Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population

Publication date: Available online 1 August 2017
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Huntürk Atilla, Sibel Özdaş, Talih Özdaş, Sibel Baştimur, Sami Engin Muz, Işılay Öz, Kenan Kurt, Afife İzbirak, Mehmet Ali Babademez, Nilgün Vatandaş
IntroductionAdenoid hypertrophy (AH) is a condition that presents itself as the chronic enlargement of adenoid tissues; it is frequently observed in the pediatric population. The Ugrp2 gene, a member of the secretoglobin superfamily, encodes a low-molecular weight protein that functions in the differentiation of upper airway epithelial cells. However, little is known about the association of Ugrp2 genetic variations with AH.ObjectiveThe aim of this study is to investigate the association of single nucleotide polymorphisms (SNPs) in the Ugrp2 gene with AH and its related phenotypes.MethodsA total of 219 children, comprising 114 patients suffering from AH and 105 healthy patients without AH, were enrolled in this study. Genotypes of the Ugrp2 gene were determined by DNA sequencing.ResultsWe identified four SNPs (IVS1-189G>A, IVS1-89T>G, c.201delC, and IVS2-15G>A) in the Ugrp2 gene. Our genotype analysis showed that the Ugrp2 (IVS1-89T>G) TG and (c.201delC) CdelC genotypes and their minor alleles were associated with a considerable increase in the risk of AH compared with the controls (p=0.012, p=0.009, p=0.013, and p=0.037, respectively). Furthermore, Ugrp2 (GTdelCG, GTdelCA) haplotypes were significantly associated with AH (four SNPs ordered from 5′ to 3′; p=0.0001). SNP–SNP interaction analysis indicated a strong interaction between combined genotypes of the Ugrp2 gene contributing to AH, as well as an increased chance of diagnosis of AH (p<0.0001). In addition, diplotypes carrying the mutant Ugrp2 (c.201delC) allele were strongly associated with an increased risk of AH with asthma and AH with allergies (p=0.003 and p=0.0007, respectively).ConclusionSome SNPs and their combinations in the Ugrp2 gene are associated with an increased risk of developing AH. Therefore, we tried to underline the importance of genetic factors associated with AH and AH-related clinical phenotypes.



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