Sinonasal mucosal melanoma: A 12-year experience of 58 cases.

Sinonasal mucosal melanoma: A 12-year experience of 58 cases.

Head Neck. 2015 Dec 17;

Authors: Lombardi D, Bottazzoli M, Turri-Zanoni M, Raffetti E, Villaret AB, Morassi ML, Ungari M, Vermi W, Battaglia P, Castelnuovo P, Facco C, Sessa F, Donato F, Nicolai P

Abstract
BACKGROUND: Sinonasal mucosal melanoma is a rare malignancy with poor prognosis.
METHODS: Patients with sinonasal malignant melanoma who underwent surgery by different approaches were included in this study. Overall survival (OS) and event-free survival were calculated, and statistically significant variables by univariate analysis were entered in a multivariate Cox regression model.
RESULTS: Pathological staging was pT3, pT4a, and pT4b in 30 cases (51.7%), 17 cases (29.3%), and 11 cases (19.0%). At 3 and 5 years, OS was 43.5% and 29% and event-free survival was 23.6% and 12.4%, respectively. At univariate analysis, OS was significantly influenced by male sex, advanced pT classification, positive margins, and surgical approach; event-free survival was affected by positive margins. At multivariate analysis, the risk of death was independently associated with male sex (hazard ratio [HR] = 2.27; p = .04) and positive margins (HR = 2.32; p = .03).
CONCLUSION: Male sex and positive margins were negative prognostic factors. Endoscopic resection did not show an increased risk of death compared with more extensive surgical approaches. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26676523 [PubMed - as supplied by publisher]

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