Treatment of squamous cell carcinoma of the posterior pharyngeal wall: Radiotherapy versus surgery.

Treatment of squamous cell carcinoma of the posterior pharyngeal wall: Radiotherapy versus surgery.

Head Neck. 2015 Nov 28;

Authors: De Felice F, Blanchard P, Levy A, Nguyen F, Gorphe P, Janot F, Temam S, Tao Y

Abstract
BACKGROUND: Treatment strategy in squamous cell carcinoma (SCC) of the posterior pharyngeal wall is still being debated.
METHODS: We performed a retrospective analysis according to delivered treatment.
RESULTS: One hundred eighty patients were treated between 1997 and 2011. Eighty-nine patients (49.4%) received surgery +/- radiotherapy (RT), whereas 91 (50.6%) received definitive RT +/- chemoradiotherapy (RT/CRT). Five-year overall survival (OS) was 33.4%. There was a significant 5-year OS benefit in surgical treatment versus RT/CRT (43% vs 24.1%; p = .002). Multivariate analysis showed that current smokers, T3 to T4 classification, well-differentiated SCC, and nonsurgical treatment were associated with reduced OS. Subgroup analysis showed significant survival benefit of surgical treatment compared with RT/CRT in patients with T1 to T2 but not in T3 to T4 disease.
CONCLUSION: Surgical management translated into a survival benefit, even in early T classification. These results should be interpreted with caution for selection bias. Surgery remains the standard of care in localized posterior pharyngeal wall SCC. Primary CRT should be considered for nonoperable disease. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26613802 [PubMed - as supplied by publisher]

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