Ameloblastic carcinoma (secondary type) with extensive squamous differentiation areas and dedifferentiated regions.

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Ameloblastic carcinoma (secondary type) with extensive squamous differentiation areas and dedifferentiated regions.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Oct 13;

Authors: Fonseca FP, de Almeida OP, Vargas PA, Gonçalves F, Corrêa Pontes FS, Rebelo Pontes HA

Abstract
Ameloblastic carcinoma is rare, accounting for 1.5%-2.0% of all odontogenic tumors. Few small series are available, but data on its clinicopathologic characteristics derive mainly from single case reports; therefore, descriptions of new cases may help to better understand the biological characteristics of this rare odontogenic malignancy. In the current report we describe an ameloblastic carcinoma affecting a 27-year-old female patient who had a previous diagnosis of ameloblastoma 7 years before. The carcinoma featured extensive areas of squamous differentiation resembling a primary intraosseous squamous cell carcinoma, as well as areas of dedifferentiation, a poorly documented histologic characteristic of ameloblastic carcinoma. This case provides new insights on the microscopic spectrum of ameloblastic carcinoma, permitting a critical discussion of the current World Health Organization classification of this odontogenic tumor.

PMID: 26768075 [PubMed - as supplied by publisher]

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