, Yigit O

Abstract
OBJECTIVE: To evaluate the effectiveness of malleus to stapes bone cement rebridging (MS-BCR) for Austin Kartush group A ossicular defects and compare the audiological results with incus interposition (IP) and incus to stapes bone cement rebridging (IS-BCR).
METHODS: Patients for whom type 2 tympanoplasty had been performed in a tertiary referral center were examined. Revision cases and those with graft failure were excluded. Three treatment groups were IS-BCR, IP, and MS-BCR. Preoperative and postoperative audiological results were compared.
RESULTS: A total of 92 patients were enrolled. The IS-BCR was performed in 42 (45.65%), IP in 18 (19.56%), and MS-BCR in 32 (34.78%) patients. Postoperative mean air bone gap was 20.1 ± 9.8 dB HL and did not differ significantly between the groups (P = .271). Postoperative mean air bone gap less than 20 dB HL was achieved in 23 (54.7%) patients in IS-BCR, 10 (55.5%) patients in IP group, and 24 (75%) patients in MS-BCR group (P = .06). Mean closure in air bone gap was 14.0 ± 11.6 dB HL. The changes in mean and frequency-specific air bone gap were not significantly different between treatment groups (P > .05).
CONCLUSION: Malleus to stapes bone cement rebridging may provide hearing results comparable to IS-BCR and IP.

PMID: 26631763 [PubMed - as supplied by publisher]

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Identifying musical difficulties as they relate to congenital amusia in the pediatric population.

Identifying musical difficulties as they relate to congenital amusia in the pediatric population.

Int J Pediatr Otorhinolaryngol. 2015 Nov 10;

Authors: Wilcox LJ, He K, Derkay CS

Abstract
INTRODUCTIONS/OBJECTIVES: Approximately 4% of the population fails to develop basic music skills and can be identified as "amusic". Congenital amusia (CA), or "tone deafness", is thought to be a hereditary disordera predominantly affecting the perception and production of music. The gold standard for diagnosis is the Montreal Battery for Evaluation of Amusia (MBEA). This study aims to pinpoint factors in the history that may help identify amusic children and to determine if amusic pediatric patients can be identified using a widely available, shorter test validated in adults.
METHODS: Subjects ages 7-17 years were recruited to take an online test, validated against the MBEA, for CA. The sections tested recognition of "off-beat" (OB), "mistuned" (MT), and "out-of-key" (OOK) conditions. Parents filled out a questionnaire regarding the subject's past medical, educational, musical exposure, and family history.
RESULTS: Of 114 subjects recruited, complete data was available on 105 with a mean age of 12.5 years. According to adult criteria, 63/105 (60%) of subjects scored in the "amusic" range. Children >10 years of age scored significantly higher on the off-beat section (p=0.001) and total scores (p=0.025). Subjects who were born prematurely scored significantly lower (p=0.045). Children whose father had difficulties with music scored significantly lower on the off-beat section (p=0.003) and total scores (p=0.008).
CONCLUSIONS: CA is a disorder that has implications for quality of life. Earlier identification may help elucidate the pathogenesis of the condition and, in the future, the institution of prompt treatment. Further studies are needed to identify the most appropriate and convenient tests, as well as the optimal timing of testing, for reliably diagnosing CA in children.

PMID: 26631597 [PubMed - as supplied by publisher]

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Submandibular Lateral Ectopic Thyroid Tissue: Ultrasonography, Computed Tomography, and Scintigraphic Findings.

Submandibular Lateral Ectopic Thyroid Tissue: Ultrasonography, Computed Tomography, and Scintigraphic Findings.

Case Rep Otolaryngol. 2015;2015:769604

Authors: Çeliker M, Beyazal Çeliker F, Turan A, Beyazal M, Beyazal Polat H

Abstract
Ectopic thyroid can be encountered anywhere between the base of tongue and pretracheal region. The most common form is euthyroid neck mass. Herein, we aimed to present the findings of a female case with ectopic thyroid tissue localized in the left submandibular region. A 44-year-old female patient, who underwent bilateral subtotal thyroidectomy four years ago with the diagnosis of multinodular goiter, was admitted to our hospital due to a mass localized in the left submandibular area that gradually increased in the last six months. Neck ultrasonography, contrast-enhanced computed tomography, and scintigraphic examination were performed on the patient. On thyroid scintigraphy with Tc-99m pertechnetate, thyroid tissue activity uptake showing massive radioactivity was observed in the normal localization of the thyroid gland and in the submandibular localization. The focus in the submandibular region was excised. Pathological examination of the specimen showed normal thyroid follicle cells with no signs of malignancy. The submandibular mass is a rarely encountered lateral ectopic thyroid tissue. Accordingly, ectopic thyroid tissue should also be considered in the differential diagnosis of masses in the submandibular region.

