A comparative histopathological study of vocal fold polyps in smokers versus non-smokers.

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A comparative histopathological study of vocal fold polyps in smokers versus non-smokers.

J Laryngol Otol. 2015 May;129(5):484-8

Authors: Effat KG, Milad M

Abstract
BACKGROUND: A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been performed.
METHODS: A prospective histopathological study of vocal fold polyps excised from 29 patients was undertaken. This comprised a comparative analysis of polyp histopathology in smokers versus non-smokers and a review of the pertinent literature.
RESULTS: Vocal fold polyps were larger in smokers than in non-smokers. Histopathological features significantly associated with the polyps of smokers versus those of non-smokers were increased keratinisation, dysplasia, a basement membrane thinning and hyaline degeneration.
CONCLUSION: Cigarette smoke has an injurious effect on vocal fold polyp epithelium and leads to increased hyaline degeneration in polyps.

PMID: 25788125 [PubMed - indexed for MEDLINE]

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