Risk factors for patients with multiple synchronous primary cancers involving oral and oropharyngeal subsites.

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Risk factors for patients with multiple synchronous primary cancers involving oral and oropharyngeal subsites.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Nov 14;

Authors: Feng Z, Xu QS, Niu QF, Qin LZ, Li JZ, Su M, Li H, Han Z

Abstract
OBJECTIVE: To evaluate risk factors and prognosis for multiple synchronous primary cancers (MSPCs) associated with head and neck squamous cell carcinoma.
STUDY DESIGN: The retrospective study included 1623 patients.
RESULTS: The most common MSPC site involved was the head and neck region. The presence of multiple oral dysplastic lesions (P < .001) was the sole risk factor for the occurrence of MSPCs. A multivariate survival analysis showed that the pathologic grade (P = .003) was an independent predictive factor for the 5-year disease-specific survival of patients with MSPCs. A Kaplan-Meier analysis showed that the 5-year disease-specific survival of patients who developed MSPCs was worse than that of patients who did not develop MSPCs (P = .020).
CONCLUSIONS: MSPCs are a significant negative prognostic factor for patients with head and neck squamous cell carcinoma. However, a worse prognosis is predicted for patients with MSPCs with several features: a higher pathologic grade, a more aggressive growth pattern, male gender plus a tobacco or alcohol habit, and no multiple oral dysplastic lesions.

PMID: 26899291 [PubMed - as supplied by publisher]

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