Noncentrosomal Microtubules Regulate Autophagosome Transport through CAMSAP2-EB1 Cross-Talk.

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Noncentrosomal Microtubules Regulate Autophagosome Transport through CAMSAP2-EB1 Cross-Talk.

FEBS Lett. 2017 Jul 20;:

Authors: Wei J, Xu H, Meng W

Abstract
Microtubules (MTs) play essential roles in many steps of autophagy, an important degradation pathway in the maintenance of cellular homoeostasis. In many cells, MT networks are comprised of centrosomal MTs and noncentrosomal MTs. However, it is unknown whether noncentrosomal MTs and its binding proteins are involved in autophagy. Here, we show in HeLa cells that CAMSAP2, a noncentrosomal MT minus-end stabilizing protein, regulates retrograde transport of autophagosomes through MT dynamics. CAMSAP2 cooperates with EB1 to regulate EB1 behavior at MT plus-ends, MT growth directions and autophagosome transport. An association between CAMSAP2 and EB1 in the cytosol may modulate EB1 binding to MT plus- ends. Collectively, our data indicate that noncentrosomal MTs regulate autophagy through a cross-talk between CAMSAP2 and EB1. This article is protected by copyright. All rights reserved.

PMID: 28726242 [PubMed - as supplied by publisher]

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