PMID: 26634164 [PubMed - as supplied by publisher]

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OtoRhinoLaryngology & Medicine,New Articles,December 4th,2015,a

Breast cancer stem cells: are we ready to go from bench to bedside?

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Since the discovery of breast cancer stem cells (BCSCs) more than 10 years ago, a body of exciting research has developed. The intrinsic properties of BCSCs, including self-renewal and the ability to give rise to heterogeneous progeny, make BCSCs a likely source of tumour initiation, heterogeneity, progression and metastasis. BCSCs are also inherently resistant to conventional therapies and are therefore thought to contribute to disease recurrence. In this review, we will focus on both the challenges and recent advances in the characterization of BCSCs with respect to phenotype, ... περισσότερα »

Annual Review Issue: Breast Pathology

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

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Ductal carcinoma in situ – update on risk assessment and management

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Ductal carcinoma *in situ* (DCIS) accounts for ~20–25% of breast cancers. While DCIS is not life-threatening, it may progress to invasive carcinoma over time, and treatment intended to prevent invasive progression may itself cause significant morbidity. Accurate risk assessment is therefore necessary to avoid over- or undertreatment of an individual patient. In this review we will outline the evidence for current management of DCIS, discuss approaches to DCIS risk assessment and challenges facing identification of novel DCIS biomarkers. from Anatomy Pathology via xlomafota13 on ... περισσότερα »

Recommendations for excision following core needle biopsy of the breast: a contemporary evaluation of the literature

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Pathologists frequently encounter non-malignant histological findings in percutaneous core needle biopsies (CNBs). Standards for the management of patients with lesions such as atypical ductal hyperplasia, atypical lobular hyperplasia, and lobular carcinoma *in situ*, as well as other benign lesions, are not well defined, and recommendations for surgical biopsy or continued clinical and radiological follow-up are inconsistent. The frequency with which these lesions are 'upgraded' to carcinoma in excision specimens is widely variable in the literature. Many CNB studies lack carefu... περισσότερα »

Οtosclerosis and osteoporosis

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 25 δευτερόλεπτα

Relation of otosclerosis and osteoporosis: A bone mineral density study: Otosclerosis and osteoporosis are metabolic bone diseases. In this paper, we investigated presence of osteoporosis with bone mineral density test in patients who had surgery for otosclerosis. AbstractObjective Otosclerosis and osteoporosis are metabolic bone diseases. In this paper, we investigated presence of osteoporosis with bone mineral density test in patients who had surgery for otosclerosis. Methods We included 27 patients who had conductive hearing loss and diagnosed with otosclerosis during an explorat...περισσότερα »

Cholinergic deafferentation of the hippocampus causes non-temporally graded retrograde amnesia in an odor discrimination task

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 25 δευτερόλεπτα

[image: alertIcon.gif] Publication date: 15 February 2016 *Source:*Behavioural Brain Research, Volume 299 Author(s): Jenny R. Köppen, Sarah L. Stuebing, Megan L. Sieg, Ashley A. Blackwell, Philip A. Blankenship, Joseph L. Cheatwood, Douglas G. Wallace Dementia of the Alzheimer's type (DAT) is a neurodegenerative disorder marked by loss of hippocampal cholinergic tone and significant memory impairments, specifically for memories acquired prior to disease onset. The nature of this relationship, however, remains debated. The current study used the string pulling task to evaluate the tem...περισσότερα »

Mitigating aflatoxin exposure to improve child growth

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα

Mitigating aflatoxin exposure to improve child growth in Eastern Kenya: study protocol for a randomized controlled trial: Background: While the few studies that have looked at the association between stunting and aflatoxin exposure have found surprisingly large effects, the results remain inconclusive due to a lack of randomized controlled studies. This protocol describes a non-blinded, cluster-randomized controlled trial with the specific objective of testing the impact of reduced aflatoxin exposure on (individual) child linear growth.Methods/DesignParticipants were recruited from a... περισσότερα »

