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Epiglottic Squamous Cell Carcinoma Showing Unexpected 18F-FDOPA Uptake on PET/CT Investigation.
Clin Nucl Med. 2015 Jul;40(7):e370-1
Authors: Dietemann S, Debry C, Onea A, Namer IJ, Imperiale A
Abstract
We report the unexpected findings of ¹⁸F-fluorodihydroxyphenylalanine (¹⁸F-FDOPA) PET/CT performed in a patient with a history of ileal carcinoid. A focally increased ¹⁸F-FDOPA uptake was detected in the left side of the epiglottis corresponding to a laryngeal squamous cell carcinoma. Interestingly, uptake of 3-O-methyl-6-¹⁸F-fluoro-L-dihydroxyphenylalanine, a metabolite of ¹⁸F-FDOPA, has been previously reported in both squamous cell carcinoma cell lines and the corresponding mouse tumor xenograft models. Although ¹⁸F-FDOPA is mainly used in patients with neuroendocrine tumors, ¹⁸F-FDOPA is not a neuroendocrine tumor-specific radiotracer.
PMID: 26018705 [PubMed - indexed for MEDLINE]
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