Photodynamic therapy for the endodontic treatment of primary teeth

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα

Evaluation of the effectiveness of photodynamic therapy for the endodontic treatment of primary teeth: study protocol for a randomized controlled clinical trial: Background: The elimination of pathogenic microorganisms from the root canal system is one of the major steps required for successful endodontic treatment. The aim of the proposed study is to conduct a randomized, controlled, clinical trial for the clinical and radiographic evaluation of the effectiveness of photodynamic therapy during the endodontic treatment of primary teeth. Methods: Thirty primary anterior teeth in childr... περισσότερα »

RhoA-JNK Regulates the E-Cadherin Junctions of Human Gingival Epithelial Cells

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα

The junctional epithelium (JE) is unique with regard to its wide intercellular spaces and sparsely developed intercellular junctions. Thus, knowledge of the molecular mechanisms that regulate the formation of the intercellular junctions of the junctional epithelium may be essential to understand the pathophysiology of the JE. HOK-16B cells, a normal human gingival epithelial cell line, were used to identify the molecules involved in the regulation of the formation of intercellular E-cadherin junctions between human gingival epithelial cells. Activation of c-Jun N-terminal kinase (... περισσότερα »

Low Signals on T2* and SWI Sequences in Patients with MS with Progressive Multifocal Leukoencephalopathy [LETTERS]

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

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Reply: [letter]

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

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A Systematic Review and Meta-Analysis of Treatment and Outcome of Blister-Like Aneurysms [ADULT BRAIN]

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

BACKGROUND AND PURPOSE: Blister-like aneurysms are uncommon but challenging lesions. Their small size and atypical location often make the diagnosis difficult. Microsurgery and endovascular procedures have been used for their treatment, but there is no consensus on the best treatment technique. We conducted a systematic review and meta-analysis of treatments and outcomes of these vascular lesions. MATERIALS AND METHODS: We reviewed English-language articles on "blood blister-like aneurysms" published between January 1997 and November 2014. All studies reporting patients with th... περισσότερα »

Radiographic Local Control of Spinal Metastases with Percutaneous Radiofrequency Ablation and Vertebral Augmentation [INTERVENTIONAL]

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

BACKGROUND AND PURPOSE: Combination radiofrequency ablation and vertebral augmentation is an emerging minimally invasive therapy for patients with metastatic spine disease who have not responded to or have contraindications to radiation therapy. The purpose of this study was to evaluate the rate of radiographic local control of spinal metastases treated with combination radiofrequency ablation and vertebral augmentation. MATERIALS AND METHODS: We retrospectively reviewed our tumor ablation database for all patients who underwent radiofrequency ablation and vertebral augmentation...περισσότερα »

Asymptomatic Interhypothalamic Adhesions in Children [PEDIATRICS]

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

SUMMARY: With the use of high-resolution MR imaging techniques, we have increasingly observed anomalies of the hypothalamus characterized by a band of tissue spanning the third ventricle between the hypothalami, often without associated clinical sequelae. Historically, hypothalamic anomalies are highly associated with symptoms referable to a hypothalamic hamartoma, midline congenital disorder, hypothalamic-pituitary dysfunction, or seizures, with very few asymptomatic patients reported. The interhypothalamic tissue described in our cohort was observed incidentally through the ro... περισσότερα »

Prevalence of Brain Microbleeds in Alzheimer Disease: A Systematic Review and Meta-Analysis on the Influence of Neuroimaging Techniques [ADULT BRAIN]

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

BACKGROUND AND PURPOSE: The literature on the prevalence of Alzheimer disease–associated cerebral microbleeds assessed with MR imaging shows considerable heterogeneity in terms of imaging techniques and parameters. Our aim was to perform a meta-analysis of the role of imaging techniques, including image acquisition, field strength and scanner type, and clinical and demographic factors on the reported prevalence of microbleeds in Alzheimer disease. MATERIALS AND METHODS: The prevalence of microbleeds was examined with respect to a priori–selected moderating variables via meta-ana... περισσότερα »

RhoA-JNK Regulates the E-Cadherin Junctions of Human Gingival Epithelial Cells

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Light-Cured Self-Etch Adhesives Undergo Hydroxyapatite-Triggered Self-Cure

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Light cure is a popular mode of curing for dental adhesives. However, it suffers from inadequate light delivery when the restoration site is less accessible, in which case a self-cure mechanism is desirable to salvage any compromised polymerization. We previously reported a novel self-cure system mediated by ethyl 4-(dimethylamino)-benzoate (4E) and hydroxyapatite (HAp). The present work aims to investigate if such self-cure phenomenon takes place in adhesives that underwent prior inadequate light cure and to elucidate if HAp released from the dental etching process is sufficient t...περισσότερα »